King's College London

Research portal

Dr Elisabeth Ehler

  1. Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant

    Jiang, H., Hooper, C., Kelly, M., Steeples, V., Simon, J. N., Beglov, J., Azad, A. J., Leinhos, L., Bennett, P., Ehler, E., Kalisch-Smith, J. I., Sparrow, D. B., Fischer, R., Heilig, R., Isackson, H., Ehsan, M., Patone, G., Huebner, N., Davies, B., Watkins, H. & 1 others, Gehmlich, K., Dec 2021, In: Basic Research in Cardiology. 116, 1, 14.

    Research output: Contribution to journalArticlepeer-review

  2. "Meet the Editor Series"-Elisabeth Ehler

    Ehler, E., Oct 2021, In: Biophysical Reviews. 13, 5, p. 579-581 3 p.

    Research output: Contribution to journalEditorialpeer-review

  3. The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles

    van der Pijl, R. J., Domenighetti, A. A., Sheikh, F., Ehler, E., Ottenheijm, C. A. C. & Lange, S., Oct 2021, In: Biophysical Reviews. 13, 5, p. 653-677 25 p.

    Research output: Contribution to journalArticlepeer-review

  4. Electrical stimulation applied during differentiation drives the hiPSC-CMs towards a mature cardiac conduction-like cells

    Crestani, T., Steichen, C., Neri, E., Rodrigues, M., Fonseca-Alaniz, M. H., Ormrod, B., Holt, M. R., Pandey, P., Harding, S., Ehler, E. & Krieger, J. E., 10 Dec 2020, In: Biochemical and Biophysical Research Communications. 533, 3, p. 376-382 7 p.

    Research output: Contribution to journalArticlepeer-review

  5. Receptor-independent modulation of cAMP-dependent protein kinase and protein phosphatase signaling in cardiac myocytes by oxidizing agents

    Diering, S., Stathopoulou, K., Goetz, M., Rathjens, L., Harder, S., Piasecki, A., Raabe, J., Schulz, S., Brandt, M., Pflaumenbaum, J., Fuchs, U., Donzelli, S., Sadayappan, S., Nikolaev, V. O., Flenner, F., Ehler, E. & Cuello, F., 6 Nov 2020, In: The Journal of biological chemistry. 295, 45, p. 15342-15365 24 p.

    Research output: Contribution to journalArticlepeer-review

  6. The intercalated disc: a mechanosensing signalling node in cardiomyopathy

    Pruna, M. & Ehler, E., 1 Aug 2020, In: Biophysical Reviews. 12, 4, p. 931-946 16 p.

    Research output: Contribution to journalReview articlepeer-review

  7. Prelamin A mediates myocardial inflammation in dilated and HIV-Associated cardiomyopathies

    Brayson, D., Frustaci, A., Verardo, R., Chimenti, C., Russo, M. A., Hayward, R., Ahmad, S. M., Vizcay-barrena, G., Protti, A., Zammit, P. S., Dos Remedios, C. G., Ehler, E., Shah, A. M. & Shanahan, C. M., 14 Nov 2019, In: JCI Insight. 4, 22, e126315.

    Research output: Contribution to journalArticlepeer-review

  8. The European Muscle Conference 2019 Special Issue

    Ehler, E. & Marston, S. B., 1 Jun 2019, In: Journal of Muscle Research and Cell Motility. 40, 2, 1 p.

    Research output: Contribution to journalEditorialpeer-review

  9. PKC and PKN in heart disease

    Marrocco, V., Bogomolovas, J., Ehler, E., dos Remedios, C. G., Yu, J., Gao, C. & Lange, S., 1 Mar 2019, In: Journal of Molecular and Cellular Cardiology. 128, p. 212-226 15 p.

    Research output: Contribution to journalReview articlepeer-review

  10. The M-band: The underestimated part of the sarcomere

    Lange, S., Pinotsis, N., Agarkova, I. & Ehler, E., 7 Feb 2019, (E-pub ahead of print) In: Biochimica et Biophysica Acta - Molecular Cell Research.

    Research output: Contribution to journalReview articlepeer-review

  11. The MEF2 transcriptional target DMPK induces loss of sarcomere structure and cardiomyopathy

    Damanafshan, A., Elzenaar, I., Samson-Couterie, B., Van Der Made, I., Bourajjaj, M., Van Den Hoogenhof, M. M., Van Veen, H. A., Picavet, D. I., Beqqali, A., Ehler, E., De Windt, L. J., Pinto, Y. M. & Van Oort, R. J., 1 Sep 2018, In: Cardiovascular Research. 114, 11, p. 1474-1486 13 p.

    Research output: Contribution to journalArticlepeer-review

  12. Genetics of and pathogenic mechanisms in arrhythmogenic right ventricular cardiomyopathy

    Vimalanathan, A. K., Ehler, E. & Gehmlich, K., Aug 2018, In: Biophysical Reviews. 10, 4, p. 973-982 10 p.

    Research output: Contribution to journalReview articlepeer-review

  13. Non-sarcomeric causes of heart failure

    Gehmlich, K. & Ehler, E., Aug 2018, In: Biophysical Reviews. 10, 4, p. 943-947 5 p.

    Research output: Contribution to journalArticle

  14. Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions

    Pandey, P., Hawkes, W., Hu, J., Megone, W. V., Gautrot, J., Anilkumar, N., Zhang, M., Hirvonen, L., Cox, S., Ehler, E., Hone, J., Sheetz, M. & Iskratsch, T., 5 Feb 2018, In: Developmental Cell. 44, 3, p. 326-336

    Research output: Contribution to journalArticlepeer-review

  15. Actin-associated proteins and cardiomyopathy-the 'unknown' beyond troponin and tropomyosin.

    Ehler, E., 2018, In: Biophysical Reviews. 10, 4, p. 1121 1128 p., 10.1007/s12551-018-0428-1.

    Research output: Contribution to journalReview articlepeer-review

  16. Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion

    Ehsan, M., Kelly, M., Hooper, C., Yavari, A., Beglov, J., Bellahcene, M., Ghataorhe, K., Poloni, G., Goel, A., Kyriakou, T., Fleischanderl, K., Ehler, E., Makeyev, E., Lange, S., Ashrafian, H., Redwood, C., Davies, B., Watkins, H. & Gehmlich, K., 2018, In: Journal of Molecular and Cellular Cardiology.

    Research output: Contribution to journalArticlepeer-review

  17. RNAseq reveals mechanisms of cardiomyopathy in Mlp-C58G knock-in mice: SI:Abstracts ISHR-ES Amsterdam

    Ehsan, M., Kelly, M., Hooper, C., Beglov, J., Davies, B., Fleischanderld, K., Ehler, E., Redwood, C., Watkins, H. & Gehmlich, K., 2018, In: Journal of Molecular and Cellular Cardiology. 120

    Research output: Contribution to journalMeeting abstract

  18. Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development

    Ridge, L. A., Mitchell, K., Al-Anbaki, A., Shaikh Qureshi, W. M., Stephen, L. A., Tenin, G., Lu, Y., Lupu, I. E., Clowes, C., Robertson, A., Barnes, E., Wright, J. A., Keavney, B., Ehler, E., Lovell, S. C., Kadler, K. E. & Hentges, K. E., 30 Oct 2017, (E-pub ahead of print) In: PL o S Genetics. 13, 10, e1007068.

    Research output: Contribution to journalArticlepeer-review

  19. Ryanodine receptors are part of the myospryn complex in cardiac muscle

    Benson, M. A., Tinsley, C. L., Waite, A. J., Carlisle, F. A., Sweet, S. M. M., Ehler, E., George, C. H., Lai, F. A., Martin-Rendon, E. & Blake, D. J., 24 Jul 2017, (E-pub ahead of print) In: Scientific Reports. 7, 1, 6312.

    Research output: Contribution to journalArticlepeer-review

  20. Tropomyosin 1: Multiple roles in the developing heart and in the formation of congenital heart defects

    England, J., Granados-Riveron, J., Polo-Parada, L., Kuriakose, D., Moore, C., Brook, J. D., Rutland, C. S., Setchfield, K., Gell, C., Ghosh, T. K., Bu'Lock, F., Thornborough, C., Ehler, E. & Loughna, S., 27 Mar 2017, (E-pub ahead of print) In: Journal of Molecular and Cellular Cardiology.

    Research output: Contribution to journalArticlepeer-review

  21. Combination of Whole Genome Sequencing, Linkage, and Functional Studies Implicates a Missense Mutation in Titin as a Cause of Autosomal Dominant Cardiomyopathy with Features of Left Ventricular Noncompaction

    Hastings, R., De Villiers, C. P., Hooper, C., Ormondroyd, L., Pagnamenta, A., Lise, S., Salatino, S., Knight, S. J. L., Taylor, J. C., Thomson, K. L., Arnold, L., Chatziefthimiou, S. D., Konarev, P. V., Wilmanns, M., Ehler, E., Ghisleni, A., Gautel, M., Blair, E., Watkins, H. & Gehmlich, K., 1 Oct 2016, In: Circulation-Cardiovascular Genetics. 9, 5, p. 426-435 10 p.

    Research output: Contribution to journalArticlepeer-review

  22. Cardiac cytoarchitecture: why the "hardware" is important for heart function!

    Ehler, E., Jul 2016, In: Biochimica et biophysica acta-Molecular cell research. 1863, 7, p. 1857-1863 7 p.

    Research output: Contribution to journalReview articlepeer-review

  23. MLP and CARP are linked to chronic PKCα signaling in dilated cardiomyopathy

    Lange, S., Gehmlich, K., Lun, A. S., Blondelle, J., Hooper, C., Dalton, N. D., Alvarez, E. A., Zhang, X., Bang, M-L., Abassi, Y. A., dos Remedios, C. G., Peterson, K. L., Chen, J. & Ehler, E., 29 Jun 2016, In: Nature Communications. 7, 1, 11 p., 12120.

    Research output: Contribution to journalArticlepeer-review

  24. The cardiac stress response factor Ms1 Can Bind to DNA and Has a function in the nucleus

    Zaleska, M., Fogl, C., Kho, A. L., Ababou, A., Ehler, E. & Pfuhl, M., 14 Dec 2015, In: PL o S One . 10, 12, A1025.

    Research output: Contribution to journalArticlepeer-review

  25. OBSCN mutations associated with dilated cardiomyopathy and haploinsufficiency

    Marston, S., Montgiraud, C., Munster, A. B., Copeland, ON., Choi, O., dos Remedios, C., Messer, A. E., Ehler, E. & Knöll, R., 25 Sep 2015, In: PL o S One . 10, 9, e0138568.

    Research output: Contribution to journalArticlepeer-review

  26. α5β1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3

    Paul, N. R., Allen, J. L., Chapman, A., Morlan-Mairal, M., Zindy, E., Jacquemet, G., Fernandez del Ama, L., Ferizovic, N., Green, D. M., Howe, J. D., Ehler, E., Hurlstone, A. & Caswell, P. T., 14 Sep 2015, In: Journal of Cell Biology. 210, 6, p. 1013-1031 19 p.

    Research output: Contribution to journalArticlepeer-review

  27. Involvement of unconventional myosin VI in myoblast function and myotube formation

    Karolczak, J., Pavlyk, I., Majewski, Ł., Sobczak, M., Niewiadomski, P., Rzhepetskyy, Y., Sikorska, A., Nowak, N., Pomorski, P., Prószyński, T., Ehler, E. & Rędowicz, M. J., 18 Jul 2015, In: Histochemistry and Cell Biology. 144, 1, p. 21-38 18 p.

    Research output: Contribution to journalArticlepeer-review

  28. Cardiac cytoarchitecture: How to maintain a working heart

    Ehler, E., 1 Jan 2015, Springer International Publishing Switzerland. 309 p.

    Research output: Book/ReportBookpeer-review

  29. Cell electrospinning cardiac patches for tissue engineering the heart

    Ehler, E. & Jayasinghe, S. N., 21 Sep 2014, In: Analyst. 139, 18, p. 4449-4452 4 p.

    Research output: Contribution to journalArticlepeer-review

  30. Myosin VI Localization and Expression in Striated Muscle Pathology

    Karolczak, J., Weis, S., Ehler, E., Kierdaszuk, B., Berdynski, M., Zekanowski, C., Kaminska, A. M. & Redowicz, M. J., Sep 2014, In: Anatomical record-Advances in integrative anatomy and evolutionary biology. 297, 9, p. 1706-1713 8 p.

    Research output: Contribution to journalArticlepeer-review

  31. The formin FHOD1 in cardiomyocytes

    Dwyer, J., Pluess, M., Iskratsch, T., Dos Remedios, C. G. & Ehler, E., Sep 2014, In: Anatomical Record. 297, 9, p. 1560-1570 11 p.

    Research output: Contribution to journalArticlepeer-review

  32. Cardiomyocyte growth and sarcomerogenesis at the intercalated disc

    Wilson, A. J., Schoenauer, R., Ehler, E., Agarkova, I. & Bennett, P. M., Jan 2014, In: Cellular and molecular life sciences : CMLS. 71, 1, p. 165-181 17 p.

    Research output: Contribution to journalArticlepeer-review

  33. A formin-g role during development and disease

    Randall, T. S. & Ehler, E., 2014, In: European Journal of Cell Biology. 93, 5-6, p. 205-211

    Research output: Contribution to journalLiterature reviewpeer-review

  34. FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migration

    Iskratsch, T., Yu, C-H., Mathur, A., Liu, S., Stévenin, V., Dwyer, J., Hone, J., Ehler, E. & Sheetz, M., 9 Dec 2013, In: Developmental Cell. 27, 5, p. 545-559 15 p.

    Research output: Contribution to journalArticlepeer-review

  35. Two distinct phosphorylation events govern the function of muscle FHOD3

    Iskratsch, T., Reijntjes, S., Dwyer, J., Toselli, P., Dégano, I. R., Dominguez, I. & Ehler, E., Mar 2013, In: Cellular and Molecular Life Sciences. 70, 5, p. 893-908 16 p.

    Research output: Contribution to journalArticlepeer-review

  36. Molecular changes in the heart of a severe case of arrhythmogenic right ventricular cardiomyopathy caused by a desmoglein-2 null allele

    Gehmlich, K., Syrris, P., Reimann, M., Asimaki, A., Ehler, E., Evans, A., Quarta, G., Pantazis, A., Saffitz, J. E. & McKenna, W. J., Jul 2012, In: CARDIOVASCULAR PATHOLOGY. 21, 4, p. 275-282 8 p.

    Research output: Contribution to journalArticlepeer-review

  37. RBM24: a 'Regional Business Manager' in charge of the maintenance of sarcomeric protein expression 24 h a day?

    Ehler, E., 1 Jun 2012, In: Cardiovascular Research. 94, 3, p. 393-394 2 p.

    Research output: Contribution to journalEditorialpeer-review

  38. The intercalated disc - a truly special type of cell-cell contact in dilated cardiomyopathy

    Hirschy, A. & Ehler, E., May 2012, In: Cell and Tissue Research. 348, 2, p. 340-341 2 p.

    Research output: Contribution to journalMeeting abstractpeer-review

  39. Actin in striated muscle: recent insights into assembly and maintenance

    Dwyer, J., Iskratsch, T. & Ehler, E., Mar 2012, In: Biophysical Reviews. 4, 1, p. 17-25 9 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  40. Knockdown of embryonic myosin heavy chain reveals an essential role in the morphology and function of the developing heart

    Rutland, C. S., Polo-Parada, L., Ehler, E., Alibhai, A., Thorpe, A., Suren, S., Emes, R. D., Patel, B. & Loughna, S., 15 Sep 2011, In: Development (Cambridge): for advances in developmental biology and stem cells. 138, 18, p. 3955 - 3966 12 p.

    Research output: Contribution to journalArticlepeer-review

  41. A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions

    Gehmlich, K., Lambiase, P. D., Asimaki, A., Ciaccio, E. J., Ehler, E., Syrris, P., Saffitz, J. E. & McKenna, W. J., May 2011, In: HEART RHYTHM. 8, 5, p. 711 - 718 8 p.

    Research output: Contribution to journalArticlepeer-review

  42. Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations

    Gehmlich, K., Syrris, P., Peskett, E., Evans, A., Ehler, E., Asimaki, A., Anastasakis, A., Tsatsopoulou, A., Vouliotis, A-I., Stefanadis, C., Saffitz, J. E., Protonotarios, N. & McKenna, W. J., 1 Apr 2011, In: Cardiovascular Research. 90, 1, p. 77 - 87 11 p.

    Research output: Contribution to journalArticlepeer-review

  43. Formin-g muscle cytoarchitecture

    Iskratsch, T. & Ehler, E., 15 Mar 2011, In: BioArchitecture. 1, 2, p. 66-68 3 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  44. EH-myomesin splice isoform is a novel marker for dilated cardiomyopathy

    Schoenauer, R., Emmert, M. Y., Felley, A., Ehler, E., Brokopp, C., Weber, B., Nemir, M., Faggian, G. G., Pedrazzini, T., Falk, V., Hoerstrup, S. P. & Agarkova, I., Mar 2011, In: Basic Research in Cardiology. 106, 2, p. 233 - 247 15 p.

    Research output: Contribution to journalArticlepeer-review

  45. Novel Role for p90 Ribosomal S6 Kinase in the Regulation of Cardiac Myofilament Phosphorylation

    Cuello, F., Bardswell, S. C., Haworth, R. S., Ehler, E., Sadayappan, S., Kentish, J. C. & Avkiran, M., 18 Feb 2011, In: Journal of Biological Chemistry. 286, 7, p. 5300 - 5310 11 p.

    Research output: Contribution to journalArticlepeer-review

  46. Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance

    Iskratsch, T., Lange, S., Dwyer, J., Kho, A. L., dos Remedios, C. & Ehler, E., 13 Dec 2010, In: The Journal of cell biology. 191, 6, p. 1159 - 1172 14 p.

    Research output: Contribution to journalArticlepeer-review

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