Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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RPA exhaustion activates SLFN11 to eliminate cells with heightened replication stress
Stanage, T. H., Li, S., Segura-Bayona, S., Idilli, A. I., Millar, R., Hewitt, G. & Boulton, S. J., Feb 2026, In: Nature cell biology. 28, 2, p. 240-254 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
EXO1 as a therapeutic target for Fanconi Anaemia, ZRSR2 and BRCA1-A complex deficient cancers
Maric, M., Segura-Bayona, S., Kuthethur, R., Takaki, T., Borel, V., Stanage, T. H., Ivanov, M. P., Parnandi, N., Hewitt, G., Millar, R., Fonseca, C. S., Patel, H., Llorian, M., Warchal, S., Howell, M., Chaudhuri, A. R., Kotsantis, P. & Boulton, S. J., 26 Sept 2025, (E-pub ahead of print) In: Nature communications. 16, 8476.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus) -
Quantitative, titratable and high-throughput reporter assays to measure DNA double strand break repair activity in cells
Rajendra, E., Grande, D., Mason, B., Marcantonio, D. D., Armstrong, L., Hewitt, G., Elinati, E., Galbiati, A., Boulton, S. J., Heald, R. A., Smith, G. C. M. & Robinson, H. M. R., 28 Feb 2024, In: Nucleic Acids Research. 52, 4, p. 1736-1752 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)5 Downloads (Pure) -
RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks
Zhao, S., Cordes, J., Caban, K. M., Götz, M. J., Mackens-Kiani, T., Veltri, A. J., Sinha, N. K., Weickert, P., Kaya, S., Hewitt, G., Nedialkova, D. D., Fröhlich, T., Beckmann, R., Buskirk, A. R., Green, R. & Stingele, J., 7 Dec 2023, In: MOLECULAR CELL. 83, 23, p. 4290-4303.e9Research output: Contribution to journal › Article › peer-review
Open Access34 Citations (Scopus) -
H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ
Bayley, R., Borel, V., Moss, R. J., Sweatman, E., Ruis, P., Ormrod, A., Goula, A., Mottram, R. M. A., Stanage, T., Hewitt, G., Saponaro, M., Stewart, G. S., Boulton, S. J. & Higgs, M. R., 19 May 2022, In: MOLECULAR CELL. 82, 10, p. 1924-1939.e10Research output: Contribution to journal › Article › peer-review
Open Access29 Citations (Scopus)
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CoLCRISPRa: Establishment of a Whole-Genome CRISPRa Gain-of-Function Screening Pipeline to Identify Novel Regulators of Radiation Response
Hewitt, G. (Primary Investigator)
1/10/2025 → 30/09/2026
Project: Research
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iCASE - Whole genome CRISPR screens to map genetic determinants of radionuclide therapy of cancer
Hewitt, G. (Primary Investigator)
1/10/2024 → 30/09/2028
Project: Research
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DDR-FATE-CoL: DDR-Fate: Single-Cell Phenotypic Characterisation of DNA- Damage Response Dependencies Identified from Whole Genome CRISPR Screens.
Hewitt, G. (Primary Investigator)
23/09/2024 → 22/09/2028
Project: Research
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Smart+: MRC mid-range equipment - State-of-the-Art Equipment for Preclinical Targeted Radiotherapy
Terry, S. (Primary Investigator), Barrington, S. (Co-Investigator), Blower, P. (Co-Investigator), Fruhwirth, G. (Co-Investigator), Hewitt, G. (Co-Investigator), Kong, A. (Co-Investigator), Modarai, B. (Co-Investigator), Southworth, R. (Co-Investigator), Stasiuk, G. (Co-Investigator), Sunassee, K. (Co-Investigator), T. M. de Rosales, R. (Co-Investigator), Tavassoli, M. (Co-Investigator), Witney, T. (Co-Investigator) & Yan, R. (Co-Investigator)
1/08/2023 → 29/02/2024
Project: Research
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Re-awakening radiation sensitivity - Understanding the role of Schlafen11 in mediating radioresistance.
Hewitt, G. (Primary Investigator)
5/09/2022 → 4/12/2022
Project: Research