King's College London

Research portal

Professor Geoffrey Savidge

  1. Effectiveness in controlling haemorrhage after dental scaling in people with haemophilia by using tranexamic acid mouthwash

    Lee, A. P., Boyle, C. A., Savidge, G. F. & Fiske, J., 8 Jan 2005, In: British Dental Journal. 198, 1, p. 33 - 8; discuss 6 p.

    Research output: Contribution to journalArticlepeer-review

  2. Superwarfarin poisoning

    Pavlu, F., Harrington, D. J., Voong, K., Savidge, G. F., JAn-Mohamed, R. & Kaczmarski, R., 2005, In: The Lancet. 365, 9459, p. 628 - 628 1 p.

    Research output: Contribution to journalEditorialpeer-review

  3. Alteration in the laboratory profile of a lupus anticoagulant in a patient with non-Hodgkin's lymphoma

    Moore, G. W., Kamat, A. V., Gurney, D. A., O'Connor, O., Rangarajan, S., Carr, R. & Savidge, G. F., Dec 2004, In: Clinical and Laboratory Haematology. 26, 6, p. 429 - 434 6 p.

    Research output: Contribution to journalArticlepeer-review

  4. The profibrinolytic effect of plasma thrombomodulin in factor XI deficiency and its implications in hemostasis

    Dai, L., Mitchell, M., Savidge, G. & Alhaq, A., Dec 2004, In: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2, 12, p. 2200 - 2204 5 p.

    Research output: Contribution to journalArticlepeer-review

  5. An Alu-mediated 31.5-kb deletion as the cause of factor XI deficiency in 2 unrelated patients

    Mitchell, M., Dai, L. T., Savidge, G. & Alhaq, A., 15 Oct 2004, In: Blood. 104, 8, p. 2394 - 2396 3 p.

    Research output: Contribution to journalArticlepeer-review

  6. Low molecular weight heparin (tinzaparin) therapy for moderate risk thromboprophylaxis during pregnancy - A pharmacokinetic study

    Norris, L. A., Bonnar, J., Smith, M. R., Steer, P. J. & Savidge, G., Oct 2004, In: Thrombosis and Haemostasis. 92, 4, p. 791 - 796 6 p.

    Research output: Contribution to journalArticlepeer-review

  7. Real-time quantitative PCR analysis of factor XI mRNA variants in human platelets

    Podmore, A., Smith, M., Savidge, G. & Alhaq, A., Oct 2004, In: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2, 10, p. 1713 - 1719 7 p.

    Research output: Contribution to journalArticlepeer-review

  8. Continuous infusion of B-domain deleted recombinant factor VIII (ReFacto) in patients with haemophilia A undergoing surgery: clinical experience

    Stieltjes, N., Altisent, C., Auerswald, G., Negrier, C., Pouzol, P., Reynaud, J., Roussel-Robert, V., Savidge, G. F., Villar, A. & Schulman, S., Sep 2004, In: HAEMOPHILIA. 10, 5, p. 452 - 458 7 p.

    Research output: Contribution to journalArticlepeer-review

  9. Germline mosaicism resulting in the transmission of severe hemophilia B from a grandfather with a mild deficiency

    Cutler, J. A., Mitchell, M. J., Smith, M. P. & Savidge, G. F., 15 Aug 2004, In: American Journal of Medical Genetics. 129A, 1, p. 13 - 15 3 p.

    Research output: Contribution to journalArticlepeer-review

  10. Severe factor XI deficiency caused by compound heterozygosity

    Dai, L., Mitchell, M., Carson, P., Creagh, D., Cutler, J., Savidge, G. & Alhaq, A., Jun 2004, In: British Journal of Haematology. 125, 6, p. 817 - 818 2 p.

    Research output: Contribution to journalLetterpeer-review

  11. Fibronectin promotes VEGF-induced CD34 cell differentiation into endothelial cells

    Wijelath, E. S., Rahman, S., Murray, J., Patel, Y., Savidge, G. & Sobel, M., Mar 2004, In: Journal of Vascular Surgery. 39, 3, p. 655 - 660 6 p.

    Research output: Contribution to journalArticlepeer-review

  12. Validation of a quantitative SPR assay for recombinant FVIII

    McCormick, A. N., Leach, M. E., Savidge, G. & Alhaq, A., Feb 2004, In: Clinical and Laboratory Haematology. 26, 1, p. 57 - 64 8 p.

    Research output: Contribution to journalArticlepeer-review

  13. Heterogeneity of Russell's viper venom affects the sensitivity of the dilute Russell's viper venom time to lupus anticoagulants

    Moore, G. W. & Savidge, G. F., 2004, In: Blood Coagulation and Fibrinolysis. 15, 3, p. 279 - 282 4 p.

    Research output: Contribution to journalArticlepeer-review

  14. More on: unusual expression of the F9 gene in peripheral lymphocytes hinders investigation of F9 mRNA in hemophilia B patients

    Cutler, J. A., Mitchell, M. J. & Savidge, G. F., 2004, In: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2, 6, p. 1021 - 1021 1 p.

    Research output: Contribution to journalLetterpeer-review

  15. Eighteen unrelated patients with factor XI deficiency, four novel mutations and a 100% detection rate by denaturing high-performance liquid chromatography

    Mitchell, M., Harrington, P., Cutler, J., Rangarajan, S., Savidge, G. & Alhaq, A., May 2003, In: British Journal of Haematology. 121, 3, p. 500 - 502 3 p.

    Research output: Contribution to journalArticlepeer-review

  16. The Ecarin time is an improved confirmatory test for the Taipan snake venom time in warfarinized patients with lupus anticoagulants

    Moore, G. W., Smith, M. P. & Savidge, G. F., Apr 2003, In: Blood Coagulation and Fibrinolysis. 14, 3, p. 307 - 312 6 p.

    Research output: Contribution to journalArticlepeer-review

  17. A prospective study of recombinant activated factor VII administered by continuous infusion to inhibitor patients undergoing elective major orthopaedic surgery: a pharmacokinetic and efficacy evaluation

    Ludlam, C. A., Smith, M. P., Morfini, M., Gringeri, A., Santagostino, E. & Savidge, G. F., 1 Mar 2003, In: British Journal of Haematology. 120, 5, p. 808 - 813 6 p.

    Research output: Contribution to journalArticlepeer-review

  18. Nanofiltration of single plasma donations: feasibility study

    Burnouf, T., Radosevich, M., El-Ekiaby, M., Satoh, S., Sato, T., Amin, S. N., Savidge, G. F. & Goubran, H. A., Feb 2003, In: Vox Sanguinis. 84, 2, p. 111 - 119 9 p.

    Research output: Contribution to journalArticlepeer-review

  19. An Alu-mediated 31.5 kb deletion as the cause of factor XI deficiency in two unrelated patients.

    Mitchell, M. J., Alhaq, A., Dai, L. & Savidge, G. F., 2003, In: Blood. 102, 11, p. 444 1 p.

    Research output: Contribution to journalMeeting abstract

  20. Evidence for a role for G alpha(i1) in mediating weak agonist-induced platelet aggregation in human platelets: reduced G alpha(i1) expression and defective G(i) signaling in the platelets of a patient with a chronic bleeding disorder

    Patel, Y. M., Patel, K., Rahman, S., Smith, M. P., Spooner, G., Sumathipala, R., Mitchell, M., Flynn, G., Aitken, A. & Savidge, G., 2003, In: Blood. 101, 12, p. 4828 - 4835 8 p.

    Research output: Contribution to journalArticlepeer-review

  21. Fibrinogen concentration, gene polymorphisms and venous thrombosis in the black population.

    Patel, R. K., Cutler, J., Ford, E., Thumpston, J., Madan, B., Rangarajan, S., Savidge, G. F. & Arya, R., 2003, In: Blood. 102, 11, p. 1126 1 p.

    Research output: Contribution to journalMeeting abstract

  22. Genetic variations observed in arterial and venous thromboembolism - Relevance for therapy, risk prevention and prognosis

    Harrington, D. J., Malefora, A., Schmeleva, V., Kapustin, S., Papayan, L., Blinov, M., Harrington, P., Mitchell, M. & Savidge, G. F., 2003, In: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 41, 4, p. 496 - 500 5 p.

    Research output: Contribution to journalConference paper

  23. Glanzmann's thrombasthenia proposed optimal management during surgery and delivery

    Bell, J. A. & Savidge, G. F., 2003, In: CLINICAL AND APPLIED THROMBOSIS HEMOSTASIS. 9, 2, p. 167 - 170 4 p.

    Research output: Contribution to journalArticlepeer-review

  24. Hepatocyte growth factor (HGF) binding domains on fibronectin and vitronectin promote enhanced endothelial cell migration via a specific ras and PI3-kinase dependent pathway.

    Patel, K. V., Wijelath, E. S., Patel, Y. M., Sumathipala, R., Sobel, M. S., Murray, J., Seago, J., Savidge, G. F. & Rahman, S., 2003, In: Blood. 102, 11, p. 1955 1 p.

    Research output: Contribution to journalMeeting abstract

  25. Prevalence of hyperhomocysteinemia and the MTHFR C677T polymorphism in patients with arterial and venous thrombosis from North Western Russia

    Shmeleva, V. M., Kapustin, S. I., Papayan, L. P., Sobczynska-Malefora, A., Harrington, D. J. & Savidge, G. F., 2003, In: Thrombosis Research. 111, 6, p. 351 - 356 6 p.

    Research output: Contribution to journalArticlepeer-review

  26. The profibrinolytic effect of plasma thrombomodulin in factor XI deficient patients.

    Dai, L. T., Mitchell, M. J., Savidge, G. F. & Alhaq, A., 2003, In: Blood. 102, 11, p. 1098 1 p.

    Research output: Contribution to journalMeeting abstract

  27. The significance of published polymorphisms in seven cases of mild factor VII deficiency.

    Cutler, J. A., Patel, R., Mitchell, M. J., Rangarajan, S. & Savidge, G. F., 2003, In: Blood. 102, 11, p. 1106 1 p.

    Research output: Contribution to journalMeeting abstract

  28. Evaluation of an automated screening assay for von Willebrand Disease Type 2N

    Taylor, S. L., Bromidge, E., Savidge, G. F. & Alhaq, A., Dec 2002, In: Clinical and Laboratory Haematology. 24, 6, p. 369 - 375 7 p.

    Research output: Contribution to journalArticlepeer-review

  29. Novel vascular endothelial growth factor binding domains of fibronectin enhance vascular endothelial growth factor biological activity

    Wijelath, E. S., Murray, J., Rahman, S., Patel, Y., Ishida, A., Strand, K., Aziz, S., Cardona, C., Hammond, W. P., Savidge, G. F., Rafii, S. & Sobel, M., 12 Jul 2002, In: Circulation Research. 91, 1, p. 25 - 31 7 p.

    Research output: Contribution to journalArticlepeer-review

  30. Experiences of continuous infusion of B-domain deleted recombinant factor VIII (ReFacto (R)) for major surgery.

    Schulman, S., Roussel-Robert, V., Stieltjes, N., Negrier, C., Reynaud, J., Villar, A., Pouzol, P., Savidge, G. F., Altisent, C. & Auerswald, G., 2002, In: Blood. 100, 11, p. 3920 1 p.

    Research output: Contribution to journalMeeting abstract

  31. Measurement of urinary metabolites of vitamin K

    Harrington, D., Soper, R., Edwards, C., Savidge, G. F., Hodges, S. & Shearer, M., 2002, In: Bone. 30, 3, p. 28S - 28S

    Research output: Contribution to journalMeeting abstract

  32. Mutation analysis of 28 unrelated cases of factor XI deficiency - 9 Previously unreported mutations.

    Mitchell, M., Harrington, P., Cutler, J., Storey, H., Alhaq, A. & Savidge, G., 2002, In: Blood. 100, 11, p. 58 1 p.

    Research output: Contribution to journalMeeting abstract

  33. Prevalence of hyperhomocysteinemia in patients with a history of thromboembolic disease after cessation of oral anticoagulation therapy.

    Sobczynska-Malefora, A., Rangarajan, S., Harrington, D. J., Shearer, M. J. & Savidge, G. F., 2002, In: Blood. 100, 11, p. 2761 1 p.

    Research output: Contribution to journalMeeting abstract

  34. Severe and mild von Willebrand disease in non-consanguineous dizygotic twins - The result of two novel mutations.

    Mitchell, M., Harrington, P., Cutler, J. & Savidge, G., 2002, In: Blood. 100, 11, p. 1913 1 p.

    Research output: Contribution to journalMeeting abstract

  35. The identification and classification of 41 novel mutations in the factor VIII gene (F8C)

    Cutler, J. A., Mitchell, M. J., Smith, M. P. & Savidge, G. F., 2002, In: Human Mutation. 19, 3, p. 274 - 278 5 p.

    Research output: Contribution to journalArticlepeer-review

  36. The treatment needs of adults with inherited bleeding disorders

    Fiske, J., McGeoch, R. J., Savidge, G. F. & Smith, M. P., 2002, In: Journal of Disability and Oral Health. 3, 2, p. 59 - 61 3 p.

    Research output: Contribution to journalArticlepeer-review

  37. The uptake of lipoprotein-borne phylloquinone (vitamin K-1) by osteoblasts and osteoblast-like cells: Role of heparan sulfate proteoglycans and apolipoprotein E

    Newman, P., Bonello, F., Wierzbicki, A. S., Lumb, P., Savidge, G. F. & Shearer, M. J., 2002, In: Journal of Bone and Mineral Research. 17, 3, p. 426 - 433 8 p.

    Research output: Contribution to journalArticlepeer-review

  38. Three novel mutations in the beta fibrinogen gene (FGB) as the cause of a bleeding diathesis.

    Mitchell, M., Arnold, A., Harrington, P., Cutler, J. & Savidge, G., 2002, In: Blood. 100, 11, p. 1914 1 p.

    Research output: Contribution to journalMeeting abstract

  39. Two patients with acquired Factor V deficiency associated with a myeloproliferative disorder.

    Cheung, B., Arnold, A., Rangarajan, S., Cutler, J. & Savidge, G. F., 2002, In: Blood. 100, 11, p. 2756 1 p.

    Research output: Contribution to journalMeeting abstract

  40. Under-representation of the-455A beta-fibrinogen allele in survivors of pulmonary embolism

    Kapustin, S. I., Blinov, M. N., Papayan, L. P., Imyanitov, E. N., Mitchell, M. J. & Savidge, G. F., 2002, In: Thrombosis Research. 106, 1, p. 89 - 90 2 p.

    Research output: Contribution to journalLetterpeer-review

  41. Oncostatin M promotes biphasic tissue factor expression in smooth muscle cells: evidence for Erk-1/2 activation

    Nishibe, T., Parry, G., Ishida, A., Aziz, S., Murray, J., Patel, Y., Rahman, S., Strand, K., Saito, K., Saito, Y., Hammond, W. P., Savidge, G. F., Mackman, N. & Wijelath, E. S., 1 Feb 2001, In: Blood. 97, 3, p. 692 - 699 8 p.

    Research output: Contribution to journalArticlepeer-review

  42. 100% detection of FXI mutations by dHPLC

    Patel, P., Mitchell, M., Smith, M. P. & Savidge, G. F., 2001, In: Journal of Medical Genetics. 38, p. S61 - S61

    Research output: Contribution to journalMeeting abstract

  43. A novel mutation in the fibrinogen beta gene as a cause of a hemorrhagic tendency in a family complicated by valproate usage.

    Patel, P., Cutler, J. A., Mitchell, M. J., Koh, M., Rajan, S., Smith, M. P. & Savidge, G. F., 2001, In: Blood. 98, 11, p. 261A - 261A

    Research output: Contribution to journalMeeting abstract

  44. A rapid and cost-effective method for analysis of three common genetic risk factors for thrombosis

    Cutler, J. A., Mitchell, M. J., Greenslade, K., Smith, M. P. & Savidge, G. F., 2001, In: Blood Coagulation and Fibrinolysis. 12, 1, p. 33 - 36 4 p.

    Research output: Contribution to journalArticlepeer-review

  45. Chromogenic vs. one-stage measurement of residual factor VIII activity in the Bethesda assay: A methodological comparison.

    Macartney, A. R., King, E., Moore, G., Alhaq, A. & Savidge, G. F., 2001, In: Blood. 98, 11, p. 82B - 82B

    Research output: Contribution to journalMeeting abstract

  46. Elective surgery on factor VIII inhibitor patients using continuous infusion of recombinant activated factor VII - Plasma factor VII activity of 10 IU/ml is associated with an increased incidence of bleeding

    Smith, M. P., Ludlam, C. A., Collins, P. W., Hay, C. R. M., Wilde, J. T., Grigeri, A., Melsen, T. & Savidge, G. F., 2001, In: Thrombosis and Haemostasis. 86, 4, p. 949 - 953 5 p.

    Research output: Contribution to journalArticlepeer-review

  47. Genetic basis of inherited bleeding and thrombolic disorders

    Savidge, G. F., 2001, In: Bailliere's Best Practice in Clinical Anaesthesiology. 15, 2, p. 213 1 p.

    Research output: Contribution to journalArticlepeer-review

  48. Management strategy to prevent inhibitor development/recurrence in patients with mild/moderate haemophilia A.

    Rangarajan, S., Raj, K. K., Cutler, J., Mitchell, M. & Savidge, G. F., 2001, In: Blood. 98, 11, p. 76B - 76B

    Research output: Contribution to journalMeeting abstract

  49. Mutations in the factor XI gene

    Alhaq, A., Mitchell, M., Savidge, G. & Smith, M., 2001, In: American Journal of Hematology. 66, 1, p. 67 - 67 1 p.

    Research output: Contribution to journalLetterpeer-review

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