Research output per year
Research output per year
- 1 - 50 out of 75 results
Search results
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2023
Optogenetic cleavage of the Miro GTPase reveals the direct consequences of real-time loss of function in Drosophila.
Vagnoni, A., Mattedi, F., Lloyd-Morris, E. & Hirth, F., 3 Aug 2023, (Accepted/In press) In: PLoS biology.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Phylogenetic Tracing of Midbrain-Specific Regulatory Sequences Suggests Single Origin of Eubilaterian Brains
Schuster, H. & Hirth, F., 12 Apr 2023, In: Science Advances. 9, 21, eade8259.Research output: Contribution to journal › Article › peer-review
Open Access -
Yeast NDI1 reconfigures neuronal metabolism and prevents the unfolded protein response in mitochondrial complex I deficiency
Granat, L., Ranson, D., Knorr, D., Hamer, E., Chakrabarty, R. P., Mattedi, F., Fort-Aznar, L., Hirth, F., Sweeney, S., Vagnoni, A., Chandel, N. S. & Bateman, J., 3 Jul 2023, In: PLoS genetics. 19, 7, e1010793.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
2022
Alpha-synucleinopathy reduces NMNAT3 protein levels and neurite formation that can be rescued by targeting the NAD+ pathway
Parsons, R. B., Kocinaj, A., Ruiz Pulido, G., Prendergast, S. A., Parsons, A. E., Facey, P. D. & Hirth, F., 25 Aug 2022, In: Human Molecular Genetics. 31, 17, p. 2918-2933 16 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
The lower Cambrian lobopodian Cardiodictyon resolves the origin of euarthropod brains.
Strausfeld, N. J., Hou, X., Sayre, M. E. & Hirth, F., 24 Nov 2022, In: Science. 378, 6622, p. 905-909 5 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
2021
Karyopherin abnormalities in neurodegenerative proteinopathies
Pasha, T., Zatorska, A., Sharipov, D., Rogelj, B., Hortobágyi, T. & Hirth, F., 1 Oct 2021, In: Brain. 144, 10, p. 2915-2932 18 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus) -
Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration in Drosophila
Bridi, J., Bereczki, E., Smith, S., Pocas, G., Kottler, B., Domingos, P., Elliott, C., Aarsland, D. & Hirth, F., 22 Mar 2021, In: Brain Communications.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)60 Downloads (Pure) -
Triad of TDP43 control in neurodegeneration: autoregulation, localization and aggregation
Tziortzouda, P., Van Den Bosch, L. & Hirth, F., Apr 2021, In: Nature Reviews Neuroscience. 22, 4, p. 197-208 12 p.Research output: Contribution to journal › Review article › peer-review
55 Citations (Scopus) -
2020
A miRNA screen procedure identifies garz as an essential factor in adult glia functions and validates Drosophila as a beneficial 3Rs model to study glial functions and GBF1 biology
Fanto, M., Gonçalves-Pimentel, C., Mazaud, D., Kottler, B., Proelss, S. & Hirth, F., 1 Jan 2020, In: F1000Research. 9, 317.Research output: Contribution to journal › Article › peer-review
Open Access -
Ancestral regulatory mechanisms specify conserved midbrain circuitry in arthropods and vertebrates
Bridi, J., Ludlow, Z., Kottler, B., Hartmann, B., Vanden Broeck, L., Dearlove, J., Göker, M., Strausfeld, N. J., Callaerts, P. & Hirth, F., 3 Jun 2020, (Accepted/In press) In: Proceedings of the National Academy of Sciences of the United States of America.Research output: Contribution to journal › Article › peer-review
Open AccessFile84 Downloads (Pure) -
Immunostaining of the Embryonic and Larval Drosophila Brain
Hirth, F. & Diaper, D. C., 1 Jan 2020, In: Methods in molecular biology (Clifton, N.J.). 2047, p. 81-96 16 p.Research output: Contribution to journal › Article › peer-review
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2019
Inverse Control of Turning Behavior by Dopamine D1 Receptor Signaling in Columnar and Ring Neurons of the Central Complex in Drosophila
Kottler, B., Faville, R., Bridi, J. C. & Hirth, F., 18 Feb 2019, In: Current Biology. 29, 4, p. 567-577.e6Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)68 Downloads (Pure) -
Inverse control of turning behaviour by dopamine D1 receptor signalling in columnarwedge and ring neurons of the central complex in Drosophila
Kottler, B. D., Faville, R., Bridi, J. C. & Hirth, F., 9 Jan 2019, (Accepted/In press) In: Current biology : CB.Research output: Contribution to journal › Article › peer-review
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Lineage-specific determination of ring neuron circuitry in the central complex of Drosophila
Bridi, J. C., Ludlow, Z. & Hirth, F., 8 Jul 2019, (E-pub ahead of print) In: Biology Open. 8, 7, 045062.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)98 Downloads (Pure) -
Thimerosal inhibits Drosophila melanogaster tyrosine hydroxylase (DmTyrH) leading to changes in dopamine levels and impaired motor behavior: implications for neurotoxicity
Bianchini, M. C., Gularte, C. O. A., Nogara, P. A., Krum, B. N., Gayer, M. C., Bridi, J. C., Roos, D. H., Roehrs, R., Fachinetto, R., Pinton, S., Avila, D. S., Hirth, F., Rocha, J. B. T. & Puntel, R. L., 1 Feb 2019, In: Metallomics. 11, 2, p. 362-374 13 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
Transcriptional regulation of the Glutamate/GABA/Glutamine cycle in adult glia controls motor activity and seizures in Drosophila
Mazaud, D., Kottler, B. D., Goncalves Pimentel, C. S., Proelss, S., Tuechler, N., Deneubourg, C. L., Yuasa, Y., Diebold, C., Jungbluth, H., Lai, E. C., Hirth, F., Giangrande, A. & Fanto, M., 3 Jul 2019, In: Journal of Neuroscience. 39, 27, p. 5269-5283 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)204 Downloads (Pure) -
2018
A feedback loop between dipeptide-repeat protein, TDP-43 and karyopherin-α mediates C9orf72-related neurodegeneration
Solomon, D. A., Stepto, A., Au, W. H., Adachi, Y., Diaper, D. C., Hall, R., Rekhi, A., Boudi, A., Tziortzouda, P., Lee, Y. B., Smith, B., Bridi, J. C., Spinelli, G., Dearlove, J., Humphrey, D. M., Gallo, J. M., Troakes, C., Fanto, M., Soller, M., Rogelj, B., & 4 others, 1 Oct 2018, In: Brain. 141, 10, p. 2908-2924 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile50 Citations (Scopus)225 Downloads (Pure) -
In vivo expansion of functionally integrated GABAergic interneurons by targeted increase in neural progenitors
Shaw, R. E., Kottler, B., Ludlow, Z. N., Buhl, E., Kim, D., Morais da Silva, S., Miedzik, A., Coum, A., Hodge, J. JL., Hirth, F. & Sousa-Nunes, R., 2 Jul 2018, In: The EMBO journal. 37, 13, p. 1-16 16 p., e98163.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)202 Downloads (Pure) -
Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease
Bridi, J. C. & Hirth, F., 19 Feb 2018, In: Frontiers in Neuroscience. 12, p. 80Research output: Contribution to journal › Review article › peer-review
Open AccessFile189 Citations (Scopus)266 Downloads (Pure) -
2017
C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity
Lee, Y-B., Baskaran, P., Gomez-Deza, J., Chen, H-J., Nishimura, A. L., Smith, B. N., Troakes, C., Adachi, Y., Stepto, A., Petrucelli, L., Gallo, J-M., Hirth, F., Rogelj, B., Guthrie, S. & Shaw, C. E., 15 Dec 2017, In: Human Molecular Genetics. 26, 24, p. 4765-4777 13 p.Research output: Contribution to journal › Article › peer-review
Open Access47 Citations (Scopus) -
In silico interrogation of insect central complex suggests computational roles for the ellipsoid body in spatial navigation
Fiore, V. G., Kottler, B., Gu, X. & Hirth, F., 2017, In: Frontiers in Behavioral Neuroscience. 11, p. 1-13 142.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)155 Downloads (Pure) -
2016
Changing pattern in the basal ganglia: Motor switching under reduced dopaminergic drive
Fiore, V. G., Rigoli, F., Stenner, M. P., Zaehle, T., Hirth, F., Heinze, H. J. & Dolan, R. J., 2016, In: Scientific Reports. 6, p. 1-15 23327.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)137 Downloads (Pure) -
Introduction to ‘Homology and convergence in nervous system evolution’
Strausfeld, N. J. & Hirth, F., Jan 2016, In: Philosophical Transactions of the Royal Society of London Series B: Biological Sciences. 371, 1685, p. 1-6 20150034.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)93 Downloads (Pure) -
Stem cells and asymmetric cell division
Sousa-Nunes, R. & Hirth, F., 25 Apr 2016, (E-pub ahead of print) Regenerative Medicine - from Protocol to Patient: 1. Biology of Tissue Regeneration: Third Edition. Springer International Publishing Switzerland, p. 87-121 35 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
3 Citations (Scopus) -
2015
Evolutionarily conserved mechanisms for the selection and maintenance of behavioural activity
Fiore, V. G., Dolan, R. J., Strausfeld, N. J. & Hirth, F., 19 Dec 2015, In: Philosophical Transactions of the Royal Society of London Series B: Biological Sciences. 370, 1684, 17 p., 20150053.Research output: Contribution to journal › Article › peer-review
Open AccessFile44 Citations (Scopus)193 Downloads (Pure) -
Introduction to ‘Origin and evolution of the nervous system’
Strausfeld, N. J. & Hirth, F., Dec 2015, In: Philosophical Transactions of the Royal Society of London Series B: Biological Sciences. 370, 1684, p. 1-7 20150033.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
2014
Immunostaining of the developing embryonic and larval Drosphila brain
Diaper, D. C. & Hirth, F., 1 Jan 2014, Methods in Molecular Biology: Methods and Protocols. Sprecher, S. G. (ed.). New York: Humana Press, Vol. 1082. p. 3-17 15 p. (Methods in Molecular Biology; vol. 1082).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
2 Citations (Scopus) -
Modelling C9ORF72 hexanucleotide repeat expansion in amyotrophic lateral sclerosis and frontotemporal dementia
Stepto, A., Gallo, J-M., Shaw, C. E. & Hirth, F., Mar 2014, In: Acta Neuropathologica. 127, 3, p. 377-389 13 p., N/A.Research output: Contribution to journal › Literature review › peer-review
35 Citations (Scopus) -
2013
Deep homology of arthropod central complex and vertebrate basal ganglia
Strausfeld, N. J. & Hirth, F., 12 Apr 2013, In: Science. 340, 6129, p. 157-161 5 p.Research output: Contribution to journal › Article › peer-review
219 Citations (Scopus) -
Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioral phenotypes that characterize ALS and FTLD
Diaper, D. C., Adachi, Y., Lazarou, L., Greenstein, M., Simoes, F. A., Di Domenico, A., Solomon, D. A., Lowe, S., Alsubaie, R., Cheng, D., Buckley, S., Humphrey, D. M., Shaw, C. E. & Hirth, F., 1 Oct 2013, In: Human Molecular Genetics. 22, 19, p. 3883-3893 11 p.Research output: Contribution to journal › Article › peer-review
Open Access52 Citations (Scopus) -
Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic
Lee, Y., Chen, H-J., Peres, J. N., Gomez Deza, J., Attig, J., Stalekar, M., Troakes, C., Nishimura, A. L., Scotter, E. L., Vance, C., Adachi, Y., Sardone, V., Miller, J. W., Smith, B. N., Gallo, J-M., Ule, J., Hirth, F., Rogelj, B., Houart, C. & Shaw, C. E., 12 Dec 2013, In: Cell Reports. 5, 5, p. 1178-1186 9 p.Research output: Contribution to journal › Article › peer-review
Open Access325 Citations (Scopus) -
Homology versus convergence in resolving transphyletic correspondences of brain organisation
Strausfeld, N. J. & Hirth, F., 1 Dec 2013, In: Brain Behavior and Evolution. 82, 4, p. 215-219 5 p., N/A.Research output: Contribution to journal › Article › peer-review
27 Citations (Scopus) -
Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes
Diaper, D., Adachi, Y., Sutcliffe, B., Humphrey, D. M., Elliott, C. J. H., Stepto, A., Ludlow, Z. N., Vanden Broeck, L., Callaerts, P., Dermaut, B., Al-Chalabi, A., Shaw, C. E., Robinson, I. M. & Hirth, F., 15 Apr 2013, In: Human Molecular Genetics. 22, 8, p. 1539-1557 19 p.Research output: Contribution to journal › Article › peer-review
Open Access90 Citations (Scopus) -
TDP-43 Loss-of-Function Causes Neuronal Loss Due to Defective Steroid Receptor-Mediated Gene Program Switching in Drosophilia
Vanden Broeck, L., Naval-Sánchez, M., Adachi, Y., Diaper, D., Dourlen, P., Chapuis, J., Kleinberger, G., Gistelinck, M., Van Broeckhoven, C., Lambert, J-C., Hirth, F., Aerts, S., Callaerts, P. & Dermaut, B., 31 Jan 2013, In: Cell Reports. 3, 1, p. 160-172 13 p.Research output: Contribution to journal › Article › peer-review
Open Access42 Citations (Scopus) -
2012
Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila
Humphrey, D. M., Parsons, R. B., Ludlow, Z. N., Riemensperger, T., Esposito, G., Verstreken, P., Jacobs, H. T., Birman, S. & Hirth, F., 15 Jun 2012, In: Human Molecular Genetics. 21, 12, p. 2698-2712 15 p., dds096.Research output: Contribution to journal › Article › peer-review
48 Citations (Scopus) -
Both loss and gain of TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration in Drosophilia
Diaper, D. C., Adachi, Y., Sutcliffe, B., Humphrey, D. M., Elliott, C., Fielding, T., Burki, M., Ludlow, Z. N., Vanden Broeck, L., Callaerts, P., Dermaut, B., Al-Chalabi, A., Shaw, C. E. & Hirth, F., Sept 2012, In: Dementia and Geriatric Cognitive Disorders. 34, S1, p. 51-51 1 p., P10.Research output: Contribution to journal › Meeting abstract › peer-review
Open Access40 Citations (Scopus) -
Memory Circuits in Drosophila
Furukubo-Tokunaga, K. & Hirth, F., 1 Jan 2012, Memory Mechanisms in Health and Disease. Giese, P. (ed.). Singapore: World Scientific, p. 269-306 38 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
4 Citations (Scopus) -
TDP-43 neurotoxicity by failed steroid receptor-dependent transcriptional program switching
Vanden Broeck, L., Sanchez, N. M., Adachi, Y., Diaper, D., Dourlen, P., Gistelinck, M., Hirth, F., Aerts, S., Callaerts, P. & Dermaut, B., Dec 2012, In: Journal of Neurogenetics. 26, S1, p. 80-81 2 p., P281.Research output: Contribution to journal › Meeting abstract › peer-review
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2011
Stem Cells and Asymmetric Cell Division
Hirth, F., 2011, Regenerative Medicine: From Protocol to Patient. Steinhoff, G. (ed.). Netherlands: Springer, p. 103-123 21 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
1 Citation (Scopus) -
2010
Drosophila melanogaster in the Study of Human Neurodegeneration
Hirth, F., 2010, In: Cns & Neurological Disorders-Drug Targets. 9, 4, p. 504 - 523 20 p.Research output: Contribution to journal › Article › peer-review
138 Citations (Scopus) -
Drosophila models of TDP-43 proteinopathy
Adachi, Y., Diaper, D., Burki, M. & Hirth, F., 16 Feb 2010, In: Journal of Neurogenetics. 24, 7, p. 60 - 60 1 p.Research output: Contribution to journal › Meeting abstract
217 Citations (Scopus) -
Genetic mechanisms regulating neural stem cell self-renewal and differentiation in the central nervous system of Drosophila
Kim, D. & Hirth, F., 2010, In: Journal of Neurogenetics. 24, p. 76 - 76 1 p.Research output: Contribution to journal › Meeting abstract
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Green Tea Catechin Antagonizes Amyloid-Related Toxicity
Hirth, F., 2010, In: Cns & Neurological Disorders-Drug Targets. 9, 4, p. 383 - 383 1 p.Research output: Contribution to journal › Editorial › peer-review
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Mitochondrial dysfunction causes age-related and cell type-specific neurodegeneration in Drosophila
Humphrey, D. M. & Hirth, F., 2010, In: Journal of Neurogenetics. 24, p. 61 - 61 1 p.Research output: Contribution to journal › Meeting abstract
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On the Origin and Evolution of the Tripartite Brain
Hirth, F., Oct 2010, In: Brain Behavior and Evolution. 76, 1, p. 3 - 10 8 p.Research output: Contribution to journal › Literature review › peer-review
48 Citations (Scopus) -
TDP-43 in motor neuron disease formation in Drosophila
Diaper, D., Adachi, Y. & Hirth, F., 2010, In: Journal of Neurogenetics. 24, p. 66 - 67 2 p.Research output: Contribution to journal › Meeting abstract
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The dopaminergic system in the aging brain of Drosophila
White, K. E., Humphrey, D. M. & Hirth, F., 8 Dec 2010, In: Frontiers in Neuroscience. 4, 205.Research output: Contribution to journal › Article › peer-review
95 Citations (Scopus) -
2009
Developmental origin of a motor control centre in Drosophila
Ludlow, Z., White, K. E. & Hirth, F., 2009, In: Journal of Neurogenetics. 23, p. S18 - S19Research output: Contribution to journal › Meeting abstract
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Genetic mechanisms regulating stem cell self-renewal and differentiation in the central nervous system of Drosophila
Kim, D. W. & Hirth, F., 2009, In: Cell Adhesion & Migration. 3, 4, p. 402-411 10 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
Loss of heterozygosity of TRIM3 in malignant gliomas
Boulay, J-L., Stiefel, U., Taylor, E., Dolder, B., Merlo, A. & Hirth, F., 27 Feb 2009, In: BMC Cancer. 9, 71.Research output: Contribution to journal › Article › peer-review
45 Citations (Scopus)