Research output per year
Research output per year
Personal profile
Research interests
<p>Regulation of redox signaling and Nrf2/antioxidant response element mediated gene expression in vascular endothelial and smooth muscle cells; influence of epigenetics on fetal programing of endothelial dysfunction in offspring born to mothers with pre-eclampsia and gestational diabetes.</p>
Research interests (short)
Impaired redox signalling in endothelial and smooth muscle in pre-eclampsia, diabetes and atherosclerosis.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Physiology, Master in Science, UCL University College London
1 Sept 1973 → 30 Aug 1974
Award Date: 1 Jul 1974
Zoology, Bachelor of Science, George Washington University
1 Sept 1969 → 1 Jun 1973
Award Date: 3 Sept 1973
Physiology, Doctor of Philosophy, UCL University College London
1 Oct 1974 → 30 Sept 1977
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Interactions between zinc and NRF2 in vascular redox signalling
Yang, F., Smith, M. J., Siow, R. C. M., Aarsland, D., Maret, W. & Mann, G. E., Feb 2024, In: Biochemical Society Transactions. 52, 1, p. 269-278 10 p.Research output: Contribution to journal › Review article › peer-review
Open Access8 Citations (Scopus) -
Control of Redox Homeostasis by Short-Chain Fatty Acids: Implications for the Prevention and Treatment of Breast Cancer
González-Bosch, C., Zunszain, P. A. & Mann, G. E., Mar 2023, In: Pathogens. 12, 3, 486.Research output: Contribution to journal › Review article › peer-review
Open Access10 Citations (Scopus) -
Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity
Romeo, S., Secco, I., Schneider, E., Reumiller, C. M., Santos, C. X. C., Zoccarato, A., Musale, V., Pooni, A., Yin, X., Theofilatos, K., Cellone Trevelin, S., Zeng, L., Mann, G., Pathak, V., Harkin, K., Stitt, A. W., Medina, R. J., Margariti, A., Mayr, M. & Shah, A. & 2 others, , 30 Aug 2023, (Accepted/In press) In: Nature Communications. 19 p.Research output: Contribution to journal › Article › peer-review
File224 Downloads (Pure) -
Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity
Romeo, S. G., Secco, I., Schneider, E., Reumiller, C. M., Santos, C. X. C., Zoccarato, A., Musale, V., Pooni, A., Yin, X., Theofilatos, K., Trevelin, S. C., Zeng, L., Mann, G. E., Pathak, V., Harkin, K., Stitt, A. W., Medina, R. J., Margariti, A., Mayr, M. & Shah, A. M. & 2 others, , Dec 2023, In: Nature Communications. 14, 1, 5552.Research output: Contribution to journal › Article › peer-review
Open Access12 Citations (Scopus) -
Introduction to Special Issue on “Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases”
Cuadrado, A., Dinkova-Kostova, A. T. & Mann, G. E., 1 Feb 2023, In: Free Radical Biology and Medicine. 195, p. 258-260 3 p.Research output: Contribution to journal › Editorial › peer-review
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Importance of zinc in nitric oxide and NRF2-regulated redox signalling in human brain microvascular endothelial cells under physiological shear stress and oxygen levels
Mann, G. (Primary Investigator), Chapple, S. (Co-Investigator) & Morrell, A. (Co-Investigator)
1/04/2024 → 31/03/2027
Project: Research
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Patient-derived organoids under physiological oxygen: an improved pre-clinical model for hypoxia induced lung cancer metastasis
Mann, G. (Primary Investigator)
31/03/2024 → 30/03/2026
Project: Research
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The role of LOC105 in endothelial cell dysfunction in diabetes mellitus
Zampetaki, A. (Primary Investigator), Shah, A. (Co-Investigator) & Mann, G. (Co-Investigator)
1/12/2019 → 30/11/2022
Project: Research
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Neurovascular protection afforded by stabilised sulforaphane in a murine model of ischaemic stroke: a role for Nrf2-regulated redox signalling in the blood-brain barrier endothelium
Mann, G. (Primary Investigator) & Williams, S. (Co-Investigator)
1/08/2019 → 31/07/2022
Project: Research
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Metallomic profiling and redox signalling in human coronary artery endothelial and smooth muscle cells in physiological normoxia and ischaemia/reperfusion injury
Mann, G. (Primary Investigator), Maret, W. (Co-Investigator), Chapple, S. (Co-Investigator) & Stewart, T. (Co-Investigator)
2/02/2019 → 28/09/2021
Project: Research
Activities
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Chairman (prev. Deputy Chairman) of the Executive Committee, Physiological Society
Mann, G. (Chair)
2001 → …Activity: Other › Types of External academic engagement - Membership of external research organisation
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international research symposia in Budapest
Mann, G. (Organiser)
2001 → …Activity: Participating in or organising an event › Participation in conference
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international research symposia in Seville
Mann, G. (Organiser)
2001 → …Activity: Participating in or organising an event › Participation in conference
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14 international/national symposia
Mann, G. (Keynote/plenary speaker)
2001 → …Activity: Participating in or organising an event › Participation in conference
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international research symposia in Rio de Janeiro
Mann, G. (Organiser)
2001 → …Activity: Participating in or organising an event › Participation in conference