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Personal profile

Research interests

Tau, a microtubule-associated protein implicated in the development of pathology in Alzheimers disease, progressive supranuclear palsy and related tauopathies. This laboratory is particularly interested in the phosphorylation status of tau in disease and in the protein kinases involved in pathological and physiological phosphorylation of tau. Alpha-synuclein, a pre-synaptic protein present in Lewy bodies in the brain of people with Parkinsons disease, dementia with Lewy bodies, multiple system atrophy and related disorders. We are investigating biochemical modifications and functional abnormalities in disease-relevant proteins and the implications for diseases in which they play a pathological role. A wide range of techniques is used in our research, including protein chemistry, and cell and molecular biology. Table of tau phosphorylation sites compiled by Diane Hanger: https://bit.ly/2JyZTbS

Research interests (short)

Biochemistry, molecular and cell biology of proteins involved in the pathogenesis of neurodegenerative disease. Table of tau phosphorylation sites compiled by Diane Hanger: https://bit.ly/2JyZTbS

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Doctor of Philosophy, University of London

Award Date: 1 Jan 1991

Bachelor of Science, University of Leeds

Award Date: 1 Jan 1980

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