I am interested in the signalling pathways involved in the modulation of smooth muscle contractility, with a focus on the RhoA/Rho-kinase pathway and non-receptor tyrosine kinases and their regulation by G protein-coupled receptors, reactive oxygen species and inflammatory mediators.  I am currently investigating these signalling pathways and how they interact, in both airway smooth muscle and pulmonary artery smooth muscle with an aim, therefore, to establishing the relevance of that interaction to both airway hyper-responsiveness in asthma and pulmonary hypertension.

More recently I began a Kings Together funded project investigating the effects of gain-of function mutations in the RyR1 receptor on vascualr and respiratory smooth muscle function, in collaboration with Prof Heinz Jungbluth, IOPPN.