Frank Hirth

Parsons, R. B., Kocinaj, A., Ruiz Pulido, G., Prendergast, S. A., Parsons, A. E., Facey, P. D. & Hirth, F., 25 Aug 2022, In: Human Molecular Genetics. 31, 17, p. 2918-2933 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

The lower Cambrian lobopodian Cardiodictyon resolves the origin of euarthropod brains.

Strausfeld, N. J., Hou, X., Sayre, M. E. & Hirth, F., 24 Nov 2022, In: Science. 378, 6622, p. 905-909 5 p.

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

2021

Karyopherin abnormalities in neurodegenerative proteinopathies

Pasha, T., Zatorska, A., Sharipov, D., Rogelj, B., Hortobágyi, T. & Hirth, F., 1 Oct 2021, In: Brain. 144, 10, p. 2915-2932 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Citations (Scopus)

Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration in Drosophila

Bridi, J., Bereczki, E., Smith, S., Pocas, G., Kottler, B., Domingos, P., Elliott, C., Aarsland, D. & Hirth, F., 22 Mar 2021, In: Brain Communications.

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Open Access

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11 Citations (Scopus)

131 Downloads (Pure)

2020

A miRNA screen procedure identifies garz as an essential factor in adult glia functions and validates Drosophila as a beneficial 3Rs model to study glial functions and GBF1 biology

Fanto, M., Gonçalves-Pimentel, C., Mazaud, D., Kottler, B., Proelss, S. & Hirth, F., 1 Jan 2020, In: F1000Research. 9, 317.

Research output: Contribution to journal › Article › peer-review

Open Access

Ancestral regulatory mechanisms specify conserved midbrain circuitry in arthropods and vertebrates

Bridi, J., Ludlow, Z., Kottler, B., Hartmann, B., Vanden Broeck, L., Dearlove, J., Göker, M., Strausfeld, N. J., Callaerts, P. & Hirth, F., 3 Jun 2020, (Accepted/In press) In: Proceedings of the National Academy of Sciences of the United States of America.

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123 Downloads (Pure)

Immunostaining of the Embryonic and Larval Drosophila Brain

Hirth, F. & Diaper, D. C., 1 Jan 2020, In: Methods in molecular biology (Clifton, N.J.). 2047, p. 81-96 16 p.

Research output: Contribution to journal › Article › peer-review

2019

Inverse Control of Turning Behavior by Dopamine D1 Receptor Signaling in Columnar and Ring Neurons of the Central Complex in Drosophila

Kottler, B., Faville, R., Bridi, J. C. & Hirth, F., 18 Feb 2019, In: Current Biology. 29, 4, p. 567-577.e6

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29 Citations (Scopus)

113 Downloads (Pure)

Inverse control of turning behaviour by dopamine D1 receptor signalling in columnarwedge and ring neurons of the central complex in Drosophila

Kottler, B. D., Faville, R., Bridi, J. C. & Hirth, F., 9 Jan 2019, (Accepted/In press) In: Current biology : CB.

Research output: Contribution to journal › Article › peer-review

Lineage-specific determination of ring neuron circuitry in the central complex of Drosophila

Bridi, J. C., Ludlow, Z. & Hirth, F., 8 Jul 2019, (E-pub ahead of print) In: Biology Open. 8, 7, 045062.

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5 Citations (Scopus)

136 Downloads (Pure)

Thimerosal inhibits Drosophila melanogaster tyrosine hydroxylase (DmTyrH) leading to changes in dopamine levels and impaired motor behavior: implications for neurotoxicity

Bianchini, M. C., Gularte, C. O. A., Nogara, P. A., Krum, B. N., Gayer, M. C., Bridi, J. C., Roos, D. H., Roehrs, R., Fachinetto, R., Pinton, S., Avila, D. S., Hirth, F., Rocha, J. B. T. & Puntel, R. L., 1 Feb 2019, In: Metallomics. 11, 2, p. 362-374 13 p.

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Transcriptional regulation of the Glutamate/GABA/Glutamine cycle in adult glia controls motor activity and seizures in Drosophila

Mazaud, D., Kottler, B. D., Goncalves Pimentel, C. S., Proelss, S., Tuechler, N., Deneubourg, C. L., Yuasa, Y., Diebold, C., Jungbluth, H., Lai, E. C., Hirth, F., Giangrande, A. & Fanto, M., 3 Jul 2019, In: Journal of Neuroscience. 39, 27, p. 5269-5283 15 p.

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Open Access

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24 Citations (Scopus)

254 Downloads (Pure)

2018

A feedback loop between dipeptide-repeat protein, TDP-43 and karyopherin-α mediates C9orf72-related neurodegeneration

Solomon, D. A., Stepto, A., Au, W. H., Adachi, Y., Diaper, D. C., Hall, R., Rekhi, A., Boudi, A., Tziortzouda, P., Lee, Y. B., Smith, B., Bridi, J. C., Spinelli, G., Dearlove, J., Humphrey, D. M., Gallo, J. M., Troakes, C., Fanto, M., Soller, M., Rogelj, B., & 4 othersParsons, R. B., Shaw, C. E., Hortobágyi, T. & Hirth, F., 1 Oct 2018, In: Brain. 141, 10, p. 2908-2924 17 p.

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66 Citations (Scopus)

294 Downloads (Pure)

In vivo expansion of functionally integrated GABAergic interneurons by targeted increase in neural progenitors

Shaw, R. E., Kottler, B., Ludlow, Z. N., Buhl, E., Kim, D., Morais da Silva, S., Miedzik, A., Coum, A., Hodge, J. JL., Hirth, F. & Sousa-Nunes, R., 2 Jul 2018, In: The EMBO journal. 37, 13, p. 1-16 16 p., e98163.

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Open Access

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14 Citations (Scopus)

288 Downloads (Pure)

2017

C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity

Lee, Y-B., Baskaran, P., Gomez-Deza, J., Chen, H-J., Nishimura, A. L., Smith, B. N., Troakes, C., Adachi, Y., Stepto, A., Petrucelli, L., Gallo, J-M., Hirth, F., Rogelj, B., Guthrie, S. & Shaw, C. E., 15 Dec 2017, In: Human Molecular Genetics. 26, 24, p. 4765-4777 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

64 Citations (Scopus)

In silico interrogation of insect central complex suggests computational roles for the ellipsoid body in spatial navigation

Fiore, V. G., Kottler, B., Gu, X. & Hirth, F., 2017, In: Frontiers in Behavioral Neuroscience. 11, p. 1-13 142.

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13 Citations (Scopus)

191 Downloads (Pure)

2016

Changing pattern in the basal ganglia: Motor switching under reduced dopaminergic drive

Fiore, V. G., Rigoli, F., Stenner, M. P., Zaehle, T., Hirth, F., Heinze, H. J. & Dolan, R. J., 2016, In: Scientific Reports. 6, p. 1-15 23327.

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Open Access

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12 Citations (Scopus)

160 Downloads (Pure)

Introduction to ‘Homology and convergence in nervous system evolution’

Strausfeld, N. J. & Hirth, F., Jan 2016, In: Philosophical Transactions of the Royal Society of London Series B: Biological Sciences. 371, 1685, p. 1-6 20150034.

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9 Citations (Scopus)

121 Downloads (Pure)

2015

Evolutionarily conserved mechanisms for the selection and maintenance of behavioural activity

Fiore, V. G., Dolan, R. J., Strausfeld, N. J. & Hirth, F., 19 Dec 2015, In: Philosophical Transactions of the Royal Society of London Series B: Biological Sciences. 370, 1684, 17 p., 20150053.

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47 Citations (Scopus)

238 Downloads (Pure)

Introduction to ‘Origin and evolution of the nervous system’

Strausfeld, N. J. & Hirth, F., Dec 2015, In: Philosophical Transactions of the Royal Society of London Series B: Biological Sciences. 370, 1684, p. 1-7 20150033.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

2013

Deep homology of arthropod central complex and vertebrate basal ganglia

Strausfeld, N. J. & Hirth, F., 12 Apr 2013, In: Science. 340, 6129, p. 157-161 5 p.

Research output: Contribution to journal › Article › peer-review

256 Citations (Scopus)

Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioral phenotypes that characterize ALS and FTLD

Diaper, D. C., Adachi, Y., Lazarou, L., Greenstein, M., Simoes, F. A., Di Domenico, A., Solomon, D. A., Lowe, S., Alsubaie, R., Cheng, D., Buckley, S., Humphrey, D. M., Shaw, C. E. & Hirth, F., 1 Oct 2013, In: Human Molecular Genetics. 22, 19, p. 3883-3893 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

65 Citations (Scopus)

Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic

Lee, Y., Chen, H-J., Peres, J. N., Gomez Deza, J., Attig, J., Stalekar, M., Troakes, C., Nishimura, A. L., Scotter, E. L., Vance, C., Adachi, Y., Sardone, V., Miller, J. W., Smith, B. N., Gallo, J-M., Ule, J., Hirth, F., Rogelj, B., Houart, C. & Shaw, C. E., 12 Dec 2013, In: Cell Reports. 5, 5, p. 1178-1186 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

378 Citations (Scopus)

Homology versus convergence in resolving transphyletic correspondences of brain organisation

Strausfeld, N. J. & Hirth, F., 1 Dec 2013, In: Brain Behavior and Evolution. 82, 4, p. 215-219 5 p., N/A.

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes

Diaper, D., Adachi, Y., Sutcliffe, B., Humphrey, D. M., Elliott, C. J. H., Stepto, A., Ludlow, Z. N., Vanden Broeck, L., Callaerts, P., Dermaut, B., Al-Chalabi, A., Shaw, C. E., Robinson, I. M. & Hirth, F., 15 Apr 2013, In: Human Molecular Genetics. 22, 8, p. 1539-1557 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

104 Citations (Scopus)

TDP-43 Loss-of-Function Causes Neuronal Loss Due to Defective Steroid Receptor-Mediated Gene Program Switching in Drosophilia

Vanden Broeck, L., Naval-Sánchez, M., Adachi, Y., Diaper, D., Dourlen, P., Chapuis, J., Kleinberger, G., Gistelinck, M., Van Broeckhoven, C., Lambert, J-C., Hirth, F., Aerts, S., Callaerts, P. & Dermaut, B., 31 Jan 2013, In: Cell Reports. 3, 1, p. 160-172 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Citations (Scopus)

2012

Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila

Humphrey, D. M., Parsons, R. B., Ludlow, Z. N., Riemensperger, T., Esposito, G., Verstreken, P., Jacobs, H. T., Birman, S. & Hirth, F., 15 Jun 2012, In: Human Molecular Genetics. 21, 12, p. 2698-2712 15 p., dds096.

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

2010

Drosophila melanogaster in the Study of Human Neurodegeneration

Hirth, F., 2010, In: Cns & Neurological Disorders-Drug Targets. 9, 4, p. 504 - 523 20 p.

Research output: Contribution to journal › Article › peer-review

166 Citations (Scopus)

The dopaminergic system in the aging brain of Drosophila

White, K. E., Humphrey, D. M. & Hirth, F., 8 Dec 2010, In: Frontiers in Neuroscience. 4, 205.

Research output: Contribution to journal › Article › peer-review

110 Citations (Scopus)

2009

Genetic mechanisms regulating stem cell self-renewal and differentiation in the central nervous system of Drosophila

Kim, D. W. & Hirth, F., 2009, In: Cell Adhesion & Migration. 3, 4, p. 402-411 10 p.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Loss of heterozygosity of TRIM3 in malignant gliomas

Boulay, J-L., Stiefel, U., Taylor, E., Dolder, B., Merlo, A. & Hirth, F., 27 Feb 2009, In: BMC Cancer. 9, 71.

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

2006

Expression and function of the columnar patterning gene msh in late embryonic brain development of Drosophila

Sprecher, S. G. & Hirth, F., Nov 2006, In: Developmental dynamics : an official publication of the American Association of Anatomists. 235, 11, p. 2920-9 10 p.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila

Bello, B., Reichert, H. & Hirth, F., Jul 2006, In: Development (Cambridge): for advances in developmental biology and stem cells. 133, 14, p. 2639 - 2648 10 p.

Research output: Contribution to journal › Article › peer-review

207 Citations (Scopus)

The columnar gene vnd is required for tritocerebral neuromere formation during embryonic brain development of Drosophila

Sprecher, S. G., Urbach, R., Technau, G. M., Rijli, F. M., Reichert, H. & Hirth, F., Nov 2006, In: Development (Cambridge): for advances in developmental biology and stem cells. 133, 21, p. 4331 - 4339 9 p.

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

ventral veins lacking is required for specification of the tritocerebrum in embryonic brain development of Drosophila

Meier, S., Sprecher, S. G., Reichert, H. & Hirth, F., Jan 2006, In: Mechanisms of Development. 123, 1, p. 76-83 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Citations (Scopus)

2004

Hox gene cross-regulatory interactions in the embryonic brain of Drosophila

Sprecher, S. G., Müller, M., Kammermeier, L., Miller, D. F. B., Kaufman, T. C., Reichert, H. & Hirth, F., Jun 2004, In: Mechanisms of Development. 121, 6, p. 527-536 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Citations (Scopus)

Transcriptional signature of an adult brain tumor in Drosophila

Loop, T., Leemans, R., Stiefel, U., Hermida, L., Egger, B., Xie, F., Primig, M., Certa, U., Fischbach, K-F., Reichert, H. & Hirth, F., 16 Apr 2004, In: BMC GENOMICS. 5, 22 p., 24.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Citations (Scopus)

2003

An urbilaterian origin of the tripartite brain: developmental genetic insights from Drosophila

Hirth, F., Kammermeier, L., Frei, E., Walldorf, U., Noll, M. & Reichert, H., Jun 2003, In: Development (Cambridge): for advances in developmental biology and stem cells. 130, 11, p. 2365 - 2373 9 p.

Research output: Contribution to journal › Article › peer-review

154 Citations (Scopus)

A pulse of the Drosophila Hox protein Abdominal-A schedules the end of neural proliferation via neuroblast apoptosis

Bello, B. C., Hirth, F. & Gould, A. P., 23 Jan 2003, In: Neuron. 37, 2, p. 209 - 219 11 p.

Research output: Contribution to journal › Article › peer-review

160 Citations (Scopus)

Commissure formation in the embryonic insect brain

Boyan, G., Reichert, H. & Hirth, F., Aug 2003, In: Arthropod structure & development. 32, 1, p. 61-77 17 p.

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

2001

Differential expression and function of the Drosophila Pax6 genes eyeless and twin of eyeless in embryonic central nervous system development

Kammermeier, L., Leemans, R., Hirth, F., Flister, S., Wenger, U., Walldorf, U., Gehring, W. J. & Reichert, H., May 2001, In: Mechanisms of Development. 103, 1-2, p. 71-8 8 p.

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Drosophila transcription factor AP-2 in proboscis, leg and brain central complex development

Monge, I., Krishnamurthy, R., Sims, D., Hirth, F., Spengler, M., Kammermeier, L., Reichert, H. & Mitchell, P., Apr 2001, In: Development (Cambridge): for advances in developmental biology and stem cells. 128, 8, p. 1239-52 14 p.

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Expression and function of the LIM homeodomain protein Apterous during embryonic brain development of Drosophila

Herzig, M. C., Thor, S., Thomas, J. B., Reichert, H. & Hirth, F., Dec 2001, In: DEVELOPMENT GENES AND EVOLUTION. 211, 11, p. 545-554 10 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Functional equivalence of Hox gene products in the specification of the tritocerebrum during embryonic brain development of Drosophila

Hirth, F., Loop, T., Egger, B., Miller, D. F., Kaufman, T. C. & Reichert, H., 2001, In: Development (Cambridge): for advances in developmental biology and stem cells. 128, 23, p. 4781 - 4788 8 p.

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Identification of candidate downstream genes for the homeodomain transcription factor Labial in Drosophila through oligonucleotide-array transcript imaging

Leemans, R., Loop, T., Egger, B., He, H., Kammermeier, L., Hartmann, B., Certa, U., Reichert, H. & Hirth, F., 2001, In: GENOME BIOLOGY. 2, 5, p. RESEARCH0015

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32 Citations (Scopus)

87 Downloads (Pure)

2000

Expression, regulation and function of the homeobox gene empty spiracles in brain and ventral nerve cord development of Drosophila

Hartmann, B., Hirth, F., Walldorf, U. & Reichert, H., Feb 2000, In: Mechanisms of Development. 90, 2, p. 143-53 11 p.

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Frank Hirth

Research output

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