King's College London

Research portal

Professor George Santis

  1. The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers

    Zanetti-Domingues, L. C., Korovesis, D., Needham, S. R., Tynan, C. J., Sagawa, S., Roberts, S. K., Kuzmanic, A., Ortiz-Zapater, E., Jain, P., Roovers, R. C., Lajevardipour, A., van Bergen en Henegouwen, P. M. P., Santis, G., Clayton, A. H. A., Clarke, D. T., Gervasio, F. L., Shan, Y., Shaw, D. E., Rolfe, D. J., Parker, P. J. & 1 others, Martin-Fernandez, M. L., 1 Dec 2018, In : Nature Communications. 9, 1, 4325.

    Research output: Contribution to journalArticle

  2. CAR: A key regulator of adhesion and inflammation

    Ortiz-Zapater, E., Santis, G. & Parsons, M., 1 Aug 2017, In : The international journal of biochemistry & cell biology. 89, p. 1-5 5 p.

    Research output: Contribution to journalShort survey

  3. The transcriptional signature of active tuberculosis reflects symptom status in extra-pulmonary and pulmonary tuberculosis

    Blankley, S., Graham, C. M., Turner, J., Berry, M. P. R., Bloom, C. I., Xu, Z., Pascual, V., Banchereau, J., Chaussabel, D., Breen, R., Santis, G., Blankenship, D. M., Lipman, M. & O'Garra, A., 5 Oct 2016, In : PL o S One . 11, 10, 14 p., e0162220.

    Research output: Contribution to journalArticle

  4. Challenges in molecular testing in non-small-cell lung cancer patients with advanced disease

    Hiley, C. T., Le Quesne, J., Santis, G., Sharpe, R., de Castro, D. G., Middleton, G. & Swanton, C., 3 Sep 2016, In : Lancet. 388, 10048, p. 1002-1011 10 p.

    Research output: Contribution to journalReview article

  5. A rare intravascular tumour diagnosed by endobronchial ultrasound

    Owen, W. T., Karampini, E., Breen, R. A., Moonim, M., Nair, A., Barrington, S. F. & Santis, G., Sep 2016, In : Thorax. 71, 9, p. 869-70 2 p.

    Research output: Contribution to journalArticle

  6. A 380-gene meta-signature of active tuberculosis compared with healthy controls

    Blankley, S., Graham, C. M., Levin, J., Turner, J., Berry, M. P. R., Bloom, C. I., Xu, Z., Pascual, V., Banchereau, J., Chaussabel, D., Breen, R., Santis, G., Blankenship, D. M., Lipman, M. & O'Garra, A., 1 Jun 2016, In : European Respiratory Journal. 47, 6, p. 1873-1876 4 p.

    Research output: Contribution to journalLetter

  7. TNFα promotes CAR-dependent migration of leukocytes across epithelial monolayers

    Morton, P. E., Hicks, A., Ortiz-Zapater, E., Raghavan, S., Pike, R., Noble, A., Woodfin, A., Jenkins, G., Rayner, E., Santis, G. & Parsons, M., 19 May 2016, In : Scientific Reports. 6, 26321.

    Research output: Contribution to journalArticle

  8. The LungPath study: variation in the diagnostic and staging pathway for patients with lung cancer in England

    Cane, P., Linklater, K., Santis, G., Møller, H. & Peake, M., 15 Jul 2015, In : Thorax. 3 p., 206779.

    Research output: Contribution to journalArticle

  9. The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility

    Kiuchi, T., Ortiz-Zapater, E., Monypenny, J., Matthews, D. R., Nguyen, L. K., Barbeau, J., Coban, O., Lawler, K., Burford, B., Rolfe, D. J., de Rinaldis, E., Dafou, D., Simpson, M. A., Woodman, N., Pinder, S., Gillett, C. E., Devauges, V., Poland, S. P., Fruhwirth, G., Marra, P. & 12 others, Boersma, Y. L., Plückthun, A., Gullick, W. J., Yarden, Y., Santis, G., Winn, M., Kholodenko, B. N., Martin-Fernandez, M. L., Parker, P., Tutt, A., Ameer-Beg, S. M. & Ng, T., 19 Aug 2014, In : Science Signaling. 7, 339, ra78.

    Research output: Contribution to journalArticle

  10. ALK rearrangements in EBUS-derived transbronchial needle aspiration cytology in lung cancer

    Neat, M. J., Foot, N. J., Hicks, A., Breen, R., Wilkins, B., McLean, E. & Santis, G., Dec 2013, In : Cytopathology. 24, 6, p. 356-364 9 p.

    Research output: Contribution to journalArticle

  11. Routine EGFR and KRAS Mutation analysis using COLD-PCR in non-small cell lung cancer

    Pennycuick, A., Simpson, T., Crawley, D., Lal, R., Santis, G., Cane, P., Tobal, K. & Spicer, J., Aug 2012, In : International Journal of Clinical Practice. 66, 8, p. 748-752 5 p.

    Research output: Contribution to journalArticle

  12. The changing numbers and indications of mediastinoscopy procedures performed following the introduction of endobronchical ultrasound at a UK tertiary centre (vol 66, pg A140, 2011)

    Bakir, M., Breen, R., Quinn, A., King, J. & Santis, G., 2012, In : Thorax. 67, 2, p. 178 - 178 1 p.

    Research output: Contribution to journalArticle

  13. Utility of endobronchial ultrasound-guided transbronchial needle aspiration in patients with tuberculous intrathoracic lymphadenopathy: a multicentre study

    Navani, N., Molyneaux, P. L., Breen, R. A., Connell, D. W., Jepson, A., Nankivell, M., Brown, J. M., Morris-Jones, S., Ng, B., Wickremasinghe, M., Lalvani, A., Rintoul, R. C., Santis, G., Kon, O. M. & Janes, S. M., Oct 2011, In : Thorax. 66, 10, p. 889-893 5 p.

    Research output: Contribution to journalArticle

  14. Screening for EGFR and KRAS mutations in endobronchial ultrasound derived transbronchial needle aspirates in non-small cell lung cancer using COLD-PCR

    Santis, G., Angell, R., Nickless, G., Quinn, A., Herbert, A., Cane, P., Spicer, J., Breen, R., McLean, E. & Tobal, K., 19 Sep 2011, In : PL o S One . 6, 9, 7 p., e25191.

    Research output: Contribution to journalArticle

  15. The challenges of integrating molecular imaging into the optimization of cancer therapy

    Patel, G. S., Kiuchi, T., Lawler, K., Ofo, E., Fruhwirth, G. O., Kelleher, M., Shamil, E., Zhang, R., Selvin, P. R., Santis, G., Spicer, J., Woodman, N., Gillett, C. E., Barber, P. R., Vojnovic, B., Kéri, G., Schaeffter, T., Goh, V., O'Doherty, M. J., Ellis, P. A. & 1 others, Ng, T., Jun 2011, In : Integrative Biology. 3, 6, p. 603 - 631 29 p.

    Research output: Contribution to journalLiterature review

  16. CAR Modulates E-Cadherin Dynamics in the Presence of Adenovirus Type 5

    Hussain, F., Morton, P. E., Snippe, M., Sullivan, J., Farmer, C., Martin-Fernandez, M. L., Parsons, M. & Santis, G., 2011, In : PL o S One . 6, 8, e23056.

    Research output: Contribution to journalArticle

  17. Phase II feasibility study of autologous vaccine (HSPPC-96) in patients with resectable lung cancer

    Santis, G., Senzer, N. N., Champagne, P., Isakov, L. & Teofilovici, F., 20 May 2008, In : Journal of Clinical Oncology. 26, 15S, 1 p., 7584.

    Research output: Contribution to journalArticle

  18. Adenovirus type-5 entry and disassembly followed in living cells by FRET, fluorescence anisotropy, and FLIM

    Martin-Fernandez, M., Longshaw, S. V., Kirby, I., Santis, G., Tobin, M. J., Clarke, D. T. & Jones, G. R., Aug 2004, In : Biophysical Journal. 87, 2, p. 1316 - 1327 12 p.

    Research output: Contribution to journalArticle

  19. Adenovirus type 5 uptake by lung adenocarcinoma cells in culture correlates with Ad5 fibre binding is mediated by alpha(v)beta1 integrin and can be modulated by changes in beta1 integrin function

    Davison, E., Kirby, I., Whitehouse, J., Hart, I., Marshall, J. F. & Santis, G., Nov 2001, In : JOURNAL OF GENE MEDICINE. 3, 6, p. 550 - 559 10 p.

    Research output: Contribution to journalArticle

  20. Adenovirus type 9 fiber knob binds to the coxsackie B virus-adenovirus receptor (CAR) with lower affinity than fiber knobs of other CAR-binding adenovirus serotypes

    Kirby, I., Lord, R., Davison, E., Wickham, T. J., Roelvink, P. W., Kovesdi, I., Sutton, B. J. & Santis, G., 2001, In : Journal of Virology. 75, 15, p. 7210 - 7214 5 p.

    Research output: Contribution to journalArticle

  21. Identification of contact residues and definition of the CAR-binding site of adenovirus type 5 fiber protein

    Kirby, I., Davison, E., Beavil, A. J., Soh, C. P. C., Wickham, T. J., Roelvink, P. W., Kovesdi, I., Sutton, B. J. & Santis, G., 2000, In : Journal of Virology. 74, 6, p. 2804 - 2813 10 p.

    Research output: Contribution to journalArticle

  22. Transcriptional regulation of thyroid transcription factor-1 (TTF-1) (vol 93, pg A 14, 1999)

    Whitehouse, J. L., Lee, Y. C., Bingle, C. D., Antoniou, M. & Santis, G., 2000, In : Respiratory Medicine. 94, 3, p. 295 - 295 1 p.

    Research output: Contribution to journalArticle

  23. Mutations in the DG loop of adenovirus type 5 fiber knob protein abolish high-affinity binding to its cellular receptor CAR

    Kirby, I., Davison, E., Beavil, A. J., Soh, C. P., Wickham, T. J., Roelvink, P. W., Kovesdi, I., Sutton, B. J. & Santis, G., Nov 1999, In : Journal of Virology. 73, 11, p. 9508-14 7 p.

    Research output: Contribution to journalArticle

  24. Molecular determinants of adenovirus serotype 5 fibre binding to its cellular receptor CAR

    Santis, G., Legrand, V., Hong, S. S., Davison, E., Kirby, I., Imler, J. L., Finberg, R. W., Bergelson, J. M., Mehtali, M. & Boulanger, P., Jun 1999, In : Journal of General Virology. 80 ( Pt 6), p. 1519-27 9 p.

    Research output: Contribution to journalArticle

  25. Molecular biology for the critical care physician. Part II: where are we now?

    Santis, G. & Evans, T. W., May 1999, In : Critical Care Medicine. 27, 5, p. 997-1003 7 p.

    Research output: Contribution to journalArticle

  26. The human HLA-A*0201 allele, expressed in hamster cells, is not a high-affinity receptor for adenovirus type 5 fiber

    Davison, E., Kirby, I., Elliott, T. & Santis, G., May 1999, In : Journal of Virology. 73, 5, p. 4513 4517 p.

    Research output: Contribution to journalArticle

  27. Integrin alpha 5 beta 1-mediated adenovirus infection is enhanced by the integrin-activating antibody TS2/16

    Davison, E., Diaz, RM., Hart, I. R., Santis, G. & Marshall, J., Aug 1997, In : Journal of Virology. 71, 8, p. 6204 6207 p.

    Research output: Contribution to journalArticle

  28. Heterogeneity in the severity of cystic fibrosis and the role of CFTR gene mutations

    Dean, M. & Santis, G., Apr 1994, In : Human Genetics. 93, 4, p. 364-8 5 p.

    Research output: Contribution to journalArticle

  29. Recent advances in cystic fibrosis

    Santis, G. & Geddes, D., Apr 1994, In : Postgraduate Medical Journal. 70, 822, p. 247-51 5 p.

    Research output: Contribution to journalArticle

  30. NASAL EPITHELIAL ION-TRANSPORT AND GENETIC-ANALYSIS OF INFERTILE MEN WITH CONGENITAL BILATERAL ABSENCE OF THE VAS-DEFERENS

    Osborne, L., Lynch, M., Middleton, P., Alton, E., Geddes, D., Pryor, J., Hodson, M. & Santis, G., Oct 1993, In : Human Molecular Genetics. p. 1605 1609 p.

    Research output: Contribution to journalArticle

  31. Pleural effusions associated with pancreaticopleural fistula

    Williams, S. G., Bhupalan, A., Zureikat, N., Thuluvath, P. J., Santis, G., Theodorou, N. & Westaby, D., Aug 1993, In : Thorax. 48, 8, p. 867-8 2 p.

    Research output: Contribution to journalArticle

  32. Incidence and expression of the N1303K mutation of the cystic fibrosis (CFTR) gene

    Osborne, L., Santis, G., Schwarz, M., Klinger, K., Dörk, T., McIntosh, I., Schwartz, M., Nunes, V., Macek, M. & Reiss, J., Aug 1992, In : Human Genetics. 89, 6, p. 653-8 6 p.

    Research output: Contribution to journalArticle

  33. High resolution computed tomography in adult cystic fibrosis patients with mild lung disease

    Santis, G., Hodson, M. E. & Strickland, B., Jul 1991, In : Clinical Radiology. 44, 1, p. 20-2 3 p.

    Research output: Contribution to journalArticle

  34. Independent genetic determinants of pancreatic and pulmonary status in cystic fibrosis

    Santis, G., Osborne, L., Knight, R. A. & Hodson, M. E., 3 Nov 1990, In : The Lancet. 336, 8723, p. 1081 1084 p.

    Research output: Contribution to journalArticle

  35. LINKED MARKER HAPLOTYPES AND THE DELTA-F508 MUTATION IN ADULTS WITH MILD PULMONARY-DISEASE AND CYSTIC-FIBROSIS

    Santis, G., Osborne, L., Knight, R. & Hodson, M., Jun 1990, In : The Lancet. 335, 8703, p. 1426-1429

    Research output: Contribution to journalArticle

  36. Severe extravasation injury: an avoidable iatrogenic disaster?

    Burd, D. A., Santis, G. & Milward, T. M., 25 May 1985, In : BMJ, British Medical Journal (Clinical Research Ed.). 290, 6481, p. 1579-80 2 p.

    Research output: Contribution to journalArticle

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