Giovanna Lombardi

Lombardi, G. (Primary Investigator), Peng, Q. (Co-Investigator), Safinia, N. (Co-Investigator), Sanchez Fueyo, A. (Co-Investigator) & Sharpe, C. (Co-Investigator)

KIDNEY RESEARCH UK

7/05/2022 → 31/07/2024

Project: Research

Optimization of the potency, specificity and survival properties of engineered regulatory T cells to treat inflammatory liver diseases

Sanchez Fueyo, A. (Primary Investigator), Fruhwirth, G. (Co-Investigator), Lombardi, G. (Co-Investigator) & Safinia, N. (Co-Investigator)

Rosetrees Trust

1/12/2021 → 30/11/2024

Project: Research

Generation of Liver-Immune Double Chimeric Humanised Mouse Models: A Platform for Simultaneous Assessment of Function and Immunogenicity of Liver-Specific Cellular Therapies

Lombardi, G. (Primary Investigator)

MRC Medical Research Council

1/10/2021 → 20/02/2023

Project: Research

CAR-Treg therapy in metabolic and inflammatory disorders: Targeting the Nrf2/HO-1 pathway

Safinia, N. (Primary Investigator) & Lombardi, G. (Co-Investigator)

MRC Medical Research Council

1/11/2020 → 12/07/2022

Project: Research

Regulatory T cells in Highly Sensitised Renal Patients to Improve Outcomes after HLA-Ab Incompatible Transplantation

Dorling, A. (Primary Investigator), Bunce, C. (Co-Investigator), Lombardi, G. (Co-Investigator), Sanchez Fueyo, A. (Co-Investigator) & Robinson, E. (Co-Investigator)

MRC Medical Research Council

30/09/2020 → 29/05/2024

Project: Research

Exploring the Links Between Regulatory T cell Populations and Development of HLA Antibodies in Renal Patients Awaiting Transplantation.

Dorling, A. (Primary Investigator), Basu, S. (Co-Investigator) & Lombardi, G. (Co-Investigator)

MRC Medical Research Council

1/03/2020 → 28/02/2023

Project: Research

INsTRuCT: INnovative Training in myeloid Regulatory Cell Therapy

Martinez-Llordella, M. (Primary Investigator) & Lombardi, G. (Co-Investigator)

EC European Commission

1/01/2020 → 31/12/2023

Project: Research

Production of expanded autologous regulatory T cells to treat patients with refractory aplastic anaemia in a phase I dose study

Mufti, G. (Primary Investigator), Lombardi, G. (Primary Investigator), Flach, C. (Primary Investigator) & Farzaneh, F. (Primary Investigator)

Aplastic Anaemia Trust

18/11/2019 → 31/01/2023

Project: Research

Immunogenicity test platform - in vitro and in vivo

Lombardi, G. (Primary Investigator)

MRC Medical Research Council

1/01/2019 → 31/12/2021

Project: Research

Regulatory T cells in Highly Sensitised Renal Patients to Improve Outcomes after HLA-Antibody Incompatible Transplantation

Dorling, A. (Primary Investigator), Lombardi, G. (Co-Investigator) & Dudreuilh, C. (Co-Investigator)

MRC Medical Research Council

1/10/2018 → 30/11/2022

Project: Research

Targeting Nox2 to improve regulatory T cell function and immune tolerance in heart transplantation

Shah, A. (Primary Investigator), Cellone Trevelin, S. (Co-Investigator), Lombardi, G. (Co-Investigator), Ivetic, A. (Co-Investigator) & Lechler, R. (Co-Investigator)

BHF British Heart Foundation

10/08/2018 → 9/08/2021

Project: Research

Creating new opportunities for highly sensitised patients waiting for a kidney transplant

Lombardi, G. (Primary Investigator) & Dorling, A. (Co-Investigator)

Rosetrees Trust

1/03/2018 → 31/05/2021

Project: Research

Targeting recipient antigen-presenting cells with sialic acid-modified alloantigen to promote transplantation tolerance

Lombardi, G. (Primary Investigator), Lechler, R. (Co-Investigator) & Smyth, L. A. (Co-Investigator)

BHF British Heart Foundation

1/10/2017 → 30/09/2020

Project: Research

Investigation of a novel cell therapy with regulatory T cells in the treatment of SLE

Scotta, C. (Primary Investigator), Lombardi, G. (Co-Investigator) & Robson, M. (Co-Investigator)

Lupus UK

1/10/2017 → 30/09/2018

Project: Research

NIHR Biomedical Research Centre. Funding for Financial Years 2017/18, 2018/19

Wolfe, C. (Primary Investigator), Parsons, M. (Primary Investigator), Gould, H. (Primary Investigator), Corrigan, C. (Primary Investigator), Greenough, A. (Primary Investigator), Peakman, M. (Primary Investigator), Vyse, T. (Primary Investigator), Antoniou, M. (Primary Investigator), Oakey, R. (Primary Investigator), McGrath, J. (Primary Investigator), Karagiannis, S. (Primary Investigator), Barker, J. (Primary Investigator), Flohr, C. (Primary Investigator), Tziotzios, C. (Primary Investigator), Whittaker, S. (Primary Investigator), Spector, T. (Primary Investigator), Watt, F. (Primary Investigator), Hayday, A. (Primary Investigator), Spencer, J. (Primary Investigator), Cope, A. (Primary Investigator), Malim, M. (Primary Investigator), Martin Serrano, J. (Primary Investigator), Edgeworth, J. (Primary Investigator), Cason, J. (Primary Investigator), Lord, G. (Primary Investigator), Dorling, A. (Primary Investigator), Sacks, S. (Primary Investigator), Sanchez Fueyo, A. (Primary Investigator), Lombardi, G. (Primary Investigator), Ostermann, M. (Primary Investigator), Shah, A. (Primary Investigator), Marber, M. (Primary Investigator), Mayr, M. (Primary Investigator), Chowienczyk, P. (Primary Investigator), Wells, C. (Primary Investigator), Grigoriadis, A. (Primary Investigator), Sawyer, E. (Primary Investigator), Maher, J. (Primary Investigator), Tribe, R. (Primary Investigator), Ilic, D. (Primary Investigator), Poston, L. (Primary Investigator), Rutherford, M. (Primary Investigator), Gee, T. (Primary Investigator), Blower, P. (Primary Investigator), Edwards, D. (Primary Investigator), Sharpe, P. (Primary Investigator), Streit, A. (Primary Investigator), Naglik, J. (Primary Investigator), Tavassoli, M. (Primary Investigator) & McNaughton, P. (Primary Investigator)

NIHR National Institute For Health & Care Research

1/04/2017 → 31/03/2022

Project: Research

Use of Low-Dose IL-2 to expand endogenous regulatory T Cells and achieve transplantation tolerance

Sanchez Fueyo, A. (Primary Investigator), Douiri, A. (Co-Investigator), Lombardi, G. (Co-Investigator), Martinez-Llordella, M. (Co-Investigator) & Tree, T. (Co-Investigator)

MRC Medical Research Council

15/02/2017 → 14/01/2021

Project: Research

The TWO Study: A Phase II trial of regulatory T cells in renal transplantation - can we achieve sirolimus monotherapy?

Lombardi, G. (Primary Investigator)

MRC Medical Research Council

1/02/2017 → 31/01/2022

Project: Research

Defining the mechanisms underlying the role of regulatory T cells in the establishment of tolerance

Lombardi, G. (Primary Investigator), Sanchez Fueyo, A. (Primary Investigator), Douiri, A. (Co-Investigator), Lechler, R. (Co-Investigator) & Martinez-Llordella, M. (Co-Investigator)

9/01/2017 → 8/01/2022

Project: Research

Thymus derived Tregs expanded in vitro as a treatment for paediatric heart transplant patients to prevent cardiac allograft vasculopathy.

Lombardi, G. (Primary Investigator), Botnar, R. (Co-Investigator), Lechler, R. (Co-Investigator) & Scotta, C. (Co-Investigator)

BHF British Heart Foundation

1/01/2017 → 31/12/2018

Project: Research

In vivo analysis of Rho GTPase signalling in T-cell transendothelial migration

Ridley, A. (Primary Investigator) & Lombardi, G. (Co-Investigator)

KHP King's Health Partners

14/10/2016 → 13/10/2017

Project: Research

mTOR and the dark side of regulatory T cells: In search of a common mechanism underlying regulatory T cell dysfunction in immune-mediated inflammatory disease

Lombardi, G. (Primary Investigator)

1/10/2016 → 30/09/2018

Project: Research

Investigation of a novel cell therapy with regulatory t cells in the treatment of Systemic Lupus Erythematosus

Scotta, C. (Primary Investigator), Lombardi, G. (Co-Investigator), Robson, M. (Co-Investigator) & Spencer, J. (Co-Investigator)

1/10/2016 → 30/09/2019

Project: Research

Integrating imaging into immunotherapy - developing PET traceable CAR T-cells

Fruhwirth, G. (Primary Investigator), Lombardi, G. (Co-Investigator) & Maher, J. (Co-Investigator)

Worldwide Cancer Research

1/07/2016 → 14/09/2018

Project: Research

Defining the mechanisms underlying the role of regulatory t cells in the establishment of tolerance

Lombardi, G. (Primary Investigator), Lechler, R. (Co-Investigator), Martinez-Llordella, M. (Co-Investigator), Rebollo-Mesa, I. (Co-Investigator) & Sanchez Fueyo, A. (Co-Investigator)

1/06/2016 → 31/05/2021

Project: Research

Targeted Regulatory T Cell Therapy for Inflammatory Bowel Disease

Lord, G. (Primary Investigator), Lombardi, G. (Co-Investigator), Powell, N. (Co-Investigator) & Prevost, T. (Co-Investigator)

1/05/2016 → 1/08/2019

Project: Research

Multilayered nanocoatings for depot delivery of therapeutic agents to islet grafts: strategies for improving outcome of islet transplantation

Zhi, L. (Primary Investigator), Jones, P. (Co-Investigator) & Lombardi, G. (Co-Investigator)

1/02/2016 → 31/01/2019

Project: Research

Manipulating the molecular responses of fibrocytes to prevent intimal hyperplasia.

Dorling, A. (Primary Investigator), Chen, D. (Co-Investigator) & Lombardi, G. (Co-Investigator)

1/01/2016 → 31/12/2018

Project: Research

Preclinical assessment of targeting DCs directly in vivo to prevent human islet transplant rejection as a cure for Type 1 diabetes

Lombardi, G. (Primary Investigator), Huang, G. (Co-Investigator), Jones, P. (Co-Investigator), Lechler, R. (Co-Investigator) & Xiao, F. (Co-Investigator)

1/01/2016 → 31/12/2018

Project: Research

MICA: Targeted Regulatory T Cell Therapy for Inflammatory Bowel Disease

Lord, G. (Primary Investigator), Lombardi, G. (Co-Investigator), Powell, N. (Co-Investigator) & Prevost, T. (Co-Investigator)

MRC Medical Research Council

1/01/2016 → 31/03/2024

Project: Research

Preclinical assessment of targeting DCs directly in vivo to prevent human islet transplant rejection as a cure for Type 1 diabetes

Lombardi, G. (Primary Investigator), Huang, G. (Co-Investigator), Jones, P. (Co-Investigator), Lechler, R. (Co-Investigator) & Xiao, F. (Co-Investigator)

1/01/2016 → 31/12/2018

Project: Research

Preclinical assessment of targeting DCs directly in vivo to prevent human islettransplant rejection as a cure for Type 1 diabetes

Lombardi, G. (Primary Investigator), Huang, G. (Co-Investigator), Jones, P. (Co-Investigator), Lechler, R. (Co-Investigator) & Xiao, F. (Co-Investigator)

1/01/2016 → 31/12/2018

Project: Research

NIHR Blood and Transplant Unit (Organ Donation and Transplantation)

Dorling, A. (Primary Investigator), Dazzi, F. (Co-Investigator), Hernandez Fuentes, M. (Co-Investigator), Lombardi, G. (Co-Investigator), Sacks, S. (Co-Investigator) & Smith, R. (Co-Investigator)

1/10/2015 → 30/09/2020

Project: Research

Investigation of a novel cell therapy with regulatory T cells in systemic Lupus erythematosus

Lombardi, G. (Primary Investigator)

1/10/2015 → 30/09/2017

Project: Research

Intestinal Graft Versus Host Disease, a new diagnostic and therapeutic paradigm

Powell, N. (Primary Investigator) & Lombardi, G. (Co-Investigator)

1/09/2015 → 31/08/2018

Project: Research

Integrating imaging into Immunotherapy - Developing in vivo traceable CAR T-cells

Fruhwirth, G. (Primary Investigator), Lombardi, G. (Co-Investigator) & Maher, J. (Co-Investigator)

1/08/2015 → 31/01/2017

Project: Research

Identifying new targets for treating gut damage in graft versus host disease

Powell, N. (Primary Investigator) & Lombardi, G. (Co-Investigator)

Rosetrees Trust

1/05/2015 → 30/04/2018

Project: Research

Regulatory T cell derived Exosomes: possible therapeutic and diagnostic tools in transplantation

Lombardi, G. (Primary Investigator) & Smyth, L. (Primary Investigator)

1/04/2015 → 31/03/2016

Project: Research

Integrating imaging into Immunotherapy - Developing in vivo traceable CAR T-cells

Fruhwirth, G. (Primary Investigator), Lombardi, G. (Co-Investigator) & Maher, J. (Co-Investigator)

KHP King's Health Partners

1/04/2015 → 7/07/2016

Project: Research

EMI-TB - Eliciting Mucosal Immunity to Tuberculosis

Ivanyi, J. (Primary Investigator), Lombardi, G. (Co-Investigator) & Naglik, J. (Co-Investigator)

EC European Commission

1/01/2015 → 31/12/2018

Project: Research

Regulatory T-cell therapy for Orthotopic Heart Transplantation in Children

Botnar, R. (Primary Investigator), Hussain, M. (Primary Investigator), Greil, G. (Co-Investigator) & Lombardi, G. (Co-Investigator)

MRC Medical Research Council

1/01/2015 → 2/08/2016

Project: Research

Manipulating protease activated receptor (PAR) signalling on mononuclear cells to prevent intimal hyperplasia / chronic fibrosis AND promote regenerative repair

Dorling, A. (Primary Investigator), Chen, D. (Co-Investigator), Lombardi, G. (Co-Investigator), Smith, R. (Co-Investigator) & Zhou, W. (Co-Investigator)

1/10/2014 → 30/09/2019

Project: Research

In vitro manipulation of defective TREGS as therapy for systemic lupus erythematosus

Lombardi, G. (Primary Investigator) & Scotta, C. (Co-Investigator)

Guy's & St Thomas' Charity

1/09/2014 → 30/09/2015

Project: Research

Overcoming immunological barriers to regenerative medicine

Watt, F. (Primary Investigator), Dazzi, F. (Co-Investigator), Geissmann, F. (Co-Investigator), Lombardi, G. (Co-Investigator) & Sacks, S. (Co-Investigator)

MRC Medical Research Council

1/04/2014 → 31/03/2018

Project: Research