Research output per year
Research output per year
Personal profile
Research interests
We want to look at the organisation of the heart cell (cardiomyocyte) at a subcellular level; being interested mainly in cytoskeletal and signalling aspects:
- How are myofibrils and intercalated disks assembled in heart cells during development?
- How and if are myofibrils and intercalated disks affected in the diseased heart?
- What is the functional basis for the adaptations of cardiomyocytes during development and disease?
Research interests (short)
What makes a heart work from a cell biologist's point of view.
Click here for the Ehler group webpage
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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In situ FRET-based localization of the N-terminus of myosin binding protein-C in heart muscle cells
Chandler, J., Treacy, C., Ameer-Beg, S., Ehler, E., Irving, M. & Kampourakis, T., 21 Mar 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 12, e2222005120.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)69 Downloads (Pure) -
Sulforaphane induced NRF2 activation in obese pregnancy attenuates developmental redox imbalance and improves early-life cardiovascular function in offspring
Psefteli, P. M., Morris, J., Ehler, E., Smith, L., Bowe, J., Mann, G., Taylor, P. & Chapple, S., 9 Sept 2023, (Accepted/In press) In: Redox Biology. REDOX-D-23-01559.Research output: Contribution to journal › Article › peer-review
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CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes
Stathopoulou, K., Schnittger, J., Raabe, J., Fleischer, F., Mangels, N., Piasecki, A., Findlay, J., Hartmann, K., Krasemann, S., Schlossarek, S., Uebeler, J., Wixler, V., Blake, D. J., Baillie, G. S., Carrier, L., Ehler, E. & Cuello, F., Aug 2022, In: FEBS Journal. 289, 15, p. 4622-4645 24 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)126 Downloads (Pure) -
Polarized illumination coded structured illumination microscopy (picoSIM): Experimental results
Appelt, D., Ehler, E., Shukla Mukherjee, S., Heintzmann, R. & Wicker, K., 2022, In: Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 380, 2220, 20210193.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant
Jiang, H., Hooper, C., Kelly, M., Steeples, V., Simon, J. N., Beglov, J., Azad, A. J., Leinhos, L., Bennett, P., Ehler, E., Kalisch-Smith, J. I., Sparrow, D. B., Fischer, R., Heilig, R., Isackson, H., Ehsan, M., Patone, G., Huebner, N., Davies, B., Watkins, H., & 1 others, Dec 2021, In: Basic Research in Cardiology. 116, 1, 14.Research output: Contribution to journal › Article › peer-review
Open Access9 Citations (Scopus)
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BHF Centre Theme 2 Pump prime Burnello
Brunello, E., Ehler, E. & Giacca, M.
4/01/2021 → 31/03/2024
Project: Research
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A cryo-electron microscope for structural biology (including single-particle and tomography) at KCL.
Conte, M., Atherton, J., Beavil, A., Bergeron, J., Booth, P., Burrone, J., Carlton, J., De Nicola, G., Ehler, E., Fleck, R., Fraternali, F., Garnett, J., Gautel, M., Isaacson, R., Kampourakis, T., Malim, M., McDonnell, J., Neil, S., Odendall, C., Pfuhl, M., Politis, A., Steiner, R. & Sutton, B.
BBSRC Biotechnology and Biological Sciences Research Council
1/08/2022 → 31/07/2023
Project: Research
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UKRI CoA: MICA: Interfering with pathological signalling in dilated cardiomyopathy
EPSRC Engineering and Physical Sciences Research Council
1/08/2021 → 30/09/2021
Project: Research
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Validating the maturation status of iPSC-derived cardiomyocytes
31/12/2019 → 30/12/2020
Project: Research
Activities
- 3 Participation in conference
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the International Muscle Energetics Conference, Banff, Canada
Elisabeth Ehler (Keynote/plenary speaker)
2006 → …Activity: Participating in or organising an event › Participation in conference
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the session "Myofibrillogenesis" at the XVIII World Congress of the International Society of Heart Research in Brisbane, Australia,
Elisabeth Ehler (Chair)
2004 → …Activity: Participating in or organising an event › Participation in conference
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the session "Myofibrillogenesis" at the XVIII World Congress of the International Society of Heart Research in Brisbane, Australia
Elisabeth Ehler (Keynote/plenary speaker)
2004 → …Activity: Participating in or organising an event › Participation in conference