I obtained my DPhil from the University of Oxford, and carried out postdoctoral research at M.I.T., Cambridge, USA.  I established my first lab at the Kennedy Institute of Rheumatology in London, and then moved to London Research Institute.  From 2006 to 2012 I was Deputy Director of the Cancer Research UK Cambridge Research Institute and Deputy Director of the Wellcome Trust Centre for Stem Cell Research, University of Cambridge.  

My major research interest is in the role of stem cells in adult tissue maintenance. For many of our studies we use mammalian epidermis as a model system, both in the context of genetically modified mice and epidermal reconstitution in culture.

Current projects are exploring self-renewal and lineage selection by human and mouse epidermal stem cells, the role of stem cells in epidermal and oral tumour formation, and the nature of mesenchymal cells in skin. We have active collaborations with bioengineers and chemists in order to study stem cell-niche interactions in vitro.

We are also collaborating with bioinformaticians and computational biologists who are helping us to explore stem cell heterogeneity at single cell resolution. With Richard Durbin at the Wellcome Trust Sanger Institute I lead HIPSCI – the Human Induced Pluripotent Stem Cell Initiative – to examine how genetic variation between cells impacts on their phenotypic behaviour in culture. 

My major research interest is in how the differentiated state of adult tissues is maintained. I study this using mammalian epidermis as a model system. Current projects in my laboratory are concerned with self-renewal and lineage selection by human and mouse epidermal stem cells, the role of stem cells in epidermal and oral tumour formation, and the assembly and function of the epidermal cornified envelope.