Research output per year
Research output per year
Personal profile
Research interests
My research focuses on adeno-associated virus (AAV), an intriguing human parvovirus which displays features that are unique among DNA viruses. In addition, AAV has become a frontrunner as a vector for human gene therapy based on results from a number of clinical trials. Although AAV is the most commonly used vector, there are limitations due to its restricted biological activity and the challenge with respect to commercial manufacturing. Owing to its complex life cycle and dependence on helper viruses, molecular insights into viral replication are essential for the development of vectors with increased bioactivity and production schemes that promise maximal output. My laboratory aims to provide the critical link between basic AAV research and AAV gene therapy.
Research interests (short)
Virology; molecular biology; gene therapy
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Comparative structural, biophysical, and receptor binding study of true type and wild type AAV2
Bennett, A., Hull, J., Jolinon, N., Tordo, J., Moss, K., Binns, E., Mietzsch, M., Hagemann, C., Linden, R. M., Serio, A., Chipman, P., Sousa, D., Broecker, F., Seeberger, P., Henckaerts, E., McKenna, R. & Agbandje-McKenna, M., Dec 2021, In: Journal of Structural Biology. 213, 4, 107795.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
Herpes simplex virus 1 coinfection modifies adeno-associated virus genome end recombination
Meier, A. F., Tobler, K., Michaelsen, K., Vogt, B., Henckaerts, E. & Fraefel, C., Jun 2021, In: Journal of Virology. 95, 13, e00486-21.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Generation of light-producing somatic-transgenic mice using adeno-associated virus vectors
Karda, R., Rahim, A. A., Wong, A. M. S., Suff, N., Diaz, J. A., Perocheau, D. P., Tijani, M., Ng, J., Baruteau, J., Martin, N. P., Hughes, M., Delhove, J. M. K. M., Counsell, J. R., Cooper, J. D., Henckaerts, E., Mckay, T. R., Buckley, S. M. K. & Waddington, S. N., 7 Feb 2020, (E-pub ahead of print) In: Scientific Reports. 10, 1, 2121.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)138 Downloads (Pure) -
An Improved Adeno-Associated Virus Vector for Neurological Correction of the Mouse Model of Mucopolysaccharidosis IIIA
Gray, A. L., O'Leary, C., Liao, A., Agúndez, L., Youshani, A. S., Gleitz, H. F., Parker, H., Taylor, J. T., Danos, O., Hocquemiller, M., Palomar, N., Linden, R. M., Henckaerts, E., Holley, R. J. & Bigger, B. W., 1 Sept 2019, In: Human Gene Therapy. 30, 9, p. 1052-1066 15 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson's disease
Rosenblad, C., Li, Q., Pioli, E. Y., Dovero, S., Antunes, A. S., Agúndez, L., Bardelli, M., Linden, R. M., Henckaerts, E., Björklund, A., Bezard, E. & Björklund, T., 1 Aug 2019, In: Brain : a journal of neurology. 142, 8, p. 2402-2416 15 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Citations (Scopus)
Projects
- 12 Finished
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Characterisation of a novel AAV vector with enhanced neurotropism
Henckaerts, E. (Primary Investigator)
14/01/2019 → 13/01/2022
Project: Research
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Developing new imaging tools to study the spatiotemporal landscape of immune responses
Barral, P. (Primary Investigator) & Henckaerts, E. (Co-Investigator)
1/02/2017 → 31/01/2018
Project: Research
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Establishment of adeno-associated virus latency by the recruitment of KAP1
Henckaerts, E. (Primary Investigator)
1/05/2016 → 30/04/2019
Project: Research
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Rejuvenating beta-cell antigen-specific regulatory T-cells for adoptive therapy for type 1 diabetes
Henckaerts, E. (Primary Investigator), Peakman, M. (Co-Investigator) & Tree, T. (Co-Investigator)
1/06/2014 → 31/05/2015
Project: Research
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Confidence in Concept 2013
Blower, P. (Primary Investigator), Henckaerts, E. (Primary Investigator), Howell, S. (Primary Investigator), Maccabe, J. (Primary Investigator), Rahman, M. (Primary Investigator), Rashid, T. (Primary Investigator), Wardle, F. (Primary Investigator), Dobson, R. (Co-Investigator), McGuire, P. (Co-Investigator) & Page, C. (Co-Investigator)
1/03/2014 → 30/04/2016
Project: Research
Activities
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XIth Parvovirus Workshop, Les Diablerets, Switzerland
Henckaerts, E. (Speaker)
2006 → …Activity: Participating in or organising an event › Participation in conference
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International Society for Stem Cell Research
Henckaerts, E. (Member)
2005 → …Activity: Other › Types of External academic engagement - Membership of external research organisation
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American Society of Gene Therapy
Henckaerts, E. (Member)
2005 → …Activity: Other › Types of External academic engagement - Membership of external research organisation
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Charles H. Revson Senior Fellow in Biomedical Sciences
Henckaerts, E. (Fellow)
2005 → 2007Activity: Other › Types of External academic engagement - Membership of external research organisation
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8th Annual Meeting of the American Society of Gene Therapy, St. Louis, MO
Henckaerts, E. (Speaker)
2005 → …Activity: Participating in or organising an event › Participation in conference
Prizes
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Charles H. Revson Fellowship in Biomedical Sciences. Postdoctoral fellowship providing 2-year salary and $30,000 for research expenses.
Henckaerts, E. (Recipient), 2001
Prize: Fellowship awarded competitively