Research output per year
Research output per year
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Dive into the research topics where Gian De Nicola is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Research output
- 7 Article
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A New Crystal Form of the SARS-CoV-2 Receptor Binding Domain: CR3022 Complex—An Ideal Target for In-Crystal Fragment Screening of the ACE2 Binding Site Surface
Nichols, C., Ng, J., Keshu, A., Fraternali, F. & De Nicola, G. F., 14 Dec 2020, In: Frontiers in Pharmacology. 11, 615211.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)22 Downloads (Pure) -
Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1β-IL1R and p38α-TAB1 Complexes
Nichols, C., Ng, J., Keshu, A., Kelly, G., Conte, M. R., Marber, M. S., Fraternali, F. & De Nicola, G. F., 23 Jul 2020, In: Journal of Medicinal Chemistry. 63, 14, p. 7559-7568 10 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
TAB1-induced autoactivation of p38α mitogen-activated protein kinase is crucially dependent on threonine 185
Thapa, D., Nichols, C., Bassi, R., Martin, E. D., Verma, S., Conte, M. R., De Santis, V., De Nicola, G. F. & Marber, M. S., 1 Mar 2018, In: Molecular and Cellular Biology. 38, 5, e00449-17.Research output: Contribution to journal › Article › peer-review
Open Access18 Citations (Scopus) -
The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules
De Nicola, G. F., Bassi, R., Nichols, C., Fernandez-Caggiano, M., Golforoush, P. A., Thapa, D., Anderson, R., Martin, E. D., Verma, S., Kleinjung, J., Laing, A., Hutchinson, J. P., Eaton, P., Clark, J. & Marber, M. S., 23 Aug 2018, In: JCI Insight. 3, 16, p. 1-17Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)215 Downloads (Pure) -
Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1
De Nicola, G. F., Martin, E. D., Chaikuad, A., Bassi, R., Clark, J., Martino, L., Verma, S., Sicard, P., Tata, R., Atkinson, R. A., Knapp, S., Conte, M. R. & Marber, M. S., Oct 2013, In: NATURE STRUCTURAL AND MOLECULAR BIOLOGY. 20, 10, p. 1182-1190 9 p.Research output: Contribution to journal › Article › peer-review
84 Citations (Scopus)
Projects
- 7 Finished
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A cryo-electron microscope for structural biology (including single-particle and tomography) at KCL.
Conte, M., Atherton, J., Beavil, A., Bergeron, J., Booth, P., Burrone, J., Carlton, J., De Nicola, G., Ehler, E., Fleck, R., Fraternali, F., Garnett, J., Gautel, M., Isaacson, R., Kampourakis, T., Malim, M., McDonnell, J., Neil, S., Odendall, C., Pfuhl, M., Politis, A., Steiner, R. & Sutton, B.
BBSRC Biotechnology and Biological Sciences Research Council
1/08/2022 → 31/07/2023
Project: Research
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Can AI guided by in-crystal fragment screening crack the protein-protein interaction inhibitors problem?
Fraternali, F. & De Nicola, G.
1/02/2022 → 1/07/2023
Project: Research
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Isothermal titration calorimetry instrumentation for structural biology, biological mechanisms and drug discovery
Conte, M., Gautel, M., McDonnell, J., Isaacson, R., Barry, S., Garnett, J., Steiner, R., Muller, M., Pfuhl, M., Bergeron, J., Malim, M., Naglik, J., Kampourakis, T., Burgoyne, J., Pastore, A. & De Nicola, G.
BBSRC Biotechnology and Biological Sciences Research Council
1/10/2020 → 30/09/2021
Project: Research
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Using protein-protein inhibitors to target p38α during myocardial ischemia
19/05/2019 → 18/03/2020
Project: Research
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