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Deborah Cunninghame Graham

Dr

    • SE1 9RT

      United Kingdom

    • 4167
      Citations
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    Personal profile

    Research interests

    • Genetic basis of SLE and other autoimmune disease
    • The relationship between common and rare variants as risk factors for SLE and other autoimmune disease
    • The role of structural variation in systemic and autoimmune disease

    The focus of my research is the genetic basis of Systemic Lupus Erythematosus and other autoimmune disease.

    I am interested in understanding the role of genetic variation in the function of members of the Ikaros family of transcription factors, including IKZF1 (Ikaros) and IKZF3 (Aiolos), and of molecules involved in interferon signalling.

    Through collaboration with the SLEGEN consortium I am exploring commonality of autoimmune susceptibility loci in SLE and fine-mapping known lupus susceptibility genes, using the ImmunoChip genotyping platform

    Using data taken from genome-wide association studies in SLE, I am seeking to both discover structural variation associated with lupus and then to explore the functional consequences of those CNVs. This work is being done in collaboration with Dr Lachlan Coin at Imperial College.

    Biographical details

    Following my undergraduate studies in Applied Biology at the University of Hull, I completed my PhD in Molecular Cell Biology at King’s College Hospital, London.

    I then undertook post-doctoral work in the Haematology Department at Imperial College (St. Mary’s) and then in the Section of Rheumatology at Imperial College (Hammersmith). Following my first academic appointment as non-clinical lecturer at Imperial College in 2007, I moved to King’s College at Guy’s Hospital in 2010.

    Expertise related to UN Sustainable Development Goals

    In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

    • SDG 3 - Good Health and Well-being

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