Gillian Bates

2010

Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease

Sathasivam, K., Lane, A., Legleiter, J., Warley, A., Woodman, B., Finkbeiner, S., Paganetti, P., Muchowski, P. J., Wilson, S. & Bates, G. P., Jan 2010, In: Human Molecular Genetics. 19, 1, p. 65 - 78 14 p.

Research output: Contribution to journal › Article › peer-review

139 Citations (Scopus)

Proteolysis of Mutant Huntingtin Produces an Exon 1 Fragment That Accumulates as an Aggregated Protein in Neuronal Nuclei in Huntington Disease

Landles, C., Sathasivam, K., Weiss, A., Woodman, B., Moffitt, H., Finkbeiner, S., Sun, B., Gafni, J., Ellerby, L. M., Trottier, Y., Richards, W. G., Osmand, A., Paganetti, P. & Bates, G. P., 19 Mar 2010, In: Journal of Biological Chemistry. 285, 12, p. 8808 - 8823 16 p.

Research output: Contribution to journal › Article › peer-review

255 Citations (Scopus)

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

Luthi-Carter, R., Taylor, D. M., Pallos, J., Lambert, E., Amore, A., Parker, A., Moffitt, H., Smith, D. L., Runne, H., Gokce, O., Kuhn, A., Xiang, Z., Maxwell, M. M., Reeves, S. A., Bates, G. P., Neri, C., Thompson, L. M., Marsh, J. L. & Kazantsev, A. G., 27 Apr 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 17, p. 7927 - 7932 6 p.

Research output: Contribution to journal › Article › peer-review

285 Citations (Scopus)

Treatment Efficacy of Transplanted Human Striatal Neural Stem/Progenitor Cells in the R6/2 Mouse Model of Huntington's Disease

El-Akabawy, G., Rattray, I., Solanky, B., Gale, R., Bates, G. & Modo, M., 2010, In: Cell Transplantation. 19, 3, p. 338 - 338 1 p.

Research output: Contribution to journal › Meeting abstract

2009

A Large Number of Protein Expression Changes Occur Early in Life and Precede Phenotype Onset in a Mouse Model for Huntington Disease

Zabel, C., Mao, L., Woodman, B., Rohe, M., Wacker, M. A., Klaere, Y., Koppelstaetter, A., Nebrich, G., Klein, O., Grams, S., Strand, A., Luthi-Carter, R., Hartl, D., Klose, J. & Bates, G. P., Apr 2009, In: MOLECULAR AND CELLULAR PROTEOMICS. 8, 4, p. 720 - 734 15 p.

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Exendin-4 Improves Glycemic Control, Ameliorates Brain and Pancreatic Pathologies, and Extends Survival in a Mouse Model of Huntington's Disease

Martin, B., Golden, E., Carlson, O. D., Pistell, P., Zhou, J., Kim, W., Frank, B. P., Thomas, S., Chadwick, W. A., Greig, N. H., Bates, G. P., Sathasivam, K., Bernier, M., Maudsley, S., Mattson, M. P. & Egan, J. M., Feb 2009, In: Diabetes. 58, 2, p. 318 - 328 11 p.

Research output: Contribution to journal › Article › peer-review

153 Citations (Scopus)

Formation of Polyglutamine Inclusions in a Wide Range of Non-CNS Tissues in the HdhQ150 Knock-In Mouse Model of Huntington's Disease

Moffitt, H., McPhail, G. D., Woodman, B., Hobbs, C. & Bates, G. P., 2009, In: PL o S One . 4, 11, e8025.

Research output: Contribution to journal › Article › peer-review

126 Citations (Scopus)

Genetic knock-down of HDAC7 does not ameliorate disease pathogenesis in the R6/2 mouse model of Huntington's disease.

Benn, CL., Butler, R., Mariner, L., Nixon, J., Moffitt, H., Mielcarek, M., Woodman, B. & Bates, GP., 1 Jun 2009, In: PL o S One . 4, 6, e5747.

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

Thompson, L. M., Aiken, C. T., Kaltenbach, L. S., Agrawal, N., Illes, K., Khoshnan, A., Martinez-Vincente, M., Arrasate, M., O'Rourke, J. G., Khashwji, H., Lukacsovich, T., Zhu, Y-Z., Lau, A. L., Massey, A., Hayden, M. R., Zeitlin, S. O., Finkbeiner, S., Green, K. N., LaFerla, F. M., Bates, G., & 6 othersHuang, L., Patterson, P. H., Lo, D. C., Cuervo, A. M., Marsh, J. L. & Steffan, J. S., 28 Dec 2009, In: Journal of Cell Biology. 187, 7, p. 1083 - 1099 17 p.

Research output: Contribution to journal › Article › peer-review

314 Citations (Scopus)

Juvenile HD and mouse models of Huntington's disease

Bates, GP. & Woodman, B., 2009, Juvenile huntington's disease and other trinucleotide repeat disorders. Quarrell, OWJ., Brewer, HM., Squitieri F, Barker, RA., Manca, MA. & Mandwehrmeyer, GB. (eds.). Oxford: Oxford University Press, p. 101 - 115 15 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

The polyubiquitin Ubc gene modulates histone H2A monoubiquitylation in the R6/2 mouse model of Huntington's disease

Bett, J. S., Benn, C. L., Ryu, K-Y., Kopito, R. R. & Bates, G. P., Aug 2009, In: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 13, 8B, p. 2645 - 2657 13 p.

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

The Ubiquitin-Proteasome Reporter GFPu Does Not Accumulate in Neurons of the R6/2 Transgenic Mouse Model of Huntington's Disease

Bett, J. S., Cook, C., Petrucelli, L. & Bates, G. P., 8 Apr 2009, In: PL o S One . 4, 4, e5128.

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

2008

A large number of protein expression changes in a mouse model of Huntington's disease early in life precede overt disease symptoms

Zabel, C., Mao, L., Woodman, B., Rohe, M., Wacker, M. A., Klaere, Y., Koppelstaetter, A., Nebrich, G., Klein, O., Grams, S., Strand, A., Luthi-Carter, R., Hartl, D., Klose, J. & Bates, G. P., 2008, In: Journal of Neurology, Neurosurgery and Psychiatry. 79, p. A3 - A3

Research output: Contribution to journal › Meeting abstract

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

Bjorkqvist, M., Wild, E. J., Thiele, J., Silvestroni, A., Andre, R., Lahiri, N., Raibon, E., Lee, R. V., Benn, C. L., Soulet, D., Magnusson, A., Woodman, B., Landles, C., Pouladi, M. A., Hayden, M. R., Khalili-Shirazi, A., Lowdell, M. W., Brundin, P., Bates, G. P., Leavitt, B. R., & 2 othersMoller, T. & Tabrizi, S. J., 4 Aug 2008, In: Journal of Experimental Medicine. 205, 8, p. 1869 - 1877 9 p.

Research output: Contribution to journal › Article › peer-review

516 Citations (Scopus)

Development small molecule inhibitors of deacetylasee sirtuin 2 for treatment aggregate-associated neurodegenerative diseases

Kazantsev, A. G., Outeiro, T. F., Amore, A. M., Pallos, J., Kontopoulos, E., Atmann, S., Kufareva, I., Strathearn, K. E., Lambert, E., Volk, C. B., Parker, A., Maxwell, M. M., Young, A. B., Rochet, J. C., Lowden, P., McLean, P. J., Abagyan, R., Thompson, L. M., Feany, M. B., Neri, C., & 3 othersBates, G. P., Hyman, B. T. & Marsh, J. L., 2008, In: Journal of Neurochemistry. 104, p. 93 - 93 1 p., C14-01.

Research output: Contribution to journal › Meeting abstract

Distribution of polyglutamine inclusions in non-central nervous system tissue in the HdhQ150 knock-in mouse model of Huntington's disease

Moffitt, H., Hobbs, C., Woodman, B. & Bates, G., 2008, In: Journal of Neurology, Neurosurgery and Psychiatry. 79, p. A4 - A5

Research output: Contribution to journal › Meeting abstract

DNA instability in postmitotic neurons

Gonitel, R., Moffitt, H., Sathasivam, K., Woodman, B., Detloff, P. J., Faull, R. L. M. & Bates, G. P., 4 Mar 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 9, p. 3467 - 3472 6 p.

Research output: Contribution to journal › Article › peer-review

170 Citations (Scopus)

Genetic knock-down of HDAC 4 improves motor impairment in the R6/2 mouse model of Huntington's disease

Mielcarek, M., Benn, C., Butler, R., Robertson, J., Moffitt, H., Olson, E. N., Woodman, B. & Bates, G., 2008, In: Journal of Neurology, Neurosurgery and Psychiatry. 79, p. A8 - A8

Research output: Contribution to journal › Meeting abstract

Increased metabolism in the R6/2 mouse model of Huntington's disease

van der Burg, J. M. M., Bacos, K., Wood, N. I., Lindqvist, A., Wierup, N., Woodman, B., Wamsteeker, J. I., Smith, R., Deierborg, T., Kuhar, M. J., Bates, G. P., Mulder, H., Erlanson-Albertsson, C., Morton, A. J., Brundin, P., Petersen, A. & Bjorkqvist, M., Jan 2008, In: Neurobiology of Disease. 29, 1, p. 41 - 51 11 p.

Research output: Contribution to journal › Article › peer-review

113 Citations (Scopus)

Optimisation of region-specific reference gene selection and relative gene expression analysis methods for pre-clinical trials of Huntington's disease

Benn, C. L., Fox, H. & Bates, G. P., Dec 2008, In: Molecular Neurodegeneration. 3, 3, 17.

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Sensitive biochemical aggregate detection reveals aggregation onset before symptom development in cellular and murine models of Huntington's disease

Weiss, A., Klein, C., Woodman, B., Sathasivam, K., Bibel, M., Regulier, E., Bates, G. P. & Paganetti, P., Feb 2008, In: Journal of Neurochemistry. 104, 3, p. 846 - 858 13 p.

Research output: Contribution to journal › Article › peer-review

101 Citations (Scopus)

The use of quantitative real-time PCR to characterise transcriptional dysregulation in mouse models of Huntington's disease

Fox, H., Benn, C. & Bates, G., 2008, In: Journal of Neurology, Neurosurgery and Psychiatry. 79, p. A2 - A3

Research output: Contribution to journal › Meeting abstract

2007

Global changes to the ubiquitin system in Huntington's disease

Bennett, E. J., Shaler, T. A., Woodman, B., Ryu, K. Y., Zaitseva, T. S., Becker, C. H., Bates, G. P., Schulman, H. & Kopito, R. R., 9 Aug 2007, In: NATURE. 448, 7154, p. 704 - 708 5 p.

Research output: Contribution to journal › Article › peer-review

443 Citations (Scopus)

Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation

Zourlidou, A., Gidalevitz, T., Kristiansen, M., Landles, C., Woodman, B., Wells, D. J., Latchman, D. S., de Belleroche, J., Tabrizi, S. J., Morimoto, R. I. & Bates, G. P., May 2007, In: Human Molecular Genetics. 16, 9, p. 1078 - 1090 13 p.

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

Kuhn, A., Goldstein, D. R., Hodges, A., Strand, A. D., Sengstag, T., Kooperberg, C., Becanovic, K., Pouladi, M. A., Sathasivam, K., Cha, J. H. J., Hannan, A. J., Hayden, M. R., Leavitt, B. R., Dunnett, S. B., Ferrante, R. J., Albin, R., Shelbourne, P., Delorenzi, M., Augood, S. J., Faull, R. L. M., & 4 othersOlson, J. M., Bates, G. P., Jones, L. & Luthi-Carter, R., 1 Aug 2007, In: Human Molecular Genetics. 16, 15, p. 1845 - 1861 17 p.

Research output: Contribution to journal › Article › peer-review

279 Citations (Scopus)

Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates

Dalrymple, A., Wild, E. J., Joubert, R., Sathasivam, K., Bjorkqvist, M., Petersen, A., Jackson, G. S., Isaacs, J. D., Kristiansen, M., Bates, G. P., Leavitt, B. R., Keir, G., Ward, M. & Tabrizi, S. J., Jul 2007, In: JOURNAL OF PROTEOME RESEARCH. 6, 7, p. 2833 - 2840 8 p.

Research output: Contribution to journal › Article › peer-review

194 Citations (Scopus)

The Hdh(Q150/Q150) knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes

Woodman, B., Butler, R., Landles, C., Lupton, M. K., Tse, J., Hockly, E., Moffitt, H., Sathasivam, K. & Bates, G. P., 30 Apr 2007, In: Brain Research Bulletin. 72, 2-3, p. 83 - 97 15 p.

Research output: Contribution to journal › Article › peer-review

147 Citations (Scopus)

2006

Early and transient alteration of adenosine A2A receptor signaling in a mouse model of Huntington disease.

Tarditi, A., Camurri, A., Varani, K., Borea, P. A., Woodman, B., Bates, G., Cattaneo, E. & Abbracchio, M. P., Jul 2006, In: Neurobiology of Disease. 23, 1, p. 44 - 53 10 p.

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice

Guidetti, P., Bates, G. P., Graham, R. K., Hayden, M. R., Leavitt, B. R., MacDonald, M. E., Slow, E. J., Wheeler, V. C., Woodman, B. & Schwarcz, R., Jul 2006, In: Neurobiology of Disease. 23, 1, p. 190 - 197 8 p.

Research output: Contribution to journal › Article › peer-review

134 Citations (Scopus)

Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington's disease.

Hockly, E., Tse, J., Barker, A. L., Moolman, D. L., Beunard, J. L., Revington, A. P., Holt, K., Sunshine, S., Moffitt, H., Sathasivum, K., Woodman, B., Wanker, E. E., Lowden, P. A. & Bates, G. P., Jan 2006, In: Neurobiology of Disease. 21, 1, p. 228 - 236 9 p.

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Histone deacetylase inhibitors as therapeutics for polyglutamine disorders.

Butler, R. & Bates, GP., Oct 2006, In: NATURE REVIEWS NEUROSCIENCE. 7, 10, p. 784 - 796 13 p.

Research output: Contribution to journal › Article › peer-review

189 Citations (Scopus)

Huntington's disease: molecular pathogenesis and therapeutic approaches.

Bates, G., 2006, In: European Journal of Human Genetics. 14, p. 73 - 73 1 p., PL6.

Research output: Contribution to journal › Meeting abstract

Metabolic characterization of the R6/2 transgenic mouse model of Huntington's disease by high-resolution MAS H-1 NMR spectroscopy

Tsang, T. A., Woodman, B., McLoughlin, G. A., Griffin, J. L., Tabrizi, S. J., Bates, G. P. & Holmes, E., Mar 2006, In: JOURNAL OF PROTEOME RESEARCH. 5, 3, p. 483 - 492 10 p.

Research output: Contribution to journal › Article › peer-review

103 Citations (Scopus)

Mouse models of triplet repeat diseases

Bates, G. P. & Gonitel, R., Feb 2006, In: Molecular Biotechnology. 32, 2, p. 147 - 158 12 p.

Research output: Contribution to journal › Literature review › peer-review

21 Citations (Scopus)

One misfolded protein allows others to sneak by

Bates, G. P., May 2006, In: Science. 311, 5766, p. 1385 - 1386 2 p.

Research output: Contribution to journal › Editorial › peer-review

62 Citations (Scopus)

Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's disease

Bjorkqvist, M., Petersen, A., Bacos, K., Isaacs, J., Norlen, P., Gil, J., Popovic, N., Sundler, F., Bates, G. P., Tabrizi, S. J., Brundin, P. & Mulder, H., 2006, In: Human Molecular Genetics. 15, 10, p. 1713 - 1721 9 p.

Research output: Contribution to journal › Article › peer-review

126 Citations (Scopus)

Proteasome impairment does not contribute to pathogenesis in R6/2 Huntington's disease mice: exclusion of proteasome activator REG(gamma) as atherapeutic target.

Bett, J. S., Goellner, G. M., Woodman, B., Pratt, G., Rechsteiner, M. & Bates, G. P., 1 Jan 2006, In: Human Molecular Genetics. 15, 1, p. 33 - 44 12 p.

Research output: Contribution to journal › Article › peer-review

89 Citations (Scopus)

2005

A human single-chain Fv intrabody preferentially targets amino-terminal huntingtin fragments in striatal models of Huntington's disease

Miller, T. W., Zhou, C., Gines, S., MacDonald, M. E., Mazarakis, N. D., Bates, G. P., Huston, J. S. & Messer, A., Jun 2005, In: Neurobiology of Disease. 19, 1-2, p. 47 - 56 10 p.

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo

Zhang, X. Q., Smith, D. L., Meriin, A. B., Engemann, S., Russel, D. E., Roark, M., Washington, S. L., Maxwell, M. M., Marsh, J. L., Thompson, L. M., Wanker, E. E., Young, A. B., Housman, D. E., Bates, G. P., Sherman, M. Y. & Kazantsev, A. G., 18 Jan 2005, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 3, p. 892 - 897 6 p.

Research output: Contribution to journal › Article › peer-review

237 Citations (Scopus)

Contributions of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease.

Benn, C., Landles, C., Li, H., Strand, A. D., Woodman, B., Sathasivam, K., Li, S. H., Ghazi-Noori, S., Hockly, E., Faruque, S. M. N. N., Cha, J. H. J., Sharpe, P. T., Olson, J. M., Li, X. J. & Bates, G. P., Oct 2005, In: Human Molecular Genetics. 14, 20, p. 3065 - 3078 14 p.

Research output: Contribution to journal › Article › peer-review

103 Citations (Scopus)

Depletion of rabphilin 3A in a transgenic mouse model (R6/1) of Huntington's disease, a possible culprit in synaptic dysfunction.

Smith, R., Petersen, A., Bates, G. P., Brundin, P. & Li, J. Y., Dec 2005, In: Neurobiology of Disease. 20, 3, p. 673 - 684 12 p.

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Dynamics of somatic CAG instability in Huntington's disease.

Gonitel, R., Woodman, B., Sathasivam, K., Bates, G., Faull, R., Detloff, P. & Lucas, J., 2005, In: Journal of Neurology, Neurosurgery and Psychiatry. 76, p. U8 - U8

Research output: Contribution to journal › Meeting abstract

Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease.

Valenza, M., Rigamonti, D., Goffredo, D., Zuccato, C., Fenu, S., Jamot, L., Strand, A., Tarditi, A., Woodman, B., Racchi, M., Mariotti, C., Di Donato, S., Corsini, A., Bates, G., Pruss, R., Olson, J. M., Sipione, S., Tartari, M. & Cattaneo, E., 26 Oct 2005, In: Journal of Neuroscience. 25, 43, p. 9932 - 9939 8 p.

Research output: Contribution to journal › Article › peer-review

214 Citations (Scopus)

Experimental therapeutics in mouse models of Huntington's disease.

Hockly, E., Lupton, M. K., Sunshine, S., Tse, J., Woodman, B., Bates, G. P., Revington, A. P. & Lowden, P. A. S., 2005, In: Journal of Neurology, Neurosurgery and Psychiatry. 76, p. U11 - U11

Research output: Contribution to journal › Meeting abstract

Polyglutamine expansion of huntingtin impairs its nuclear export

Cornett, J., Cao, F. K., Wang, C. E., Ross, C. A., Bates, G. P., Li, S. H. & Li, X. J., Feb 2005, In: Nature Genetics. 37, 2, p. 198 - 204 7 p.

Research output: Contribution to journal › Article › peer-review

142 Citations (Scopus)

Reduction of GnRH and infertility in the R6/2 mouse model in Huntington's disease.

Papalexi, E., Persson, A., Bjorkqvisk, M., Petersen, A., Woodman, B., Bates, G. P., Sundler, F., Mulder, H., Brundin, P. & Popovic, N., Sept 2005, In: European Journal of Neuroscience. 22, 6, p. 1541 - 1546 6 p.

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

The molecular genetics of Huntington disease - a history.

Bates, G. P., Oct 2005, In: NATURE REVIEWS GENETICS. 6, 10, p. 766 - 773 8 p.

Research output: Contribution to journal › Literature review › peer-review

149 Citations (Scopus)

2004

Huntingtin and the molecular pathogenesis of Huntington's disease.

Landles, C. & Bates, G. P., Oct 2004, In: EMBO Reports. 5, 10, p. 958 - 963 6 p.

Research output: Contribution to journal › Literature review › peer-review

377 Citations (Scopus)

Monitoring aggregate formation in organotypic slice cultures from transgenic mice

Smith, D. L. & Bates, G. P., 2004, Trinucleotide repeat protocols.. Totowa, M. J. & Kohwi, Y. (eds.). Totowa: Humana Press Inc, p. 161 - 171 11 p. (Methods in Molecular Biology, 277).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Citations (Scopus)

Mouse models of triplet repeat diseases

Bates, G. P. & Hay, D. G., 2004, In: Methods in Molecular Biology. 277, p. 3 - 15 13 p.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Gillian Bates

Research output

Search results