Francesca Spagnoli

2024

3D Bioprinting of Multicellular Stem Cell-Derived Constructs to Model Pancreatic Cell Differentiation

Edri, S., Newman Frisch, A., Safina, D., Machour, M., Zavin, J., Landsman, L., Pierreux, C. E., Spagnoli, F. M. & Levenberg, S., 24 Jul 2024, In: Advanced Functional Materials. 34, 30, 2315488.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Acinar-ductal cell rearrangement drives branching morphogenesis of the murine pancreas in an IGF/PI3K-dependent manner

Darrigrand, J.-F., Salowka, A., Torres-Cano, A., Tapia-Rojo, R., Zhu, T., Garcia-Manyes, S. & Spagnoli, F. M., 5 Feb 2024, In: Developmental Cell. 59, 3, p. 326-338.E5

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

Heterozygous missense variant in GLI2 impairs human endocrine pancreas development

Mueller, L. M., Isaacson, A., Wilson, H., Salowka, A., Tay, I., Gong, M., Elbarbary, N. S., Raile, K. & Spagnoli, F. M., 20 Mar 2024, In: Nature Communications. 15, 1, 2483.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

In-Depth Analysis of the Pancreatic Extracellular Matrix during Development for Next-Generation Tissue Engineering

Glorieux, L., Vandooren, L., Derclaye, S., Pyr dit Ruys, S., Oncina-Gil, P., Salowka, A., Herinckx, G., Aajja, E., Lemoine, P., Spourquet, C., Lefort, H., Henriet, P., Tyteca, D., Spagnoli, F. M., Alsteens, D., Vertommen, D. & Pierreux, C. E., Jun 2023, In: International Journal of Molecular Sciences. 24, 12, 10268.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Understanding cell fate acquisition in stem-cell-derived pancreatic islets using single-cell multiome-inferred regulomes

Zhu, H., Wang, G., Nguyen-Ngoc, K. V., Kim, D., Miller, M., Goss, G., Kovsky, J., Harrington, A. R., Saunders, D. C., Hopkirk, A. L., Melton, R., Powers, A. C., Preissl, S., Spagnoli, F. M., Gaulton, K. J. & Sander, M., 8 May 2023, In: Developmental Cell. 58, 9, p. 727-743.e11

Research output: Contribution to journal › Article › peer-review

Open Access

33 Citations (Scopus)

2022

Development of a 3D atlas of the embryonic pancreas for topological and quantitative analysis of heterologous cell interactions

Glorieux, L., Sapala, A., Willnow, D., Moulis, M., Salowka, A., Darrigrand, J. F., Edri, S., Schonblum, A., Sakhneny, L., Schaumann, L., Gómez, H. F., Lang, C., Conrad, L., Guillemot, F., Levenberg, S., Landsman, L., Iber, D., Pierreux, C. E. & Spagnoli, F. M., 1 Feb 2022, In: Development (Cambridge, England). 149, 3, dev199655.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Citations (Scopus)

Identification and implication of tissue-enriched ligands in epithelial–endothelial crosstalk during pancreas development

Moulis, M., Runser, S. V. M., Glorieux, L., Dauguet, N., Vanderaa, C., Gatto, L., Tyteca, D., Henriet, P., Spagnoli, F. M., Iber, D. & Pierreux, C. E., Dec 2022, In: Scientific Reports. 12, 1, 12498.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

2021

Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche

Willnow, D., Benary, U., Margineanu, A., Vignola, M. L., Konrath, F., Pongrac, I. M., Karimaddini, Z., Vigilante, A., Wolf, J. & Spagnoli, F. M., 2 Sept 2021, In: Nature. 597, 7874, p. 87-91 5 p.

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

The postnatal pancreatic microenvironment guides β cell maturation through BMP4 production

Sakhneny, L., Mueller, L., Schonblum, A., Azaria, S., Burganova, G., Epshtein, A., Isaacson, A., Wilson, H., Spagnoli, F. M. & Landsman, L., 11 Oct 2021, In: Developmental Cell. 56, 19, p. 2703-2711.e5

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

The transCampus Metabolic Training Programme Explores the Link of SARS-CoV-2 Virus to Metabolic Disease

Bornstein, S. R., Guan, K., Brunβen, C., Mueller, G., Kamvissi-Lorenz, V., Lechler, R., Trembath, R., Mayr, M., Poston, L., Sancho, R., Ahmed, S., Alfar, E., Aljani, B., Alves, T. C., Amiel, S., Andoniadou, C. L., Bandral, M., Belavgeni, A., Berger, I. & Birkenfeld, A. & 74 others, Bonifacio, E., Chavakis, T., Chawla, P., Choudhary, P., Cujba, A. M., Delgadillo Silva, L. F., Demcollari, T., Drotar, D. M., Duin, S., El-Agroudy, N. N., El-Armouche, A., Eugster, A., Gado, M., Gavalas, A., Gelinsky, M., Guirgus, M., Hansen, S., Hanton, E., Hasse, M., Henneicke, H., Heller, C., Hempel, H., Hogstrand, C., Hopkins, D., Jarc, L., Jones, P. M., Kamel, M., Kämmerer, S., King, A. J. F., Kurzbach, A., Lambert, C., Latunde-Dada, Y., Lieberam, I., Liers, J., Li, J. W., Linkermann, A., Locke, S., Ludwig, B., Manea, T., Maremonti, F., Marinicova, Z., McGowan, B. M., Mickunas, M., Mingrone, G., Mohanraj, K., Morawietz, H., Ninov, N., Peakman, M., Persaud, S. J., Pietzsch, J., Cachorro, E., Pullen, T. J., Pyrina, I., Rubino, F., Santambrogio, A., Schepp, F., Schlinkert, P., Scriba, L. D., Siow, R., Solimena, M., Spagnoli, F. M., Speier, S., Stavridou, A., Steenblock, C., Strano, A., Taylor, P., Tiepner, A., Tonnus, W., Tree, T., Watt, F., Werdermann, M., Wilson, M., Yusuf, N. & Ziegler, C. G., 1 Mar 2021, In: Hormone and Metabolic Research. 53, 3, p. 204-206 3 p.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

2020

A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation

Cozzitorto, C., Mueller, L., Ruzittu, S., Mah, N., Willnow, D., Darrigrand, J. F., Wilson, H., Khosravinia, D., Mahmoud, A. A., Risolino, M., Selleri, L. & Spagnoli, F. M., 26 Oct 2020, In: Developmental Cell. 55, 2, p. 150-162.e6

Research output: Contribution to journal › Article › peer-review

Open Access

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37 Citations (Scopus)

168 Downloads (Pure)

2019

A whole organism small molecule screen identifies novel regulators of pancreatic endocrine development

Helker, C. S. M., Mullapudi, S.-T., Mueller, L. M., Preussner, J., Tunaru, S., Skog, O., Kwon, H.-B., Kreuder, F., Lancman, J. J., Bonnavion, R., Dong, P. D. S., Looso, M., Offermanns, S., Korsgren, O., Spagnoli, F. M. & Stainier, D. Y. R., 1 Jul 2019, In: Development (Cambridge): for advances in developmental biology and stem cells. 146, 14, p. dev.172569 dev172569.

Research output: Contribution to journal › Article › peer-review

Open Access

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30 Citations (Scopus)

180 Downloads (Pure)

2018

Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors

Escot, S., Willnow, D., Naumann, H. A., DiFrancescantonio, S. & Spagnoli, F., 30 Nov 2018, In: Nature Communications. 9, 1, 12 p., 5082.

Research output: Contribution to journal › Article › peer-review

Open Access

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26 Citations (Scopus)

174 Downloads (Pure)

The RhoGAP Stard13 controls insulin secretion through F-actin remodeling

Naumann, H., Rathjen, T., Poy, M. N. & Spagnoli, F. M., 28 Feb 2018, In: Molecular Metabolism. 8, p. 96-105 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Citations (Scopus)

2017

Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2

Cerdá-Esteban, N., Naumann, H., Ruzittu, S., Mah, N., Pongrac, I. M., Cozzitorto, C., Hommel, A., Andrade-Navarro, M. A., Bonifacio, E. & Spagnoli, F. M., Feb 2017, In: Nature Communications. 8, 14127.

Research output: Contribution to journal › Article › peer-review

Open Access

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40 Citations (Scopus)

97 Downloads (Pure)

2016

The histone methyltransferase Setd7 promotes pancreatic progenitor identity

Kofent, J., Zhang, J. & Spagnoli, F. M., 30 Oct 2016, In: Development. 143, 19, p. 3573-3581 9 p.

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

2014

Recessive mutations in PCBD1 cause a new type of early-onset diabetes

Simaite, D., Kofent, J., Gong, M., Rüschendorf, F., Jia, S., Arn, P., Bentler, K., Ellaway, C., Kühnen, P., Hoffmann, G. F., Blau, N., Spagnoli, F. M., Hübner, N. & Raile, K., Oct 2014, In: Diabetes. 63, 10, p. 3557-3564 8 p.

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

2013

Mutually exclusive signaling signatures define the hepatic and pancreatic progenitor cell lineage divergence

Rodríguez-Seguel, E., Mah, N., Naumann, H. A., Pongrac, I. M., Cerdá-Esteban, N., Fontaine, J.-F., Wang, Y. W., Chen, W., Andrade-Navarro, M. & Spagnoli, F. M., 2013, In: Genes and Development. p. 1932–1946

Research output: Contribution to journal › Article › peer-review

Open Access

66 Citations (Scopus)

Rho signalling restriction by the RhoGAP Stard13 integrates growth and morphogenesis in the pancreas

Petzold, K., Naumann, H. A. & Spagnoli, F. M., 2013, In: Development (Cambridge). 140, p. 126-135

Research output: Contribution to journal › Article › peer-review

Open Access

30 Citations (Scopus)

Two novel GATA6 mutations cause childhood-onset diabetes mellitus, pancreas malformation and congenital heart disease

Spagnoli, F. M., 2013, In: Hormone research in paediatrics. 79, p. 250-256

Research output: Contribution to journal › Article › peer-review

Open Access

31 Citations (Scopus)

Francesca Spagnoli

Research output

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