Research output per year
Research output per year
SE1 9RT
United Kingdom
The focus of my research is the genetic basis of Systemic Lupus Erythematosus and other autoimmune disease.
I am interested in understanding the role of genetic variation in the function of members of the Ikaros family of transcription factors, including IKZF1 (Ikaros) and IKZF3 (Aiolos), and of molecules involved in interferon signalling.
Through collaboration with the SLEGEN consortium I am exploring commonality of autoimmune susceptibility loci in SLE and fine-mapping known lupus susceptibility genes, using the ImmunoChip genotyping platform
Using data taken from genome-wide association studies in SLE, I am seeking to both discover structural variation associated with lupus and then to explore the functional consequences of those CNVs. This work is being done in collaboration with Dr Lachlan Coin at Imperial College.
Following my undergraduate studies in Applied Biology at the University of Hull, I completed my PhD in Molecular Cell Biology at King’s College Hospital, London.
I then undertook post-doctoral work in the Haematology Department at Imperial College (St. Mary’s) and then in the Section of Rheumatology at Imperial College (Hammersmith). Following my first academic appointment as non-clinical lecturer at Imperial College in 2007, I moved to King’s College at Guy’s Hospital in 2010.
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Vyse, T. (Primary Investigator) & Cunninghame Graham, D. (Co-Investigator)
Project: Research
Vyse, T. (Primary Investigator), Cunninghame Graham, D. (Co-Investigator) & Karrar, S. (Co-Investigator)
1/09/2018 → 31/08/2019
Project: Research
Vyse, T. (Primary Investigator), Cunninghame Graham, D. (Co-Investigator) & Morris, D. (Co-Investigator)
1/02/2017 → 31/01/2022
Project: Research
Vyse, T. (Primary Investigator) & Cunninghame Graham, D. (Co-Investigator)
1/10/2016 → 30/09/2020
Project: Research
Vyse, T. (Primary Investigator), Cunninghame Graham, D. (Co-Investigator) & Karrar, S. (Co-Investigator)
1/04/2016 → 31/03/2019
Project: Research
Wang, Y., Guga, S., Wu, K., Khaw, Z., Tzoumkas, K., Tombleson, P., E. Comeau, M., D. Langefeld, C., Cunninghame Graham, D., Morris, D. & Vyse, T., King's College London, 30 Sept 2022
DOI: 10.18742/19758484, https://kcl.figshare.com/articles/dataset/COVID-19_and_systemic_lupus_erythematosus_genetics_a_balance_between_autoimmune_disease_risk_and_protection_against_infection/19758484
Dataset