Research output per year
Research output per year
- 30 results
Search results
-
2023
Extracellular vesicles in COVID-19 convalescence can regulate T cell metabolism and function
George, M. S., Sanchez, J., Rollings, C., Fear, D., Irving, P., Sinclair, L. V. & Schurich, A., 18 Aug 2023, In: iScience. 26, 8, 107280.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)62 Downloads (Pure) -
2022
SARS-CoV-2-Specific Memory B Cell Responses Are Maintained After Recovery from Natural Infection and Postvaccination
Moore, T., Hossain, R., Doores, K. J., Shankar-Hari, M. & Fear, D. J., 2 Aug 2022, In: Viral Immunology. 35, 6, p. 425-436 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)77 Downloads (Pure) -
SARS-CoV-2-specific memory B cell responses are maintained after recovery from natural infection and post vaccination
Fear, D., 1 Jul 2022, (Accepted/In press) In: Viral Immunology.Research output: Contribution to journal › Article › peer-review
File47 Downloads (Pure) -
2021
Exosome-mediated RNAi of PAK4 prolongs survival of pancreatic cancer mouse model after loco-regional treatment
Xu, L., Faruqu, F. N., Lim, Y. M., Lim, K. Y., Liam-Or, R., Walters, A. A., Lavender, P., Fear, D., Wells, C. M., Tzu-Wen Wang, J. & Al-Jamal, K. T., Jan 2021, In: Biomaterials. 264, 120369.Research output: Contribution to journal › Article › peer-review
50 Citations (Scopus) -
Human marginal zone B cell development from early T2 progenitors
Spencer, J., Tull, T., Pitcher, M., Guesdon, W., Siu, J. HY., Lebraro-Fernandez, C., Zhao, Y., Petrov, N., Heck, S., Ellis, R., Dhami, P., kadolsky, U., Kleeman, M., Kamra, Y., Fear, D., John, S., Jassem, W., Groves, R., Sanderson, J. D., Robson, M., & 2 others, 5 Apr 2021, In: Journal of Experimental Medicine. 218, 4, e20202001.Research output: Contribution to journal › Article › peer-review
Open AccessFile47 Citations (Scopus)223 Downloads (Pure) -
Quantitative assessment of NFκB transcription factor activity
Hunter, T. T. J., Fear, D., Lavender, P., Spencer, J., Peakman, M. & Ibrahim, M. A. A., May 2021, In: Journal of Immunological Methods. 492, 112954.Research output: Contribution to journal › Article › peer-review
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2020
Altered chromatin landscape in circulating T follicular helper and regulatory cells following grass pollen subcutaneous and sublingual immunotherapy
Sharif, H., Acharya, S., Dhondalay, G. K. R., Varricchi, G., Krasner-Macleod, S., Laisuan, W., Switzer, A., Lenormand, M., Kashe, E., Parkin, R. V., Yi, Y., Koc, M., Fedina, O., Vilà-Nadal, G., Marone, G., Eifan, A., Scadding, G. W., Fear, D. J., Nadeau, K. C., Durham, S. R., & 1 others, 2020, (Accepted/In press) In: Journal of Allergy and Clinical Immunology.Research output: Contribution to journal › Article › peer-review
Open Access52 Citations (Scopus) -
2019
Transcriptional analysis of the human IgE-expressing plasma cell differentiation pathway
Ramadani, F., Bowen, H., Gould, H. J. & Fear, D. J., 11 Mar 2019, In: Frontiers in Immunology. 10, MAR, 1 p., 402.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)61 Downloads (Pure) -
2018
miR-29b directly targets activation-induced cytidine deaminase in human B cells and can limit its inappropriate expression in naïve B cells
Recaldin, T., Hobson, P. S., Mann, E. H., Ramadani, F., Cousins, D. J., Lavender, P. & Fear, D. J., Sept 2018, In: Molecular Immunology. 101, p. 419-428Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)343 Downloads (Pure) -
Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue
Zhao, Y., Uduman, M., Siu, J., Tull, T. J., Sanderson, J., Wu, Y-C. B., Zhou, J. Q., Petrov, N., Ellis, R. J., Todd, S. K., Chavele, K-M., Guesdon, W. W. J., Vossenkamper, A., Jassem, W., D’Cruz, D., Fear, D. J., John, S., Scheel-Toellner, D., hopkins, C., Moreno, E., & 6 others, 21 Sept 2018, In: Nature Communications. 9, 1, 15 p., 3857.Research output: Contribution to journal › Article › peer-review
Open AccessFile75 Citations (Scopus)336 Downloads (Pure) -
2017
Activation-Associated Accelerated Apoptosis of Memory B Cells in Critically Ill Patients With Sepsis
Shankar-Hari, M., Fear, D., Lavender, P., Mare, T., Beale, R., Swanson, C., Singer, M. & Spencer, J., May 2017, In: Critical Care Medicine. 45, 5, p. 875-882 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile76 Citations (Scopus)450 Downloads (Pure) -
BET proteins are a key component of immunoglobulin gene expression
Shim, J. M., Lee, J. S., Russell, K. E., Wiegman, C. H., Barnes, P. J., Fear, D., Adcock, I. M. & Durham, A. L., 1 Apr 2017, In: Epigenomics. 9, 4, p. 393-406 14 p.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
Ontogeny of Human IgE-expressing B Cells and Plasma Cells
Ramadani, F., Bowen, H., Upton, N., Hobson, P. S., Chan, Y-C., Chen, J-B., Chang, T. W., McDonnell, J. M., Sutton, B. J., Fear, D. J. & Gould, H. J., 1 Jan 2017, In: Allergy. 72, 1, p. 66-76 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile40 Citations (Scopus)203 Downloads (Pure) -
2016
Global gene regulation during activation of immunoglobulin class switching in human B cells
Zhang, Y., Fear, D. J., Willis-Owen, S. A. G., Cookson, W. O. & Moffatt, M. F., 29 Nov 2016, In: Scientific Reports. 6, 37988.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)166 Downloads (Pure) -
IgG subclass switching and clonal expansion in cutaneous melanoma and normal skin
Saul, L., Ilieva, K. M., Bax, H. J., Karagiannis, P., Correa, I., Rodriguez-Hernandez, I., Josephs, D. H., Tosi, I., Egbuniwe, I. U., Lombardi, S., Crescioli, S., Hobbs, C., Villanova, F., Cheung, A., Geh, J. L. C., Healy, C., Harries, M., Sanz-Moreno, V., Fear, D. J., Spicer, J. F., & 3 others, 14 Jul 2016, In: Scientific Reports. 6, 29736.Research output: Contribution to journal › Article › peer-review
Open AccessFile47 Citations (Scopus)213 Downloads (Pure) -
Transcription factors regulating B cell fate in the germinal centre
Recaldin, T. & Fear, D. J., Jan 2016, In: Clinical and Experimental Immunology. 183, 1, p. 65-75 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile38 Citations (Scopus)61 Downloads (Pure) -
2015
Intrinsic Properties of Germinal Centre-derived B cells Promote their Enhanced Class Switching to IgE
Ramadani, F., Upton, N. E. G., Hobson, P. S., Chan, Y-C., Mzinza, D., Bowen, H., Kerridge, C., Sutton, B. J., Fear, D. J. & Gould, H. J., 25 Oct 2015, In: Allergy. 70, 10, p. 1269-1277 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)49 Downloads (Pure) -
2013
IgG4 subclass antibodies impair antitumor immunity in melanoma
Karagiannis, P., Gilbert, A. E., Josephs, D. H., Ali, N., Dodev, T., Saul, L., Correa, I., Roberts, L., Beddowes, E., Koers, A., Hobbs, C., Ferreira, S., Geh, J., Healy, C., Harries, M., Acland, K. M., Blower, P. J., Mitchell, T., Fear, D. J., Spicer, J. F., & 3 others, 1 Apr 2013, In: Journal of Clinical Investigation. 123, 4, p. 1457–1474 18 p.Research output: Contribution to journal › Article › peer-review
178 Citations (Scopus) -
Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps
Gevaert, P., Nouri-Aria, K. T., Wu, H., Harper, C. E., Takhar, P., Fear, D. J., Acke, F., De Ruyck, N., Banfield, G., Kariyawasam, H. H., Bachert, C., Durham, S. R. & Gould, H., Jan 2013, In: Allergy. 68, 1, p. 55-63 9 p.Research output: Contribution to journal › Article › peer-review
129 Citations (Scopus) -
Mechanisms regulating the targeting and activity of Activation Induced cytidine Deaminase
Fear, D., Oct 2013, In: Current Opinion in Immunology. 25, 5, p. 619–628 10 p., N/A.Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus) -
2012
Comprehensive FISH Probe Design Tool Applied to Imaging Human Immunoglobulin Class Switch Recombination
Nedbal, J., Hobson, P. S., Fear, D. J., Heintzmann, R. & Gould, H., 14 Dec 2012, In: PLoS ONE. 7, 12, p. N/A 7 p., e51675.Research output: Contribution to journal › Article › peer-review
Open Access9 Citations (Scopus) -
Soluble CD23 Controls IgE Synthesis and Homeostasis in Human B Cells
Cooper, A. M., Hobson, P. S., Jutton, M. R., Kao, M. W., Drung, B., Schmidt, B., Fear, D. J., Beavil, A. J., McDonnell, J. M., Sutton, B. J. & Gould, H. J., 1 Apr 2012, In: Journal of Immunology. 188, 7, p. 3199 - 3207 9 p.Research output: Contribution to journal › Article › peer-review
58 Citations (Scopus) -
2011
High Resolution Analysis of the Chromatin Landscape of the IgE Switch Region in Human B Cells
Dayal, S., Nedbal, J., Hobson, P., Cooper, A. M., Gould, H. J., Gellert, M., Felsenfeld, G. & Fear, D. J., 20 Sept 2011, In: PL o S One . 6, 9, e24571.Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus) -
2008
Analysis of intergenic transcription and histone modification across the human immunoglobulin heavy-chain locus
Chowdhury, M., Forouhi, O., Dayal, S., McCloskey, N., Gould, H. J., Felsenfeld, G. & Fear, D. J., 14 Oct 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 41, p. 15872 - 15877 6 p.Research output: Contribution to journal › Article › peer-review
40 Citations (Scopus) -
Gene expression subtypes in patients with chronic fatigue syndrome/myalgic encephalomyelitis
Kerr, J. R., Petty, R., Burke, B., Gough, J., Fear, D., Sinclair, L. I., Mattey, D. L., Richards, S. C. M., Montgomery, J., Baldwin, D. A., Kellam, P., Harrison, T. J., Griffin, G. E., Main, J., Enlander, D., Nutt, D. J. & Holgate, S. T., 15 Apr 2008, In: Journal of Infectious Diseases. 197, 8, p. 1171 - 1184 14 p.Research output: Contribution to journal › Article › peer-review
109 Citations (Scopus) -
Seven genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis: a detailed analysis of gene networks and clinical phenotypes
Kerr, J. R., Burke, B., Petty, R., Gough, J., Fear, D., Mattey, D. L., Axford, J. S., Dalgleish, A. G. & Nutt, D. J., Jun 2008, In: Journal of Clinical Pathology. 61, 6, p. 730 - 739 10 p.Research output: Contribution to journal › Article › peer-review
49 Citations (Scopus) -
2007
IgE-antibody-dependent immunotherapy of solid tumors: Cytotoxic and phagocytic mechanisms of eradication of ovarian cancer cells
Karagiannis, S., Bracher, M. G., Hunt, J., McCloskey, N., Beavil, R. L., Beavil, A. J., Fear, D. J., Thompson, R. G., East, N., Burke, F., Moore, R. J., Dombrowicz, D. D., Balkwill, F. R. & Gould, H. J., 1 Sept 2007, In: Journal of Immunology. 179, 5, p. 2832 - 2843 12 p.Research output: Contribution to journal › Article › peer-review
94 Citations (Scopus) -
Soluble CD23 monomers inhibit and oligomers stimulate IGE synthesis in human B cells
McCloskey, N., Hunt, J., Beavil, R. L., Jutton, M. R., Grundy, G. J., Girardi, E., Fabiane, S. M., Fear, D. J., Conrad, D. H., Sutton, B. J. & Gould, H. J., 17 Aug 2007, In: Journal of Biological Chemistry. 282, 33, p. 24083 - 24091 9 p.Research output: Contribution to journal › Article › peer-review
66 Citations (Scopus) -
2005
Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis
Takhar, P., Smurthwaite, L., Coker, H. A., Fear, D. J., Banfield, G. K., Carr, V. A., Durham, S. R. & Gould, H. J., 15 Apr 2005, In: Journal of Immunology. 174, 8, p. 5024 - 5032 9 p.Research output: Contribution to journal › Article › peer-review
187 Citations (Scopus) -
2004
Transcription of Ig germline genes in single human B cells and the role of cytokines in isotype determination
Fear, D. J., McCloskey, N., O'Connor, B., Felsenfeld, G. & Gould, H. J., 1 Oct 2004, In: Journal of Immunology. 173, 7, p. 4529 - 4538 10 p.Research output: Contribution to journal › Article › peer-review
40 Citations (Scopus)