Search results

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  A cryo-electron microscope for structural biology (including single-particle and tomography) at KCL.

  Conte, M. (Primary Investigator), Atherton, J. (Co-Investigator), Beavil, A. (Co-Investigator), Bergeron, J. (Co-Investigator), Booth, P. (Co-Investigator), Burrone, J. (Co-Investigator), Carlton, J. (Co-Investigator), De Nicola, G. (Co-Investigator), Ehler, E. (Co-Investigator), Fleck, R. (Co-Investigator), Fraternali, F. (Co-Investigator), Garnett, J. (Co-Investigator), Gautel, M. (Co-Investigator), Isaacson, R. (Co-Investigator), Kampourakis, T. (Co-Investigator), Malim, M. (Co-Investigator), McDonnell, J. (Co-Investigator), Neil, S. (Co-Investigator), Odendall, C. (Co-Investigator), Pfuhl, M. (Co-Investigator), Politis, A. (Co-Investigator), Steiner, R. (Co-Investigator) & Sutton, B. (Co-Investigator)

  BBSRC Biotechnology and Biological Sciences Research Council

  1/08/2022 → 31/07/2023

  Project: Research

• Can AI guided by in-crystal fragment screening crack the protein-protein interaction inhibitors problem?

  Fraternali, F. (Primary Investigator) & De Nicola, G. (Co-Investigator)

  Royal Society of Chemistry

  1/02/2022 → 1/07/2023

  Project: Research

• Enabling the big data revolution through skills training

  Oakey, R. (Primary Investigator), Brown, M. (Co-Investigator), Cardoso, J. (Co-Investigator), Curcin, V. (Co-Investigator), Fraternali, F. (Co-Investigator), Ourselin, S. (Co-Investigator), Stahl, D. (Co-Investigator), Vigilante, A. (Co-Investigator) & academic, A. (Co-Investigator)

  MRC Medical Research Council

  1/05/2021 → 30/09/2024

  Project: Research

• Mapping antibody class switch mechanisms and function

  Fraternali, F. (Primary Investigator)

  BBSRC Biotechnology and Biological Sciences Research Council

  1/02/2020 → 31/01/2025

  Project: Research

• Perturbation of the human interactome by C9orf72 repeat expansions: Identification of pathogenic mechanisms and therapeutic entry points

  Gallo, J.-M. (Primary Investigator) & Fraternali, F. (Co-Investigator)

  Motor Neurone Disease Association

  1/02/2018 → 4/06/2021

  Project: Research

  • Interactome 100%
  • C9orf72 100%

• LiSA - Linking Smart Data to Compositional Learning Architectures

  Fraternali, F. (Primary Investigator)

  1/09/2016 → 31/08/2020

  Project: Research

• De novo peptide self-assembly for antimicrobial and gene delivery strategies

  Fraternali, F. (Primary Investigator) & Lorenz, C. (Co-Investigator)

  NPL Management Ltd

  1/10/2015 → 30/09/2019

  Project: Research

• A comprehensive approach to the genetic, molecular and functional impact of rare titinvariants in hypertrophic cardiomyopathy

  Gautel, M. (Primary Investigator), Alexandrovich, A. (Co-Investigator), Fraternali, F. (Co-Investigator) & Rees, M. (Co-Investigator)

  BHF British Heart Foundation

  1/09/2015 → 30/06/2021

  Project: Research

• SmiLE - Smart Data in Learning Architecture

  Fraternali, F. (Primary Investigator)

  1/06/2015 → 31/05/2019

  Project: Research

• Constructing the phase space of prion-like peptide sequences (PHASPRIO)

  Fraternali, F. (Primary Investigator)

  1/05/2015 → 30/04/2017

  Project: Research

• A method for high throughput analysis of cognate pairs in immunoglobulin repertoire

  Dunn-Walters, D. (Primary Investigator) & Fraternali, F. (Co-Investigator)

  1/05/2015 → 30/04/2016

  Project: Research

• In silico tools to study compensatory mechanisms in proteins: the novel double-force scanning method

  Fornili, A. (Primary Investigator) & Fraternali, F. (Primary Investigator)

  BBSRC Biotechnology and Biological Sciences Research Council

  1/04/2015 → 30/09/2016

  Project: Research

• Flexible approach to RBR Ubiquitin Ligases

  Fraternali, F. (Primary Investigator)

  1/02/2015 → 31/01/2018

  Project: Research

• A resolution-replica-exchange software for multiscale simulation of biosystems

  Fraternali, F. (Primary Investigator) & Lorenz, C. (Co-Investigator)

  5/01/2015 → 4/01/2018

  Project: Research

• Characterisation of human antibodies removed from the repertoire in central tolerance

  Dunn-Walters, D. (Primary Investigator) & Fraternali, F. (Co-Investigator)

  MedImmune Ltd

  1/10/2014 → 30/09/2018

  Project: Research

• Systems biology approaches for drug discovery in acute myeloid leukaemia

  Pandini, A. (Primary Investigator), Fraternali, F. (Co-Investigator) & Thomas, S. (Co-Investigator)

  1/07/2014 → 30/06/2019

  Project: Research

• Medical Bioinformatics - building capability, capacity and infrastructure

  Lovestone, S. (Primary Investigator), Breen, G. (Co-Investigator), Delaney, B. (Co-Investigator), Dobson, R. (Co-Investigator), Fraternali, F. (Co-Investigator), McBurney, P. (Co-Investigator), Miles, S. (Co-Investigator), Møller, H. (Co-Investigator), Szmukler, G. (Co-Investigator) & academic, A. (Co-Investigator)

  1/04/2014 → 31/03/2019

  Project: Research

• Mechanical role of Nesprins at the Nuclear Envelope: Modelling of interactions involved in ForceTransduction

  Fraternali, F. (Primary Investigator)

  1/03/2014 → 29/02/2016

  Project: Research

• Multi-scale analysis of B cell responses in ageing

  Fraternali, F. (Primary Investigator), Dunn-Walters, D. (Co-Investigator) & Coolen, T. (Co-Investigator)

  MRC Medical Research Council

  1/01/2014 → 31/01/2020

  Project: Research

• Protein interaction abnormalities in leukaemia: effects of patient-specific genetic variation

  Thomas, S. (Primary Investigator) & Fraternali, F. (Co-Investigator)

  Blood Cancer UK

  1/10/2013 → 30/09/2017

  Project: Research

• King's Health Partners Centre of Excellence in the Pathogenesis of Rheumatoid Arthritis (KHP CEPRA)

  Geissmann, F. (Primary Investigator), Ameer-Beg, S. (Co-Investigator), Cason, J. (Co-Investigator), Coolen, T. (Co-Investigator), Cope, A. (Co-Investigator), Dionne, M. (Co-Investigator), Fraternali, F. (Co-Investigator), Guermonprez, P. (Co-Investigator), Knight, R. (Co-Investigator), Ridley, A. (Co-Investigator), Scott, D. (Co-Investigator), Spencer, J. (Co-Investigator), Stramer, B. (Co-Investigator), Taams, L. (Co-Investigator) & academic, A. (Co-Investigator)

  2/01/2013 → 1/01/2017

  Project: Research

• Nanomechanics of heart disease: investigating the effects of phosphorylation and HCM-causing mutations at the head-tail junction in cardiac myosin

  Fornili, A. (Primary Investigator), Fraternali, F. (Primary Investigator) & Garcia-Manyes, S. (Co-Investigator)

  BHF British Heart Foundation

  1/12/2012 → 31/03/2017

  Project: Research

• Statistical mechanics on graphs with many short loops

  Coolen, T. (Primary Investigator), Annibale, A. (Co-Investigator) & Fraternali, F. (Co-Investigator)

  1/09/2012 → 31/08/2014

  Project: Research

• Greater proteome coverage by derived separations mechanisms

  Fraternali, F. (Primary Investigator), Lorenz, C. (Primary Investigator), Parkin, M. (Primary Investigator) & Thomas, S. (Primary Investigator)

  1/08/2012 → 31/07/2015

  Project: Research

• Biophysical investigation of nesprin spectrin repeats: implications for cardiovascular cell function

  Fraternali, F. (Primary Investigator), Garcia-Manyes, S. (Co-Investigator), Pfuhl, M. (Co-Investigator) & Shanahan, C. (Co-Investigator)

  BHF British Heart Foundation

  1/06/2012 → 10/01/2016

  Project: Research

• Constructing a multi-scale mechanical model of two-headed cardiac myosin

  Fornili, A. (Primary Investigator) & Fraternali, F. (Primary Investigator)

  1/04/2012 → 31/03/2016

  Project: Research

• Protein-protein interaction networks and DNA methylation

  Fraternali, F. (Primary Investigator) & Holzwarth, J. (Co-Investigator)

  BBSRC Biotechnology and Biological Sciences Research Council

  1/07/2011 → 31/12/2011

  Project: Research

• Novel tools to map allosteric networks in proteins

  Fraternali, F. (Primary Investigator)

  BBSRC Biotechnology and Biological Sciences Research Council

  1/07/2011 → 31/07/2012

  Project: Research

• Fluorescent probes of protein conformation in cells

  Fraternali, F. (Primary Investigator), Irving, M. (Primary Investigator) & Sun, Y.-B. (Primary Investigator)

  1/10/2010 → 30/09/2013

  Project: Research

• Structural modelling of the dystrophin spectrin repeats in sickness and in health

  Fraternali, F. (Primary Investigator) & Roberts, R. (Primary Investigator)

  1/10/2010 → 30/09/2014

  Project: Research

• Transcriptional programs in melanoma metastasis

  Sanz Moreno, V. (Primary Investigator), Fraternali, F. (Co-Investigator), Marais, R. (Co-Investigator), Ng, T. (Co-Investigator) & Ridley, A. (Co-Investigator)

  CRUK Cancer Research UK

  1/07/2010 → 31/05/2017

  Project: Research

• Transcriptional programs in melanoma metastasis

  Sanz Moreno, V. (Primary Investigator), Fraternali, F. (Co-Investigator), Marais, R. (Co-Investigator), Ng, T. (Co-Investigator) & Ridley, A. (Co-Investigator)

  1/07/2010 → 30/06/2016

  Project: Research

• Transcriptional programs in melanoma metastasis

  Sanz Moreno, V. (Primary Investigator), Fraternali, F. (Co-Investigator), Marais, R. (Co-Investigator), Ng, T. (Co-Investigator) & Ridley, A. (Co-Investigator)

  1/06/2010 → 31/05/2016

  Project: Research

• Rigorous information-theoretic tools for comparative interactomics

  Fraternali, F. (Primary Investigator) & Coolen, T. (Co-Investigator)

  BBSRC Biotechnology and Biological Sciences Research Council

  2/04/2010 → 24/12/2013

  Project: Research

• Molecular determinants in the action on ErbB tyrosine kinase inhibitors on receptor trafficking processes.

  Fraternali, F. (Primary Investigator) & Ng, T. (Primary Investigator)

  1/10/2009 → 28/02/2010

  Project: Research

• Exploiting virus adaptation to understand the interplay between HIV and the cellular anti-viral protein APOBEC3G

  Malim, M. (Primary Investigator), academic, A. (Primary Investigator) & Fraternali, F. (Co-Investigator)

  1/08/2009 → 31/07/2012

  Project: Research

• Materials modelling across the scales - Doctoral Training Centre

  Mainwood, A. (Primary Investigator), Doltsinis, N. (Co-Investigator), Fraternali, F. (Co-Investigator), Miodownik, M. (Co-Investigator), Richards, D. (Co-Investigator) & Sollich, P. (Co-Investigator)

  1/04/2009 → 30/09/2017

  Project: Research

• Investigating antibiotic resistance in bacteria: the molecular mechanism of efflux

  Fraternali, F. (Primary Investigator)

  8/01/2009 → 31/12/2010

  Project: Research

• Systems biology analysis of nuclear protein interaction networks in human T cells during cell cycle entry

  Thomas, S. (Primary Investigator) & Fraternali, F. (Co-Investigator)

  1/12/2008 → 30/11/2011

  Project: Research

• Role of solvent in protein-protein interactions and aggregation

  Fraternali, F. (Primary Investigator)

  1/07/2008 → 30/06/2011

  Project: Research

• The role of solvent in protein aggregation: implications for protein misfolding diseases.

  Fraternali, F. (Primary Investigator)

  1/05/2008 → 30/04/2011

  Project: Research

• The role of surface flexibility in protein interaction networks.

  Fraternali, F. (Primary Investigator)

  Leverhulme Trust

  1/04/2008 → 30/06/2011

  Project: Research

• Functional Biodynamics: Advanced photonics for systems biology and drug discovery

  Richards, D. (Primary Investigator), Ameer-Beg, S. (Co-Investigator), Coolen, T. (Co-Investigator), Festy, F. (Co-Investigator), Fraternali, F. (Co-Investigator), Green, M. (Co-Investigator), Ng, T. (Co-Investigator) & Suhling, K. (Co-Investigator)

  1/04/2008 → 30/09/2012

  Project: Research

• Rational design of PrP conversion inhibitors: a new structure-based approach toward anti-prion chemotherapeutics

  Fraternali, F. (Primary Investigator)

  Alliance Biosecure Research Foundation

  8/02/2008 → 31/07/2010

  Project: Research

• Validation of the APOBEC3G-Vif interaction as a drug target

  Huthoff, H. (Primary Investigator), Fraternali, F. (Co-Investigator) & Malim, M. (Co-Investigator)

  Wellcome Trust

  1/02/2008 → 31/01/2013

  Project: Research

• Modelling of transcription factors and their interaction with DNA

  Fraternali, F. (Primary Investigator)

  Nestec Ltd, EPSRC Engineering and Physical Sciences Research Council

  1/11/2007 → 29/02/2012

  Project: Research