Guangju Zhai

2014

Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies

Rodriguez-Fontenla, C., Calaza, M., Evangelou, E., Valdes, A. M., Arden, N., Blanco, F. J., Carr, A., Chapman, K., Deloukas, P., Doherty, M., Esko, T., Garcés Aletá, C. M., Gomez-Reino Carnota, J. J., Helgadottir, H., Hofman, A., Jonsdottir, I., Kerkhof, H. J. M., Kloppenburg, M., McCaskie, A. & Ntzani, E. E. & 27 others, Ollier, W. E. R., Oreiro, N., Panoutsopoulou, K., Ralston, S. H., Ramos, Y. F., Riancho, J. A., Rivadeneira, F., Slagboom, P. E., Styrkarsdottir, U., Thorsteinsdottir, U., Thorleifsson, G., Tsezou, A., Uitterlinden, A. G., Wallis, G. A., Wilkinson, J. M., Zhai, G., Zhu, Y., Felson, D. T., Ioannidis, J. P. A., Loughlin, J., Metspalu, A., Meulenbelt, I., Stefansson, K., Van Meurs, J. B., Zeggini, E., Spector, T. D. & Gonzalez, A., 2014, In: Arthritis and Rheumatology. 66, 4, p. 940-949 10 p.

Research output: Contribution to journal › Article › peer-review

98 Citations (Scopus)

Interrogating causal pathways linking genetic variants, small molecule metabolites, and circulating lipids

Shin, S. Y., Petersen, A. K., Wahl, S., Zhai, G., Römisch-Margl, W., Small, K. S., Döring, A., Kato, B. S., Peters, A., Grundberg, E., Prehn, C., Wang-Sattler, R., Wichmann, H. E., de Angelis, M. H., Illig, T., Adamski, J., Deloukas, P., Spector, T. D., Suhre, K. & Gieger, C. & 1 others, Soranzo, N., 28 Mar 2014, In: Genome medicine. 6, 3, 16 p., 25.

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

2013

A Meta-Analysis of Thyroid-Related Traits Reveals Novel Loci and Gender-Specific Differences in the Regulation of Thyroid Function

Porcu, E., Medici, M., Pistis, G., Volpato, C. B., Wilson, S. G., Cappola, A. R., Bos, S. D., Deelen, J., den Heijer, M., Freathy, R. M., Lahti, J., Liu, C., Lopez, L. M., Nolte, I. M., O'Connell, J. R., Tanaka, T., Trompet, S., Arnold, A., Bandinelli, S. & Beekman, M. & 74 others, Bohringer, S., Brown, S. J., Buckley, B. M., Camaschella, C., de Craen, A. J. M., Davies, G., de Visser, M. C. H., Ford, I., Forsen, T., Frayling, T. M., Fugazzola, L., Goegele, M., Hattersley, A. T., Hermus, A. R., Hofman, A., Houwing-Duistermaat, J. J., Jensen, R. A., Kajantie, E., Kloppenburg, M., Lim, E. M., Masciullo, C., Mariotti, S., Minelli, C., Mitchell, B. D., Nagaraja, R., Netea-Maier, R. T., Palotie, A., Persani, L., Piras, M. G., Psaty, B. M., Raikkonen, K., Richards, J. B., Rivadeneira, F., Sala, C., Sabra, M. M., Sattar, N., Shields, B. M., Soranzo, N., Starr, J. M., Stott, D. J., Sweep, F. C. G. J., Usala, G., van der Klauw, M. M., van Heemst, D., van Mullem, A., Vermeulen, S. H., Visser, W. E., Walsh, J. P., Westendorp, R. G. J., Widen, E., Zhai, G., Cucca, F., Deary, I. J., Eriksson, J. G., Ferrucci, L., Fox, C. S., Jukema, J. W., Kiemeney, L. A., Pramstaller, P. P., Schlessinger, D., Shuldiner, A. R., Slagboom, E. P., Uitterlinden, A. G., Vaidya, B., Visser, T. J., Wolffenbuttel, B. H. R., Meulenbelt, I., Rotter, J. I., Spector, T. D., Hicks, A. A., Toniolo, D., Sanna, S., Peeters, R. P. & Naitza, S., 7 Feb 2013, In: PL o S Genetics. 9, 2, p. N/A 20 p., e1003266.

Research output: Contribution to journal › Article › peer-review

Open Access

187 Citations (Scopus)

Association of Adiposity Genetic Variants With Menarche Timing in 92,105 Women of European Descent

Fernandez-Rhodes, L., Demerath, E. W., Cousminer, D. L., Tao, R., Dreyfus, J. G., Esko, T., Smith, A. V., Gudnason, V., Harris, T. B., Launer, L., McArdle, P. F., Yerges-Armstrong, L. M., Elks, C. E., Strachan, D. P., Kutalik, Z., Vollenweider, P., Feenstra, B., Boyd, H. A., Metspalu, A. & Mihailov, E. & 55 others, Broer, L., Zillikens, M. C., Oostra, B., van Duijn, C. M., Lunetta, K. L., Perry, J. R. B., Murray, A., Koller, D. L., Lai, D., Corre, T., Toniolo, D., Albrecht, E., Stoeckl, D., Grallert, H., Gieger, C., Hayward, C., Polasek, O., Rudan, I., Wilson, J. F., He, C., Kraft, P., Hu, F. B., Hunter, D. J., Hottenga, J.-J., Willemsen, G., Boomsma, D. I., Byrne, E. M., Martin, N. G., Montgomery, G. W., Warrington, N. M., Pennell, C. E., Stolk, L., Visser, J. A., Hofman, A., Uitterlinden, A. G., Rivadeneira, F., Lin, P., Fisher, S. L., Bierut, L. J., Crisponi, L., Porcu, E., Mangino, M., Zhai, G., Spector, T. D., Buring, J. E., Rose, L. M., Ridker, P. M., Poole, C., Hirschhorn, J. N., Murabito, J. M., Chasman, D. I., Widen, E., North, K. E., Ong, K. K. & Franceschini, N., 1 Aug 2013, In: American Journal of Epidemiology. 178, 3, p. 451-460 10 p., N/A.

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Targeted metabolomics profiles are strongly correlated with nutritional patterns in women

Menni, C., Zhai, G., Macgregor, A., Prehn, C., Römisch-Margl, W., Suhre, K., Adamski, J., Cassidy, A., Illig, T., Spector, T. D. & Valdes, A. M., Apr 2013, In: Metabolomics. 9, 2, p. 506-514 9 p., N/A.

Research output: Contribution to journal › Article › peer-review

Open Access

110 Citations (Scopus)

2012

A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone-Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

Coviello, A. D., Haring, R., Wellons, M., Vaidya, D., Lehtimaki, T., Keildson, S., Lunetta, K. L., He, C., Fornage, M., Lagou, V., Mangino, M., Onland-Moret, N. C., Chen, B., Eriksson, J., Garcia, M., Mei, Y., Koster, A., Lohman, K., Lyytikainen, L.-P. & Petersen, A.-K. & 79 others, Prescott, J., Stolk, L., Vandenput, L., Wood, A. R., Zhuang, W. V., Ruokonen, A., Hartikainen, A.-L., Pouta, A., Bandinelli, S., Biffar, R., Brabant, G., Cox, D. G., Chen, Y., Cummings, S., Ferrucci, L., Gunter, M. J., Hankinson, S. E., Martikainen, H., Hofman, A., Homuth, G., Illig, T., Jansson, J.-O., Johnson, A. D., Karasik, D., Karlsson, M., Kettunen, J., Kiel, D. P., Kraft, P., Liu, J., Ljunggren, O., Lorentzon, M., Maggio, M., Markus, M. R. P., Mellstrom, D., Miljkovic, I., Mirel, D., Nelson, S., Papunen, L. M., Peeters, P. H. M., Prokopenko, I., Raffel, L., Reincke, M., Reiner, A. P., Rexrode, K., Rivadeneira, F., Schwartz, S. M., Siscovick, D., Soranzo, N., Stockl, D., Tworoger, S., Uitterlinden, A. G., van Gils, C. H., Vasan, R. S., Wichmann, H.-E., Zhai, G., Bhasin, S., Bidlingmaier, M., Chanock, S. J., De Vivo, I., Harris, T. B., Hunter, D. J., Kahonen, M., Liu, S., Ouyang, P., Spector, T. D., van der Schouw, Y. T., Viikari, J., Wallaschofski, H., McCarthy, M. I., Frayling, T. M., Murray, A., Franks, S., Jarvelin, M.-R., de Jong, F. H., Raitakari, O., Teumer, A., Ohlsson, C., Murabito, J. M. & Perry, J. R. B., 19 Jul 2012, In: PL o S Genetics. 8, 7, p. N/A 12 p., e1002805.

Research output: Contribution to journal › Article › peer-review

Open Access

148 Citations (Scopus)

Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population

Bell, J. T., Tsai, P.-C., Yang, T.-P., Pidsley, R., Nisbet, J., Glass, D., Mangino, M., Zhai, G., Zhang, F., Valdes, A., Shin, S.-Y., Dempster, E. L., Murray, R. M., Grundberg, E., Hedman, A. K., Nica, A., Small, K. S., Dermitzakis, E. T., McCarthy, M. I. & Mill, J. & 3 others, Spector, T. D., Deloukas, P. & MuTHER Consortium, Apr 2012, In: PL o S Genetics. 8, 4, p. 189-200 12 p., e1002629.

Research output: Contribution to journal › Article › peer-review

Open Access

564 Citations (Scopus)

Human serum metabolic profiles are age dependent

Yu, Z., Zhai, G., Singmann, P., He, Y., Xu, T., Prehn, C., Roemisch-Margl, W., Lattka, E., Gieger, C., Soranzo, N., Heinrich, J., Standl, M., Thiering, E., Mittelstrass, K., Wichmann, H.-E., Peters, A., Suhre, K., Li, Y., Adamski, J. & Spector, T. D. & 2 others, Illig, T. & Wang-Sattler, R., Dec 2012, In: AGING CELL. 11, 6, p. 960-967 8 p., N/A.

Research output: Contribution to journal › Article › peer-review

Open Access

279 Citations (Scopus)

Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study

Zeggini, E., Panoutsopoulou, K., Southam, L., Rayner, N. W., Day-Williams, A. G., Lopes, M. C., Boraska, V., Esko, T., Evangelou, E., Hofman, A., Houwing-Duistermaat, J. J., Ingvarsson, T., Jonsdottir, I., Jonsson, H., Kerkhof, H. J. M., Kloppenburg, M., Bos, S. D., Mangino, M., Metrustry, S. & Slagboom, P. E. & 31 others, Thorleifsson, G., Raine, E. V. A., Ratnayake, M., Ricketts, M., Beazley, C., Blackburn, H., Bumpstead, S., Elliott, K. S., Hunt, S. E., Potter, S. C., Shin, S.-Y., Yadav, V. K., Zhai, G., Sherburn, K., Dixon, K., Arden, E., Aslam, N., Battley, P.-K., Carluke, I., Doherty, S., Gordon, A., Joseph, J., Keen, R., Koller, N. C., Mitchell, S., O'Neill, F., Paling, E., Reed, M. R., Valdes, A. M., Spector, T. D. & arcOGEN Consortium & arcOGEN Colla, 1 Sept 2012, In: The Lancet. 380, 9844, p. 815-823 9 p.

Research output: Contribution to journal › Article › peer-review

333 Citations (Scopus)

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

Stolk, L., Perry, J. R. B., Chasman, D. I., He, C., Mangino, M., Sulem, P., Barbalic, M., Broer, L., Byrne, E. M., Ernst, F., Esko, T., Franceschini, N., Gudbjartsson, D. F., Hottenga, J.-J., Kraft, P., McArdle, P. F., Porcu, E., Shin, S.-Y., Smith, A. V. & van Wingerden, S. & 159 others, Zhai, G., Zhuang, W. V., Albrecht, E., Alizadeh, B. Z., Aspelund, T., Bandinelli, S., Lauc, L. B., Beckmann, J. S., Boban, M., Boerwinkle, E., Broekmans, F. J., Burri, A., Campbell, H., Chanock, S. J., Chen, C., Cornelis, M. C., Corre, T., Coviello, A. D., d'Adamo, P., Davies, G., de Faire, U., de Geus, E. J. C., Deary, I. J., Dedoussis, G. V. Z., Deloukas, P., Ebrahim, S., Eiriksdottir, G., Emilsson, V., Eriksson, J. G., Fauser, B. C. J. M., Ferreli, L., Ferrucci, L., Fischer, K., Folsom, A. R., Garcia, M. E., Gasparini, P., Gieger, C., Glazer, N., Grobbee, D. E., Hall, P., Haller, T., Hankinson, S. E., Hass, M., Hayward, C., Heath, A. C., Hofman, A., Ingelsson, E., Janssens, A. C. J. W., Johnson, A. D., Karasik, D., Kardia, S. L. R., Keyzer, J., Kiel, D. P., Kolcic, I., Kutalik, Z., Lahti, J., Lai, S., Laisk, T., Laven, J. S. E., Lawlor, D. A., Liu, J., Lopez, L. M., Louwers, Y. V., Magnusson, P. K. E., Marongiu, M., Martin, N. G., Klaric, I. M., Masciullo, C., McKnight, B., Medland, S. E., Melzer, D., Mooser, V., Navarro, P., Newman, A. B., Nyholt, D. R., Onland-Moret, N. C., Palotie, A., Pare, G., Parker, A. N., Pedersen, N. L., Peeters, P. H. M., Pistis, G., Plump, A. S., Polasek, O., Pop, V. J. M., Psaty, B. M., Raikkonen, K., Rehnberg, E., Rotter, J. I., Rudan, I., Sala, C., Salumets, A., Scuteri, A., Singleton, A., Smith, J. A., Snieder, H., Soranzo, N., Stacey, S. N., Starr, J. M., Stathopoulou, M. G., Stirrups, K., Stolk, R. P., Styrkarsdottir, U., Sun, Y. V., Tenesa, A., Thorand, B., Toniolo, D., Tryggvadottir, L., Tsui, K., Ulivi, S., van Dam, R. M., van der Schouw, Y. T., van Gils, C. H., van Nierop, P., Vink, J. M., Visscher, P. M., Voorhuis, M., Waeber, G., Wallaschofski, H., Wichmann, H. E., Widen, E., Wijnands-van Gent, C. J. M., Willemsen, G., Wilson, J. F., Wolffenbuttel, B. H. R., Wright, A. F., Yerges-Armstrong, L. M., Zemunik, T., Zgaga, L., Zillikens, M. C., Zygmunt, M., Arnold, A. M., Boomsma, D. I., Buring, J. E., Crisponi, L., Demerath, E. W., Gudnason, V., Harris, T. B., Hu, F. B., Hunter, D. J., Launer, L. J., Metspalu, A., Montgomery, G. W., Oostra, B. A., Ridker, P. M., Sanna, S., Schlessinger, D., Spector, T. D., Stefansson, K., Streeten, E. A., Thorsteinsdottir, U., Uda, M., Uitterlinden, A. G., van Duijn, C. M., Voelzke, H., Murray, A., Murabito, J. M., Visser, J. A. & Lunetta, K. L., Mar 2012, In: Nature Genetics. 44, 3, p. 260 - U55 9 p.

Research output: Contribution to journal › Article › peer-review

310 Citations (Scopus)

Serum Metabolite Concentrations and Decreased GFR in the General Population

Goek, O.-N., Doering, A., Gieger, C., Heier, M., Koenig, W., Prehn, C., Roemisch-Margl, W., Wang-Sattler, R., Illig, T., Suhre, K., Sekula, P., Zhai, G., Adamski, J., Koettgen, A. & Meisinger, C., Aug 2012, In: American Journal of Kidney Diseases. 60, 2, p. 197-206 10 p.

Research output: Contribution to journal › Article › peer-review

102 Citations (Scopus)

2011

A Comprehensive Evaluation of Potential Lung Function Associated Genes in the SpiroMeta General Population Sample

Obeidat, M., Wain, L. V., Shrine, N., Kalsheker, N., Artigas, M. S., Repapi, E., Burton, P. R., Johnson, T., Ramasamy, A., Zhao, J. H., Zhai, G., Huffman, J. E., Vitart, V., Albrecht, E., Igl, W., Hartikainen, A.-L., Pouta, A., Cadby, G., Hui, J. & Palmer, L. J. & 44 others, Hadley, D., McArdle, W. L., Rudnicka, A. R., Barroso, I., Loos, R. J. F., Wareham, N. J., Mangino, M., Soranzo, N., Spector, T. D., Glaeser, S., Homuth, G., Voelzke, H., Deloukas, P., Granell, R., Henderson, J., Grkovic, I., Jankovic, S., Zgaga, L., Polasek, O., Rudan, I., Wright, A. F., Campbell, H., Wild, S. H., Wilson, J. F., Heinrich, J., Imboden, M., Probst-Hensch, N. M., Gyllensten, U., Johansson, A., Zaboli, G., Mustelin, L., Rantanen, T., Surakka, I., Kaprio, J., Jarvelin, M.-R., Hayward, C., Evans, D. M., Koch, B., Musk, A. W., Elliott, P., Strachan, D. P., Tobin, M. D., Sayers, I. & Hall, I. P., 2011, In: PL o S One . 6, 5, e19382.

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study

Fox, E. R., Young, J. H., Li, Y., Dreisbach, A. W., Keating, B. J., Musani, S. K., Liu, K., Morrison, A. C., Ganesh, S., Kutlar, A., Ramachandran, V. S., Polak, J. F., Fabsitz, R. R., Dries, D. L., Farlow, D. N., Redline, S., Adeyemo, A., Hirschorn, J. N., Sun, Y. V. & Wyatt, S. B. & 347 others, Penman, A. D., Palmas, W., Rotter, J. I., Townsend, R. R., Doumatey, A. P., Tayo, B. O., Mosley, T. H., Lyon, H. N., Kang, S. J., Rotimi, C. N., Cooper, R. S., Franceschini, N., Curb, J. D., Martin, L. W., Eaton, C. B., Kardia, S. L. R., Taylor, H. A., Caulfield, M. J., Ehret, G. B., Johnson, T., Munroe, P. B., Rice, K. M., Bochud, M., Johnson, A. D., Chasman, D. I., Smith, A. V., Tobin, M. D., Verwoert, G. C., Hwang, S.-J., Pihur, V., Vollenweider, P., O'reilly, P. F., Amin, N., Bragg-gresham, J. L., Teumer, A., Glazer, N. L., Launer, L., Zhao, J. H., Aulchenko, Y., Heath, S., Sober, S., Parsa, A., Luan, J., Arora, P., Dehghan, A., Zhang, F., Lucas, G., Hicks, A. A., Jackson, A. U., Peden, J. F., Tanaka, T., Wild, S. H., Rudan, I., Igl, W., Milaneschi, Y., Parker, A. N., Fava, C., Chambers, J. C., Kumari, M., Jingo, M., Van Der Harst, P., Kao, W. H. L., Sjogren, M., Vinay, D. G., Alexander, M., Tabara, Y., Shaw-hawkins, S., Whincup, P. H., Liu, Y., Shi, G., Kuusisto, J., Seielstad, M., Sim, X., Nguyen, K.-D. H., Lehtimaki, T., Matullo, G., Wu, Y., Gaunt, T. R., Charlotte Onland-moret, N., Cooper, M. N., Platou, C. G. P., Org, E., Hardy, R., Dahgam, S., Palmen, J., Vitart, V., Braund, P. S., Kuznetsova, T., Uiterwaal, C. S. P. M., Campbell, H., Ludwig, B., Tomaszewski, M., Tzoulaki, I., Palmer, N. D., Aspelund, T., Garcia, M., Chang, Y.-P. C., O'connell, J. R., Steinle, N. I., Grobbee, D. E., Arking, D. E., Hernandez, D., Najjar, S., Mcardle, W. L., Hadley, D., Brown, M. J., Connell, J. M., Hingorani, A. D., Day, I. N. M., Lawlor, D. A., Beilby, J. P., Lawrence, R. W., Clarke, R., Collins, R., Hopewell, J. C., Ongen, H., Bis, J. C., Kahonen, M., Viikari, J., Adair, L. S., Lee, N. R., Chen, M.-H., Olden, M., Pattaro, C., Hoffman Bolton, J. A., Kottgen, A., Bergmann, S., Mooser, V., Chaturvedi, N., Frayling, T. M., Islam, M., Jafar, T. H., Erdmann, J., Kulkarni, S. R., Bornstein, S. R., Grassler, J., Groop, L., Voight, B. F., Kettunen, J., Howard, P., Taylor, A., Guarrera, S., Ricceri, F., Emilsson, V., Plump, A., Barroso, I., Khaw, K.-T., Weder, A. B., Hunt, S. C., Bergman, R. N., Collins, F. S., Bonnycastle, L. L., Scott, L. J., Stringham, H. M., Peltonen, L., Perola, M., Vartiainen, E., Brand, S.-M., Staessen, J. A., Wang, T. J., Burton, P. R., Solerartigas, M., Dong, Y., Snieder, H., Wang, X., Zhu, H., Lohman, K. K., Rudock, M. E., Heckbert, S. R., Smith, N. L., Wiggins, K. L., Shriner, D., Veldre, G., Viigimaa, M., Kinra, S., Prabhakaran, D., Tripathy, V., Langefeld, C. D., Rosengren, A., Thelle, D. S., Mariacorsi, A., Singleton, A., Forrester, T., Hilton, G., Mckenzie, C. A., Salako, T., Iwai, N., Kita, Y., Ogihara, T., Ohkubo, T., Okamura, T., Ueshima, H., Umemura, S., Eyheramendy, S., Meitinger, T., Wichmann, H. E., Cho, Y. S., Kim, H.-L., Lee, J.-Y., Scott, J., Sehmi, J. S., Zhang, W., Hedblad, B., Nilsson, P., Smith, G. D., Wong, A., Narisu, N., Stancakova, A., Raffel, L. J., Yao, J., Kathiresan, S., O'donnell, C., Schwartz, S. M., Arfan Ikram, M., Longstreth, W. T., Seshadri, S., Shrine, N. R. G., Wain, L. V., Morken, M. A., Swift, A. J., Laitinen, J., Prokopenko, I., Zitting, P., Cooper, J. A., Humphries, S. E., Danesh, J., Rasheed, A., Goel, A., Hamsten, A., Watkins, H., Bakker, S. J. L., Van Gilst, W. H., Janipalli, C. S., Radha Mani, K., Yajnik, C. S., Hofman, A., Mattace-raso, F. U. S., Oostra, B. A., Demirkan, A., Isaacs, A., Rivadeneira, F., Lakatta, E. G., Orru, M., Scuteri, A., Ala-korpela, M., Kangas, A. J., Lyytikainen, L.-P., Soininen, P., Tukiainen, T., Wurz, P., Twee-hee Ong, R., Dorr, M., Kroemer, H. K., Volker, U., Volzke, H., Galan, P., Hercberg, S., Lathrop, M., Zelenika, D., Deloukas, P., Mangino, M., Spector, T. D., Zhai, G., Meschia, J. F., Nalls, M. A., Sharma, P., Terzic, J., Kranthi Kumar, M. J., Denniff, M., Zukowska-szczechowska, E., Wagenknecht, L. E., Fowkes, G. R., Charchar, F. J., Schwarz, P. E. H., Hayward, C., Guo, X., Bots, M. L., Brand, E., Samani, N. J., Polasek, O., Talmud, P. J., Nyberg, F., Kuh, D., Laan, M., Hveem, K., Palmer, L. J., Van Der Schouw, Y. T., Casas, J. P., Mohlke, K. L., Vineis, P., Raitakari, O., Wong, T. Y., Shyong Tai, E., Laakso, M., Rao, D. C., Harris, T. B., Morris, R. W., Dominiczak, A. F., Kivimaki, M., Marmot, M. G., Miki, T., Saleheen, D., Chandak, G. R., Coresh, J., Navis, G., Salomaa, V., Han, B.-G., Kooner, J. S., Melander, O., Ridker, P. M., Bandinelli, S., Gyllensten, U. B., Wright, A. F., Wilson, J. F., Ferrucci, L., Farrall, M., Tuomilehto, J., Pramstaller, P. P., Elosua, R., Soranzo, N., Sijbrands, E. J. G., Altshuler, D., Loos, R. J. F., Shuldiner, A. R., Gieger, C., Meneton, P., Uitterlinden, A. G., Wareham, N. J., Gudnason, V., Rettig, R., Uda, M., Strachan, D. P., Witteman, J. C. M., Hartikainen, A.-L., Beckmann, J. S., Boerwinkle, E., Boehnke, M., Larson, M. G., Jarvelin, M.-R., Psaty, B. M., Abecasis, G. R., Elliott, P., Van Duijn, C. M., Newton-cheh, C., Chakravarti, A., Zhu, X. & Levy, D., 1 Jun 2011, In: Human Molecular Genetics. 20, 11, p. 2273-2284 12 p., N/A.

Research output: Contribution to journal › Article › peer-review

Open Access

147 Citations (Scopus)

Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms

Zhai, G., Teumer, A., Stolk, L., Perry, J. R. B., Vandenput, L., Coviello, A. D., Koster, A., Bell, J. T., Bhasin, S., Eriksson, J., Eriksson, A., Ernst, F., Ferrucci, L., Frayling, T. M., Glass, D., Grundberg, E., Haring, R., Hedman, A. K., Hofman, A. & Kiel, D. P. & 26 others, Kroemer, H. K., Liu, Y., Lunetta, K. L., Maggio, M., Lorentzon, M., Mangino, M., Melzer, D., Miljkovic, I., Nica, A., Penninx, B. W. J. H., Vasan, R. S., Rivadeneira, F., Small, K. S., Soranzo, N., Uitterlinden, A. G., Voelzke, H., Wilson, S. G., Xi, L., Zhuang, W. V., Harris, T. B., Murabito, J. M., Ohlsson, C., Murray, A., de Jong, F. H., Spector, T. D. & Wallaschofski, H., Apr 2011, In: PL o S Genetics. 7, 4, e1002025.

Research output: Contribution to journal › Article › peer-review

85 Citations (Scopus)

EIGHT COMMON GENETIC VARIANTS ASSOCIATED WITH SERUM DHEAS LEVELS SUGGESTS A KEY ROLE IN AGEING MECHANISMS

Zhai, G., Teumer, A., Stolk, L., Perry, J. R. B., Vandenput, L., Coviello, A. D., Koster, A., Bandinelli, S., Bell, J. T., Bhasin, S., Eriksson, J., Eriksson, A., Ernst, F., Ferrucci, L., Frayling, T. M., Glass, D., Grundberg, E., Haring, R., Hedman, A. K. & Hofman, A. & 22 others, Kiel, D. P., Kroemer, H. K., Liu, Y., Lunetta, L., Lorentzon, M., Mangino, M., Melzer, D., Nica, A., Vasan, R. S., Small, K. S., Soranzo, N., Uitterlinden, A. G., Voelzke, H., Wilson, S., Zhuang, W., Harris, T., Murabito, J. M., Ohlsson, C., Murray, A., Jong, F., Spector, T. D. & Wallaschofski, H., Apr 2011, In: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 49, 4, p. S425 - S425 e1002025.

Research output: Contribution to journal › Meeting abstract

85 Citations (Scopus)

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Ehret, G. B., Munroe, P. B., Rice, K. M., Bochud, M., Johnson, A. D., Chasman, D. I., Smith, A. V., Tobin, M. D., Verwoert, G. C., Hwang, S.-J., Pihur, V., Vollenweider, P., O'Reilly, P., Amin, N., Bragg-Gresham, J. L., Teumer, A., Glazer, N. L., Launer, L., Zhao, J. H. & Aulchenko, Y. & 31 others, Heath, S., Sõber, S., Parsa, A., Luan, J., Arora, P., Dehghan, A., Zhang, F., Lucas, G., Hicks, A. A., Jackson, A. U., Peden, J. F., Tanaka, T., Wild, S. H., Rudan, I., Igl, W., Milaneschi, Y., Parker, A. N., Fava, C., Chambers, J. C., Fox, E. R., Kumari, M., Go, M. J., van der Harst, P., Kao, W. H. L., Wong, A., Spector, T. D., Zhai, G., Morris, R. W., Wilson, J. F., International Consortium for Blood Pressure Genome-Wide Association Studies & Hernandez Fuentes, M., 6 Oct 2011, In: NATURE. 478, 7367, p. 103-109 7 p., N/A.

Research output: Contribution to journal › Article › peer-review

1739 Citations (Scopus)

Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

Schumann, G., Coin, L. J., Lourdusamy, A., Charoen, P., Berger, K. H., Stacey, D., Desrivieres, S., Aliev, F. A., Khan, A. A., Amin, N., Aulchenko, Y. S., Bakalkin, G., Bakker, S. J., Balkau, B., Beulens, J. W., Bilbao, A., de Boer, R. A., Beury, D., Bots, M. L. & Breetvelt, E. J. & 96 others, Cauchi, S., Cavalcanti-Proenca, C., Chambers, J. C., Clarke, T.-K., Dahmen, N., de Geus, E. J., Dick, D., Ducci, F., Easton, A., Edenberg, H. J., Esk, T., Fernandez-Medarde, A., Foroud, T., Freimer, N. B., Girault, J.-A., Grobbee, D. E., Guarrera, S., Gudbjartsson, D. F., Hartikainen, A.-L., Heath, A. C., Hesselbrock, V., Hofman, A., Hottenga, J.-J., Isohanni, M. K., Kaprio, J., Khaw, K.-T., Kuehnel, B., Laitinen, J., Lobbens, S., Luan, J., Mangino, M., Maroteaux, M., Matullo, G., McCarthy, M. I., Mueller, C., Navis, G., Numans, M. E., Nunez, A., Nyholt, D. R., Onland-Moret, C. N., Oostra, B. A., O'Reilly, P. F., Palkovits, M., Penninx, B. W., Polidoro, S., Pouta, A., Prokopenko, I., Ricceri, F., Santos, E., Smit, J. H., Soranzo, N., Song, K., Sovio, U., Stumvoll, M., Surakk, I., Thorgeirsson, T. E., Thorsteinsdottir, U., Troakes, C., Tyrfingsson, T., Toenjes, A., Uiterwaal, C. S., Uitterlinden, A. G., van der Harst, P., van der Schouw, Y. T., Staehlin, O., Vogelzangs, N., Vollenweider, P., Waeber, G., Wareham, N. J., Waterworth, D. M., Whitfield, J. B., Wichmann, E. H., Willemsen, G., Witteman, J. C., Yuan, X., Zhai, G., Zhao, J. H., Zhang, W., Martin, N. G., Metspalu, A., Doering, A., Scott, J., Spector, T. D., Loos, R. J., Boomsma, D. I., Mooser, V., Peltonen, L., Stefansson, K., van Duijn, C. M., Vineis, P., Sommer, W. H., Kooner, J. S., Spanagel, R., Heberlein, U. A., Jarvelin, M.-R. & Elliott, P., 26 Apr 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 17, p. 7119 - 7124 6 p.

Research output: Contribution to journal › Article › peer-review

230 Citations (Scopus)

Human metabolic individuality in biomedical and pharmaceutical research

Suhre, K., Shin, S.-Y., Petersen, A.-K., Mohney, R. P., Meredith, D., Wägele, B., Altmaier, E., Deloukas, P., Erdmann, J., Grundberg, E., Hammond, C. J., de Angelis, M. H., Kastenmüller, G., Köttgen, A., Kronenberg, F., Mangino, M., Meisinger, C., Meitinger, T., Mewes, H.-W. & Milburn, M. V. & 14 others, Prehn, C., Raffler, J., Ried, J. S., Römisch-Margl, W., Samani, N. J., Small, K. S., Wichmann, H.-E., Zhai, G., Illig, T., Spector, T. D., Adamski, J., Soranzo, N., Gieger, C. & CARDIoGRAM, 1 Sept 2011, In: NATURE. 477, 7362, p. 54-60 7 p.

Research output: Contribution to journal › Article › peer-review

876 Citations (Scopus)

Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study

Panoutsopoulou, K., Southam, L., Elliott, K. S., Wrayner, N., Zhai, G., Beazley, C., Thorleifsson, G., Arden, N. K., Carr, A., Chapman, K., Deloukas, P., Doherty, M., McCaskie, A., Ollier, W. E. R., Ralston, S. H., Spector, T. D., Valdes, A. M., Wallis, G. A., Wilkinson, J. M. & Arden, E. & 55 others, Battley, K., Blackburn, H., Blanco, F. J., Bumpstead, S., Cupples, L. A., Day-Williams, A. G., Dixon, K., Doherty, S. A., Esko, T., Evangelou, E., Felson, D., Gomez-Reino, J. J., Gonzalez, A., Gordon, A., Gwilliam, R., Halldorsson, B. V., Hauksson, V. B., Hofman, A., Hunt, S. E., Ioannidis, J. P. A., Ingvarsson, T., Jonsdottir, I., Jonsson, H., Keen, R., Kerkhof, H. J. M., Kloppenburg, M. G., Koller, N., Lakenberg, N., Lane, N. E., Lee, A. T., Metspalu, A., Meulenbelt, I., Nevitt, M. C., O'Neill, F., Parimi, N., Potter, S. C., Rego-Perez, I., Riancho, J. A., Sherburn, K., Slagboom, P. E., Stefansson, K., Styrkarsdottir, U., Sumillera, M., Swift, D., Thorsteinsdottir, U., Tsezou, A., Uitterlinden, A. G., van Meurs, J. B. J., Watkins, B., Wheeler, M., Mitchell, S., Zhu, Y., Zmuda, J. M., Zeggini, E. & Loughlin, J., May 2011, In: Annals of the Rheumatic Diseases. 70, 5, p. 864 - 867 4 p.

Research output: Contribution to journal › Article › peer-review

103 Citations (Scopus)

Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis

Kerkhof, H. J. M., Doherty, M., Arden, N. K., Abramson, S. B., Attur, M., Bos, S. D., Cooper, C., Dennison, E. M., Doherty, S. A., Evangelou, E., Hart, D. J., Hofman, A., Javaid, K., Kerna, I., Kisand, K., Kloppenburg, M., Krasnokutsky, S., Maciewicz, R. A., Meulenbelt, I. & Muir, K. R. & 14 others, Rivadeneira, F., Samuels, J., Sezgin, M., Slagboom, E., Smith, A. J. P., Spector, T. D., Tamm, A., Tamm, A., Uitterlinden, A. G., Wheeler, M., Zhai, G., Zhang, W., van Meurs, J. B. J. & Valdes, A. M., Mar 2011, In: Osteoarthritis and Cartilage. 19, 3, p. 265 - 271 7 p.

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22

Evangelou, E., Valdes, A. M., Kerkhof, H. J. M., Styrkarsdottir, U., Zhu, Y., Meulenbelt, I., Lories, R. J., Karassa, F. B., Tylzanowski, P., Bos, S. D., Akune, T., Arden, N. K., Carr, A., Chapman, K., Cupples, L. A., Dai, J., Deloukas, P., Doherty, M., Doherty, S. & Engstrom, G. & 51 others, Gonzalez, A., Halldorsson, B. V., Hammond, C. L., Hart, D. J., Helgadottir, H., Hofman, A., Ikegawa, S., Ingvarsson, T., Jiang, Q., Jonsson, H., Kaprio, J., Kawaguchi, H., Kisand, K., Kloppenburg, M., Kujala, U. M., Lohmander, L. S., Loughlin, J., Luyten, F. P., Mabuchi, A., McCaskie, A., Nakajima, M., Nilsson, P. M., Nishida, N., Ollier, W. E. R., Panoutsopoulou, K., van de Putte, T., Ralston, S. H., Rivadeneira, F., Saarela, J., Schulte-Merker, S., Shi, D., Slagboom, P. E., Sudo, A., Tamm, A., Tamm, A., Thorleifsson, G., Thorsteinsdottir, U., Tsezou, A., Wallis, G. A., Wilkinson, J. M., Yoshimura, N., Zeggini, E., Zhai, G., Zhang, F., Jonsdottir, I., Uitterlinden, A. G., Felson, D. T., van Meurs, J. B., Stefansson, K., Ioannidis, J. P. A. & Spector, T. D., Feb 2011, In: Annals of the Rheumatic Diseases. 70, 2, p. 349 - 355 7 p.

Research output: Contribution to journal › Article › peer-review

117 Citations (Scopus)

2010

A Genome-Wide Association Study Identifies an Osteoarthritis Susceptibility Locus on Chromosome 7q22

Kerkhof, H. J. M., Lories, R. J., Meulenbelt, I., Jonsdottir, I., Valdes, A. M., Arp, P., Ingvarsson, T., Jhamai, M., Jonsson, H., Stolk, L., Thorleifsson, G., Zhai, G., Zhang, F., Zhu, Y., van der Breggen, R., Carr, A., Doherty, M., Doherty, S., Felson, D. T. & Gonzalez, A. & 22 others, Halldorsson, B. V., Hart, D. J., Hauksson, V. B., Hofman, A., Ioannidis, J. P. A., Kloppenburg, M., Lane, N. E., Loughlin, J., Luyten, F. P., Nevitt, M. C., Parimi, N., Pols, H. A. P., Rivadeneira, F., Slagboom, E. P., Styrkarsdottir, U., Tsezou, A., van de Putte, T., Zmuda, J., Spector, T. D., Stefansson, K., Uitterlinden, A. G. & van Meurs, J. B. J., Feb 2010, In: Arthritis & Rheumatism. 62, 2, p. 499 - 510 12 p.

Research output: Contribution to journal › Article › peer-review

186 Citations (Scopus)

A genome-wide perspective of genetic variation in human metabolism

Illig, T., Gieger, C., Zhai, G., Roemisch-Margl, W., Wang-Sattler, R., Prehn, C., Altmaier, E., Kastenmueller, G., Kato, B. S., Mewes, H.-W., Meitinger, T., de Angelis, M. H., Kronenberg, F., Soranzo, N., Wichmann, H.-E., Spector, T. D., Adamski, J. & Suhre, K., Feb 2010, In: Nature Genetics. 42, 2, p. 137 - U66 5 p.

Research output: Contribution to journal › Article › peer-review

569 Citations (Scopus)

An Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis-Related Traits

Hsu, Y.-H., Zillikens, M. C., Wilson, S. G., Farber, C. R., Demissie, S., Soranzo, N., Bianchi, E. N., Grundberg, E., Liang, L., Richards, J. B., Estrada, K., Zhou, Y., van Nas, A., Moffatt, M. F., Zhai, G., Hofman, A., van Meurs, J. B., Pols, H. A. P., Price, R. I. & Nilsson, O. & 10 others, Pastinen, T., Cupples, L. A., Lusis, A. J., Schadt, E. E., Ferrari, S., Uitterlinden, A. G., Rivadeneira, F., Spector, T. D., Karasik, D. & Kiel, D. P., 2010, In: PL o S Genetics. 6, 6, e1000977.

Research output: Contribution to journal › Article › peer-review

176 Citations (Scopus)

Association of JAG1 with Bone Mineral Density and Osteoporotic Fractures: A Genome-wide Association Study and Follow-up Replication Studies

Kung, A. W. C., Xiao, S.-M., Cherny, S., Li, G. H. Y., Gao, Y., Tso, G., Lau, K. S., Luk, K. D. K., Liu, J.-M., Cui, B., Zhang, M.-J., Zhang, Z.-L., He, J.-W., Yue, H., Xia, W.-B., Luo, L.-M., He, S.-L., Kiel, D. P., Karasik, D. & Hsu, Y.-H. & 13 others, Cupples, L. A., Demissie, S., Styrkarsdottir, U., Halldorsson, B. V., Sigurdsson, G., Thorsteinsdottir, U., Stefansson, K., Richards, J. B., Zhai, G., Soranzo, N., Valdes, A., Spector, T. D. & Sham, P. C., 12 Feb 2010, In: American Journal of Human Genetics. 86, 2, p. 229 - 239 11 p.

Research output: Contribution to journal › Article › peer-review

154 Citations (Scopus)

Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults

Dore, D., Martens, A., Quinn, S., Ding, C., Winzenberg, T., Zhai, G., Pelletier, J.-P., Martel-Pelletier, J., Abram, F., Cicuttini, F. & Jones, G., 29 Dec 2010, In: Arthritis Research and Therapy. 12, 6, R222.

Research output: Contribution to journal › Article › peer-review

96 Citations (Scopus)

Common genetic determinants of vitamin D insufficiency: a genome-wide association study

Wang, T. J., Zhang, F., Richards, J. B., Kestenbaum, B., van Meurs, J. B., Berry, D., Kiel, D. P., Streeten, E. A., Ohlsson, C., Koller, D. L., Peltonen, L., Cooper, J. D., O'Reilly, P., Houston, D. K., Glazer, N. L., Vandenput, L., Peacock, M., Shi, J., Rivadeneira, F. & McCarthy, M. I. & 56 others, Anneli, P., de Boer, I. H., Mangino, M., Kato, B., Smyth, D. J., Booth, S. L., Jacques, P. F., Burke, G. L., Goodarzi, M., Cheung, C.-L., Wolf, M., Rice, K., Goltzman, D., Hidiroglou, N., Ladouceur, M., Wareham, N. J., Hocking, L. J., Hart, D., Arden, N. K., Cooper, C., Malik, S., Fraser, W. D., Hartikainen, A.-L., Zhai, G., Macdonald, H. M., Forouhi, N. G., Loos, R. J. F., Reid, D. M., Hakim, A., Dennison, E., Liu, Y., Power, C., Stevens, H. E., Jaana, L., Vasan, R. S., Soranzo, N., Bojunga, J., Psaty, B. M., Lorentzon, M., Foroud, T., Harris, T. B., Hofman, A., Jonsson, J.-O., Cauley, J. A., Uitterlinden, A. G., Gibson, Q., Jarvelin, M.-R., Karasik, D., Siscovick, D. S., Econs, M. J., Kritchevsky, S. B., Florez, J. C., Todd, J. A., Dupuis, J., Hyppoenen, E. & Spector, T. D., 1 Jul 2010, In: The Lancet. 376, 9736, p. 180 - 188 9 p.

Research output: Contribution to journal › Article › peer-review

1388 Citations (Scopus)

Common variants near TERC are associated with mean telomere length

Codd, V., Mangino, M., van der Harst, P., Braund, P. S., Kaiser, M., Beveridge, A. J., Rafelt, S., Moore, J., Nelson, C., Soranzo, N., Zhai, G., Valdes, A. M., Blackburn, H., Leach, I. M., de Boer, R. A., Goodall, A. H., Ouwehand, W., van Veldhuisen, D. J., van Gilst, W. H. & Navis, G. & 6 others, Burton, P. R., Tobin, M. D., Hall, A. S., Thompson, J. R., Spector, T. & Samani, N. J., Mar 2010, In: Nature Genetics. 42, 3, p. 197 - 199 3 p.

Research output: Contribution to journal › Article › peer-review

293 Citations (Scopus)

Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults

Dore, D., Quinn, S., Ding, C., Winzenberg, T., Zhai, G., Cicuttini, F. & Jones, G., 29 Dec 2010, In: Arthritis Research and Therapy. 12, 6, R223.

Research output: Contribution to journal › Article › peer-review

117 Citations (Scopus)

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A. U., Wheeler, E., Glazer, N. L., Bouatia-Naji, N., Gloyn, A. L., Lindgren, C. M., Magi, R., Morris, A. P., Randall, J., Johnson, T., Elliott, P., Rybin, D., Thorleifsson, G., Steinthorsdottir, V. & Henneman, P. & 283 others, Grallert, H., Dehghan, A., Hottenga, J. J., Franklin, C. S., Navarro, P., Song, K., Goel, A., Perry, J. R. B., Egan, J. M., Lajunen, T., Grarup, N., Sparso, T., Doney, A., Voight, B. F., Stringham, H. M., Li, M., Kanoni, S., Shrader, P., Cavalcanti-Proenca, C., Kumari, M., Qi, L., Timpson, N. J., Gieger, C., Zabena, C., Rocheleau, G., Ingelsson, E., An, P., O'Connell, J., Luan, J., Elliott, A., McCarroll, S. A., Payne, F., Roccasecca, R. M., Pattou, F., Sethupathy, P., Ardlie, K., Ariyurek, Y., Balkau, B., Barter, P., Beilby, J. P., Ben-Shlomo, Y., Benediktsson, R., Bennett, A. J., Bergmann, S., Bochud, M., Boerwinkle, E., Bonnefond, A., Bonnycastle, L. L., Borch-Johnsen, K., Boettcher, Y., Brunner, E., Bumpstead, S. J., Charpentier, G., Chen, Y.-D. I., Chines, P., Clarke, R., Coin, L. J. M., Cooper, M. N., Cornelis, M., Crawford, G., Crisponi, L., Day, I. N. M., de Geus, E. J. C., Delplanque, J., Dina, C., Erdos, M. R., Fedson, A. C., Fischer-Rosinsky, A., Forouhi, N. G., Fox, C. S., Frants, R., Franzosi, M. G., Galan, P., Goodarzi, M. O., Graessler, J., Groves, C. J., Grundy, S., Gwilliam, R., Gyllensten, U., Hadjadj, S., Hallmans, G., Hammond, N., Han, X., Hartikainen, A.-L., Hassanali, N., Hayward, C., Heath, S. C., Hercberg, S., Herder, C., Hicks, A. A., Hillman, D. R., Hingorani, A. D., Hofman, A., Hui, J., Hung, J., Isomaa, B., Johnson, P. R. V., Jorgensen, T., Jula, A., Kaakinen, M., Kaprio, J., Kesaniemi, Y. A., Kivimaki, M., Knight, B., Koskinen, S., Kovacs, P., Kyvik, K. O., Lathrop, G. M., Lawlor, D. A., Le Bacquer, O., Lecoeur, C., Li, Y., Lyssenko, V., Mahley, R., Mangino, M., Manning, A. K., Teresa Martinez-Larrad, M., McAteer, J. B., McCulloch, L. J., McPherson, R., Meisinger, C., Melzer, D., Meyre, D., Mitchell, B. D., Morken, M. A., Mukherjee, S., Naitza, S., Narisu, N., Neville, M. J., Oostra, B. A., Orru, M., Pakyz, R., Palmer, C. N. A., Paolisso, G., Pattaro, C., Pearson, D., Peden, J. F., Pedersen, N. L., Perola, M., Pfeiffer, A. F. H., Pichler, I., Polasek, O., Posthuma, D., Potter, S. C., Pouta, A., Province, M. A., Psaty, B. M., Rathmann, W., Rayner, N. W., Rice, K., Ripatti, S., Rivadeneira, F., Roden, M., Rolandsson, O., Sandbaek, A., Sandhu, M., Sanna, S., Sayer, A. A., Scheet, P., Scott, L. J., Seedorf, U., Sharp, S. J., Shields, B., Sigurosson, G., Sijbrands, E. J. G., Silveira, A., Simpson, L., Singleton, A., Smith, N. L., Sovio, U., Swift, A., Syddall, H., Syvanen, A.-C., Tanaka, T., Thorand, B., Tichet, J., Tonjes, A., Tuomi, T., Uitterlinden, A. G., van Dijk, K. W., van Hoek, M., Varma, D., Visvikis-Siest, S., Vitart, V., Vogelzangs, N., Waeber, G., Wagner, P. J., Walley, A., Walters, G. B., Ward, K. L., Watkins, H., Weedon, M. N., Wild, S. H., Willemsen, G., Witteman, J. C. M., Yarnell, J. W. G., Zeggini, E., Zelenika, D., Zethelius, B., Zhai, G., Zhao, J. H., Zillikens, M. C., Borecki, I. B., Loos, R. J. F., Meneton, P., Magnusson, P. K. E., Nathan, D. M., Williams, G. H., Hattersley, A. T., Silander, K., Salomaa, V., Smith, G. D., Bornstein, S. R., Schwarz, P., Spranger, J., Karpe, F., Shuldiner, A. R., Cooper, C., Dedoussis, G. V., Serrano-Rios, M., Morris, A. D., Lind, L., Palmer, L. J., Hu, F. B., Franks, P. W., Ebrahim, S., Marmot, M., Kao, W. H. L., Pankow, J. S., Sampson, M. J., Kuusisto, J., Laakso, M., Hansen, T., Pedersen, O., Pramstaller, P. P., Wichmann, H. E., Illig, T., Rudan, I., Wright, A. F., Stumvoll, M., Campbell, H., Wilson, J. F., Bergman, R. N., Buchanan, T. A., Collins, F. S., Mohlke, K. L., Tuomilehto, J., Valle, T. T., Altshuler, D., Rotter, J. I., Siscovick, D. S., Penninx, B. W. J. H., Boomsma, D. I., Deloukas, P., Spector, T. D., Frayling, T. M., Ferrucci, L., Kong, A., Thorsteinsdottir, U., Stefansson, K., van Duijn, C. M., Aulchenko, Y. S., Cao, A., Scuteri, A., Schlessinger, D., Uda, M., Ruokonen, A., Jarvelin, M.-R., Waterworth, D. M., Vollenweider, P., Peltonen, L., Mooser, V., Abecasis, G. R., Wareham, N. J., Sladek, R., Froguel, P., Watanabe, R. M., Meigs, J. B., Groop, L., Boehnke, M., McCarthy, M. I., Florez, J. C. & Barroso, I., Feb 2010, In: Nature Genetics. 42, 2, p. 105 - U32 12 p.

Research output: Contribution to journal › Article › peer-review

1830 Citations (Scopus)

Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis

Zhai, G., Wang-Sattler, R., Hart, D. J., Arden, N. K., Hakim, A. J., Illig, T. & Spector, T. D., Jun 2010, In: Annals of the Rheumatic Diseases. 69, 6, p. 1227 - 1231 5 p.

Research output: Contribution to journal › Article › peer-review

157 Citations (Scopus)

THE arcOGEN CONSORTIUM: STAGE 1 OF A GENOME-WIDE ASSOCIATION SCAN FOR OSTEOARTHRITIS

Panoutsopoulou, K., Southam, L., Rayner, W., Zhai, G., Beazley, C., Arden, N., Carr, A., Chapman, K., Deloukas, P., Doherty, M., McCaskie, A., Olher, W., Ralston, S., Spector, T., Valdes, A., Wallis, G., Wilkinson, M., Arden, E., Battley, K. & Blackburn, H. & 46 others, Blanco, F., Bumpstead, S., Cupples, A., Day-Williams, A., Dixon, K., Dohertys, S., Elliott, K., Evangelou, E., Felson, D., Gomez-Reino, J., Gonzalez, A., Gordon, A., Gwilliam, R., Hofman, A., Hunt, S., Ioannidis, J., Jonsdottir, I., Keen, R., Kerkhof, H., Kloppenburg, M., Koller, N., Lakenberg, N., Lane, N., Lee, A., Meulenbelt, I., Nevitt, M., O'Neill, F., Parimi, N., Potter, S., Rego-Perez, I., Riancho, J., Sherburn, K., Slagboom, E., Styrkarsdottir, U., Sumillera, M., Swift, D., Tsezou, A., Uitterlinden, A., van Meurs, J., Watkins, B., Wheeler, M., Mitchelle, S., Zhu, Y., Zmuda, J., Zeggini, E. & Loughlin, J., 2010, In: Osteoarthritis and Cartilage. 18, p. S166 - S167

Research output: Contribution to journal › Meeting abstract

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Elks, C. E., Perry, J. R. B., Sulem, P., Chasman, D. I., Franceschini, N., He, C., Lunetta, K. L., Visser, J. A., Byrne, E. M., Cousminer, D. L., Gudbjartsson, D. F., Esko, T., Feenstra, B., Hottenga, J.-J., Koller, D. L., Kutalik, Z., Lin, P., Mangino, M., Marongiu, M. & McArdle, P. F. & 154 others, Smith, A. V., Stolk, L., Van Wingerden, S. H., Zhao, J. H., Albrecht, E., Corre, T., Ingelsson, E., Hayward, C., Magnusson, P. K. E., Smith, E. N., Ulivi, S., Warrington, N. M., Zgaga, L., Alavere, H., Amin, N., Aspelund, T., Bandinelli, S., Barroso, I., Berenson, G. S., Bergmann, S., Blackburn, H., Boerwinkle, E., Buring, J. E., Busonero, F., Campbell, H., Chanock, S. J., Chen, W., Cornelis, M. C., Couper, D., Coviello, A. D., d'Adamo, P., de Faire, U., de Geus, E. J. C., Deloukas, P., Doering, A., Smith, G. D., Easton, D. F., Eiriksdottir, G., Emilsson, V., Eriksson, J., Ferrucci, L., Folsom, A. R., Foroud, T., Garcia, M., Gasparini, P., Geller, F., Gieger, C., Gudnason, V., Hall, P., Hankinson, S. E., Ferreli, L., Heath, A. C., Hernandez, D. G., Hofman, A., Hu, F. B., Illig, T., Jaervelin, M.-R., Johnson, A. D., Karasik, D., Khaw, K.-T., Kiel, D. P., Kilpelaeinen, T. O., Kolcic, I., Kraft, P., Launer, L. J., Laven, J. S. E., Li, S., Liu, J., Levy, D., Martin, N. G., McArdle, W. L., Melbye, M., Mooser, V., Murray, J. C., Murray, S. S., Nalls, M. A., Navarro, P., Nelis, M., Ness, A. R., Northstone, K., Oostra, B. A., Peacock, M., Palmer, L. J., Palotie, A., Pare, G., Parker, A. N., Pedersen, N. L., Peltonen, L., Pennell, C. E., Pharoah, P., Polasek, O., Plump, A. S., Pouta, A., Porcu, E., Rafnar, T., Rice, J. P., Ring, S. M., Rivadeneira, F., Rudan, I., Sala, C., Salomaa, V., Sanna, S., Schlessinger, D., Schork, N. J., Scuteri, A., Segre, A. V., Shuldiner, A. R., Soranzo, N., Sovio, U., Srinivasan, S. R., Strachan, D. P., Tammesoo, M.-L., Tikkanen, E., Toniolo, D., Tsui, K., Tryggvadottir, L., Tyrer, J., Uda, M., van Dam, R. M., van Meurs, J. B. J., Vollenweider, P., Waeber, G., Wareham, N. J., Waterworth, D. M., Weedon, M. N., Wichmann, H. E., Willemsen, G., Wilson, J. F., Wright, A. F., Young, L., Zhai, G., Zhuang, W. V., Bierut, L. J., Boomsma, D. I., Boyd, H. A., Crisponi, L., Demerath, E. W., van Duijn, C. M., Econs, M. J., Harris, T. B., Hunter, D. J., Loos, R. J. F., Metspalu, A., Montgomery, G. W., Ridker, P. M., Spector, T. D., Streeten, E. A., Stefansson, K., Thorsteinsdottir, U., Uitterlinden, A. G., Widen, E., Murabito, J. M., Ong, K. K. & Murray, A., Dec 2010, In: Nature Genetics. 42, 12, p. 1077 - U73 9 p.

Research output: Contribution to journal › Article › peer-review

440 Citations (Scopus)

2009

A genome-wide association study identifies a common variant near the GRP22 gene as a new locus involved in prevalence and progression of osteoarthritis

Kerkhof, H. J. M., Jonsdottir, I., Meulenbelt, I., Stolk, L., Valdes, A. M., Zhai, G., Zhu, Y., Doherty, M., Doherty, S., Tsezou, A., Gonzalez, A., Carr, A., Felson, D. T., Styrkarsdottir, U., Slagboom, E. P., Loughlin, J., Rivadeneira, F., Hofman, A., Pols, H. A. P. & Spector, T. D. & 2 others, Uitterlinden, A. G. & van Meurs, J. B. J., 2009, In: Bone. 44, 2, p. S224 - S224

Research output: Contribution to journal › Meeting abstract

A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length

Mangino, M., Richards, J. B., Soranzo, N., Zhai, G., Aviv, A., Valdes, A. M., Samani, N. J., Deloukas, P. & Spector, T. D., Jul 2009, In: Journal of Medical Genetics. 46, 7, p. 451 - 454 4 p.

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium

Zhai, G., van Meurs, J. B. J., Livshits, G., Meulenbelt, I., Valdes, A. M., Soranzo, N., Hart, D., Zhang, F., Kato, B. S., Richards, J. B., Williams, F. M. K., Inouye, M., Kloppenburg, M., Deloukas, P., Slagboom, E., Uitterlinden, A. & Spector, T. D., Sept 2009, In: Journal of Medical Genetics. 46, 9, p. 614 - 616 3 p.

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

An Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis Related Traits

Hsu, Y.-H., Zillikens, M. C., Wilson, S. G., Farber, C. R., Demissie, S., Bianchi, E. N., Liang, L., Richards, J. B., Estrada, K., Zhou, Y., Soranzo, N., van Nas, A., Moffatt, M. F., Zhai, G., Hofman, A., van Meurs, J. B., Price, R. I., Cupples, L. A., Lusis, A. J. & Schadt, E. E. & 6 others, Ferrari, S., Uitterlinden, A. G., Rivadeneira, F., Spector, T. D., Karasik, D. & Kiel, D. P., 2009, In: Genetic Epidemiology. 33, 8, p. 752 - 753 2 p.

Research output: Contribution to journal › Meeting abstract

Common variants in the region around Osterix are associated with bone mineral density and growth in childhood

Timpson, N. J., Tobias, J. H., Richards, J. B., Soranzo, N., Duncan, E. L., Sims, A.-M., Whittaker, P., Kumanduri, V., Zhai, G., Glaser, B., Eisman, J., Jones, G., Nicholson, G., Prince, R., Seeman, E., Spector, T. D., Brown, M. A., Peltonen, L., Smith, G. D. & Deloukas, P. & 1 others, Evans, D. M., 2009, In: Human Molecular Genetics. 18, 8, p. 1510 - 1517 8 p.

Research output: Contribution to journal › Article › peer-review

109 Citations (Scopus)

Effective measurements of knee alignment using AP knee radiographs

Colebatch, A., Hart, D., Zhai, G., Williams, F., Spector, T. & Arden, N., Jan 2009, In: Knee. 16, 1, p. 42 - 45 4 p.

Research output: Contribution to journal › Article › peer-review

100 Citations (Scopus)

Genetic and environmental determinants on bone loss in postmenopausal Caucasian women: a 14-year longitudinal twin study

Zhai, G., Andrew, T., Kato, B. S., Blake, G. M. & Spector, T. D., Jun 2009, In: Osteoporosis International. 20, 6, p. 949 - 953 5 p.

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Interleukin-6 Is a Significant Predictor of Radiographic Knee Osteoarthritis The Chingford Study

Livshits, G., Zhai, G., Hart, D. J., Kato, B. S., Wang, H., Williams, F. M. K. & Spector, T. D., Jul 2009, In: Arthritis & Rheumatism. 60, 7, p. 2037 - 2045 9 p.

Research output: Contribution to journal › Article › peer-review

341 Citations (Scopus)

Loci at chromosomes 13, 19 and 20 influence age at natural menopause

Stolk, L., Zhai, G., van Meurs, J. B. J., Verbiest, M. M. P. J., Visser, J. A., Estrada, K., Rivadeneira, F., Williams, F. M., Cherkas, L., Deloukas, P., Soranzo, N., de Keyzer, J. J., Pop, V. J. M., Lips, P., Lebrun, C. E. I., van der Schouw, Y. T., Grobbee, D. E., Witteman, J., Hofman, A. & Pols, H. A. P. & 3 others, Laven, J. S. E., Spector, T. D. & Uitterlinden, A. G., Jun 2009, In: Nature Genetics. 41, 6, p. 645 - 647 3 p.

Research output: Contribution to journal › Article › peer-review

147 Citations (Scopus)

Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

Perry, J. R. B., Stolk, L., Franceschini, N., Lunetta, K. L., Zhai, G., McArdle, P. F., Smith, A. V., Aspelund, T., Bandinelli, S., Boerwinkle, E., Cherkas, L., Eiriksdottir, G., Estrada, K., Ferrucci, L., Folsom, A. R., Garcia, M., Gudnason, V., Hofman, A., Karasik, D. & Kiel, D. P. & 19 others, Launer, L. J., van Meurs, J., Nalls, M. A., Rivadeneira, F., Shuldiner, A. R., Singleton, A., Soranzo, N., Tanaka, T., Visser, J. A., Weedon, M. N., Wilson, S. G., Zhuang, V., Streeten, E. A., Harris, T. B., Murray, A., Spector, T. D., Demerath, E. W., Uitterlinden, A. G. & Murabito, J. M., Jun 2009, In: Nature Genetics. 41, 6, p. 648 - 650 3 p.

Research output: Contribution to journal › Article › peer-review

253 Citations (Scopus)

2008

A genome-wide association study reveals a novel locus for hand osteoarthritis

Zhai, G., van Meurs, J., Valdes, A., Hart, D., Livshits, G., Inouye, M., Soranzo, N., Deloukas, P., Uitterlinden, A. & Spector, T., 2008, In: Osteoarthritis and Cartilage. 16, p. S31 - S31

Research output: Contribution to journal › Meeting abstract

Association between leptin, body composition, sex and knee cartilage morphology in older adults: the Tasmanian older adult cohort (TASOAC) study

Ding, C., Parameswaran, V., Cicuttini, F., Burgess, J., Zhai, G., Quinn, S. & Jones, G., Sept 2008, In: Annals of the Rheumatic Diseases. 67, 9, p. 1256 - 1261 6 p.

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study: a genome-wide association study

Richards, J. B., Rivadeneira, F., Inouye, M., Pastinen, T. M., Soranzo, N., Wilson, S. G., Andrew, T., Falchi, M., Gwilliam, R., Ahmadi, K. R., Valdes, A. M., Arp, P., Whittaker, P., Verlaan, D. J., Jhamai, M., Kumanduri, V., Moorhouse, M., van Meurs, J. B., Hofman, A. & Pols, H. A. P. & 8 others, Hart, D., Zhai, G., Kato, B. S., Mullin, B. H., Zhang, F., Deloukas, P., Uitterlinden, A. G. & Spector, T. D., 3 May 2008, In: The Lancet. 371, 9623, p. 1505-12 8 p.

Research output: Contribution to journal › Article › peer-review

590 Citations (Scopus)

Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis

Valdes, A. M., Loughlin, J., Timms, K. M., van Meurs, J. J. B., Southam, L., Wilson, S. G., Doherty, S., Lories, R. J., Luyten, F. P., Gutin, A., Abkevich, V., Ge, D., Hofman, A., Uitterlinden, A. G., Hart, D. J., Zhang, F., Zhai, G., Egli, R. J., Doherty, M. & Lanchbury, J. & 1 others, Spector, T. D., 6 Jun 2008, In: American Journal of Human Genetics. 82, 6, p. 1231 - 1240 10 p.

Research output: Contribution to journal › Article › peer-review