Frank Hirth

Frank Hirth


  • Phone80786
  • SE5 8AF

    United Kingdom

  • 3858

Personal profile

Research interests

Current research in the lab addresses two fundamental questions: How is genetic information converted into neural circuits and behaviour? How are these processes affected in disorders of the brain? To address these questions in a systematic way in vivo, we are using the fruitfly Drosophila as a model system and investigate how neural lineages form neural circuit elements mediating adaptive motor behaviour. We currently focus on neural circuits of the central complex, including inhibitory GABAergic and modulatory dopaminergic circuits, and use neurogenetic as well as thermogenetic manipulations to study how these circuitries coordinate the selection and maintenance of behavioural actions driven by internal and external cues, such as temperature and dietary restriction. We apply our insights into neural circuit formation and motor control to investigate pathogenic mechanisms underlying neurodegenerative movement disorders, including Parkinson's and Motor Neurone Disease, as well as Fronto-temporal Dementia. Specifically, we are investigating how mitochondrial dysfunction, deregulated TDP-43 and C9-related hexanucleotide repeat expansion cause age and cell type specific neurodegeneration.

Research interests (short)

Evolution, development, and disease of the brain

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Doctor of Philosophy, The role of developmental control genes in patterning the embryonic brain of Drosophila, University of Basel

Award Date: 1 Jan 1999

Bachelor of Science, Universität Freiburg

Award Date: 1 Jan 1995


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