Research output per year
Research output per year
Personal profile
Research interests
Vascular smooth muscle cell (VSMC) phenotypic transition, from a contractile to a migratory phenotype is essential for vascular repair and is associated with dramatic changes in cytoskeletal organisation. We are interested in understanding the importance of nesprins, a family of cytoskeletal binding proteins that are highly enriched in contractile VSMCs and function at the nuclear envelope within the LInker of Nucleoskeleton and Cytoskeleton (LINC) complex. This complex forms a specialised structure that physically connects the plasma membrane, cytoskeleton and nuclear lamina to form a single mechanically coupled system, essential for cytoskeletal organisation, differentiation and cell motility. We use molecular biological and biochemical approaches combined with state of the art cell biological and biophysical techniques to study the complex roles of this family of proteins.
Research interests (short)
Smooth muscle cell phenotypic modulation, mechanotransduction, mechanical coupling of the nuclear envelope
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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- 1 Similar Profiles
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SUN1/2 are essential for RhoA/ROCK regulated actomyosin activity in isolated vascular smooth muscle cells
Porter, L. J., Minaisah, R.-M., Ahmed, S., Ali, S., Norton, R., Zhang, Q., Ferraro, E., Molenaar, C., Holt, M. R., Cox, S., Fountain, S., Shanahan, C. M. & Warren, D. T., Jan 2020, In: Cells. 9, 132Research output: Contribution to journal › Article › peer-review
File24 Citations (Scopus)120 Downloads (Pure) -
Mouse models of nesprin related diseases
Zhou, C., Rao, L., Warren, D. T., Shanahan, C. M. & Zhang, Q., 20 Apr 2018, (Accepted/In press) In: Biochemical Society Transactions.Research output: Contribution to journal › Literature review › peer-review
Open AccessFile101 Downloads (Pure) -
Adventitial SCA-1+ Progenitor Cell Gene Sequencing Reveals the Mechanisms of Cell Migration in Response to Hyperlipidemia
Kokkinopoulos, I., Wong, M. M., Potter, C. M. F., Xie, Y., Yu, B., Warren, D. T., Nowak, W. N., Le Bras, A., Ni, Z., Zhou, C., Ruan, X., Karamariti, E., Hu, Y., Zhang, L. & Xu, Q., 8 Aug 2017, In: Stem cell reports. 9, 2, p. 681-696,Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Citations (Scopus)200 Downloads (Pure) -
Clinical and Dosimetric Factors Impacting Radiation Pneumonitis in Isotoxically Dose-Escalated NSCLC: Proceedings of the American Society for Radiation OncologyASTRO's 59th Annual Meeting
Vivekanandan, S., Landau, D. B., Counsell, N., Warren, D. R., Farrelly, L., Ngai, Y., Hawkins, M. A. & Fenwick, J. D., 1 Oct 2017, In: International Journal of Radiation Oncology Biology Physics. 99, 2, Supplement, p. S153Research output: Contribution to journal › Meeting abstract › peer-review
66 Citations (Scopus) -
Novel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis
Zhou, C., Li, C., Zhou, B., Sun, H., Koullourou, V., Holt, I., Puckelwartz, M. J., Warren, D. T., Hayward, R., Lin, Z., Morris, G. E., Zhang, L., McNally, E. M., Shackleton, S., Rao, L., Shanahan, C. M. & Zhang, Q., 15 Jun 2017, In: Human Molecular Genetics. 26, 12, p. 2258-2276Research output: Contribution to journal › Article › peer-review
Open AccessFile76 Citations (Scopus)780 Downloads (Pure)
Projects
- 8 Finished
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A role for vascular smooth muscle cell mechano-signalling during aortic medial degeneration associated with Marfan syndrome
Warren, D. (Primary Investigator)
1/11/2016 → 31/10/2019
Project: Research
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Apivotal role for the LINC complex and nesprins in vascular smooth muscle cell mechanical coupling and phenotypic modulation
Warren, D. (Primary Investigator)
1/11/2015 → 31/10/2016
Project: Research
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Nuclear lamina remodelling in response to changes in the mechanical properties of the extracellular matrix defines fibroblast phenotypic transition
Warren, D. (Primary Investigator)
1/10/2013 → 30/09/2016
Project: Research
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Mechanisms of vascular smooth muscle cell ageing and calcification
Shanahan, C. (Primary Investigator) & Warren, D. (Co-Investigator)
1/05/2012 → 31/10/2022
Project: Research
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A pivotal role for the LINC complex and nesprins in vascular smooth muscle cell mechanical coupling and phenotypic modulation
Shanahan, C. (Primary Investigator) & Warren, D. (Primary Investigator)
1/10/2011 → 31/10/2016
Project: Research