Research output per year
Research output per year
Personal profile
Research interests
The use of mouse models to understand the molecular basis of Huntington's disease and to develop therapeutic approaches. Specific interests: molecular chaperones; heat shock factor 1; proteolysis of huntingtin; histone deacetylase inhibitors; HDAC4; stem cell models.
Research interests (short)
Huntington's disease: molecular pathogenesis; therapeutic target validation; preclinical compound evaluation
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Imperial College London
Award Date: 1 Jan 1987
Master in Science, Birkbeck, University of London
Award Date: 1 Jan 1984
Bachelor of Science, University of Sheffield
Award Date: 1 Jan 1979
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Dive into the research topics where Gillian Bates is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
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Genetic deletion of S6k1 does not rescue the phenotypic deficits observed in the R6/2 mouse model of Huntington’s disease
Irvine, E. E., Katsouri, L., Plattner, F., Al-Qassab, H., Al-Nackkash, R., Bates, G. P. & Withers, D. J., 1 Dec 2019, In: Scientific Reports. 9, 1, 16133.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Correlations of behavioral deficits with brain pathology assessed through longitudinal MRI and histopathology in the HdhQ150/Q150 mouse model of huntington's disease
Rattray, I., Smith, E. J., Crum, W. R., Walker, T. A., Gale, R., Bates, G. P. & Modo, M., 1 Jan 2017, In: PL o S One . 12, 1, e0168556.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)243 Downloads (Pure) -
Myostatin inhibition prevents skeletal muscle pathophysiology in Huntington's disease mice
Bondulich, M. K., Jolinon, N., Osborne, G. F., Smith, E. J., Rattray, I., Neueder, A., Sathasivam, K., Ahmed, M., Ali, N., Benjamin, A. C., Chang, X., DIck, J. R. T., Ellis, M., Franklin, S. A., Goodwin, D., Inuabasi, L., Lazell, H., Lehar, A., Richard-Londt, A. & Rosinski, J. & 9 others, , 1 Dec 2017, In: Scientific Reports. 7, 1, 14275.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Citations (Scopus)253 Downloads (Pure) -
Stall in Canonical Autophagy-Lysosome Pathways Prompts Nucleophagy-Based Nuclear Breakdown in Neurodegeneration
Baron, O., Boudi, A., Dias, C., Schilling, M., Noelle, A., Vizcay-Barrena, G., Rattray, I., Jungbluth, H., Wiep, S., Fleck, R. A., Bates, G. B. & Fanto, M., 4 Dec 2017, In: Current biology : CB. 27, 23, p. 3626-3642Research output: Contribution to journal › Article › peer-review
Open AccessFile62 Citations (Scopus)381 Downloads (Pure) -
Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific: Huntington Aggregation in Neurons and Glia
Jansen, A. H. P., Van Hal, M., Op Den Kelder, I. C., Meier, R. T., De Ruiter, A.-A., Schut, M. H., Smith, D. L., Grit, C., Brouwer, N., Kamphuis, W., Boddeke, H. W. G. M., Den Dunnen, W. F. A., Van Roon, W. M. C., Bates, G. P., Hol, E. M. & Reits, E. A., 12 Sept 2016, (E-pub ahead of print) In: Glia.Research output: Contribution to journal › Article › peer-review
Open AccessFile95 Citations (Scopus)207 Downloads (Pure)
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Development of Huntington's disease mouse embryonic stem cell lines
Bates, G. (Primary Investigator) & Minger, S. (Primary Investigator)
1/10/2009 → 31/05/2028
Project: Research
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Drug repositioning and therapeutic antibodies: Novel disease-modifying therapeutic strategies for Huntington’s disease (TREAT-HD)
Bates, G. (Primary Investigator)
1/01/2016 → 31/12/2019
Project: Research
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The roles of novel mammalian insulator factors in T-cell development
Seitan, V. (Primary Investigator), Bates, G. (Co-Investigator) & Hubbard, T. (Co-Investigator)
1/01/2015 → 31/01/2021
Project: Research
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Targeting the innate immune system in Huntington's disease
Bates, G. (Primary Investigator)
1/07/2014 → 31/08/2018
Project: Research
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Tryptophan metabolism as a regulator of protein toxicity in neurodegenerative diseases
Bates, G. (Primary Investigator)
1/01/2014 → 31/12/2016
Project: Research