King's College London

Research portal

Professor Denis Azzopardi

  1. Prospective qualification of early cerebral biomarkers in a randomised trial of treatment with xenon combined with moderate hypothermia after birth asphyxia

    Azzopardi, D., Chew, A. T., Deierl, A., Huertas, A., Robertson, N. J., Tusor, N. & Edwards, A. D., Sep 2019, In: EBioMedicine. 47, p. 484-491 8 p., EBIOM_2373.

    Research output: Contribution to journalArticlepeer-review

  2. Hypothermia for perinatal asphyxia: trial-based resource use and costs at 6textendash7 years

    Rivero-Arias, O., Eddama, O., Azzopardi, D., Edwards, A. D., Strohm, B. & Campbell, H., 11 Jul 2018, (E-pub ahead of print) In: Archives of Disease in Childhood Fetal and Neonatal Edition.

    Research output: Contribution to journalArticlepeer-review

  3. Hypothermia for perinatal asphyxia: Trial-based quality of life at 6-7 years

    Campbell, H., Eddama, O., Azzopardi, D., Edwards, A. D., Strohm, B. & Rivero-Arias, O., 1 Jan 2018, In: Archives of Disease in Childhood. 103, 7, p. 654-659 6 p.

    Research output: Contribution to journalArticlepeer-review

  4. Effect of MRI on preterm infants and their families: a randomised trial with nested diagnostic and economic evaluatio

    Edwards, A. D., Redshaw, M. E., Kennea, N., Rivero-Arias, O., Gonzales-Cinca, N., Nongena, P., Ederies, M., Falconer, S., Chew, A., Omar, O., Hardy, P., Harvey, M. E., Eddama, O., Hayward, N., Wurie, J., Azzopardi, D., Rutherford, M. A., Counsell, S. & ePrime Investigators., Jan 2018, In: ADC Fetal & Neonatal. 103, 1, p. F15-F21

    Research output: Contribution to journalArticlepeer-review

  5. Punctate White Matter Lesions Associated With Altered Brain Development And Adverse Motor Outcome In Preterm Infants

    Tusor, N., Benders, M. J., Counsell, S. J., Nongena, P., Ederies, M. A., Falconer, S., Chew, A., Gonzalez-Cinca, N., Hajnal, J. V., Gangadharan, S., Chatzi, V., Kersbergen, K. J., Kennea, N., Azzopardi, D. V. & Edwards, A. D., 16 Oct 2017, (E-pub ahead of print) In: Scientific Reports. 7, 1, p. 13250 13250.

    Research output: Contribution to journalArticlepeer-review

  6. Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial

    Azzopardi, D., Robertson, N. J., Bainbridge, A., Cady, E., Charles-Edwards, G., Deierl, A., Fagiolo, G., Franks, N. P., Griffiths, J., Hajnal, J., Juszczak, E., Kapetanakis, B., Linsell, L., Maze, M., Omar, O., Strohm, B., Tusor, N. & Edwards, A. D., Feb 2016, In: Lancet Neurology. 15, 2, p. 145–153

    Research output: Contribution to journalArticlepeer-review

  7. Neuroprotection for Perinatal Hypoxic Ischemic Encephalopathy in Low- and Middle-Income Countries

    Tagin, M., Abdel-Hady, H., Rahman, S. U., Azzopardi, D. V. & Gunn, A. J., 1 Jul 2015, In: Journal of Pediatrics. 167, 1, p. 25–28

    Research output: Contribution to journalArticlepeer-review

  8. Clinical applications of cerebral function monitoring in neonates

    Azzopardi, D., 1 Jun 2015, In: Seminars in Fetal and Neonatal Medicine. 20, 3, p. 154-163 10 p.

    Research output: Contribution to journalReview articlepeer-review

  9. Specialization and integration of functional thalamocortical connectivity in the human infant

    Toulmin, H., Beckmann, C. F., O'Muircheartaigh, J., Ball, G., Nongena, P., Makropoulos, A., Ederies, A., Counsell, S. J., Kennea, N., Arichi, T., Tusor, N., Rutherford, M. A., Azzopardi, D., Gonzalez-Cinca, N., Hajnal, J. V. & Edwards, A. D., 19 May 2015, In: Proceedings of the National Academy of Sciences. 112, 20, p. 6485-6490 6 p.

    Research output: Contribution to journalArticlepeer-review

  10. Neonatal hypoxic ischaemic encephalopathy: Current and future treatment options

    Merchant, N. M., Azzopardi, D. V. & Edwards, A. D., 1 Apr 2015, In: Expert opinion on orphan drugs. 3, 4, p. 357-377 21 p.

    Research output: Contribution to journalReview articlepeer-review

  11. Effects of Hypothermia for Perinatal Asphyxia on Childhood Outcomes

    Azzopardi, D., Strohm, B., Marlow, N., Brocklehurst, P., Deierl, A., Eddama, O., Goodwin, J., Halliday, H. L., Juszczak, E., Kapellou, O., Levene, M., Linsell, L., Omar, O., Thoresen, M., Tusor, N., Whitelaw, A. & Edwards, A. D., 10 Jul 2014, In: New England Journal of Medicine. 371, 2, p. 140-149

    Research output: Contribution to journalArticlepeer-review

  12. Predictive value of the amplitude integrated EEG in infants with hypoxic ischaemic encephalopathy: data from a randomised trial of therapeutic hypothermia

    Azzopardi, D. & TOBY study group, Jan 2014, In: ADC Fetal & Neonatal. 99, 1, p. F80-F82 3 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  13. Neonatal ECMO study of temperature (NEST): a randomized controlled trial

    Field, D., Juszczak, E., Linsell, L., Azzopardi, D., Cowan, F., Marlow, N., Edwards, D. & NEST Study Collaborative Group, Nov 2013, In: Pediatrics. 132, 5, p. e1247-e1256 10 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  14. Anticonvulsant effect of xenon on neonatal asphyxial seizures

    Azzopardi, D., Robertson, N. J., Kapetanakis, A., Griffiths, J., Rennie, J. M., Mathieson, S. R. & Edwards, A. D., Sep 2013, In: Archives of Disease in Childhood Fetal and Neonatal Edition. 98, 5, p. F437-F439 3 p.

    Research output: Contribution to journalArticlepeer-review

  15. Oxygen saturation and outcomes in preterm infants

    Stenson, B. J., Tarnow-Mordi, W. O., Darlow, B. A., Simes, J., Juszczak, E., Askie, L., Battin, M., Bowler, U., Broadbent, R., Cairns, P., Davis, P. G., Deshpande, S., Donoghoe, M., Doyle, L., Fleck, B. W., Ghadge, A., Hague, W., Halliday, H. L., Hewson, M., King, A., & 10 othersKirby, A., Marlow, N., Meyer, M., Morley, C., Simmer, K., Tin, W., Wardle, S. P., Brocklehurst, P., BOOST II United Kingdom Collaborative Group & Azzopardi, D., 30 May 2013, In: New England Journal of Medicine. 368, 22, p. 2094-2104 11 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  16. Pharmacokinetics of Melatonin in Preterm Infants

    Merchant, N. M., Azzopardi, D. V., Hawwa, A. F., McElnay, J. C., Middleton, B., Arendt, J., Arichi, T., Gressens, P. & Edwards, A. D., 21 Feb 2013, (E-pub ahead of print) In: British Journal of Clinical Pharmacology.

    Research output: Contribution to journalArticlepeer-review

  17. Changes in serum cytokine and cortisol levels in normothermic and hypothermic term neonates after perinatal asphyxia

    Róka, A., Bekő, G., Halász, J., Toldi, G., Lakatos, P., Azzopardi, D., Tulassay, T. & Szabó, M., Jan 2013, In: Inflammation Research. 62, 1, p. 81-87 7 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  18. Amplitude-integrated electroencephalography in newborns with inborn errors of metabolism

    Olischar, M., Shany, E., Aygün, C., Azzopardi, D., Hunt, R. W., Toet, M. C., Hamosh, A., de Vries, L. S., Hellström-Westas, L. & Theda, C., Sep 2012, In: Neonatology. 102, 3, p. 203-211 9 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  19. Implementation and conduct of therapeutic hypothermia for perinatal asphyxial encephalopathy in the UK--analysis of national data

    Azzopardi, D., Strohm, B., Linsell, L., Hobson, A., Juszczak, E., Kurinczuk, J. J., Brocklehurst, P., Edwards, A. D. & UK TOBY Cooling Register, 13 Jun 2012, In: PL o S One . 7, 6, e38504.

    Research output: Contribution to journalArticlepeer-review

  20. Serum S100B and neuron-specific enolase levels in normothermic and hypothermic infants after perinatal asphyxia

    Roka, A., Kelen, D., Halasz, J., Beko, G., Azzopardi, D. & Szabo, M., Mar 2012, In: Acta paediatrica (Oslo, Norway : 1992). 101, 3, p. 319-323 5 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  21. Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy

    Guillet, R., Edwards, A. D., Thoresen, M., Ferriero, D. M., Gluckman, P. D., Whitelaw, A., Gunn, A. J., CoolCap Trial Group & Azzopardi, D., Feb 2012, In: Pediatric Research. 71, 2, p. 205-209 5 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  22. Subcutaneous fat necrosis after moderate therapeutic hypothermia in neonates

    Strohm, B., Hobson, A., Brocklehurst, P., Edwards, A. D. & Azzopardi, D., Aug 2011, In: Pediatrics. 128, 2, p. e450-2

    Research output: Contribution to journalArticlepeer-review

  23. Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop

    Higgins, R. D., Raju, T., Edwards, A. D., Azzopardi, D. V., Bose, C. L., Clark, R. H., Ferriero, D. M., Guillet, R., Gunn, A. J., Hagberg, H., Hirtz, D., Inder, T. E., Jacobs, S. E., Jenkins, D., Juul, S., Laptook, A. R., Lucey, J. F., Maze, M., Palmer, C., Papile, L., & 8 othersPfister, R. H., Robertson, N. J., Rutherford, M., Shankaran, S., Silverstein, F. S., Soll, R. F., Thoresen, M. & Walsh, W. F., 2011, In: Journal of Pediatrics. 159, p. 851-858 e1 8 p.

    Research output: Contribution to journalComment/debatepeer-review

  24. Passive cooling for initiation of therapeutic hypothermia in neonatal encephalopathy

    Kendall, G. S., Kapetanakis, A., Ratnavel, N., Azzopardi, D., Robertson, N. J. & Cooling on Retrieval Study Group, Nov 2010, In: ADC Fetal & Neonatal. 95, 6, p. F408-F412 5 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  25. Magnetic resonance biomarkers of neuroprotective effects in infants with hypoxic ischemic encephalopathy

    Azzopardi, D. & Edwards, A. D., Oct 2010, In: Seminars in fetal & neonatal medicine. 15, 5, p. 261-269 9 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  26. Hypothermic neural rescue: work continues

    Edwards, A. D. & Azzopardi, D. V., Sep 2010, In: Journal of Pediatrics. 157, 3, p. 351-352 2 p.

    Research output: Contribution to journalEditorialpeer-review

  27. Temperature control during therapeutic moderate whole-body hypothermia for neonatal encephalopathy

    Strohm, B., Azzopardi, D. & UK TOBY Cooling Register Study Group, Sep 2010, In: ADC Fetal & Neonatal. 95, 5, p. F373-F375 3 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  28. Clinical management of the baby with hypoxic ischaemic encephalopathy

    Azzopardi, D., Jun 2010, In: Early Human Development. 86, 6, p. 345-350 6 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  29. Hypoxic ischaemic encephalopathy in newborn infants

    Azzopardi, D., Jun 2010, In: Early Human Development. 86, 6, p. 327-327 1 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  30. Therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy

    Roka, A. & Azzopardi, D., Jun 2010, In: Early Human Development. 86, 6, p. 361-367 7 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  31. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data

    Edwards, A. D., Brocklehurst, P., Gunn, A. J., Halliday, H., Juszczak, E., Levene, M., Strohm, B., Thoresen, M., Whitelaw, A. & Azzopardi, D., 9 Feb 2010, In: BMJ. 340, 7 p., c363.

    Research output: Contribution to journalArticlepeer-review

  32. Mild controlled hypothermia in preterm neonates with advanced necrotizing enterocolitis

    Hall, N. J., Eaton, S., Peters, M. J., Hiorns, M. P., Alexander, N., Azzopardi, D. V. & Pierro, A., Feb 2010, In: Pediatrics. 125, 2, p. e300-e308 9 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  33. Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial

    Rutherford, M., Ramenghi, L. A., Edwards, A., Brocklehurst, P., Halliday, H., Levene, M., Strohm, B., Thoresen, M., Whitelaw, A. & Azzopardi, D., Jan 2010, In: Lancet Neurology. 9, 1, p. 39-45 7 p.

    Research output: Contribution to journalArticlepeer-review

  34. Cost-effectiveness of therapeutic hypothermia to treat neonatal encephalopathy

    Regier, D. A., Petrou, S., Henderson, J., Eddama, O., Patel, N., Strohm, B., Brocklehurst, P., Edwards, A. D. & Azzopardi, D., 2010, In: Value in Health. 13, 6, p. 695-702 8 p.

    Research output: Contribution to journalArticlepeer-review

  35. Tract-based spatial statistics of magnetic resonance images to assess disease and treatment effects in perinatal asphyxial encephalopathy

    Porter, E. J., Counsell, S. J., Edwards, A. D., Allsop, J. & Azzopardi, D., 2010, In: Pediatric Research. 68, p. 205-209 5 p.

    Research output: Contribution to journalArticlepeer-review

  36. Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy

    Azzopardi, D., Strohm, B., Edwards, A., Dyet, L., Halliday, H. L., Juszczak, E., Kapellou, O., Levene, M., Marlow, N., Porter, E., Thoresen, M., Whitelaw, A., Brocklehurst, P. & TOBY Study Grp, 1 Oct 2009, In: New England Journal of Medicine. 361, 14, p. 1349-1358 10 p.

    Research output: Contribution to journalArticlepeer-review

  37. Treatment of asphyxiated newborns with moderate hypothermia in routine clinical practice: how cooling is managed in the UK outside a clinical trial

    Azzopardi, D., Strohm, B., Edwards, A. D., Halliday, H., Juszczak, E., Levene, M., Thoresen, M., Whitelaw, A., Brocklehurst, P. & Steering Group and TOBY Cooling Register participants, Jul 2009, In: ADC Fetal & Neonatal. 94, 4, p. F260-F264 5 p.

    Research output: Contribution to journalArticlepeer-review

  38. Therapeutic hypothermia for neonatal encephalopathy: a UK survey of opinion, practice and neuro-investigation at the end of 2007

    Kapetanakis, A., Azzopardi, D., Wyatt, J. & Robertson, N. J., Apr 2009, In: Acta paediatrica (Oslo, Norway : 1992). 98, 4, p. 631-5 5 p.

    Research output: Contribution to journalArticlepeer-review

  39. Elevated morphine concentrations in neonates treated with morphine and prolonged hypothermia for hypoxic ischemic encephalopathy

    Róka, A., Melinda, K. T., Vásárhelyi, B., Machay, T., Azzopardi, D. & Szabó, M., Apr 2008, In: Pediatrics. 121, 4, p. e844-e849 6 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  40. Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathy

    Gunn, A. J., Wyatt, J. S., Whitelaw, A., Barks, J., Azzopardi, D., Ballard, R., Edwards, A. D., Ferriero, D. M., Gluckman, P. D., Polin, R. A., Robertson, C. M., Thoresen, M. & CoolCap Study, G., Jan 2008, In: Journal of Pediatrics. 152, 1, p. 55-8, 58 e1

    Research output: Contribution to journalArticlepeer-review

  41. Patterns of brain injury in neonates exposed to perinatal sentinel events

    Okereafor, A., Allsop, J., Counsell, S., Fitzpatrick, J., Azzopardi, D., Rutherford, M. & Cowan, FM., 2008, In: Pediatrics. 121, 5, p. 906-14 9 p.

    Research output: Contribution to journalArticlepeer-review

  42. Determinants of outcomes after head cooling for neonatal encephalopathy

    Wyatt, J. S., Gluckman, P. D., Liu, P. Y., Azzopardi, D., Ballard, R., Edwards, A. D., Ferriero, D. M., Polin, R. A., Robertson, C. M., Thoresen, M., Whitelaw, A., Gunn, A. J. & CoolCap Study, G., May 2007, In: Pediatrics. 119, 5, p. 912-921 10 p.

    Research output: Contribution to journalArticlepeer-review

  43. Lack of influence of mild hypothermia on amplitude integrated-electroencephalography in neonates receiving extracorporeal membrane oxygenation

    Horan, M., Azzopardi, D., Edwards, A. D., Firmin, R. K. & Field, D., Feb 2007, In: Early Human Development. 83, 2, p. 69-75 7 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  44. Maturation of cerebral electrical activity and development of cortical folding in young very preterm infants

    Biagioni, E., Frisone, M. F., Laroche, S., Kapetanakis, B. A., Ricci, D., Adeyi-Obe, M., Lewis, H., Kennea, N., Cioni, G., Cowan, F., Rutherford, M., Azzopardi, D. & Mercuri, E., Jan 2007, In: Clinical Neurophysiology. 118, 1, p. 53-59 7 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  45. Hypothermia

    Azzopardi, D. & Edwards, A. D., 2007, In: Semin Fetal Neonatal Med. 12, p. 303-310 8 p.

    Research output: Contribution to journalArticlepeer-review

  46. Artifacts on electroencephalograms may influence the amplitude-integrated EEG classification: a qualitative analysis in neonatal encephalopathy

    Hagmann, C. F., Robertson, N. J. & Azzopardi, D., Dec 2006, In: Pediatrics. 118, 6, p. 2552-2554 3 p., N/A.

    Research output: Contribution to journalArticlepeer-review

  47. Therapeutic hypothermia following perinatal asphyxia

    Edwards, A. D. & Azzopardi, D. V., Mar 2006, In: Archives of Disease in Childhood Fetal and Neonatal Edition. 91, 2, p. F127-F131 5 p.

    Research output: Contribution to journalArticlepeer-review

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