Research output per year
Research output per year
Personal profile
Research interests
My research programme focuses on understanding the role of tissue-specific stem cells in the homeostasis and regeneration of striated (skeletal and cardiac) muscle. I lead a team of researchers in studying the biology of cardiac and skeletal muscle, using the techniques of cellular and molecular biology/physiology. Projects within my laboratory investigate:
- Cell homeostasis and response following injury
- Regeneration and repair therapies using resident stem-progenitor cells
- The role of stem-progenitor cells in adaptive response to physiological exercise stimuli
- The identification of mechanisms that govern stem-progenitor cell fate.
- The effects of ageing and pathological status on stem-progenitor cell biology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Myocyte Death and Renewal in Skeletal and Cardiac Muscle, Liverpool John Moores University
Award Date: 1 Jan 2004
Bachelor of Science, Liverpool John Moores University
Award Date: 1 Jan 2000
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Collaborations and top research areas from the last five years
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Myonuclear alterations associated with exercise are independent of age in humans
Battey, E., Ross, J. A., Hoang, A., Wilson, D. G. S., Han, Y., Levy, Y., Pollock, R. D., Kalakoutis, M., Pugh, J. N., Close, G. L., Ellison-Hughes, G. M., Lazarus, N. R., Iskratsch, T., Harridge, S. D. R., Ochala, J. & Stroud, M. J., 30 Jan 2023, (E-pub ahead of print) In: Journal of Physiology.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
A protocol for extracting immunolabeled murine cardiomyocytes of high-quality RNA by laser capture microdissection
Shaalan, A. K. & Ellison-Hughes, G. M., 18 Mar 2022, In: STAR Protocols. 3, 1, 101231.Research output: Contribution to journal › Article › peer-review
Open Access -
Diabetes-Induced Cellular Senescence and Senescence-Associated Secretory Phenotype Impair Cardiac Regeneration and Function Independently of Age
Marino, F., Scalise, M., Salerno, N., Salerno, L., Molinaro, C., Cappetta, D., Torella, M., Greco, M., Foti, D., Sasso, F. C., Mastroroberto, P., De Angelis, A., Ellison-Hughes, G. M., Sampaolesi, M., Rota, M., Rossi, F., Urbanek, K., Nadal-Ginard, B., Torella, D. & Cianflone, E., 1 May 2022, In: Diabetes. 71, 5, p. 1081-1098 18 p.Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus) -
Human primary skeletal muscle-derived myoblasts and fibroblasts reveal different senescent phenotypes
Francis, T., Jaka, O., Ellison, G., Lazarus, N. R. & Harridge, S., 14 Jun 2022, In: Wiley.Research output: Contribution to journal › Article
Open Access -
Receptor tyrosine kinase inhibitors negatively impact on pro-reparative characteristics of human cardiac progenitor cells
Smith, A. J., Ruchaya, P., Walmsley, R., Wright, K. E., Lewis-McDougall, F. C., Bond, J. & Ellison-Hughes, G. M., Dec 2022, In: Scientific Reports. 12, 1, 10132.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus)
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RENOIR: REcreating the ideal Niche: environmental control Of cell Identity in Regenerating and diseased muscles
1/05/2020 → 30/04/2024
Project: Research
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Homing, tracking and immunogenicity of human cardiac stem/progenitor cells in the repair and regeneration of the myocardial-infarcted heart.
1/01/2018 → 31/01/2138
Project: Research
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Targeting cellular senescence as a therapy to rejuvenate the reparative activity of human cardiomyocytes and endothelial cells
1/04/2020 → 31/05/2023
Project: Research
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Cellular and sub-cellular sampling using laser capture microdissection to understand disease mechanisms
Gautel, M., Ellison, G., Ochala, J., Oakey, R., Zammit, P., Tucker, A., Meyer, M., Knight, R., Green, J. & Shanahan, C.
1/10/2018 → 30/09/2023
Project: Research