Personal profile
Research interests (short)
Biomaterials, stem cells, regeneration medicine, organoids, disease modelling
Biographical details
Eileen Gentleman is a Professor of Bioengineering in the Centre for Craniofacial and Regenerative Biology at King's College London. She is also the Academic Lead for Impact for the Faculty of Dental, Oral and Craniofacial Sciences. Eileen joined Imperial College London in 2005 as post-doctoral research associate (Stevens Group) after completing her PhD in Biomedical Engineering (Tulane University, USA). In 2011, she was awarded a Wellcome Trust Research Career Development Fellowship and moved to King's where her research focuses on developing biomaterials to modulate the physical and biological properties of the 3D cell niche, which she uses for organoid-based disease modelling and tissue engineering applications. Her work has been published in Nature Materials, Nature Biomedical Engineering, PNAS, and Biomaterials. Eileen has received funding awards from the Wellcome Trust, the MRC, the EPSRC, the Rosetrees Trust, the Royal Society, and Orthopaedic Research UK, and is a recipient of both a Wellcome Image Award (2016) and an MIT Koch Institute Image Award (2016). In 2013 her work in regenerative medicine was recognised with a prestigious Philip Leverhulme Prize.
Follow us on twitter @GentlemanLab
Education/Academic qualification
Doctor of Philosophy, Tulane University
Award Date: 12 Aug 2005
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 9 Industry, Innovation, and Infrastructure
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Collaborations and top research areas from the last five years
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Measuring the elastic modulus of soft culture surfaces and three-dimensional hydrogels using atomic force microscopy
Norman, M. D. A., Ferreira, S. A., Jowett, G. M., Bozec, L. & Gentleman, E., May 2021, In: Nature Protocols. 16, 5, p. 2418-2449 32 p.Research output: Contribution to journal › Review article › peer-review
138 Citations (Scopus) -
ILC1 drive intestinal epithelial and matrix remodelling
Jowett, G. M., Norman, M. D. A., Yu, T. T. L., Rosell Arévalo, P., Hoogland, D., Lust, S. T., Read, E., Hamrud, E., Walters, N. J., Niazi, U., Chung, M. W. H., Marciano, D., Omer, O. S., Zabinski, T., Danovi, D., Lord, G. M., Hilborn, J., Evans, N. D., Dreiss, C. A. & Bozec, L. & 5 others, , 28 Feb 2021, In: NATURE MATERIALS. 20, 2, p. 250-259 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile95 Citations (Scopus)433 Downloads (Pure) -
RGD density along with substrate stiffness regulate hPSC hepatocyte functionality through YAP signalling
Gentleman, E., Rashid, T., Blackford, S., Jowett, G., Yan, Z., Yu, T., Norman, M., Guo, Y., Syanda, A., Riccio, F., Ng, S. S., Manolakakis, M., Lachowski, D., Garrita, E., Vernia, S. & de Rio Hernandez, A., 12 Jan 2023, In: Biomaterials. 293, 121982.Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Citations (Scopus)341 Downloads (Pure) -
Local depletion of proteoglycans mediates cartilage tissue repair in an ex vivo integration model
Gentleman, E., Merrild, N., Holzmann, V., Ariosa-Morejon, Y., Faull, P. A., Coleman, J., Barrell, W., Young, G., Fischer, R., Kelly, D., Addison, O., Vincent, T. & Grigoriadis, A., 1 Sept 2022, In: Acta Biomaterialia. 149, p. 179-188 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)104 Downloads (Pure) -
Mechanical confinement balances ECM remodeling in chondrocytes via MAPK and Hedgehog signaling
Gentleman, E., Yuan, M., Tang, C., Lust, S., Marciano, D., Gautrot, J. E., Dreiss, C., Dell'Accio, F., Eldridge, S. & Grigoriadis, A., 27 Mar 2026, (E-pub ahead of print) In: Biomaterials. 124171.Research output: Contribution to journal › Article › peer-review
Open Access
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Controlled co-delivery of exosomes and pro-regenerative factors for the repair of osteoarthritic temporomandibular joints
Tucker, A. (Primary Investigator) & Gentleman, E. (Co-Investigator)
1/07/2025 → 30/09/2026
Project: Research
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Deconstructing The Fibrotic Microenvironment In Crohn's Disease To Promote Tissue Healing
Gentleman, E. (Primary Investigator), Neves, J. (Co-Investigator) & academic, A. (Co-Investigator)
1/03/2023 → 31/05/2026
Project: Research
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Coupling optical tweezers with light microscopy to unravel the secrets of nuclear mechanobiology across-scales in health and disease
Garcia-Manyes, S. (Primary Investigator), Booth, P. (Co-Investigator), Elosegui Artola, A. (Co-Investigator), Gentleman, E. (Co-Investigator) & Parsons, M. (Co-Investigator)
1/07/2023 → 31/03/2024
Project: Research
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Establishment of an in vitro model to probe the role of perineuronal nets in the selective resistance of motor neurons to death in ALS
Gentleman, E. (Primary Investigator) & Lieberam, I. (Co-Investigator)
1/04/2023 → 31/03/2024
Project: Research
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Establishment of an in vitro model to probe the role of perineuronal nets in the selective resistance of motor neurons to death in ALS
Gentleman, E. (Primary Investigator) & Lieberam, I. (Co-Investigator)
1/04/2023 → 31/03/2024
Project: Research