Research output per year
Research output per year
Personal profile
Research interests
My research aims to understand the role of gene alterations in the development of cancer.
My group develops and applies a combination of computational and experimental methods to study cancer genes in the context of gene and network evolution. We analyse omic data deriving directly from cancer patients to identify patient-specific cancer genes and vulnerability that can be exploited in therapy. We work with pan-cancer data,but have a particular focus on colorectal and oesophageal cancers.
We set up and maintain the Network of Cancer Genes, a public resource of manually curated cancer genes (http://ncg.kcl.ac.uk/).
Research interests (short)
Cancer genomics and systems biology of cancer genes to identify novel therapeutic targets.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Ruprecht-Karls-Universität Heidelberg
Award Date: 1 Jan 2003
Master of Chemistry, Università di Bologna
Award Date: 1 Jan 1998
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A decade of the Oesophageal Cancer Clinical and Molecular Stratification Consortium
OCCAMS Consortium, Peters, C. J., Ang, Y., Ciccarelli, F. D., Coles, H., Coleman, H. G., Contino, G., Crosby, T., Devonshire, G., Eldridge, M., Freeman, A., Grehan, N., McCord, M., Nutzinger, B., Zamani, S., Parsons, S. L., Petty, R., Sharrocks, A. D., Skipworth, R. J. E., Smyth, E. C., & 31 others, Jan 2024, In: Nature Medicine. 30, 1, p. 14-16 3 p.Research output: Contribution to journal › Letter › peer-review
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Mutational signature dynamics shaping the evolution of oesophageal adenocarcinoma
Abbas, S., Pich, O., Devonshire, G., Zamani, S. A., Katz-Summercorn, A., Killcoyne, S., Cheah, C., Nutzinger, B., Grehan, N., Lopez-Bigas, N., OCCAMS Consortium, Fitzgerald, R. C., Secrier, M., Edwards, P. A. W., Fidziukiewicz, E., Redmond, A. M., Freeman, A., Smyth, E. C., O’Donovan, M., Miremadi, A., & 61 others, Dec 2023, In: Nature Communications. 14, 1, 4239.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
The transcriptional landscape of endogenous retroelements delineates esophageal adenocarcinoma subtypes
The OCCAMS Consortium, 26 Jul 2023, In: NAR Cancer. 5, 3, 20 p., zcad040.Research output: Contribution to journal › Article › peer-review
Open Access -
A SIMPLI (Single-cell Identification from MultiPLexed Images) approach for spatially-resolved tissue phenotyping at single-cell resolution
Bortolomeazzi, M., Montorsi, L., Temelkovski, D., Keddar, M. R., Acha-Sagredo, A., Pitcher, M. J., Basso, G., Laghi, L., Rodriguez-Justo, M., Spencer, J. & Ciccarelli, F. D., 9 Feb 2022, In: Nature Communications. 13, 1, 1 p., 781.Research output: Contribution to journal › Article › peer-review
Open Access20 Citations (Scopus) -
Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource
Dressler, L., Bortolomeazzi, M., Keddar, M., Misetic, H., Sartini, G., Acha-Sagredo, A., Montorsi, L., Wijewardhane, N., Repana, D., Nulsen, J., Goldman, J., Pollit, M., Davis, P., Strange, A., Ambrose, K. & Ciccarelli, F., 26 Jan 2022, In: Genome Biology. 23, 1, 35.Research output: Contribution to journal › Article › peer-review
Open Access47 Citations (Scopus)
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CoL: CRUK City of London Centre renewal (COLMC)
Ng, T., Arnold, J., Blower, P., Ciccarelli, F., Dazzi, F., Farzaneh, F., Grigoriadis, A., Hayday, A., Irshad, S., Kong, A., Kordasti, S., Lawrence, T., Mishto, M., Papa, S., Purushotham, A., Quek, L., Ramsay, A., Reis Ferreira, M., Sarker, D., Sinkus, R., Spicer, J. & Witney, T.
1/04/2022 → 31/03/2027
Project: Research
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KHP Centre Award - Non-Clinical Training Award
Parker, P., Spicer, J., Ciccarelli, F., Dazzi, F., Farzaneh, F., Hayday, A., Maher, J., Ng, T., Papa, S., Purushotham, A. & Sarker, D.
1/04/2017 → 31/03/2025
Project: Research
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Harnessing the power of data for a more tailored approach to care - Ciccarelli
23/09/2022 → 22/09/2023
Project: Research