King's College London

Research portal

Dr Eileen Gentleman

  1. Inflation comes before the fall: how epithelial stretch drives crypt fission

    Gentleman, E. & Jowett, G., 13 Aug 2021, (Accepted/In press) In: Cell Stem Cell.

    Research output: Contribution to journalComment/debate

  2. A modified glass ionomer cement to mediate dentine repair

    Alaohali, A., Brauer, D. S., Gentleman, E. & Sharpe, P. T., Aug 2021, In: Dental Materials. 37, 8, p. 1307-1315 9 p.

    Research output: Contribution to journalArticlepeer-review

  3. Measuring the elastic modulus of soft culture surfaces and three-dimensional hydrogels using atomic force microscopy

    Norman, M. D. A., Ferreira, S. A., Jowett, G. M., Bozec, L. & Gentleman, E., May 2021, In: Nature Protocols. 16, 5, p. 2418-2449 32 p.

    Research output: Contribution to journalReview articlepeer-review

  4. ILC1 drive intestinal epithelial and matrix remodelling

    Jowett, G. M., Norman, M. D. A., Yu, T. T. L., Rosell Arévalo, P., Hoogland, D., Lust, S. T., Read, E., Hamrud, E., Walters, N. J., Niazi, U., Chung, M. W. H., Marciano, D., Omer, O. S., Zabinski, T., Danovi, D., Lord, G. M., Hilborn, J., Evans, N. D., Dreiss, C. A., Bozec, L. & 5 others, Oommen, O. P., Lorenz, C. D., da Silva, R. M. P., Neves, J. F. & Gentleman, E., 28 Feb 2021, In: NATURE MATERIALS. 20, 2, p. 250-259 10 p.

    Research output: Contribution to journalArticlepeer-review

  5. GSK3 Inhibitor-Induced Dentinogenesis Using a Hydrogel

    Alaohali, A., Salzlechner, C., Zaugg, L. K., Suzano, F., Martinez, A., Gentleman, E. & Sharpe, P. T., 2021, (Accepted/In press) In: Journal of Dental Research.

    Research output: Contribution to journalArticlepeer-review

  6. Complementary techniques to analyse pericellular matrix formation by human MSC within hyaluronic acid hydrogels

    Gentleman, E., Salzlechner, C., Walther, A., Schell, S., Merrild, N., Haghighi, T., Huebscher, I., Undt, G., Fan, K., Bergholt, M. & Hedegaard, M. A. B., 16 Oct 2020, In: Materials Advances. 1, p. 2888-96

    Research output: Contribution to journalArticlepeer-review

  7. A Hydrogel-Integrated Culture Device to Interrogate T Cell Activation with Physicochemical Cues

    Chin, M., Norman, M., Gentleman, E., Coppens, M-O. & Day, R., 7 Oct 2020, In: ACS Applied Materials and Interfaces. 12, 42, p. 47355-67

    Research output: Contribution to journalArticlepeer-review

  8. Three-dimensional niche stiffness synergizes with Wnt7a to modulate the extent of satellite cell symmetric self-renewal divisions

    Moyle, L. A., Cheng, R. Y., Liu, H., Davoudi, S., Ferreira, S. A., Nissar, A. A., Sun, Y., Gentleman, E., Simmons, C. A. & Gilbert, P. M., 21 Jul 2020, In: Molecular biology of the cell. 31, 16, p. 1703-1713 11 p.

    Research output: Contribution to journalArticlepeer-review

  9. Rethinking Cancer Immunotherapy by Embracing and Engineering Complexity

    Chin, M., Gentleman, E., Coppens, M-O. & Day, R., 25 May 2020, In: TRENDS IN BIOTECHNOLOGY. 38, 10, p. 1054-65

    Research output: Contribution to journalComment/debatepeer-review

  10. Harnessing the secreted extracellular matrix to engineer tissues

    Blache, U., Stevens, M. M. & Gentleman, E., 1 Apr 2020, In: Nature Biomedical Engineering. 4, 4, p. 357-363 7 p.

    Research output: Contribution to journalComment/debatepeer-review

  11. Hypoxia Inducible Factor-1α in osteochondral tissue engineering

    Taheem, D. K., Jell, G. & Gentleman, E. D., Apr 2020, In: Tissue Engineering Part B. 26, 2, p. 105-115 11 p.

    Research output: Contribution to journalReview articlepeer-review

  12. Adhesive Hydrogels for Maxillofacial Tissue Regeneration Using Minimally Invasive Procedures

    Salzlechner, C., Haghighi, T., Huebscher, I., Walther, A. R., Schell, S., Gardner, A., Undt, G., da Silva, R. M. P., Dreiss, C. A., Fan, K. & Gentleman, E., 19 Feb 2020, In: Advanced Healthcare Materials. 9, 4, 7 p., e1901134.

    Research output: Contribution to journalArticlepeer-review

  13. Translation Approach for Dentine Regeneration Using GSK-3 Antagonists

    Zaugg, L. K., Banu, A., Walther, A. R., Chandrasekaran, D., Babb, R. C., Salzlechner, C., Hedegaard, M. A. B., Gentleman, E. & Sharpe, P. T., 1 Jan 2020, (Accepted/In press) In: Journal of Dental Research. 99, 5, p. 544-551 8 p.

    Research output: Contribution to journalArticlepeer-review

  14. Multiscale analyses reveal native-like lamellar bone repair and near perfect bone-contact with porous strontium-loaded bioactive glass

    Autefage, H., Allen, F., Tang, H. M., Kallepitis, C., Gentleman, E. D., Reznikov, N., Nutiputri, K., Nommeots-Nomm, A., O'Donnell, M. D., Lange, C., Seidt, B. M., Kim, T. B., Lee, P. D., Pierce, B. F., Wagermaier, W., Fratzl, P., Goodship, A., Jones, J. R., Blunn, G. & Stevens, M., 1 Jul 2019, In: Biomaterials. 209, p. 152-162 11 p.

    Research output: Contribution to journalArticlepeer-review

  15. A comparison of lithium-substituted phosphate and borate bioactive glasses for mineralised tissue repair

    Zhang, K., Alaohali, A., Sawangboon, N., Sharpe, P. T., Brauer, D. S. & Gentleman, E., 1 Jun 2019, In: Dental Materials. 35, 6, p. 919-927 9 p.

    Research output: Contribution to journalArticlepeer-review

  16. Hypoxia impacts human MSC response to substrate stiffness during chondrogenic differentiation

    Foyt, D. A., Taheem, D. K., Ferreira, S. A., Norman, M. D. A., Petzold, J., Jell, G., Grigoriadis, A. E. & Gentleman, E., 15 Apr 2019, In: Acta Biomaterialia. 89, p. 73-83 11 p.

    Research output: Contribution to journalArticlepeer-review

  17. An engineered, quantifiable in vitro model for analysing the effect of proteostasis-targeting drugs on tissue physical properties

    Loaiza, S., Ferreira, S. A., Chinn, T., Kirby, A., Tsolaki, E., Dondi, C., Parzych, K., Strange, A., Bozec, L., Bertazzo, S., Hedegaard, M. A. B., Gentleman, E. & Auner, H. W., Nov 2018, In: Biomaterials. 183, p. 102-113 12 p.

    Research output: Contribution to journalArticlepeer-review

  18. Bi-directional cell-pericellular matrix interactions direct stem cell fate

    Ferreira, S. A., Motwani, M. S., Faull, P. A., Seymour, A. J., Yu, T., Enayati, M., Taheem, D. K., Kania, E. M., Oommen, O. P., Ahmed, T., Loaiza, S., Parzych, K., Dazzi, F., Auner, H. W., Varghese, O. P., Festy, F., Grigoriadis, A. E., Snijders, A. P., Bozec, L. & Gentleman, E. D., 3 Oct 2018, In: Nature Communications. 9, 1, 12 p., 4049.

    Research output: Contribution to journalArticlepeer-review

  19. Differential regulation of human bone marrow mesenchymal stromal cell chondrogenesis by Hypoxia Inducible Factor-1α hydroxylase inhibitors

    Taheem, D. K., Foyt, D., Loaiza, S., Ferreira, S. A., Ilic, D., Auner, H. W., Grigoriadis, A. E., Jell, G. & Gentleman, E. D., 30 Sep 2018, In: Stem Cells. 36, 9, p. 1380-1392 13 p.

    Research output: Contribution to journalArticlepeer-review

  20. Neighboring cells override 3D hydrogel matrix cues to drive human MSC quiescence

    Ferreira, S. A., Faull, P. A., Seymour, A. J., Yu, T. T. L., Loaiza, S., Auner, H. W., Snijders, A. P. & Gentleman, E., Sep 2018, In: Biomaterials. 176, p. 13-23 11 p.

    Research output: Contribution to journalArticlepeer-review

  21. Collective Cell Behavior in Mechanosensing of Substrate Thickness

    Tusan, C., Man, Y-H., Zarkoob, H., Johnston, D., Andriotis, O., Thurner, P., Yang, S., Sander, E., Sengers, B. G., Evans, N. & Gentleman, E. D., Jun 2018, In: Biophysical Journal. 114, 11, p. 2743-2755 13 p.

    Research output: Contribution to journalArticlepeer-review

  22. Exploiting Advanced Hydrogel Technologies to Address Key Challenges in Regenerative Medicine

    Foyt, D. A., Norman, M. D. A., Yu, T. T. L. & Gentleman, E., 9 Jan 2018, In: Advanced Healthcare Materials.

    Research output: Contribution to journalLiterature reviewpeer-review

  23. Monomeric, porous type II collagen scaffolds promote chondrogenic differentiation of human bone marrow mesenchymal stem cells in vitro

    Tamaddon, M., Burrows, M., Ferreira, S. A., Dazzi, F., Apperley, J. F., Bradshaw, A., Brand, D. D., Czernuszka, J. & Gentleman, E., 3 Mar 2017, In: Scientific Reports. 7, 43519.

    Research output: Contribution to journalArticlepeer-review

  24. Optimisation of lithium-substituted bioactive glasses to tailor cell response for hard tissue repair

    da Silva, J. G., Babb, R., Salzlechner, C., Sharpe, P., Brauer, D. S. & Gentleman, E., 9 Feb 2017, In: JOURNAL OF MATERIALS SCIENCE. p. 8832–8844 13 p.

    Research output: Contribution to journalArticlepeer-review

  25. Aortic valve calcification: a bone of contention

    Bertazzo, S. & Gentleman, E., 2017, In: European Heart Journal. 38, 16, p. 1189-1193

    Research output: Contribution to journalArticlepeer-review

  26. Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97

    Parzych, K., Chinn, T. M., Chen, Z., Loaiza, S., Porsch, F., Valbuena, G. N., Kleijnen, M. F., Karadimitris, A., Gentleman, E., Keun, H. C. & Auner, H. W., 31 Dec 2015, In: Cell Death & Disease. 6, 12, 11 p., e2031.

    Research output: Contribution to journalArticlepeer-review

  27. Composition of Mineral Produced by Dental Mesenchymal Stem Cell

    Angelova Volponi, A., Gentleman, E., Fatscher, R., Pang, Y. W. Y., Gentleman, M. M. & Sharpe, P. T., Nov 2015, In: J Dent Res. 94, 11, p. 1568-1574 7 p.

    Research output: Contribution to journalArticlepeer-review

  28. Perivascular stem cells at the tip of incisors regulate tissue generation

    Pang, Y. W. Y., Feng, J., Daltoe, F., Fatscher, R., Gentleman, E. D., Gentleman, M. M. & Sharpe, P. T., 21 Oct 2015, In: Journal of Bone and Mineral Research.

    Research output: Contribution to journalArticlepeer-review

  29. Therapeutic ion-releasing bioactive glass ionomer cements with improved mechanical strength and radiopacity

    Fuchs, M., Gentleman, E., Shahid, S., Hill, R. G. & Brauer, D. S., 14 Oct 2015, In: Frontiers in Materials. 2, 63.

    Research output: Contribution to journalArticlepeer-review

  30. Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials

    Autefage, H., Gentleman, E., Littmann, E., Hedegaard, M. A. B., Von Erlach, T., O'Donnell, M., Burden, F. R., Winkler, D. A. & Stevens, M. M., 7 Apr 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 14, p. 4280-4285 6 p.

    Research output: Contribution to journalArticlepeer-review

  31. Evolving insights in cell-matrix interactions: Elucidating how non-soluble properties of the extracellular niche direct stem cell fate

    Walters, N. J. & Gentleman, E., 1 Jan 2015, In: Acta Biomaterialia. 11, 1, p. 3-16 14 p.

    Research output: Contribution to journalArticlepeer-review

  32. The role of surface free energy in osteoblast-biomaterial interactions

    Gentleman, M. M. & Gentleman, E., 1 Nov 2014, In: INTERNATIONAL MATERIALS REVIEWS. 59, 8, p. 417-429 13 p.

    Research output: Contribution to journalArticlepeer-review

  33. The role of material structure and mechanical properties in cell-matrix interactions

    Evans, N. D. & Gentleman, E., 7 May 2014, In: Journal of materials chemistry b. 2, 17, p. 2345-2356 12 p.

    Research output: Contribution to journalArticlepeer-review

  34. Surface properties and ion release from fluoride-containing bioactive glasses promote osteoblast differentiation and mineralization in vitro

    Gentleman, E., Stevens, M. M., Hill, R. G. & Brauer, D. S., Mar 2013, In: Acta Biomaterialia. 9, 3, p. 5771-5779 9 p.

    Research output: Contribution to journalArticlepeer-review

  35. Nano-analytical electron microscopy reveals fundamental insights into human cardiovascular tissue calcification

    Bertazzo, S., Gentleman, E., Cloyd, K., Chester, A., Yacoub, M. & Stevens, M., 2013, In: NATURE MATERIALS.

    Research output: Contribution to journalArticlepeer-review

  36. Characterization of Porcine Aortic Valvular Interstitial Cell 'Calcified' Nodules

    Cloyd, K. L., El-Hamamsy, I., Boonrungsiman, S., Hedegaard, M., Gentleman, E., Sarathchandra, P., Colazzo, F., Gentleman, M. M., Yacoub, M. H., Chester, A. H. & Stevens, M. M., 26 Oct 2012, In: PLoS ONE. 7, 10, p. - 9 p., e48154.

    Research output: Contribution to journalArticlepeer-review

  37. Gene-expression Analysis Reveals that Embryonic Stem Cells Cultured Under Osteogenic Conditions Produce Mineral Non-specifically Compared to Marrow Stromal Cells or Osteoblasts

    Evans, N. D., Swain, R. J., Gentleman, E., Gentleman, M. M. & Stevens, M. M., 24 Sep 2012, In: Journal of European Cells and Materials. 24, 2012, p. 211-223 13 p.

    Research output: Contribution to journalArticlepeer-review

  38. Strontium substituted bioactive glasses stimulate osteogenic differentiation of hMSCs in vitro

    Candarlioglu, P., Gentleman, E. & Stevens, M., Sep 2012, In: Journal Of Tissue Engineering And Regenerative Medicine. 6, s1, p. 204-204 1 p., P06.

    Research output: Contribution to journalMeeting abstractpeer-review

  39. The role of intracellular calcium phosphate in osteoblast-mediated bone apatite formation

    Boonrungsiman, S., Gentleman, E., Carzaniga, R., Evans, N. D., McComb, D. W., Porter, A. E. & Stevens, M. M., 28 Aug 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 35, p. 14170-14175 6 p.

    Research output: Contribution to journalArticlepeer-review

  40. Anisotropic Fibrous Scaffolds for Articular Cartilage Regeneration

    McCullen, S., Autefage, H., Callanan, A., Gentleman, E. & Stevens, M., 2012, In: Tissue Engineering Part A. 18, 19-20, p. 2073-2083 11 p.

    Research output: Contribution to journalArticlepeer-review

  41. The Benefits and Drawbacks of Zinc in Glass Ionomer Bone Cements

    Brauer, D., Gentleman, E., Farrar, D., Stevens, M. & Hill, R., 2011, In: Biomedical Materials. 6, 4, 045007.

    Research output: Contribution to journalArticlepeer-review

  42. Materials characterisation and cytotoxic assessment of strontium-substituted bioactive glasses for bone regeneration

    O’donnell, M. D., Candarlioglu, P. L., Miller, C. A., Gentleman, E. & Stevens, M. M., 10 Aug 2010, In: JOURNAL OF MATERIALS CHEMISTRY. 20, 40, p. 8934-8941 8 p.

    Research output: Contribution to journalArticlepeer-review

  43. Conference scene: Challenges to commercialization

    Ilic, D. & Gentleman, E., May 2010, In: Regenerative Medicine. 5, 3, p. 341-343 3 p., N/A.

    Research output: Contribution to journalArticle

  44. The Effects of Strontium-Substituted Bioactive Glasses on Osteoblasts and Osteoclasts in vitro

    Gentleman, E., Fredholm, YC., Jell, G., O'Donnell, MD., Lotfibakhshaiesch, N., Hill, RG. & Stevens, MM., May 2010, In: Biomaterials. 31, 14, p. 3949 - 3956 8 p.

    Research output: Contribution to journalArticlepeer-review

  45. Extracellular Matrix Mediated Osteogenic Differentiation of Murine Embryonic Stem Cells.

    Evans, ND., Gentleman, E., Polak, JM. & Stevens, MM., Apr 2010, In: Biomaterials. 31, 12, p. 3244 - 52 9 p.

    Research output: Contribution to journalArticlepeer-review

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