Elin Grundberg

2023

Rare and Common Variants in GALNT3 May Affect Bone Mass Independently of Phosphate Metabolism

Anglo-Australasian Genetics Consortium, Hassan, N., Gregson, C. L., Tang, H., van der Kamp, M., Leo, P., McInerney-Leo, A. M., Zheng, J., Brandi, M. L., Tang, J. C. Y., Fraser, W., Stone, M. D., Grundberg, E., Brown, M. A., Duncan, E. L. & Tobias, J. H., May 2023, In: Journal of Bone and Mineral Research. 38, 5, p. 678-691 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers

Christiansen, C., Tomlinson, M., Eliot, M. N., Nilsson, E., de Oliveira Costeira, R. C., Villicana Munoz, S., Xia, M., Mompeo Masachs, O., Castillo Fernandez, J., Potier, L., Vohl, M-C., Tchernof, A., El-Sayed Moustafa, J., Menni, C., Kelsey, K. T., Ling, C., Grundberg, E., Small, K. & Bell, J., 22 Jul 2022, In: Genome medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function

MuTHER Consortium, Jan 2022, In: Nature genetics. 54, 1, p. 18-29 12 p.

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

2019

Identification of Novel Loci Associated With Hip Shape: A Meta-Analysis of Genomewide Association Studies

Baird, D. A., Evans, D. S., Kamanu, F. K., Gregory, J. S., Saunders, F. R., Giuraniuc, C. V., Barr, R. J., Aspden, R. M., Jenkins, D., Kiel, D. P., Orwoll, E. S., Cummings, S. R., Lane, N. E., Mullin, B. H., Williams, F. M. K., Richards, J. B., Wilson, S. G., Spector, T. D., Faber, B. G., Lawlor, D. A., & 10 othersGrundberg, E., Ohlsson, C., Pettersson-Kymmer, U., Capellini, T. D., Richard, D., Beck, T. J., Evans, D. M., Paternoster, L., Karasik, D. & Tobias, J. H., 1 Feb 2019, In: Journal of Bone and Mineral Research. 34, 2, p. 241-251 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Citations (Scopus)

2017

Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk

CARDIoGRAM Consortium, CARDIoGRAMplusC4D Consortium, MuTHER Consortium, Wellcome Trust Case Control Consortium, Brænne, I., Zeng, L., Willenborg, C., Tragante, V., Kessler, T., Willer, C. J., Laakso, M., Wallentin, L., Franks, P. W., Salomaa, V., Dehghan, A., Meitinger, T., Samani, N. J., Asselbergs, F. W., Erdmann, J., Schunkert, H., & 34 othersDeloukas, P., Kanoni, S., Willenborg, C., Farrall, M., Assimes, T. L., Thompson, J. R., Ingelsson, E., Saleheen, D., Erdmann, J., Goldstein, B. A., Stirrups, K., König, I. R., Cazier, J. B., Johansson, Å., Hall, A. S., Lee, J. Y., Willer, C. J., Chambers, J. C., Esko, T., Folkersen, L., Goel, A., Grundberg, E., Havulinna, A. S., Ho, W. K., Hopewell, J. C., Eriksson, N., Kleber, M. E., Kristiansson, K., Lundmark, P., Lyytikäinen, L. P., Rafelt, S., Shun, D., Strawbridge, R. J. & Thorleifsson, G., 22 Aug 2017, In: PLoS ONE. 12, 8, e0182999.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

2015

Genetic sharing with cardiovascular disease risk factors and diabetes reveals novel bone mineral density loci

GEFOS Consortium, 1 Dec 2015, In: PLoS ONE. 10, 12, e0144531.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Citations (Scopus)

Whole-genome sequence-based analysis of thyroid function

Taylor, P. N., Porcu, E., Chew, S., Campbell, P. J., Traglia, M., Brown, S. J., Mullin, B. H., Shihab, H. A., Min, J., Walter, K., Memari, Y., Huang, J., Barnes, M. R., Beilby, J. P., Charoen, P., Danecek, P., Dudbridge, F., Forgetta, V., Greenwood, C., Grundberg, E., & 30 othersJohnson, A. D., Hui, J., Lim, E. M., McCarthy, S., Muddyman, D., Panicker, V., Perry, J. R. B., Bell, J. T., Yuan, W., Relton, C., Gaunt, T., Schlessinger, D., Abecasis, G., Cucca, F., Surdulescu, G. L., Woltersdorf, W., Zeggini, E., Zheng, H-F., Toniolo, D., Dayan, C. M., Naitza, S., Walsh, J. P., Spector, T., Davey Smith, G., Durbin, R., Brent Richards, J., Sanna, S., Soranzo, N., Timpson, N. J. & UK0K Consortium, 6 Mar 2015, In: Nature Communications. 6, 10 p., 5681.

Research output: Contribution to journal › Article › peer-review

Open Access

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80 Citations (Scopus)

187 Downloads (Pure)

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture

Zheng, H. F., Forgetta, V., Hsu, Y. H., Estrada, K., Rosello-Diez, A., Leo, P. J., Dahia, C. L., Park-Min, K. H., Tobias, J. H., Kooperberg, C., Kleinman, A., Styrkarsdottir, U., Liu, C. T., Uggla, C., Evans, D. S., Nielson, C. M., Walter, K., Pettersson-Kymmer, U., McCarthy, S., Eriksson, J., & 136 othersKwan, T., Jhamai, M., Trajanoska, K., Memari, Y., Min, J., Huang, J., Danecek, P., Wilmot, B., Li, R., Chou, W. C., Mokry, L. E., Moayyeri, A., Claussnitzer, M., Cheng, C. H., Cheung, W., Medina-Gómez, C., Ge, B., Chen, S. H., Choi, K., Oei, L., Fraser, J., Kraaij, R., Hibbs, M. A., Gregson, C. L., Paquette, D., Hofman, A., Wibom, C., Tranah, G. J., Marshall, M., Gardiner, B. B., Cremin, K., Auer, P., Hsu, L., Ring, S., Tung, J. Y., Thorleifsson, G., Enneman, A. W., Van Schoor, N. M., De Groot, L. C. P. G. M., Van Der Velde, N., Melin, B., Kemp, J. P., Christiansen, C., Sayers, A., Zhou, Y., Calderari, S., Van Rooij, J., Carlson, C., Peters, U., Berlivet, S., Dostie, J., Uitterlinden, A. G., Williams, S. R., Farber, C., Grinberg, D., LaCroix, A. Z., Haessler, J., Chasman, D. I., Giulianini, F., Rose, L. M., Ridker, P. M., Eisman, J. A., Nguyen, T. V., Center, J. R., Nogues, X., Garcia-Giralt, N., Launer, L. L., Gudnason, V., Mellström, D., Vandenput, L., Amin, N., Van Duijn, C. M., Karlsson, M. K., Ljunggren, Ö., Svensson, O., Hallmans, G., Rousseau, F., Giroux, S., Bussière, J., Arp, P. P., Koromani, F., Prince, R. L., Lewis, J. R., Langdahl, B. L., Hermann, A. P., Jensen, J. E. B., Kaptoge, S., Khaw, K. T., Reeve, J., Formosa, M. M., Xuereb-Anastasi, A., Åkesson, K., McGuigan, F. E., Garg, G., Olmos, J. M., Zarrabeitia, M. T., Riancho, J. A., Ralston, S. H., Alonso, N., Jiang, X., Goltzman, D., Pastinen, T., Grundberg, E., Gauguier, D., Orwoll, E. S., Karasik, D., Davey-Smith, G., Smith, A. V., Siggeirsdottir, K., Harris, T. B., Zillikens, M. C., Van Meurs, J. B. J., Thorsteinsdottir, U., Maurano, M. T., Timpson, N. J., Soranzo, N., Durbin, R., Wilson, S. G., Ntzani, E. E., Brown, M. A., Stefansson, K., Hinds, D. A., Spector, T., Cupples, L. A., Ohlsson, C., Greenwood, C. M. T., Jackson, R. D., Rowe, D. W., Loomis, C. A., Evans, D. M., Ackert-Bicknell, C. L., Joyner, A. L., Duncan, E. L., Kiel, D. P., Rivadeneira, F. & Richards, J. B., 1 Oct 2015, In: Nature. 526, 7571, p. 112-117 6 p.

Research output: Contribution to journal › Article › peer-review

443 Citations (Scopus)

2014

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Mahajan, A., Go, M. J., Zhang, W., Below, J. E., Gaulton, K. J., Ferreira, T., Horikoshi, M., Johnson, A. D., Ng, M. C. Y., Prokopenko, I., Saleheen, D., Wang, X., Zeggini, E., Abecasis, G. R., Adair, L. S., Almgren, P., Atalay, M., Aung, T., Baldassarre, D., Balkau, B., & 35 othersBao, Y., Barnett, A. H., Barroso, I., Basit, A., Been, L. F., Beilby, J., Bell, G. I., Benediktsson, R., Bergman, R. N., Boehm, B. O., Boerwinkle, E., Bonnycastle, L. L., Burtt, N., Cai, Q., Campbell, H., Carey, J., Cauchi, S., Caulfield, M., Chan, J. C. N., Chang, L-C., Chang, T-J., Chang, Y-C., Charpentier, G., Chen, C-H., Chen, H., Chen, Y-T., Chia, K-S., Chidambaram, M., Grundberg, E., Small, K. S., DIAbet Genetics Replication & Meta, Asian Genetic Epidemiology Network, South Asian Type Diabet SAT2D Cons, Mexican Amer Type 2 Diabet MAT2D C & Type 2 Diabet Genetic Exploration, Mar 2014, In: Nature Genetics. 46, 3, p. 234-+ 13 p.

Research output: Contribution to journal › Article › peer-review

832 Citations (Scopus)

Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes

The MAGIC Investigators & The GIANT consortium, 7 Aug 2014, In: PLoS Genetics. 10, 8, e1004517.

Research output: Contribution to journal › Article › peer-review

Open Access

172 Citations (Scopus)

2013

Gene expression changes with age in skin, adipose tissue, blood and brain

Glass, D., Vinuela, A., Davies, M. N., Ramasamy, A., Parts, L., Knowles, D., Brown, A. A., Hedman, A. K., Small, K. S., Buil, A., Grundberg, E., Nica, A. C., Di Meglio, P., Nestle, F. O., Ryten, M., Durbin, R., McCarthy, M. I., Deloukas, P., Dermitzakis, E. T., Weale, M. E., & 4 othersBataille, V., Spector, T. D., UK Brain Expression Consortium & MuTHER Consortium, 26 Jul 2013, In: GENOME BIOLOGY. 14, 7, p. N/A 12 p., R75.

Research output: Contribution to journal › Article › peer-review

Open Access

216 Citations (Scopus)

Global Analysis of DNA Methylation Variation in Adipose Tissue from Twins Reveals Links to Disease-Associated Variants in Distal Regulatory Elements

Grundberg, E., Meduri, E., Sandling, J. K., Hedman, A. K., Keildson, S., Buil, A., Busche, S., Yuan, W., Nisbet, J., Sekowska, M., Wilk, A., Barrett, A., Small, K. S., Ge, B., Caron, M., Shin, S-Y., Lathrop, M., Dermitzakis, E. T., McCarthy, M. I., Spector, T. D., & 3 othersBell, J. T., Deloukas, P. & Multiple Tissue Human Expression R, 7 Nov 2013, In: American Journal of Human Genetics. 93, 5, p. 876-890 15 p., N/A.

Research output: Contribution to journal › Article › peer-review

Open Access

287 Citations (Scopus)

The Presence of Methylation Quantitative Trait Loci Indicates a Direct Genetic Influence on the Level of DNA Methylation in Adipose Tissue

Drong, A. W., Nicholson, G., Hedman, A. K., Meduri, E., Grundberg, E., Small, K. S., Shin, S-Y., Bell, J. T., Karpe, F., Soranzo, N., Spector, T. D., McCarthy, M. I., Deloukas, P., Rantalainen, M., Lindgren, C. M. & MolPAGE Consortia, 19 Feb 2013, In: PL o S One . 8, 2, 12 p., 55923.

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

2012

Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population

Bell, J. T., Tsai, P-C., Yang, T-P., Pidsley, R., Nisbet, J., Glass, D., Mangino, M., Zhai, G., Zhang, F., Valdes, A., Shin, S-Y., Dempster, E. L., Murray, R. M., Grundberg, E., Hedman, A. K., Nica, A., Small, K. S., Dermitzakis, E. T., McCarthy, M. I., Mill, J., & 3 othersSpector, T. D., Deloukas, P. & MuTHER Consortium, Apr 2012, In: PL o S Genetics. 8, 4, p. 189-200 12 p., e1002629.

Research output: Contribution to journal › Article › peer-review

Open Access

548 Citations (Scopus)

Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits

Billings, L. K., Hsu, Y-H., Ackerman, R. J., Dupuis, J., Voight, B. F., Rasmussen-Torvik, L. J., Hercberg, S., Lathrop, M., Barnes, D., Langenberg, C., Hui, J., Fu, M., Bouatia-Naji, N., Lecoeur, C., An, P., Magnusson, P. K., Surakkaza, I., Ripatti, S., Christiansen, L., Dalgard, C., & 21 othersFolkersen, L., Grundberg, E., Eriksson, P., Kaprio, J., Kyvik, K. O., Pedersen, N. L., Borecki, I. B., Province, M. A., Balkau, B., Froguel, P., Shuldiner, A. R., Palmer, L. J., Wareham, N., Meneton, P., Johnson, T., Pankow, J. S., Karasik, D., Meigs, J. B., Kiel, D. P., Florez, J. C. & ASCOT Investigators, DIAGRAM Consortium, MuTHER Consortium, MAGIC Investigators, GEFOS Consortium, Aug 2012, In: Diabetes. 61, 8, p. 2176-2186 11 p.

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Mapping cis- and trans-regulatory effects across multiple tissues in twins

Grundberg, E., Small, K. S., Hedman, A. K., Nica, A. C., Buil, A., Keildson, S., Bell, J. T., Yang, T-P., Meduri, E., Barrett, A., Nisbett, J., Sekowska, M., Wilk, A., Shin, S-Y., Glass, D., Travers, M., Min, J. L., Ring, S., Ho, K., Thorleifsson, G., & 31 othersKong, A., Thorsteindottir, U., Ainali, C., Dimas, A. S., Hassanali, N., Ingle, C., Knowles, D., Krestyaninova, M., Lowe, C. E., Di Meglio, P., Montgomery, S. B., Parts, L., Potter, S., Surdulescu, G., Tsaprouni, L., Tsoka, S., Bataille, V., Durbin, R., Nestle, F. O., O'Rahilly, S., Soranzo, N., Lindgren, C. M., Zondervan, K. T., Ahmadi, K. R., Schadt, E. E., Stefansson, K., Smith, G. D., McCarthy, M. I., Deloukas, P., Spector, T. D. & Multiple Tissue Human Expression R, Oct 2012, In: Nature Genetics. 44, 10, p. 1084-1089 8 p.

Research output: Contribution to journal › Article › peer-review

573 Citations (Scopus)

2011

Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms

Zhai, G., Teumer, A., Stolk, L., Perry, J. R. B., Vandenput, L., Coviello, A. D., Koster, A., Bell, J. T., Bhasin, S., Eriksson, J., Eriksson, A., Ernst, F., Ferrucci, L., Frayling, T. M., Glass, D., Grundberg, E., Haring, R., Hedman, A. K., Hofman, A., Kiel, D. P., & 26 othersKroemer, H. K., Liu, Y., Lunetta, K. L., Maggio, M., Lorentzon, M., Mangino, M., Melzer, D., Miljkovic, I., Nica, A., Penninx, B. W. J. H., Vasan, R. S., Rivadeneira, F., Small, K. S., Soranzo, N., Uitterlinden, A. G., Voelzke, H., Wilson, S. G., Xi, L., Zhuang, W. V., Harris, T. B., Murabito, J. M., Ohlsson, C., Murray, A., de Jong, F. H., Spector, T. D. & Wallaschofski, H., Apr 2011, In: PL o S Genetics. 7, 4, e1002025.

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

Kooner, J. S., Saleheen, D., Sim, X., Sehmi, J., Zhang, W., Frossard, P., Been, L. F., Chia, K-S., Dimas, A. S., Hassanali, N., Jafar, T., Jowett, J. B. M., Li, X., Radha, V., Rees, S. D., Takeuchi, F., Young, R., Aung, T., Basit, A., Chidambaram, M., & 47 othersDas, D., Grundberg, E., Hedman, A. K., Hydrie, Z. I., Islam, M., Khor, C-C., Kowlessur, S., Kristensen, M. M., Liju, S., Lim, W-Y., Matthews, D. R., Liu, J., Morris, A. P., Nica, A. C., Pinidiyapathirage, J. M., Prokopenko, I., Rasheed, A., Samuel, M., Shah, N., Shera, A. S., Small, K. S., Suo, C., Wickremasinghe, A. R., Wong, T. Y., Yang, M., Zhang, F., Abecasis, G. R., Barnett, A. H., Caulfield, M., Deloukas, P., Frayling, T. M., Froguel, P., Kato, N., Katulanda, P., Kelly, M. A., Liang, J., Mohan, V., Sanghera, D. K., Scott, J., Seielstad, M., Zimmet, P. Z., Elliott, P., Teo, Y. Y., McCarthy, M. I., Danesh, J., Tai, E. S. & Chambers, J. C., Oct 2011, In: Nature Genetics. 43, 10, p. 984 - U94 6 p.

Research output: Contribution to journal › Article › peer-review

436 Citations (Scopus)

Human metabolic individuality in biomedical and pharmaceutical research

Suhre, K., Shin, S-Y., Petersen, A-K., Mohney, R. P., Meredith, D., Wägele, B., Altmaier, E., Deloukas, P., Erdmann, J., Grundberg, E., Hammond, C. J., de Angelis, M. H., Kastenmüller, G., Köttgen, A., Kronenberg, F., Mangino, M., Meisinger, C., Meitinger, T., Mewes, H-W., Milburn, M. V., & 14 othersPrehn, C., Raffler, J., Ried, J. S., Römisch-Margl, W., Samani, N. J., Small, K. S., Wichmann, H-E., Zhai, G., Illig, T., Spector, T. D., Adamski, J., Soranzo, N., Gieger, C. & CARDIoGRAM, 1 Sept 2011, In: NATURE. 477, 7362, p. 54-60 7 p.

Research output: Contribution to journal › Article › peer-review

840 Citations (Scopus)

Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes

Small, K. S., Hedman, A. K., Grundberg, E., Nica, A. C., Thorleifsson, G., Kong, A., Thorsteindottir, U., Shin, S-Y., Richards, H. B., Soranzo, N., Ahmadi, K. R., Lindgren, C. M., Stefansson, K., Dermitzakis, E. T., Deloukas, P., Spector, T. D. & McCarthy, M. I., Jun 2011, In: Nature Genetics. 43, 6, p. 561 - 564 4 p.

Research output: Contribution to journal › Article › peer-review

249 Citations (Scopus)

The architecture of gene regulatory variation across multiple human tissues: the MuTHER study

Nica, A. C., Parts, L., Glass, D., Nisbet, J., Barrett, A., Sekowska, M., Travers, M., Potter, S., Grundberg, E., Small, K., Hedman, A. K., Bataille, V., Bell, J. T., Surdulescu, G., Dimas, A. S., Ingle, C., Nestle, F. O., di Meglio, P., Min, J. L., Wilk, A., & 15 othersHammond, C. J., Hassanali, N., Yang, T-P., Montgomery, S. B., O'Rahilly, S., Lindgren, C. M., Zondervan, K. T., Soranzo, N., Barroso, I., Durbin, R., Ahmadi, K., Deloukas, P., McCarthy, M. I., Dermitzakis, E. T. & Spector, T. D., Feb 2011, In: PL o S Genetics. 7, 2, e1002003.

Research output: Contribution to journal › Article › peer-review

Open Access

332 Citations (Scopus)

Elin Grundberg

Research output

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