No photo of Ellen Solomon

Ellen Solomon

Professor

  • 4267
    Citations

Personal profile

Research interests

<p>Much of my work centres on the genetics of breast cancer (especially where this is of an early onset, familial nature), and adopts several approaches:<br /><br />A molecular analysis of the BRCA1 gene, which confers susceptibility to breast cancer in a proportion of women. This involves the investigation of the structure and expression of the gene product (including its role in sporadic breast and ovarian cancer), its regulation, and its behaviour as a tumour suppressor, and studies of transgenic mice with altered BRCA1 genes. Collaborative investigations of the structure of the RING finger domain of BRCA1 are also under way.&nbsp;<br /><br />The analysis of further genes implicated in the genesis of breast cancer, which exist in close proximity to BRCA1. Molecular analysis of the function, expression and regulation of these genes is gradually disentangling their complex relationship with BRCA1. <br /><br />A sib-pair genome search, which aims to identify regions of the genome containing further genes predisposing to breast cancer, is being undertaken with Professor Cathryn Lewis. <br /><br />I also have an interest in the PML/RARA translocation underlying Acute Promyelocytic Leukaemia, and with Professor David Grimwade am investigating the regulation of PML, and the structure of its RING finger domain.</p>

Research interests (short)

Breast Cancer Genetics; Acute Promyelocytic Leukaemia; Human Genetic Disease

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Fingerprint

Dive into the research topics where Ellen Solomon is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or