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Gregory Knock

Dr

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Personal profile

Research interests

I am interested in the signalling pathways involved in the modulation of smooth muscle contractility, with a focus on the RhoA/Rho-kinase pathway and non-receptor tyrosine kinases and their regulation by G protein-coupled receptors, reactive oxygen species and inflammatory mediators.  I am currently investigating these signalling pathways and how they interact, in both airway smooth muscle and pulmonary artery smooth muscle with an aim, therefore, to establishing the relevance of that interaction to both airway hyper-responsiveness in asthma and pulmonary hypertension.

More recently I began a Kings Together funded project investigating the effects of gain-of function mutations in the RyR1 receptor on vascualr and respiratory smooth muscle function, in collaboration with Prof Heinz Jungbluth, IOPPN.

 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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Collaborations and top research areas from the last five years

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