Research output per year
Research output per year
Personal profile
Research interests
Leukaemia is a clonal disease initiated from a very small number of pre-leukaemic stem cells (pre-LSCs) carrying the initiating genetic events, which subsequently convert to full blown LSCs by acquiring further mutations necessary for the overt diseases such as acute myeloid leukaemia (AML). Emerging evidence indicates that pathways critical for regulation of normal stem cells are frequently hijacked or mutated in LSCs. My group is interested in understanding the molecular and cellular mechanisms underlying the oncogenic conversion of normal cells into AML stem cells. <br /> <br /> Please visit Prof. So’s website (www.ericso.org) for further details.<br /> <br />
Research interests (short)
Biology of normal and malignant stem cells
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Hematopoietic stem cell quiescence and DNA replication dynamics maintained by the resilient β-catenin/Hoxa9/Prmt1 axis
So, C. W. E., Zeisig, B., Fung, T. K., Troadec, E., Lau, P., Cheung, N. & Lynch, J., 18 Apr 2024, In: Blood. 143, 16, p. 1586-1598 13 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
High Throughput Fluorescence-Based In Vitro Experimental Platform for the Identification of Effective Therapies to Overcome Tumour Microenvironment-Mediated Drug Resistance in AML
Arroyo-Berdugo, Y., Sendino, M., Greaves, D., Nojszewska, N., Idilli, O., So, C. W., Di Silvio, L., Quartey-Papafio, R., Farzaneh, F., Rodriguez, J. A. & Calle, Y., Apr 2023, In: Cancers. 15, 7, 1988.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
A novel network pharmacology approach for leukaemia differentiation therapy using Mogrify®
Lee, L. M., Christodoulou, E. G., Shyamsunder, P., Chen, B. J., Lee, K. L., Fung, T. K., So, C. W. E., Wong, G. C., Petretto, E., Rackham, O. J. L. & Tiong Ong, S., 25 Nov 2022, In: Oncogene. 41, 48, p. 5160-5175 16 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia
Luo, H., Zhu, G., Eshelman, M. A., Fung, T. K., Lai, Q., Wang, F., Zeisig, B. B., Lesperance, J., Ma, X., Chen, S., Cesari, N., Cogle, C., Chen, B., Xu, B., Yang, F. C., So, C. W. E., Qiu, Y., Xu, M. & Huang, S., 17 Feb 2022, In: MOLECULAR CELL. 82, 4, p. 833-851.e11Research output: Contribution to journal › Article › peer-review
Open Access57 Citations (Scopus) -
Functional reconstruction of human AML reveals stem cell origin and vulnerability of treatment resistant MLL-rearranged leukemia
So, C. W. E., Zeisig, B., Fung, T. K., Zarowiecki, M., Stanojevic, B., Lynn, C. & Mufti, G., 8 Jan 2021, (Accepted/In press) In: Science Translational Medicine.Research output: Contribution to journal › Article
Open AccessFile473 Downloads (Pure)
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Accelerated DNA replication as molecular determinant and therapeutic opportunity in haematological malignancies
So, E. (Primary Investigator)
SNSF Swiss National Science Foundation
1/01/2023 → 31/12/2026
Project: Research
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Role of HOTTIP/beta-catenin-HOXA9/PRMT1 axis in hematopoietic and leukemic stem cells
So, E. (Primary Investigator)
NIH National Institutes of Health
1/07/2022 → 30/06/2025
Project: Research
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Towards personalized and innovative treatment for acute myeloid leukaemia
So, E. (Primary Investigator)
Research Grants Council Hong Kong
1/06/2021 → 30/09/2025
Project: Research
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Targeting of aberrant epigenetic circuitries and associated DNA damage response in acute myeloid leukaemia
So, E. (Primary Investigator)
1/02/2021 → 31/01/2026
Project: Research
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Molecular dissection and targeting of corrupted epigenetic networks in acute myeloid leukaemia
So, E. (Primary Investigator)
1/04/2021 → 31/03/2023
Project: Research