King's College London

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Dr Esperanza Perucha

  1. Accepted/In press

    Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate

    Bibby, J., Purvis, H., Hayday, T., Cope, A. & Perucha, E., 4 May 2020, (Accepted/In press) In : Nature Communications. NCOMMS-19-37939D.

    Research output: Contribution to journalArticle

  2. Mechanisms of checkpoint inhibition induced adverse events

    Urwyler, P., Earnshaw, I., Bermudez, M., Perucha, E., Wu, W., Ryan, S., Mcdonald, L., Karagiannis, S. N., Taams, L. S., Powell, N., Cope, A. & Papa, S., 1 May 2020, In : Clinical and Experimental Immunology. 200, 2, p. 141-154 14 p.

    Research output: Contribution to journalReview article

  3. Pathology of immune-mediated tissue lesions following treatment with immune checkpoint inhibitors

    Ibraheim, H., Perucha, E. & Powell, N., 1 Dec 2019, In : Rheumatology (Oxford, England). 58, 7, p. vii17-vii28

    Research output: Contribution to journalArticle

  4. The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population

    The UK Ireland Renal Transplant Consortium, DeKAF Genomics and GEN03 Studies & The International Genetics and Translational Research in Transplantation Network, 1 Aug 2019, In : American Journal of Transplantation. 19, 8, p. 2262-2273 12 p.

    Research output: Contribution to journalArticle

  5. The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells

    Perucha, E., Melchiotti, R., Bibby, J. A., Wu, W., Frederiksen, K. S., Roberts, C. A., Hall, Z., LeFriec, G., Robertson, K. A., Lavender, P., Gerwien, J. G., Taams, L. S., Griffin, J. L., de Rinaldis, E., van Baarsen, L. G. M., Kemper, C., Ghazal, P. & Cope, A. P., 2019, In : Nature Communications. 10, 1, 13 p., 498.

    Research output: Contribution to journalArticle

  6. Long- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study

    United Kingdom and Ireland Renal Transplant Consortium (UKIRTC) and the Wellcome Trust Case Control Consortium (WTCCC)-3, Jun 2018, In : American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

    Research output: Contribution to journalArticle

  7. Interleukin 6 increases production of cytokines by colonic innate lymphoid cells in mice and patients with chronic intestinal inflammation

    Powell, N., Lo, J. W., Biancheri, P., Vossenkämper, A., Pantazi, E., Walker, A. W., Stolarczyk, E., Ammoscato, F., Goldberg, R., Scott, P., Canavan, J. B., Perucha, E., Garrido-Mesa, N., Irving, P. M., Sanderson, J. D., Hayee, B., Howard, J. K., Parkhill, J., MacDonald, T. T. & Lord, G. M., 1 Aug 2015, In : Gastroenterology. 149, 2, p. 456-467.e15

    Research output: Contribution to journalArticle

  8. C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation

    Asgari, E., Le Friec, G., Yamamoto, H., Perucha, E., Sacks, S. S., Köhl, J., Cook, H. T. & Kemper, C., 14 Nov 2013, In : Blood. 122, 20, p. 3473-3481 9 p., N/A.

    Research output: Contribution to journalArticle

  9. Integration of lyoplate based flow cytometry and computational analysis for standardized immunological biomarker discovery

    Villanova, F., Di Meglio, P., Inokuma, M., Aghaeepour, N., Perucha, E., Mollon, J., Nomura, L., Hernandez Fuentes, M., Cope, A., Prevost, A. T., Heck, S., Maino, V., Lord, G., Brinkman, R. R. & Nestle, F. O., 3 Jul 2013, In : PLoS ONE. 8, 7, 8 p., e65485.

    Research output: Contribution to journalArticle

  10. Improved Insulin Sensitivity despite Increased Visceral Adiposity in Mice Deficient for the Immune Cell Transcription Factor T-bet

    Stolarczyk, E., Vong, C. T., Perucha, E., Jackson, I., Cawthorne, M. A., Wargent, E. T., Powell, N., Canavan, J. B., Lord, G. M. & Howard, J. K., 2 Apr 2013, In : CELL METABOLISM. 17, 4, p. 520-533 14 p.

    Research output: Contribution to journalArticle

  11. Genome-wide regulatory analysis reveals that T-bet controls Th17 lineage differentiation through direct suppression of IRF4

    Gökmen, M. R., Dong, R., Kanhere, A., Powell, N., Perucha, E., Jackson, I., Howard, J. K., Hernandez-Fuentes, M., Jenner, R. G. & Lord, G. M., 2013, In : Journal of Immunology. 191, 12, p. 5925-5932 8 p.

    Research output: Contribution to journalArticle

  12. T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements

    Kanhere, A., Hertweck, A., Bhatia, U., Gökmen, M. R., Perucha, E., Jackson, I., Lord, G. M. & Jenner, R. G., 11 Dec 2012, In : Nature Communications. 3, 12, 1268.

    Research output: Contribution to journalArticle

  13. An Imaging Flow Cytometric Method for Measuring Cell Division History and Molecular Symmetry During Mitosis

    Filby, A., Perucha, E., Summers, H., Rees, P., Chana, P., Heck, S., Lord, G. M. & Davies, D., Jul 2011, In : CYTOMETRY PART A. 79A, 7, p. 496 - 506 11 p.

    Research output: Contribution to journalArticle

  14. Biomarkers of tolerance: searching for the hidden phenotype

    Perucha, E., Rebollo-Mesa, I., Sagoo, P. & Hernandez Fuentes, M., 2011, In : Kidney International Supplement. 1, p. 40-46 7 p.

    Research output: Contribution to journalArticle

  15. Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans

    Sagoo, P., Perucha, E., Sawitzki, B., Tomiuk, S., Stephens, D. A., Miqueu, P., Chapman, S., Craciun, L., Sergeant, R., Brouard, S., Rovis, F., Jimenez, E., Ballow, A., Giral, M., Rebollo-Mesa, I., Le Moine, A., Braudeau, C., Hilton, R., Gerstmayer, B., Bourcier, K. & 14 others, Sharif, A., Krajewska, M., Lord, G. M., Roberts, I., Goldman, M., Wood, K. J., Newell, K., Seyfert-Margolis, V., Warrens, A. N., Janssen, U., Volk, H-D., Soulillou, J-P., Hernandez-Fuentes, M. P. & Lechler, R. I., 1 Jun 2010, In : Journal of Clinical Investigation. 120, 6, p. 1848 - 1861 14 p.

    Research output: Contribution to journalArticle

  16. Genetic loci influencing kidney function and chronic kidney disease

    Chambers, J. C., Zhang, W., Lord, G. M., van der Harst, P., Lawlor, D. A., Sehmi, J. S., Gale, D. P., Wass, M. N., Ahmadi, K. R., Bakker, S. J. L., Beckmann, J., Bilo, H. J. G., Bochud, M., Brown, M. J., Caulfield, M. J., Connell, J. M. C., Cook, H. T., Cotlarciuc, I., Smith, G. D., de Silva, R. & 74 others, Deng, G., Devuyst, O., Dikkeschei, L. D., Dimkovic, N., Dockrell, M., Dominiczak, A., Ebrahim, S., Eggermann, T., Farrall, M., Ferrucci, L., Floege, J., Forouhi, N. G., Gansevoort, R. T., Han, X., Hedblad, B., van der Heide, J. J. H., Hepkema, B. G., Hernandez-Fuentes, M., Hypponen, E., Johnson, T., de Jong, P. E., Kleefstra, N., Lagou, V., Lapsley, M., Li, Y., Loos, R. J. F., Luan, J., Luttropp, K., Marechal, C., Melander, O., Munroe, P. B., Nordfors, L., Parsa, A., Peltonen, L., Penninx, B. W., Perucha, E., Pouta, A., Prokopenko, I., Roderick, P. J., Ruokonen, A., Samani, N. J., Sanna, S., Schalling, M., Schlessinger, D., Schlieper, G., Seelen, M. A. J., Shuldiner, A. R., Sjogren, M., Smit, J. H., Snieder, H., Soranzo, N., Spector, T. D., Stenvinkel, P., Sternberg, M. J. E., Swaminathan, R., Tanaka, T., Ubink-Veltmaat, L. J., Uda, M., Vollenweider, P., Wallace, C., Waterworth, D., Zerres, K., Waeber, G., Wareham, N. J., Maxwell, P. H., McCarthy, M. I., Jarvelin, M-R., Mooser, V., Abecasis, G. R., Lightstone, L., Scott, J., Navis, G., Elliott, P. & Kooner, J. S., May 2010, In : Nature Genetics. 42, 5, p. 373 - 375 3 p.

    Research output: Contribution to journalArticle

  17. Genome wide polymorphism association analysis in organ transplantation: Genómica y Proteómica en el Trasplante de Órganos Sólidos

    Perucha, E., Lord, G. & Hernandez Fuentes, M., 2010, BIBLIOTECA DE TRASPLANTES SIGLO XXI . Vol. 10. p. 51-72

    Research output: Chapter in Book/Report/Conference proceedingChapter

  18. Indices of tolerance: Interim Report

    Hernandez-Fuentes, M. P., Sawitzki, B., Sagoo, P., Rovis, F., Jimenez-Vera, E., Perucha, E., Le Moine, A., Craciun, L., Peters, B., Bradeau, C., Brouard, S., Trzonkowski, P., Warnecke, G., Chapman, S., Libin, M., Warrens, A., Goldman, M., Volk, H-D., Soulillou, J. P., Janssen, U. & 2 others, Wood, K. & Lechler, R. I., 2006, In : American Journal of Transplantation. 6, p. 403 - 403 1 p.

    Research output: Contribution to journalConference paper

  19. A new method for the simultaneous analysis of growth and death of immunophenotypically defined cells in culture

    Prieto, A., Reyes, E., Diaz, D., Hernandez-Fuentes, M. P., Monserrat, J., Perucha, E., Muñoz, L., Vangioni, R., de La Hera, A., Orfao, A., Alvarez-Mon, M. & Hernandez Fuentes, M., 1 Jan 2000, In : Cytometry. 39, 1, p. 56-66 11 p.

    Research output: Contribution to journalArticle

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