Research output per year
Research output per year
Personal profile
Research interests
Professor Santis research is addressing the biology of adenovirus/host cell interaction and particularly the role of the coxsackie B virus adenovirus receptor (CAR) in cell-cell junction formation and maintenance in the normal and inflamed airway epithelium. He is also investigating Erb receptor biology in non-small cell lung cancer and in the process he is developing small sample molecular assays for molecular stratification in lung cancer.
Research interests (short)
Gene transfer technology.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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CAR co-operates with integrins to promote lung cancer cell adhesion and invasion
Owczarek, C., Ortiz-Zapater, E., Santis, G., Papaevangelou, E., Kim, J. & Parsons, M., 14 Feb 2022, In: Frontiers in oncology. 12, 829313.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Characteristics and survival of advanced non-small cell lung cancer (NSCLC) in young Black patients: a Guy’s Cancer Centre real-world study.
Hughes, D., Kapiris, M., Podvez Nevajda, A., Stavraka, C., Cook, G., Josephs, D., Ghosh, S., Pintus, E., Gennatas, S., Ahmed, S., Santis, G., Ryanna, K., Montes, A., Smith, D., Karapanagiotou, E., Van Hemelrijck, M., Spicer, J. & Georgiou, A., Oct 2022.Research output: Contribution to conference types › Poster › peer-review
File17 Downloads (Pure) -
Epithelial Coxsackievirus Adenovirus Receptor promotes house dust mite-induced lung inflammation
Ortiz-Zapater, E., Llopis Hernandez, V., Bagley, D., Roberts, L., Maguire, T., Voss, F., Mertins, P., Kirchner, M., Peset-Martin, I., Woszczek, G., Rosenblatt, J., Gotthardt, M., Santis, G. & Parsons, M., 27 Oct 2022, In: Nature Communications. 13, 1, 6407.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Non-Small Cell Lung Cancer (NSCLC) in Young Adults, Age < 50, Is Associated with Late Stage at Presentation and a Very Poor Prognosis in Patients That Do Not Have a Targeted Therapy Option: A Real-World Study
Hughes, D., Kapiris, M., Podvez Nevajda, A., McGrath, H., Stavraka, C., Ahmad, S., Taylor, B. P., Cook, G., Ghosh, S., Josephs, D., Pintus, E., Gennatas, S., Bille, A., Ryanna, K., Santis, G., Montes, A., Van Hemelrijck, M., Eleni, K., Smith, D., Spicer, J., & 1 others, 9 Dec 2022, In: Cancers. 14, 24, 6056.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Temporospatial heterogeneity of acquired resistance mechanisms in EGFR-mutant lung adenocarcinoma: A case of concurrent EGFRT790M mutation and small cell transformation
Hughes, D., Cook, G., Mclean, E., Smith, D., King, J., Diamantopoulos, A., Jones, A., Neat, M., Santis, G., Spicer, J., Eleni, K. & Georgiou, A., 2021, In: Current Problems in Cancer: Case Reports. 4Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus)
Projects
- 32 Finished
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Defining the role of CAR in lung homeostasis and response to inflammation
1/03/2019 → 30/07/2023
Project: Research
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An automated macromolecular structure-based approach to personalised anti-cancer therapy
STFC Science and Technology Facilities Council
1/12/2018 → 30/11/2021
Project: Research
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Optical proteomics assay to assess EGFR, HER3 and MET interactions in lung cancer tissues
STFC Science and Technology Facilities Council
1/06/2016 → 31/05/2017
Project: Research
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Activities
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Journal of General Virology (Journal)
George Santis (Editor)
2001 → …Activity: Publication peer-review and editorial work › Publication peer-review
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SE Cancer Network (Lung Tumour Group)
George Santis (Chair)
2001 → …Activity: Other › Types of External academic engagement - Membership of external research organisation
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Board of Assessor Peer Review of Cancer Services
George Santis (Member)
2001 → …Activity: Other › Types of External academic engagement - Membership of external research organisation
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Reviewer for MRC
George Santis (Member)
2001 → …Activity: Other › Types of External academic engagement - Membership of external research organisation
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Reviewer for BBSRC
George Santis (Member)
2001 → …Activity: Other › Types of External academic engagement - Membership of external research organisation