Research output per year
Research output per year
- 1 - 50 out of 62 results
Search results
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2022
CAR co-operates with integrins to promote lung cancer cell adhesion and invasion
Owczarek, C., Ortiz-Zapater, E., Santis, G., Papaevangelou, E., Kim, J. & Parsons, M., 14 Feb 2022, In: Frontiers in oncology. 12, 829313.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
Characteristics and survival of advanced non-small cell lung cancer (NSCLC) in young Black patients: a Guy’s Cancer Centre real-world study.
Hughes, D., Kapiris, M., Podvez Nevajda, A., Stavraka, C., Cook, G., Josephs, D., Ghosh, S., Pintus, E., Gennatas, S., Ahmed, S., Santis, G., Ryanna, K., Montes, A., Smith, D., Karapanagiotou, E., Van Hemelrijck, M., Spicer, J. & Georgiou, A., Oct 2022.Research output: Contribution to conference types › Poster › peer-review
File81 Downloads (Pure) -
Epithelial Coxsackievirus Adenovirus Receptor promotes house dust mite-induced lung inflammation
Ortiz-Zapater, E., Llopis Hernandez, V., Bagley, D., Roberts, L., Maguire, T., Voss, F., Mertins, P., Kirchner, M., Peset-Martin, I., Woszczek, G., Rosenblatt, J., Gotthardt, M., Santis, G. & Parsons, M., 27 Oct 2022, In: Nature Communications. 13, 1, 6407.Research output: Contribution to journal › Article › peer-review
Open Access11 Citations (Scopus) -
Non-Small Cell Lung Cancer (NSCLC) in Young Adults, Age < 50, Is Associated with Late Stage at Presentation and a Very Poor Prognosis in Patients That Do Not Have a Targeted Therapy Option: A Real-World Study
Hughes, D., Kapiris, M., Podvez Nevajda, A., McGrath, H., Stavraka, C., Ahmad, S., Taylor, B. P., Cook, G., Ghosh, S., Josephs, D., Pintus, E., Gennatas, S., Bille, A., Ryanna, K., Santis, G., Montes, A., Van Hemelrijck, M., Eleni, K., Smith, D. & Spicer, J. & 1 others, , 9 Dec 2022, In: Cancers. 14, 24, 6056.Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus) -
2021
Temporospatial heterogeneity of acquired resistance mechanisms in EGFR-mutant lung adenocarcinoma: A case of concurrent EGFRT790M mutation and small cell transformation
Hughes, D., Cook, G., Mclean, E., Smith, D., King, J., Diamantopoulos, A., Jones, A., Neat, M., Santis, G., Spicer, J., Eleni, K. & Georgiou, A., 2021, In: Current Problems in Cancer: Case Reports. 4Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
2018
KIF22 coordinates CAR and EGFR dynamics to promote cancer cell proliferation
Pike, R., Ortiz-Zapater, E., Lumicisi, B., Santis, G. & Parsons, M., 30 Jan 2018, In: Science Signaling. 11, 515, eaaq1060.Research output: Contribution to journal › Article › peer-review
Open AccessFile33 Citations (Scopus)153 Downloads (Pure) -
The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers
Zanetti-Domingues, L. C., Korovesis, D., Needham, S. R., Tynan, C. J., Sagawa, S., Roberts, S. K., Kuzmanic, A., Ortiz-Zapater, E., Jain, P., Roovers, R. C., Lajevardipour, A., van Bergen en Henegouwen, P. M. P., Santis, G., Clayton, A. H. A., Clarke, D. T., Gervasio, F. L., Shan, Y., Shaw, D. E., Rolfe, D. J. & Parker, P. J. & 1 others, , 1 Dec 2018, In: Nature Communications. 9, 1, 4325.Research output: Contribution to journal › Article › peer-review
Open Access64 Citations (Scopus) -
2017
CAR: A key regulator of adhesion and inflammation
Ortiz-Zapater, E., Santis, G. & Parsons, M., 1 Aug 2017, In: The international journal of biochemistry & cell biology. 89, p. 1-5 5 p.Research output: Contribution to journal › Short survey › peer-review
Open AccessFile38 Citations (Scopus)249 Downloads (Pure) -
MET-EGFR dimerization in lung adenocarcinoma is dependent on EGFR mtations and altered by MET kinase inhibition
Ortiz-Zapater, E., Lee, R. W., Owen, W., Weitsman, G., Fruhwirth, G., Dunn, R. G., Neat, M. J., McCaughan, F., Parker, P., Ng, T. & Santis, G., 31 Jan 2017, In: PLoS ONE. 12, 1, p. e0170798Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Citations (Scopus)242 Downloads (Pure) -
2016
A 380-gene meta-signature of active tuberculosis compared with healthy controls
Blankley, S., Graham, C. M., Levin, J., Turner, J., Berry, M. P. R., Bloom, C. I., Xu, Z., Pascual, V., Banchereau, J., Chaussabel, D., Breen, R., Santis, G., Blankenship, D. M., Lipman, M. & O'Garra, A., 1 Jun 2016, In: European Respiratory Journal. 47, 6, p. 1873-1876 4 p.Research output: Contribution to journal › Letter › peer-review
39 Citations (Scopus) -
A rare intravascular tumour diagnosed by endobronchial ultrasound
Owen, W. T., Karampini, E., Breen, R. A., Moonim, M., Nair, A., Barrington, S. F. & Santis, G., Sept 2016, In: Thorax. 71, 9, p. 869-70 2 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Challenges in molecular testing in non-small-cell lung cancer patients with advanced disease
Hiley, C. T., Le Quesne, J., Santis, G., Sharpe, R., de Castro, D. G., Middleton, G. & Swanton, C., 3 Sept 2016, In: Lancet. 388, 10048, p. 1002-1011 10 p.Research output: Contribution to journal › Review article › peer-review
135 Citations (Scopus) -
The transcriptional signature of active tuberculosis reflects symptom status in extra-pulmonary and pulmonary tuberculosis
Blankley, S., Graham, C. M., Turner, J., Berry, M. P. R., Bloom, C. I., Xu, Z., Pascual, V., Banchereau, J., Chaussabel, D., Breen, R., Santis, G., Blankenship, D. M., Lipman, M. & O'Garra, A., 5 Oct 2016, In: PL o S One . 11, 10, 14 p., e0162220.Research output: Contribution to journal › Article › peer-review
Open AccessFile77 Citations (Scopus)234 Downloads (Pure) -
TNFα promotes CAR-dependent migration of leukocytes across epithelial monolayers
Morton, P. E., Hicks, A., Ortiz-Zapater, E., Raghavan, S., Pike, R., Noble, A., Woodfin, A., Jenkins, G., Rayner, E., Santis, G. & Parsons, M., 19 May 2016, In: Scientific Reports. 6, 26321.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)201 Downloads (Pure) -
2015
Simultaneous FRAP, FLIM and FAIM for measurements of protein mobility and interaction in living cells
Levitt, J. A., Morton, P. E., Fruhwirth, G. O., Santis, G., Chung, P.-H., Parsons, M. & Suhling, K., 8 Sept 2015, In: Biomedical Optics Express. 6, 10, p. 3842-3854 13 p., A025.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)245 Downloads (Pure) -
The LungPath study: variation in the diagnostic and staging pathway for patients with lung cancer in England
Cane, P., Linklater, K., Santis, G., Møller, H. & Peake, M., 15 Jul 2015, In: Thorax. 71, 3 p., 206779.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
2014
The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility
Kiuchi, T., Ortiz-Zapater, E., Monypenny, J., Matthews, D. R., Nguyen, L. K., Barbeau, J., Coban, O., Lawler, K., Burford, B., Rolfe, D. J., de Rinaldis, E., Dafou, D., Simpson, M. A., Woodman, N., Pinder, S., Gillett, C. E., Devauges, V., Poland, S. P., Fruhwirth, G. & Marra, P. & 12 others, , 19 Aug 2014, In: Science Signaling. 7, 339, 15 p., ra78.Research output: Contribution to journal › Article › peer-review
32 Citations (Scopus) -
2013
Acquired resistance to EGFR inhibition: evolution from adenocarcinoma to small cell lung cancer (SCLC)
Moss, C., Cane, R., Mclean, E., Santis, G., Tobal, K. & Spicer, J., Jan 2013, In: Lung Cancer. 79, Supplement 1, p. S5-S5 1 p., 13.Research output: Contribution to journal › Poster abstract › peer-review
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ALK rearrangements in EBUS-derived transbronchial needle aspiration cytology in lung cancer
Neat, M. J., Foot, N. J., Hicks, A., Breen, R., Wilkins, B., McLean, E. & Santis, G., Dec 2013, In: Cytopathology. 24, 6, p. 356-364 9 p.Research output: Contribution to journal › Article › peer-review
42 Citations (Scopus) -
CAR regulates epithelial cell junction stability through control of E-cadherin trafficking
Morton, P. E., Hicks, A., Nastos, T., Santis, G. & Parsons, M., 7 Oct 2013, In: Scientific Reports. 3, 13 p., 2889.Research output: Contribution to journal › Article › peer-review
Open Access33 Citations (Scopus) -
Diagnosis and Subtyping of De Novo and Relapsed Mediastinal Lymphomas by Endobronchial Ultrasound Needle Aspiration
Moonim, M., Breen, R., Fields, P. & Santis, G., 15 Nov 2013, In: American Journal of Respiratory and Critical Care Medicine. 188, 10, p. 1216-1223 8 p.Research output: Contribution to journal › Article › peer-review
88 Citations (Scopus) -
Gene expression profiling of endobronchial ultrasound (EBUS)-derived cytological fine needle aspirates from hilar and mediastinal lymph nodes in non-small cell lung cancer
Lee, R., Cousins, D. J., Ortiz-Zapater, E., Breen, R., Mclean, E. & Santis, G., Dec 2013, In: Cytopathology. 24, 6, p. 351-355 5 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
The role of Coxsackie and adenoviral receptor in TNF alpha driven inflammation in lung epithelial cells
Hicks, A. P., Morton, P., Parsons, M. & Santis, G., Sept 2013, In: Allergy. 68, s97, p. 224-225 2 p., 536.Research output: Contribution to journal › Poster abstract › peer-review
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2012
Diagnosis and subclassification of thymoma by minimally invasive fine needle aspiration directed by endobronchial ultrasound: a review and discussion of four cases
Moonim, M., Breen, R., Gill-Barman, B. & Santis, G., Aug 2012, In: Cytopathology. 23, 4, p. 220-228 9 p.Research output: Contribution to journal › Literature review › peer-review
16 Citations (Scopus) -
Routine EGFR and KRAS Mutation analysis using COLD-PCR in non-small cell lung cancer
Pennycuick, A., Simpson, T., Crawley, D., Lal, R., Santis, G., Cane, P. (Publisher), Tobal, K. & Spicer, J., Aug 2012, In: International Journal of Clinical Practice. 66, 8, p. 748-752 5 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
The changing numbers and indications of mediastinoscopy procedures performed following the introduction of endobronchical ultrasound at a UK tertiary centre (vol 66, pg A140, 2011)
Bakir, M., Breen, R., Quinn, A., King, J. & Santis, G., 2012, In: Thorax. 67, 2, p. 178 - 178 1 p.Research output: Contribution to journal › Article › peer-review
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2011
CAR Modulates E-Cadherin Dynamics in the Presence of Adenovirus Type 5
Hussain, F., Morton, P. E., Snippe, M., Sullivan, J., Farmer, C., Martin-Fernandez, M. L., Parsons, M. & Santis, G., 2011, In: PL o S One . 6, 8, e23056.Research output: Contribution to journal › Article › peer-review
16 Citations (Scopus) -
GENE EXPRESSION PROFILING OF ENDOBRONCHIAL ULTRASOUND-DERIVED CYTOLOGICAL ASPIRATES FROM HILAR AND MEDIASTINAL LYMPH NODES IN NSCLC
Lee, R. W., McClean, E., Quinn, A., Breen, R., Cousins, D. & Santis, G., 2011, In: Thorax. 66, p. A28 - A29Research output: Contribution to journal › Meeting abstract
47 Citations (Scopus) -
Prevalence of EGFR and K-RAS mutation status in clinical practice - relationship to patient characteristics
Simpson, T., Pennycuick, A., Crawley, D., Tobal, K. & Santis, G., 2011, In: Lung Cancer. 71, p. S16 - S16Research output: Contribution to journal › Meeting abstract
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Screening for EGFR and KRAS mutations in endobronchial ultrasound derived transbronchial needle aspirates in non-small cell lung cancer using COLD-PCR
Santis, G., Angell, R., Nickless, G., Quinn, A., Herbert, A., Cane, P., Spicer, J., Breen, R., McLean, E. & Tobal, K., 19 Sept 2011, In: PL o S One . 6, 9, 7 p., e25191.Research output: Contribution to journal › Article › peer-review
Open Access93 Citations (Scopus) -
Successful Radical Treatment of Midline Carcinoma With t(15;19) Diagnosed by Endobronchial Ultrasound-Derived Transbronchial Needle Aspiration
Santis, G., Landau, D., Harrison-Phipps, K., Neat, M. & Moonim, M., 20 Apr 2011, In: Journal of Clinical Oncology. 29, 12, p. e327 - e329 3 p.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
The challenges of integrating molecular imaging into the optimization of cancer therapy
Patel, G. S., Kiuchi, T., Lawler, K., Ofo, E., Fruhwirth, G. O., Kelleher, M., Shamil, E., Zhang, R., Selvin, P. R., Santis, G., Spicer, J., Woodman, N., Gillett, C. E., Barber, P. R., Vojnovic, B., Kéri, G., Schaeffter, T., Goh, V., O'Doherty, M. J. & Ellis, P. A. & 1 others, , Jun 2011, In: Integrative Biology. 3, 6, p. 603 - 631 29 p.Research output: Contribution to journal › Literature review › peer-review
13 Citations (Scopus) -
THE CHANGING NUMBERS AND INDICATIONS OF MEDIASTINOSCOPY PROCEDURES PERFORMED FOLLOWING THE INTRODUCTION OF ENDOBRONCHIAL ULTRASOUND AT A UK TERTIARY CENTRE
Bahir, M., Breen, R., Quinn, A., King, J. & Santis, G., 2011, In: Thorax. 66, p. A140 - A140Research output: Contribution to journal › Meeting abstract
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Utility of endobronchial ultrasound-guided transbronchial needle aspiration in patients with tuberculous intrathoracic lymphadenopathy: a multicentre study
Navani, N., Molyneaux, P. L., Breen, R. A., Connell, D. W., Jepson, A., Nankivell, M., Brown, J. M., Morris-Jones, S., Ng, B., Wickremasinghe, M., Lalvani, A., Rintoul, R. C., Santis, G., Kon, O. M. & Janes, S. M., Oct 2011, In: Thorax. 66, 10, p. 889-893 5 p.Research output: Contribution to journal › Article › peer-review
177 Citations (Scopus) -
2010
EBUS-TBNA: an opportunity for clinicians, cytopathologists and patients to gain from multidisciplinary collaboration
Herbert, A. & Santis, G., Feb 2010, In: Cytopathology. 21, 1, p. 3 - 5 3 p.Research output: Contribution to journal › Editorial › peer-review
7 Citations (Scopus) -
Unilateral Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia and Multiple Carcinoids Treated with Surgical Resection
Irshad, S., Mclean, E., Rankin, S., Barrington, S., Santis, G., Spicer, J. & Lang-Lazdunski, L., Jun 2010, In: Journal Of Thoracic Oncology. 5, 6, p. 921-923 3 p.Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus) -
2009
Can N2 disease be predicted by FDG uptake in the primary lung tumour or hilar lymphadenopathy: preliminary results
Szyszko, T. A., Viney, Z., O'Doherty, M. J., Nunan, T. O., Rankin, S., Santis, G., Breen, R., King, J., Lang-Lazdunski, L., Harrison-Phipps, K., Routledge, T., Cane, P., McLean, E. & Barrington, S. F., Sept 2009, In: European Journal of Nuclear Medicine and Molecular Imaging. 36, 2 Supplement, p. S332-S332 1 p., P114.Research output: Contribution to journal › Poster abstract › peer-review
4 Citations (Scopus) -
Coxsackie adenovirus receptor (CAR) regulates integrin function through activation of p44/42 MAPK
Farmer, C., Morton, P. E., Snippe, M., Santis, G. & Parsons, M., 10 Sept 2009, In: Experimental Cell Research. 315, 15, p. 2637 - 2647 11 p.Research output: Contribution to journal › Article › peer-review
38 Citations (Scopus) -
EGFR AND KRAS MUTATION ANALYSIS BY ENDOBRONCHIAL ULTRASOUND-GUIDED TRANSBRONCHIAL NEEDLE ASPIRATION IN NSCLC
Santis, G., Breen, R., Quinn, A., McLean, E. & Tobal, K., 2009, In: Thorax. 64, p. A59 - A60Research output: Contribution to journal › Meeting abstract
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2008
Phase II feasibility study of autologous vaccine (HSPPC-96) in patients with resectable lung cancer
Santis, G., Senzer, N. N., Champagne, P., Isakov, L. & Teofilovici, F., 20 May 2008, In: Journal of Clinical Oncology. 26, 15S, 1 p., 7584.Research output: Contribution to journal › Article › peer-review
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2007
Plasmacytoid dendritic cells from human lung cancer draining lymph nodes induce Tc1 responses
Faith, A., Peek, E., McDonald, J., Urry, Z., Richards, D. F., Tan, C., Santis, G. & Hawrylowicz, C., Mar 2007, In: American Journal of Respiratory Cell and Molecular Biology. 36, 3, p. 360 - 367 8 p.Research output: Contribution to journal › Article › peer-review
33 Citations (Scopus) -
2006
Analysis of the interaction between RGD-expressing adenovirus type 5 fiber knob mutant proteins and avb3 integrin reveals distinct binding profiles and intracellular trafficking
Lord, R., Parsons, M., Kirby, I., Beavil, A., Hunt, J., Sutton, B. & Santis, G., Sept 2006, In: Journal of General Virology. 87, 9, p. 2497 - 2505 9 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Citations (Scopus) -
2005
Human lung draining lymph node plasmacytoid dendritic cells respond to CD40L and CpG oligodinucleotides and induce Th1 responses
Faith, A., Peek, E., McDonald, J., Richards, D., Santis, G. & Hawrylowicz, C., Dec 2005, In: Immunology. 116, s1, p. 33-33 1 p., 10.4.Research output: Contribution to journal › Meeting abstract › peer-review
Open Access -
2004
Adenovirus type-5 entry and disassembly followed in living cells by FRET, fluorescence anisotropy, and FLIM
Martin-Fernandez, M., Longshaw, S. V., Kirby, I., Santis, G., Tobin, M. J., Clarke, D. T. & Jones, G. R., Aug 2004, In: Biophysical Journal. 87, 2, p. 1316 - 1327 12 p.Research output: Contribution to journal › Article › peer-review
45 Citations (Scopus) -
2001
Adenovirus type 5 uptake by lung adenocarcinoma cells in culture correlates with Ad5 fibre binding is mediated by alpha(v)beta1 integrin and can be modulated by changes in beta1 integrin function
Davison, E., Kirby, I., Whitehouse, J., Hart, I., Marshall, J. F. & Santis, G., Nov 2001, In: JOURNAL OF GENE MEDICINE. 3, 6, p. 550 - 559 10 p.Research output: Contribution to journal › Article › peer-review
46 Citations (Scopus) -
Adenovirus type 9 fiber knob binds to the coxsackie B virus-adenovirus receptor (CAR) with lower affinity than fiber knobs of other CAR-binding adenovirus serotypes
Kirby, I., Lord, R., Davison, E., Wickham, T. J., Roelvink, P. W., Kovesdi, I., Sutton, B. J. & Santis, G., 2001, In: Journal of Virology. 75, 15, p. 7210 - 7214 5 p.Research output: Contribution to journal › Article › peer-review
48 Citations (Scopus) -
2000
Identification of contact residues and definition of the CAR-binding site of adenovirus type 5 fiber protein
Kirby, I., Davison, E., Beavil, A. J., Soh, C. P. C., Wickham, T. J., Roelvink, P. W., Kovesdi, I., Sutton, B. J. & Santis, G., 2000, In: Journal of Virology. 74, 6, p. 2804 - 2813 10 p.Research output: Contribution to journal › Article › peer-review
151 Citations (Scopus) -
Transcriptional regulation of thyroid transcription factor-1 (TTF-1) (vol 93, pg A 14, 1999)
Whitehouse, J. L., Lee, Y. C., Bingle, C. D., Antoniou, M. & Santis, G., 2000, In: Respiratory Medicine. 94, 3, p. 295 - 295 1 p.Research output: Contribution to journal › Article › peer-review
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1999
Molecular biology for the critical care physician. Part II: where are we now?
Santis, G. & Evans, T. W., May 1999, In: Critical Care Medicine. 27, 5, p. 997-1003 7 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
Molecular determinants of adenovirus serotype 5 fibre binding to its cellular receptor CAR
Santis, G., Legrand, V., Hong, S. S., Davison, E., Kirby, I., Imler, J. L., Finberg, R. W., Bergelson, J. M., Mehtali, M. & Boulanger, P., Jun 1999, In: Journal of General Virology. 80 ( Pt 6), p. 1519-27 9 p.Research output: Contribution to journal › Article › peer-review
66 Citations (Scopus)