King's College London

Research portal

Professor Debbie Shawcross

  1. Diarrhoea and preadmission antibiotic exposure in COVID-19: a retrospective cohort study of 1153 hospitalised patients

    Mateen, B. A., Samanta, S., Tullie, S., O'Neill, S., Cargill, Z., Kelly, G., Brennan, E., Patel, M., Al-Agil, M., Galloway, J., Teo, J., Shawcross, D. L., Kent, A. J. & Hayee, BH., Sep 2021, In: BMJ open gastroenterology. 8, 1

    Research output: Contribution to journalArticlepeer-review

  2. Meeting the challenge of antimicrobial resistance in cirrhosis: the invisible threat that lies within

    Edwards, L. A., Goldenberg, S. D. & Shawcross, D. L., Aug 2021, In: Gastroenterology. 161, 2, p. 413-415 3 p.

    Research output: Contribution to journalEditorialpeer-review

  3. The microbiota in cirrhosis and its role in hepatic decompensation

    Trebicka, J., Macnaughtan, J., Schnabl, B., Shawcross, D. L. & Bajaj, J. S., Jul 2021, In: Journal of Hepatology. 75 Suppl 1, p. S67-S81

    Research output: Contribution to journalReview articlepeer-review

  4. The Level of Alcohol Consumption in the Prior Year Does Not Impact Clinical Outcomes in Patients With Alcohol-Associated Hepatitis

    Musto, J. A., Eickhoff, J., Ventura-Cots, M., Abraldes, J. G., Bosques-Padilla, F., Verna, E. C., Brown, R. S., Vargas, V., Altamirano, J., Caballería, J., Shawcross, D., Louvet, A., Mathurin, P., Garcia-Tsao, G., Schnabl, B., Bataller, R. & Lucey, M. R., 10 Jun 2021, (Accepted/In press) In: Liver Transplantation.

    Research output: Contribution to journalArticlepeer-review

  5. Soluble TIM3 and Its Ligands Galectin-9 and CEACAM1 Are in Disequilibrium During Alcohol-Related Liver Disease and Promote Impairment of Anti-bacterial Immunity

    Riva, A., Palma, E., Devshi, D., Corrigall, D., Adams, H., Heaton, N., Menon, K., Preziosi, M., Zamalloa, A., Miquel, R., Ryan, J. M., Wright, G., Fairclough, S., Evans, A., Shawcross, D., Schierwagen, R., Klein, S., Uschner, F. E., Praktiknjo, M., Katzarov, K. & 6 others, Hadzhiolova, T., Pavlova, S., Simonova, M., Trebicka, J., Williams, R. & Chokshi, S., 10 Mar 2021, In: Frontiers in Physiology. 12, p. 632502 632502.

    Research output: Contribution to journalArticlepeer-review

  6. Trajectory of Serum Bilirubin Predicts Spontaneous Recovery in a Real-World Cohort of Patients with Alcoholic Hepatitis

    Parker, R., Cabezas, J., Altamirano, J., Arab, J. P., Ventura-Cots, M., Sinha, A., Dhanda, A., Arrese, M., McCune, C. A., Rowe, I. A., Schnabl, B., Mathurin, P., Shawcross, D., Abraldes, J. J., Lucey, M. R., Garcia-Tsao, G., Verna, E., Brown, R. S., Bosques-Padilla, F., Vargas, V. & 3 others, Louvet, A., Holt, A. P. & Bataller, R., 28 Jan 2021, In: Clinical Gastroenterology and Hepatology : the official clinical practice journal of the American Gastroenterological Association.

    Research output: Contribution to journalArticlepeer-review

  7. Intestinal virome in patients with alcoholic hepatitis

    Jiang, L., Lang, S., Duan, Y., Zhang, X., Gao, B., Chopyk, J., Schwanemann, L. K., Ventura-Cots, M., Bataller, R., Bosques-Padilla, F., Verna, E. C., Abraldes, J. G., Brown, R. S., Vargas, V., Altamirano, J., Caballería, J., Shawcross, D. L., Ho, S. B., Louvet, A., Lucey, M. R. & 9 others, Mathurin, P., Garcia-Tsao, G., Kisseleva, T., Brenner, D. A., Tu, X. M., Stärkel, P., Pride, D., Fouts, D. E. & Schnabl, B., Dec 2020, In: Hepatology. 72, 6, p. 2182-2196 15 p.

    Research output: Contribution to journalArticlepeer-review

  8. Targeting the gut-liver-immune axis to treat cirrhosis

    Tranah, T. H., Edwards, L. A., Schnabl, B. & Shawcross, D. L., 15 Oct 2020, In: Gut. 320786.

    Research output: Contribution to journalArticlepeer-review

  9. Foreword

    Shawcross, D. L., 1 Sep 2020, In: British journal of nursing (Mark Allen Publishing). 29, Sup17, p. S3

    Research output: Contribution to journalEditorialpeer-review

  10. Regulation, risk and safety of Faecal Microbiota Transplant

    Merrick, B., Allen, L., Masirah M Zain, N., Forbes, B., Shawcross, D. L. & Goldenberg, S. D., Sep 2020, In: Infection prevention in practice. 2, 3, p. 100069

    Research output: Contribution to journalReview articlepeer-review

  11. Faecal microbiota transplant to ERadicate gastrointestinal carriage of Antibiotic Resistant Organisms (FERARO): a prospective, randomised placebo-controlled feasibility trial

    Merrick, B., Robinson, E., Bunce, C., Allen, L., Bisnauthsing, K., Izundu, C. C., Bell, J., Amos, G., Shankar-Hari, M., Goodman, A., Shawcross, D. L. & Goldenberg, S. D., 25 May 2020, In: BMJ Open. 10, 5, p. e038847 e038847.

    Research output: Contribution to journalArticlepeer-review

  12. Protocol: A prospective, randomised placebo-controlled feasibility trial of Faecal microbiota Transplant to ERadicate gastrointestinal carriage of Antibiotic Resistant Organisms (FERARO)

    Merrick, B., Robinson, E. J., Bunce, C., Allen, L., Bisnauthsing, K., Izundu, C. C., Bell, J., Amos, G., Shankar-Hari, M., Goodman, A., Shawcross, D. & Goldenberg, S., 3 Apr 2020, (Accepted/In press) In: BMJ Open.

    Research output: Contribution to journalArticlepeer-review

  13. Severe alcohol-related liver disease admissions post-COVID-19 lockdown: Canary in the coal mine?

    Cargill, Z., Kattiparambil, S., Hansi, N., Barnabas, A., Shawcross, D. L., Williams, R. & Agarwal, K., 2020, (Accepted/In press) In: Frontline Gastroenterology.

    Research output: Contribution to journalLetterpeer-review

  14. Hepatic encephalopathy

    Ryan, J. M. & Shawcross, D. L., 1 Dec 2019, In: Medicine (United Kingdom). 47, 12, p. 833-837 5 p.

    Research output: Contribution to journalReview articlepeer-review

  15. Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

    Duan, Y., Llorente, C., Lang, S., Brandl, K., Chu, H., Jiang, L., White, R. C., Clarke, T. H., Nguyen, K., Torralba, M., Shao, Y., Liu, J., Hernandez-Morales, A., Lessor, L., Rahman, I. R., Miyamoto, Y., Ly, M., Gao, B., Sun, W., Kiesel, R. & 26 others, Hutmacher, F., Lee, S., Ventura-Cots, M., Bosques-Padilla, F., Verna, E. C., Abraldes, J. G., Brown, R. S., Vargas, V., Altamirano, J., Caballería, J., Shawcross, D. L., Ho, S. B., Louvet, A., Lucey, M. R., Mathurin, P., Garcia-Tsao, G., Bataller, R., Tu, X. M., Eckmann, L., van der Donk, W. A., Young, R., Lawley, T. D., Stärkel, P., Pride, D., Fouts, D. E. & Schnabl, B., 21 Nov 2019, In: Nature. 575, 7783, p. 505-511 7 p.

    Research output: Contribution to journalArticlepeer-review

  16. PROFIT: PROspective, Randomised Placebo-controlled Feasibility Trial of Faecal Microbiota Transplantation in Cirrhosis Interim Analysis

    Woodhouse, C., Kronsten, V., Zamalloa, A., Hatton, G., Patel, V. C., Goldenberg, S. & Shawcross, D. L., Sep 2019, In: American Journal of Gastroenterology. 114, p. S5-S7

    Research output: Contribution to journalMeeting Abstractpeer-review

  17. Ammonia-induced brain edema requires macrophage and T cell expression of Toll-like receptor 9

    Manakkat Vijay, G. K., Hu, C., Peng, J., Martinez, I. G., Hoque, R., Verghis, R. M., Ma, Y., Mehal, W., Shawcross, D. L. & Wen, L., 8 Aug 2019, In: Cellular and molecular gastroenterology and hepatology. 8, 4, p. 609-623 15 p.

    Research output: Contribution to journalArticlepeer-review

  18. Intestinal fungal dysbiosis and systemic immune response to fungi in patients with alcoholic hepatitis

    Lang, S., Duan, Y., Liu, J., Torralba, M. G., Kuelbs, C., Ventura-Cots, M., Abraldes, J. G., Bosques-Padilla, F., Verna, E. C., Brown, R. S., Vargas, V., Altamirano, J., Caballería, J., Shawcross, D., Lucey, M. R., Louvet, A., Mathurin, P., Garcia-Tsao, G., Ho, S. B., Tu, X. M. & 4 others, Bataller, R., Stärkel, P., Fouts, D. E. & Schnabl, B., 22 Jun 2019, In: Hepatology.

    Research output: Contribution to journalArticlepeer-review

  19. Serum and Fecal Oxylipins in Patients with Alcohol-Related Liver Disease

    Gao, B., Lang, S., Duan, Y., Wang, Y., Shawcross, D. L., Louvet, A., Mathurin, P., Ho, S. B., Stärkel, P. & Schnabl, B., 10 May 2019, In: Digestive Diseases and Sciences. 64, 7, p. 1878-1892 15 p.

    Research output: Contribution to journalArticlepeer-review

  20. Is treating the gut microbiome the key to achieving better outcomes in cirrhosis?

    Hatton, G. & Shawcross, D. L., 2 Jan 2019, In: Expert Review of Gastroenterology and Hepatology. 13, 1, p. 1-2 2 p.

    Research output: Contribution to journalEditorialpeer-review

  21. In vitro efficacy of pro- and anticoagulant strategies in compensated and acutely ill patients with cirrhosis

    Lisman, T., Kleiss, S., Patel, V. C., Fisher, C., Adelmeijer, J., Bos, S., Singanayagam, A., Stoy, S. H., Shawcross, D. L. & Bernal, W., Nov 2018, In: LIVER INTERNATIONAL. 38, 11, p. 1988-1996

    Research output: Contribution to journalArticlepeer-review

  22. Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis

    Brandl, K., Hartmann, P., Jih, L. J., Pizzo, D. P., Argemi, J., Ventura-Cots, M., Coulter, S., Liddle, C., Ling, L., Rossi, S. J., DePaoli, A. M., Loomba, R., Mehal, W. Z., Fouts, D. E., Lucey, M. R., Bosques-Padilla, F., Mathurin, P., Louvet, A., Garcia-Tsao, G., Verna, E. C. & 10 others, Abraldes, J. G., Brown Jr, R. S., Vargas, V., Altamirano, J., Caballería, J., Shawcross, D., Stärkel, P., Ho, S. B., Bataller, R. & Schnabl, B., 1 Aug 2018, In: Journal of Hepatology. 69, 2, p. 396-405

    Research output: Contribution to journalArticlepeer-review

  23. Editorial: platelet transfusions in cirrhosis-do the risks outweigh the unclear benefits? Authors' reply

    Støy, S. & Shawcross, D. L., Jun 2018, In: Alimentary Pharmacology & Therapeutics. 47, 11, p. 1555-1556 2 p.

    Research output: Contribution to journalEditorialpeer-review

  24. Platelet-leucocyte aggregation is augmented in cirrhosis and further increased by platelet transfusion

    Stoy, S., Patel, V. C., Sturgeon, J. P., Vijay, G. K. M., Lisman, T., Bernal, W. & Shawcross, D. L., 31 May 2018, In: Alimentary Pharmacology & Therapeutics. 47, 10, p. 1375-1386

    Research output: Contribution to journalArticlepeer-review

  25. Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease

    Riva, A., Patel, V., Kurioka, A., Jeffery, H. C., Wright, G., Tarff, S., Shawcross, D., Ryan, J. M., Evans, A., Azarian, S., Bajaj, J. S., Fagan, A., Patel, V., Mehta, K., Lopez, C., Simonova, M., Katzarov, K., Hadzhiolova, T., Pavlova, S., Wendon, J. A. & 4 others, Htun Oo, Y., Klenerman, P., Williams, R. & Chokshi, S., 1 May 2018, In: Gut. 67, 5, p. 918-930 13 p.

    Research output: Contribution to journalArticlepeer-review

  26. Balanced haemostasis with both hypo- and hyper-coagulable features in critically ill patients with acute-on-chronic-liver failure

    Fisher, C., Patel, V. C., Stoy, S. H., Singanayagam, A., Adelmeijer, J., Wendon, J., Shawcross, D. L., Lisman, T. & Bernal, W., Feb 2018, In: Journal of Critical Care. 43, p. 54-60 7 p.

    Research output: Contribution to journalArticlepeer-review

  27. Editorial: rifaximin-a kick in the gut for spontaneous bacterial peritonitis?

    Woodhouse, C. & Shawcross, D. L., Jan 2018, In: Alimentary Pharmacology & Therapeutics. 47, 2, p. 301-303 3 p.

    Research output: Contribution to journalArticlepeer-review

  28. The impact of rifaximin-α on the hospital resource use associated with the management of patients with hepatic encephalopathy: a retrospective observational study (IMPRESS)

    Hudson, M., Radwan, A., Di Maggio, P., Cipelli, R., Ryder, S. D., Dillon, J. F., Cash, W. J., Przemioslo, R. T., Wright, M., Shawcross, D. L., Jalan, R., Saksena, S., Allison, M., Richardson, P., Farrington, E. & Aspinall, R. J., Oct 2017, In: Frontline Gastroenterology. 8, 4, p. 243-251 9 p.

    Research output: Contribution to journalArticlepeer-review

  29. Dysfunctional neutrophil effector organelle mobilisation and microbicidal protein release in alcohol-related cirrhosis

    Tranah, T. H., Manakkat Vijay, G. K., Ryan, J. M., Abeles, R. D., Middleton, P. K. & Shawcross, D. L., 1 Sep 2017, In: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 313, 3, ajpgi.00112.2016.

    Research output: Contribution to journalArticlepeer-review

  30. Ammonia Mediated Brain-oedema and Immune Dysfunction is Mediated by Toll-like Receptor (TLR) 9

    Manakkat Vijay, G., Hu, C., Peng, J., Martinez, I. G., Hoque, R., Zhang, X., Ma, Y., Mehal, W., Shawcross, D. & Wen, L., Feb 2017, In: Journal of Clinical and Experimental Hepatology. 7, Supplement 1, p. S2-S3

    Research output: Contribution to journalArticlepeer-review

  31. The changing face of hepatic encephalopathy: A projection for the next 5 years

    Shawcross, D. L., 30 Dec 2016, In: Clinical Liver Disease. 8, 6, p. 156-159 4 p.

    Research output: Contribution to journalReview articlepeer-review

  32. Clinical science workshop: targeting the gut-liver-brain axis

    Patel, V. C., White, H., Stoy, S., Bajaj, J. S. & Shawcross, D. L., 1 Dec 2016, In: Metabolic Brain Disease. 31, 6, p. 1327–1337

    Research output: Contribution to journalArticlepeer-review

  33. Multivariate metabotyping of plasma accurately predicts survival in patients with decompensated cirrhosis.

    McPhail, M., Shawcross, D. L., Lewis, M. R., Coltart, I., Want, E. J., Antoniades, C. G., Veselkov, K., Triantafyllou, E., Patel, V. C., Pop, O. T., Gomez-Romero, M., Kyriakides, M., Zia, R., Abeles, R. D., Crossey, M. M. E., Jassem, W., O'Grady, J., Heaton, N., Auzinger, G., Bernal, W. & 6 others, Quaglia, A., Coen, M., Nicholson, J. K., Wendon, J. A., Holmes, E. & Taylor-Robinson, S. D., May 2016, In: Journal of Hepatology. 64, 5, p. 1058-1067

    Research output: Contribution to journalArticlepeer-review

  34. The impact on hospital resource utilisation of treatment of hepatic encephalopathy with rifaximin-α

    Orr, J. G., Currie, C. J., Berni, E., Goel, A., Moriarty, K. J., Sinha, A., Gordon, F., Dethier, A., Dillon, J., Clark, K., Richardson, P., Middleton, P., Patel, V., Shawcross, D., Preedy, H., Aspinall, R. J. & Hudson, M., 7 Mar 2016, In: LIVER INTERNATIONAL.

    Research output: Contribution to journalArticlepeer-review

  35. Defective monocyte oxidative burst predicts infection in alcoholic hepatitis and is associated with reduced expression of NADPH oxidase

    Vergis, N., Khamri, W., Beale, K., Sadiq, F., Aletrari, M. O., Moore, C., Atkinson, S. R., Bernsmeier, C., Possamai, L. A., Petts, G., Ryan, J. M., Abeles, R. D., James, S., Foxton, M., Hogan, B., Foster, G. R., O'Brien, A. J., Ma, Y., Shawcross, D. L., Wendon, J. A. & 2 others, Antoniades, C. G. & Thursz, M. R., 9 Feb 2016, In: Gut.

    Research output: Contribution to journalArticlepeer-review

  36. High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial

    Larsen, F. S., Schmidt, L. E., Bernsmeier, C., Rasmussen, A., Isoniemi, H., Patel, V., Triantafyllou, E., Bernal, W., Auzinger, G., Shawcross, D., Eefsen, M., Bjerring, P. N., Clemmesen, J. O., Hockerstedt, K., Frederiksen, H-J., Hansen, B. A., Antoniades, C. G. & Wendon, J., 1 Jan 2016, In: Journal of Hepatology. 64, 1, p. 69-78

    Research output: Contribution to journalArticlepeer-review

  37. Neutrophil toll-like receptor 9 expression and the systemic inflammatory response in acetaminophen-induced acute liver failure

    Manakkat Vijay, G. K., Ryan, J. M., Abeles, R. D., Ramage, S., Patel, V., Bernsmeier, C., Riva, A., McPhail, M. J. W., Tranah, T. H., Markwick, L. J. L., Taylor, N. J., Bernal, W., Auzinger, G., Willars, C., Chokshi, S., Wendon, J. A., Ma, Y. & Shawcross, D. L., 1 Jan 2016, In: Critical Care Medicine. 44, 1, p. 43-53 11 p.

    Research output: Contribution to journalArticlepeer-review

  38. Altered gut microbial profile is a proponent of bacterial translocation in acute-on-chronic liver failure

    Patel, V. C., Leong, L. E. X., Koller, G., Knapp, S., Lai, G., Singanayagam, A., Bernsmeier, C., McPhail, M. J. W., Shawcross, D. L., Antoniades, C. G., Thursz, M., Wendon, J. A., Rogers, G. B. & Bruce, K. D., 2016, J Hepatol. p. S453-S454 (J Hepatol; vol. 64).

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

  39. Altered gut microbial profile is a proponent of bacterial translocation in acute-on-chronic liver failure

    Patel, V. C., Leong, L., Koller, G., Knapp, S., Lai, G. Y., Singanayagam, A., Bernsmeier, C., McPhail, M., Shawcross, D. L., Antoniades, C., Thursz, M., Wendon, J. A., Rogers, G. B. & Bruce, K., 2016, In: Journal of Hepatology. ILC2016-RS-3902.

    Research output: Contribution to journalPoster abstractpeer-review

  40. How to diagnose and manage hepatic encephalopathy: a consensus statement on roles and responsibilities beyond the liver specialist

    Shawcross, D. L., Dunk, A. A., Jalan, R., Kircheis, G., de Knegt, R. J., Laleman, W., Ramage, J. K., Wedemeyer, H. & Morgan, I. E. J., 23 Nov 2015, In: European Journal of Gastroenterology and Hepatology. 7 p.

    Research output: Contribution to journalArticlepeer-review

  41. Hepatic encephalopathy

    Ryan, J. M. & Shawcross, D. L., 1 Nov 2015, In: Medicine (United Kingdom). 43, 11, p. 679-682 4 p.

    Research output: Contribution to journalReview articlepeer-review

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