Filippo Prischi

Dr

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Personal profile

Biographical details

Dr Prischi is a Senior Lecturer at King's College London. He graduated with a BSc in Biological Sciences (summa cum laude) and an MSc in Molecular Biology (summa cum laude) from the University of Siena (Italy). He carried out a PhD in Biochemistry under the supervision of Prof Annalisa Pastore and Prof Neri Niccolai at the National Institute for Medical Research. His thesis focused on the structural characterisation of frataxin and its interaction with the central components of iron–sulphur cluster. He then spent 5 years of productive postdoctoral research in Dr Ali Maruf's group at Imperial College London, studying the Unfolded Protein Response initiation and the phosphoregulation of Ire1 RNase splicing activity. In 2015 he obtained a lectureship position at the University of Essex and was promoted to Senior Lecturer in 2020, before moving to King’s College in 2023.

Research interests

Dr Prischi is a molecular biochemist whose work spans in vitro and in silico approaches to gain a greater understanding of protein regulation and stress responses. The overall aim of his research is to understand how the molecular machines that compose signalling pathways work together to transfer information in normal and stressed conditions. Unravelling protein regulation mechanisms is critical for advancing our understanding of disease progression and for the development of novel personalised treatments. His projects focus on (i) the functional and structural characterisation of the p70 and p90 Ribosomal S6 Kinase families and their key substrates, (ii) the development and use of high-throughput bioinformatics approaches coupled with structural biology methods to increase our understanding of protein dynamics and ligand binding.

Dr Prischi’s lab use a cutting-edge multi-disciplinary approach that combines biophysical, enzymatic, cellular and structural studies. Using X-ray crystallography, Nuclear Magnetic Resonance (NMR), Electron Microscopy (cryo-EM) coupled with Molecular Dynamics simulations (MD) they visualise macromolecules at atomic and near atomic resolution. At this scale they aim to dissect cellular processes at a molecular level and describe the details at the base of disease development, thereby providing a solid base for medical advance

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Biochemistry, Doctor of Philosophy, Biophysical studies of protein interaction

Oct 2005Nov 2009

Award Date: 23 Nov 2009

Molecular Biology, Master in Science, Nuclear Magnetic Resonance study of protein aggregation processes, University of Siena

Oct 2003Sept 2005

Award Date: 30 Sept 2005

Biology, Bachelor of Science, Molecular modelling of S1 and S2 subunits of SARS coronavirus spike glycoprotein, University of Siena

Oct 2000Sept 2003

Award Date: 7 Nov 2003

External positions

Visiting Fellow, University of Essex

3 Apr 20232 Apr 2026

Keywords

  • Q Science (General)
  • Kinase
  • X-ray Crystallography
  • Structural Biology
  • Cancer biology
  • Stress response

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