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  Generation of Liver-Immune Double Chimeric Humanised Mouse Models: A Platform for Simultaneous Assessment of Function and Immunogenicity of Liver-Specific Cellular Therapies

  Lombardi, G.

  MRC Medical Research Council

  1/10/2021 → 20/02/2023

  Project: Research

• CAR-Treg therapy in metabolic and inflammatory disorders: Targeting the Nrf2/HO-1 pathway

  Safinia, N. & Lombardi, G.

  KHP R&D challenge fund

  1/11/2020 → 12/07/2022

  Project: Research

• Exploring the Links Between Regulatory T cell Populations and Development of HLA Antibodies in Renal Patients Awaiting Transplantation.

  Dorling, A., Basu, S. & Lombardi, G.

  MRC Medical Research Council

  1/03/2020 → 28/02/2023

  Project: Research

• Production of expanded autologous regulatory T cells to treat patients with refractory aplastic anaemia in a phase I dose study

  Mufti, G., Lombardi, G., Flach, C. & Farzaneh, F.

  Aplastic Anaemia Trust

  18/11/2019 → 31/01/2023

  Project: Research

• Immunogenicity test platform - in vitro and in vivo

  Lombardi, G.

  MRC Medical Research Council

  1/01/2019 → 31/12/2021

  Project: Research

• Regulatory T cells in Highly Sensitised Renal Patients to Improve Outcomes after HLA-Antibody Incompatible Transplantation

  Dorling, A., Lombardi, G. & Dudreuilh, C.

  MRC Medical Research Council

  1/10/2018 → 30/11/2022

  Project: Research

• Targeting Nox2 to improve regulatory T cell function and immune tolerance in heart transplantation

  Shah, A., Cellone Trevelin, S., Lombardi, G., Ivetic, A. & Lechler, R.

  BHF British Heart Foundation

  10/08/2018 → 9/08/2021

  Project: Research

• Creating new opportunities for highly sensitised patients waiting for a kidney transplant

  Lombardi, G. & Dorling, A.

  Rosetrees Trust

  1/03/2018 → 31/05/2021

  Project: Research

  • Patient 100%
  • Kidney Graft 100%

• Defining the mechanisms underlying the role of regulatory T cells in the establishment of tolerance

  Lombardi, G., Douiri, A., Sanchez Fueyo, A. & de Rinaldis, E.

  8/01/2018 → 7/05/2021

  Project: Research

• Targeting Nox2 to improve regulatory T cell function and immune tolerance in heart transplantation

  Shah, A., Ivetic, A., Lechler, R. & Lombardi, G.

  1/01/2018 → 31/12/2021

  Project: Research

• Targeting recipient antigen-presenting cells with sialic acid-modified alloantigen to promote transplantation tolerance

  Lombardi, G., Lechler, R. & Smyth, L.

  BHF British Heart Foundation

  1/10/2017 → 30/09/2020

  Project: Research

• Investigation of a novel cell therapy with regulatory T cells in the treatment of SLE

  Scotta, C., Lombardi, G. & Robson, M.

  Lupus UK

  1/10/2017 → 30/09/2018

  Project: Research

• NIHR Biomedical Research Centre. Funding for Financial Years 2017/18, 2018/19

  Wolfe, C., Parsons, M., Gould, H., Corrigan, C., Greenough, A., Peakman, M., Vyse, T., Antoniou, M., Oakey, R., McGrath, J., Karagiannis, S., Barker, J., Flohr, C., Tziotzios, C., Whittaker, S., Spector, T., Watt, F., Hayday, A., Spencer, J., Cope, A., Malim, M., Martin Serrano, J., Edgeworth, J., Cason, J., Lord, G., Dorling, A., Sacks, S., Sanchez Fueyo, A., Lombardi, G., Ostermann, M., Shah, A., Marber, M., Mayr, M., Chowienczyk, P., Wells, C., Grigoriadis, A., Sawyer, E., Maher, J., Tribe, R., Ilic, D., Poston, L., Rutherford, M., Gee, T., Blower, P., Edwards, D., Sharpe, P., Streit, A., Naglik, J., Tavassoli, M. & McNaughton, P.

  NIHR National Institute For Health & Care Research

  1/04/2017 → 31/03/2022

  Project: Research

  • Research Centre 100%
  • Medical Research 100%

• Use of Low-Dose IL-2 to expand endogenous regulatory T Cells and achieve transplantation tolerance

  Sanchez Fueyo, A., Douiri, A., Lombardi, G., Martinez-Llordella, M. & Tree, T.

  MRC Medical Research Council

  15/02/2017 → 14/01/2021

  Project: Research

• The TWO Study: A Phase II trial of regulatory T cells in renal transplantation - can we achieve sirolimus monotherapy?

  Lombardi, G.

  MRC Medical Research Council

  1/02/2017 → 31/01/2022

  Project: Research

• Defining the mechanisms underlying the role of regulatory T cells in the establishment of tolerance

  Lombardi, G., Sanchez Fueyo, A., Douiri, A., Lechler, R. & Martinez-Llordella, M.

  9/01/2017 → 8/01/2022

  Project: Research

• Thymus derived Tregs expanded in vitro as a treatment for paediatric heart transplant patients to prevent cardiac allograft vasculopathy.

  Lombardi, G., Botnar, R., Lechler, R. & Scotta, C.

  BHF British Heart Foundation

  1/01/2017 → 31/12/2018

  Project: Research

• In vivo analysis of Rho GTPase signalling in T-cell transendothelial migration

  Ridley, A. & Lombardi, G.

  KHP King's Health Partners

  14/10/2016 → 13/10/2017

  Project: Research

• mTOR and the dark side of regulatory T cells: In search of a common mechanism underlying regulatory T cell dysfunction in immune-mediated inflammatory disease

  Lombardi, G.

  1/10/2016 → 30/09/2018

  Project: Research

• Investigation of a novel cell therapy with regulatory t cells in the treatment of Systemic Lupus Erythematosus

  Scotta, C., Lombardi, G., Robson, M. & Spencer, J.

  1/10/2016 → 30/09/2019

  Project: Research

• Integrating imaging into immunotherapy - developing PET traceable CAR T-cells

  Fruhwirth, G., Lombardi, G. & Maher, J.

  Worldwide Cancer Research

  1/07/2016 → 14/09/2018

  Project: Research

• Defining the mechanisms underlying the role of regulatory t cells in the establishment of tolerance

  Lombardi, G., Lechler, R., Martinez-Llordella, M., Rebollo-Mesa, I. & Sanchez Fueyo, A.

  1/06/2016 → 31/05/2021

  Project: Research

• Targeted Regulatory T Cell Therapy for Inflammatory Bowel Disease

  Lord, G., Lombardi, G., Powell, N. & Prevost, T.

  1/05/2016 → 1/08/2019

  Project: Research

• TBC

  Sanchez Fueyo, A., Lombardi, G., Martinez-Llordella, M., Rebollo-Mesa, I. & Tree, T.

  25/03/2016 → 25/03/2019

  Project: Research

• Multilayered nanocoatings for depot delivery of therapeutic agents to islet grafts: strategies for improving outcome of islet transplantation

  Zhi, L., Jones, P. & Lombardi, G.

  1/02/2016 → 31/01/2019

  Project: Research

• Preclinical assessment of targeting DCs directly in vivo to prevent human islet transplant rejection as a cure for Type 1 diabetes

  Lombardi, G., Huang, G., Jones, P., Lechler, R. & Xiao, F.

  1/01/2016 → 31/12/2018

  Project: Research

• Preclinical assessment of targeting DCs directly in vivo to prevent human islet transplant rejection as a cure for Type 1 diabetes

  Lombardi, G., Huang, G., Jones, P., Lechler, R. & Xiao, F.

  1/01/2016 → 31/12/2018

  Project: Research

• Manipulating the molecular responses of fibrocytes to prevent intimal hyperplasia.

  Dorling, A., Chen, D. & Lombardi, G.

  1/01/2016 → 31/12/2018

  Project: Research

• Preclinical assessment of targeting DCs directly in vivo to prevent human islettransplant rejection as a cure for Type 1 diabetes

  Lombardi, G., Huang, G., Jones, P., Lechler, R. & Xiao, F.

  1/01/2016 → 31/12/2018

  Project: Research

• Investigation of a novel cell therapy with regulatory T cells in systemic Lupus erythematosus

  Lombardi, G.

  1/10/2015 → 30/09/2017

  Project: Research

• NIHR Blood and Transplant Unit (Organ Donation and Transplantation)

  Dorling, A., Dazzi, F., Hernandez Fuentes, M., Lombardi, G., Sacks, S. & Smith, R.

  1/10/2015 → 30/09/2020

  Project: Research

• Intestinal Graft Versus Host Disease, a new diagnostic and therapeutic paradigm

  Powell, N. & Lombardi, G.

  1/09/2015 → 31/08/2018

  Project: Research

• Integrating imaging into Immunotherapy - Developing in vivo traceable CAR T-cells

  Fruhwirth, G., Lombardi, G. & Maher, J.

  1/08/2015 → 31/01/2017

  Project: Research

• 3D optical tomography for multiplexed multi-modal in vivo imaging for translational research.

  Blower, P., Avkiran, M., Botnar, R., Fruhwirth, G., Lombardi, G., Maher, J., Mullen, G., Ng, T., Thanou, M. & Watt, F.

  1/08/2015 → 31/07/2020

  Project: Research

• Identifying new targets for treating gut damage in graft versus host disease

  Powell, N. & Lombardi, G.

  Rosetrees Trust

  1/05/2015 → 30/04/2018

  Project: Research

• Integrating imaging into Immunotherapy - Developing in vivo traceable CAR T-cells

  Fruhwirth, G., Lombardi, G. & Maher, J.

  KHP King's Health Partners

  1/04/2015 → 7/07/2016

  Project: Research

• Regulatory T cell derived Exosomes: possible therapeutic and diagnostic tools in transplantation

  Lombardi, G. & Smyth, L.

  1/04/2015 → 31/03/2016

  Project: Research

• EMI-TB - Eliciting Mucosal Immunity to Tuberculosis

  Ivanyi, J., Lombardi, G. & Naglik, J.

  EC European Commission

  1/01/2015 → 31/12/2018

  Project: Research

• Regulatory T-cell therapy for Orthotopic Heart Transplantation in Children

  Botnar, R., Hussain, M., Greil, G. & Lombardi, G.

  MRC Medical Research Council

  1/01/2015 → 2/08/2016

  Project: Research

• Manipulating protease activated receptor (PAR) signalling on mononuclear cells to prevent intimal hyperplasia / chronic fibrosis AND promote regenerative repair

  Dorling, A., Chen, D., Lombardi, G., Smith, R. & Zhou, W.

  1/10/2014 → 30/09/2019

  Project: Research

• In vitro manipulation of defective TREGS as therapy for systemic lupus erythematosus

  Lombardi, G. & Scotta, C.

  Guy's & St Thomas' Charity

  1/09/2014 → 30/09/2015

  Project: Research

• Overcoming immunological barriers to regenerative medicine

  Watt, F., Dazzi, F., Geissmann, F., Lombardi, G. & Sacks, S.

  MRC Medical Research Council

  1/04/2014 → 31/03/2018

  Project: Research

• In vitro manipulation of defective tregs as therapy for systemic Lupus erythematosus

  Lombardi, G.

  1/03/2014 → 28/02/2015

  Project: Research

• Investigating Regulatory T Cell-Based Therapy In Systemic Lupus Erythematosus

  Lombardi, G.

  1/02/2014 → 31/01/2017

  Project: Research

• BASEMENT MEMBRANE BASED BIOMATERIALS AND SCAFFOLDS - BASESCAFF

  Lombardi, G.

  1/01/2014 → 30/06/2017

  Project: Research

• Targeted Regulatory T Cell Therapy for Inflammatory Bowel Disease

  Lord, G. & Lombardi, G.

  1/01/2014 → 31/12/2018

  Project: Research

• Optimising the efficacy of regulatory T cells: informing clinical application

  Lombardi, G. & Lechler, R.

  BHF British Heart Foundation

  1/10/2013 → 30/09/2018

  Project: Research

• Optimising islet survival/performance by cytotopic inhibition of thrombin & protease activated receptors; a strategy for clinical translation

  Dorling, A., Amiel, S., Chen, D., Huang, G., Jones, P., Lombardi, G., Sacks, S., Smith, R. & Tree, T.

  1/10/2013 → 30/09/2016

  Project: Research

• An integrated approach to cell therapy at King's College London

  Watt, F., Blower, P., Lombardi, G., Sacks, S. & Sharpe, P.

  1/09/2013 → 1/09/2014

  Project: Research

• ThRIL: a 'first-in-human' study, evaluating the safety, tolerability with an investigation into the efficacy of Tregs in liver transplant recipients

  Lombardi, G., Aluvihare, V., Heaton, N., Lechler, R., Peacock, J., Rebollo-Mesa, I., Safinia, N., Sanchez Fueyo, A. & Wang, Y.

  MRC Medical Research Council

  31/08/2013 → 29/06/2018

  Project: Research