Research output per year
Research output per year
- 32 results
Search results
-
2024
Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in the cardiomyocyte sarcomere
Li, C., Warren, D. T., Zhou, C., De Silva, S., Wilson, D., Garcia Maya, M., Wheeler, M., Meinke, P., Sawyer, G., Ehler, E., Wehnert, M., Rao, L., Zhang, Q. & Shanahan, C., May 2024, In: Journal of Biological Chemistry. 300, 5, 107254.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
NRF2 activation in the heart induces glucose metabolic reprogramming and reduces cardiac dysfunction via upregulation of the pentose phosphate pathway
Zoccarato, A., Smyrnias, I., Thompson, R., Verma, S., Visnagri, A., Zhang, M., Reumiller, C. M., Hafstad, A. D., Chong, M., Richards, D., Xavier Da Costa Dos Santos, C., Bromage, D., Zhang, X., Sawyer, G. & Shah, A. M., 3 Nov 2024, (Accepted/In press) In: Cardiovascular Research.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
2021
Endothelial Nox2 Limits Systemic Inflammation and Hypotension in Endotoxemia by Controlling Expression of Toll-Like Receptor 4
Trevelin, S. C., Sag, C. M., Zhang, M., Alves-Filho, J. C., Cunha, T. M., Santos, C. X. D., Sawyer, G., Murray, T., Brewer, A., Laurindo, F. R. M., Protti, A., Lopes, L. R., Ivetic, A., Cunha, F. Q. & Shah, A. M., 1 Aug 2021, In: Shock (Augusta, Ga.). 56, 2, p. 268-277 10 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
NADPH oxidase-4 promotes eccentric cardiac hypertrophy in response to volume overload
Schnelle, M., Sawyer, I., Anilkumar, N., Mohamed, B. A., Richards, D. A., Toischer, K., Zhang, M., Catibog, N., Sawyer, G., Mongue-Din, H., Schröder, K., Hasenfuss, G. & Shah, A. M., 1 Jan 2021, In: Cardiovascular Research. 117, 1, p. 178-187 10 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Citations (Scopus) -
Nox2-deficient Tregs improve heart transplant outcomes via their increased graft recruitment and enhanced potency: Nox2-deficient Tregs improve heart allograft outcome
Cellone Trevelin, S., Zampetaki, A., Sawyer, G., Ivetic, A., Brewer, A., Smith, L. A., Marelli-Berg, F. M., Köchl, R., Lechler, R. I., Shah, A. & Lombardi, G., 22 Sept 2021, In: JCI Insight. 6, 18, p. e149301 12 p., e149301.Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus) -
2020
Fibroblast Nox2 (NADPH Oxidase-2) Regulates ANG II (Angiotensin II)–Induced Vascular Remodeling and Hypertension via Paracrine Signaling to Vascular Smooth Muscle Cells
Harrison, C., Cellone Trevelin, S., Richards, D., Xavier Da Costa Dos Santos, C., Sawyer, G., Markovinovic, A., Zhang, X., Zhang, M., Brewer, A., Yin, X., Mayr, M. & Shah, A., 15 Oct 2020, (E-pub ahead of print) In: Arteriosclerosis, Thrombosis, and Vascular Biology.Research output: Contribution to journal › Article › peer-review
Open AccessFile43 Citations (Scopus)176 Downloads (Pure) -
In vivo [U-13C]glucose labeling to assess heart metabolism in murine models of pressure and volume overload
Schnelle, M., Chong, M., Zoccarato, A., Elkenani, M., Sawyer, G. J., Hasenfuss, G., Ludwig, C. & Shah, A. M., 1 Aug 2020, In: American journal of physiology. Heart and circulatory physiology. 319, 2, p. H422-H431Research output: Contribution to journal › Article › peer-review
22 Citations (Scopus) -
2019
Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload
Smyrnias, I., Gray, S. P., Okonko, D. O., Sawyer, G., Zoccarato, A., Catibog, N., López, B., González, A., Ravassa, S., Díez, J. & Shah, A. M., 16 Apr 2019, In: Journal of the American College of Cardiology. 73, 14, p. 1795 - 1806 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile117 Citations (Scopus)331 Downloads (Pure) -
2018
Echocardiographic evaluation of diastolic function in mouse models of heart disease
Schnelle, M., Catibog, N., Zhang, M., Nabeebaccus, A. A., Anderson, G., Richards, D. A., Sawyer, G., Zhang, X., Toischer, K., Hasenfuss, G., Monaghan, M. J. & Shah, A. M., 1 Jan 2018, In: Journal of Molecular and Cellular Cardiology. 114, p. 20-28 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile122 Citations (Scopus)320 Downloads (Pure) -
Nox2 in regulatory T cells promotes angiotensin II–induced cardiovascular remodeling
Emmerson, A., Cellone Trevelin, S., Mongue-Din, H., Becker, P. D., Ortiz, C., Smyth, L. A., Peng, Q., Elgueta, R., Sawyer, G., Ivetic, A., Lechler, R. I., Lombardi, G. & Shah, A. M., 2 Jul 2018, In: The Journal of clinical investigation. 128, 7, p. 3088–3101Research output: Contribution to journal › Article › peer-review
Open AccessFile59 Citations (Scopus)140 Downloads (Pure) -
2017
Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure
Sag, C. M., Schnelle, M., Zhang, J., Murdoch, C. E., Kossmann, S., Protti, A., Santos, C. X. C., Sawyer, G. J., Zhang, X., Mongue-Din, H., Richards, D. A., Brewer, A. C., Prysyazhna, O., Maier, L. S., Wenzel, P., Eaton, P. J. & Shah, A. M., 30 May 2017, In: Circulation (Baltimore). 135, 22, p. 2163-2177Research output: Contribution to journal › Article › peer-review
Open AccessFile50 Citations (Scopus)180 Downloads (Pure) -
2016
Bone marrow transplantation modulates tissue macrophage phenotype and enhances cardiac recovery after subsequent acute myocardial infarction
Protti, A., Mongue-Din, H., Mylonas, K. J., Sirker, A., Sag, C. M., Swim, M. M., Maier, L., Sawyer, G., Dong, X., Botnar, R., Salisbury, J., Gray, G. A. & Shah, A. M., Jan 2016, In: Journal of Molecular and Cellular Cardiology. 90, p. 120-128 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)202 Downloads (Pure) -
Cell-specific effects of Nox2 on the acute and chronic response to myocardial infarction
Sirker, A., Murdoch, C. E., Protti, A., Sawyer, G. J., Santos, C. X. C., Martin, D., Zhang, X., Brewer, A. C., Zhang, M. & Shah, A. M., Sept 2016, In: Journal of Molecular and Cellular Cardiology. 98, p. 11-17 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile47 Citations (Scopus)225 Downloads (Pure) -
2015
NADPH oxidase 4 regulates homocysteine metabolism and protects against acetaminophen-induced liver damage in mice
Murray, T. V. A., Dong, X., Sawyer, G. J., Caldwell, A., Halket, J., Sherwood, R., Quaglia, A., Dew, T., Anilkumar, N., Burr, S., Mistry, R. K., Martin, D., Schröder, K., Brandes, R. P., Hughes, R. D., Shah, A. M. & Brewer, A. C., 1 Dec 2015, In: Free Radical Biology and Medicine. 89, p. 918-930 13 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Citations (Scopus) -
2012
In vivo studies on non-viral transdifferentiation of liver cells towards pancreatic beta cells
Cim, A., Sawyer, G. J., Zhang, X., Su, H., Collins, L., Jones, P., Antoniou, M., Reynes, J.-P., Lipps, H.-J. & Fabre, J. W., Sept 2012, In: Journal of Endocrinology. 214, 3, p. 277-288 12 p.Research output: Contribution to journal › Article › peer-review
32 Citations (Scopus) -
2011
Critical Physiological and Surgical Considerations for Hydrodynamic Pressurization of Individual Segments of the Pig Liver
Fabre, J. W., Whitehorne, M., Grehan, A., Sawyer, G. J., Zhang, X., Davenport, M. & Rela, M., 14 Jul 2011, In: Human Gene Therapy. 22, 7, p. 879 - 887 9 p.Research output: Contribution to journal › Article › peer-review
16 Citations (Scopus) -
2010
Critical Physiological and Surgical Considerations for Hydrodynamic Gene Delivery to Individual Segments of the Liver in the Rat and Pig Models
Fabre, J. W., Sawyer, G. J., Whitehorne, M., Grehan, A., Zhang, H., Davenport, M. & Rela, M., 2010, In: Human Gene Therapy. 21, 4, p. 498 - 498 1 p.Research output: Contribution to journal › Meeting abstract
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Evaluation of Several DNA Expression Constructs for the Level and Longevity of Expression of the Pancreatic Transcription Factor pdx1 in Rat Liver
Cim, A., Sawyer, G. J., Zhang, H., Su, H., Collins, L., Antoniou, M., Lipps, H. & Fabre, J. W., 2010, In: Human Gene Therapy. 21, 4, p. 517 - 517 1 p.Research output: Contribution to journal › Meeting abstract
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Nonviral Delivery of the Rat PDX1 Gene to Rat Liver For the In Vivo Transdifferentiation of Liver Cells to Pancreatic Beta-Cells
Cim, A., Sawyer, G., Zhang, X., Su, H., Collins, L., Jones, P., Antoniou, M., Lipps, H. J. & Fabre, J., 2010, In: Human Gene Therapy. 21, 9, p. 1182 - 1182 1 p.Research output: Contribution to journal › Meeting abstract
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Technical requirements for effective regional hydrodynamic gene delivery to the left lateral lobe of the rat liver
Sawyer, G. J., Zhang, X. & Fabre, J. W., Apr 2010, In: Gene Therapy. 17, 4, p. 560 - 564 5 p.Research output: Contribution to journal › Article › peer-review
12 Citations (Scopus) -
2009
Hydrodynamic Gene Delivery to the Liver: Theoretical and Practical Issues for Clinical Application
Sawyer, G. J., Rela, M., Davenport, M., Whitehorne, M., Zhang, X. & Fabre, J. W., 2009, In: CURRENT GENE THERAPY. 9, 2, p. 128 - 135 8 p.Research output: Contribution to journal › Literature review › peer-review
37 Citations (Scopus) -
Intestinal Lactase as an Autologous beta-Galactosidase Reporter Gene for In Vivo Gene Expression Studies
Salehi, S., Eckley, L., Sawyer, G. J., Zhang, X., Dong, X., Freund, J.-N. & Fabre, J. W., 1 Jan 2009, In: Human Gene Therapy. 20, 1, p. 21 - 30 10 p.Research output: Contribution to journal › Article › peer-review
12 Citations (Scopus) -
2008
Hydrodynamic gene delivery to the pig liver via an isolated segment of the inferior vena cava
Fabre, J. W., Grehan, A., Whitehorne, M., Sawyer, G. J., Dong, X., Salehi, S., Eckley, L., Zhang, X., Seddon, M., Shah, A. M., Davenport, M. & Rela, M., Mar 2008, In: Gene Therapy. 15, 6, p. 452 - 462 11 p.Research output: Contribution to journal › Article › peer-review
63 Citations (Scopus) -
Low-volume hydrodynamic gene delivery to the rat liver via an isolated segment of the inferior vena cava: efficiency, cardiovascular response and intrahepatic vascular dynamics
Sawyer, G. J., Grehan, A., Dong, X. B., Whitehorne, M., Seddon, M., Shah, A. M., Zhang, X. H., Salehi, S. & Fabre, J. W., May 2008, In: JOURNAL OF GENE MEDICINE. 10, 5, p. 540 - 550 11 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
2007
Cardiovascular function following acute volume overload for hydrodynamic gene delivery to the liver
Sawyer, G. J., Dong, X., Whitehorne, M., Grehan, A., Seddon, M., Shah, A. M., Zhang, X. & Fabre, J. W., Aug 2007, In: Gene Therapy. 14, 16, p. 1208 - 1217 10 p.Research output: Contribution to journal › Article › peer-review
27 Citations (Scopus) -
Pancreatic duodenal homeobox 1 expression is insufficient to transdifferentiate liver cells into insulin-secreting cells
Wu, Y., Minger, S. L., Sawyer, G. J., Fabre, J. W., Persaud, S. J. & Jones, P. M., Mar 2007, In: Pancreas. 34, 2, p. 272 - 275 4 p.Research output: Contribution to journal › Letter › peer-review
3 Citations (Scopus) -
2004
Regional hydrodynamic gene delivery to the rat liver with physiological volumes of DNA solution
Zhang, X. H., Dong, X. B., Sawyer, G. J., Collins, L. & Fabre, J. W., Jun 2004, In: JOURNAL OF GENE MEDICINE. 6, 6, p. 693 - 703 11 p.Research output: Contribution to journal › Article › peer-review
43 Citations (Scopus) -
2003
The in vivo use of chloroquine to promote non-viral gene delivery to the liver via the portal vein and bite duct
Zhang, X. H., Sawyer, G. J., Dong, X. B., Qiu, Y., Collins, L. & Fabre, J. W., Mar 2003, In: JOURNAL OF GENE MEDICINE. 5, 3, p. 209 - 218 10 p.Research output: Contribution to journal › Article › peer-review
52 Citations (Scopus) -
2001
In vivo gene delivery via portal vein and bile duct to individual lobes of the rat liver using a polylysine-based nonviral DNA vector in combination with chloroquine
Zhang, X. H., Collins, L., Sawyer, G. J., Dong, X. B., Qiu, Y. & Fabre, J. W., 2001, In: Human Gene Therapy. 12, 18, p. 2179 - 2190 12 p.Research output: Contribution to journal › Article › peer-review
47 Citations (Scopus) -
Specific suppression of interleukin-2 biosynthesis by synthetic antisense oligodeoxynucleotides does not influence allograft rejection
Yun, S., Sawyer, G., Zhang, X., Gustafsson, K. & Fabre, J. W., 2001, In: Transplantation Proceedings. 33, 1-2, p. 306 - 306 1 p.Research output: Contribution to journal › Meeting abstract
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2000
In vitro investigation of factors important for the delivery of an integrin-targeted nonviral DNA vector in organ transplantation
Collins, L., Sawyer, G. J., Zhang, X. H., Gustafsson, K. & Fabre, J. W., 27 Mar 2000, In: Transplantation. 69, 6, p. 1168 - 1176 9 p.Research output: Contribution to journal › Article › peer-review
24 Citations (Scopus) -
Specific suppression of interleukin 2 biosynthesis by synthetic antisense oligodeoxynucleotides does not influence allograft rejection
Yun, S., Sawyer, G. J., Zhang, X. H., Gustafsson, K. & Fabre, J. W., 27 Jun 2000, In: Transplantation. 69, 12, p. 2586 - 2592 7 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus)