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Guangju Zhai

Dr

  • 12586
    Citations

Search results

  • 2014

    Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies

    Rodriguez-Fontenla, C., Calaza, M., Evangelou, E., Valdes, A. M., Arden, N., Blanco, F. J., Carr, A., Chapman, K., Deloukas, P., Doherty, M., Esko, T., Garcés Aletá, C. M., Gomez-Reino Carnota, J. J., Helgadottir, H., Hofman, A., Jonsdottir, I., Kerkhof, H. J. M., Kloppenburg, M., McCaskie, A., Ntzani, E. E., & 27 othersOllier, W. E. R., Oreiro, N., Panoutsopoulou, K., Ralston, S. H., Ramos, Y. F., Riancho, J. A., Rivadeneira, F., Slagboom, P. E., Styrkarsdottir, U., Thorsteinsdottir, U., Thorleifsson, G., Tsezou, A., Uitterlinden, A. G., Wallis, G. A., Wilkinson, J. M., Zhai, G., Zhu, Y., Felson, D. T., Ioannidis, J. P. A., Loughlin, J., Metspalu, A., Meulenbelt, I., Stefansson, K., Van Meurs, J. B., Zeggini, E., Spector, T. D. & Gonzalez, A., 2014, In: Arthritis and Rheumatology. 66, 4, p. 940-949 10 p.

    Research output: Contribution to journalArticlepeer-review

    91 Citations (Scopus)
  • Interrogating causal pathways linking genetic variants, small molecule metabolites, and circulating lipids

    Shin, S. Y., Petersen, A. K., Wahl, S., Zhai, G., Römisch-Margl, W., Small, K. S., Döring, A., Kato, B. S., Peters, A., Grundberg, E., Prehn, C., Wang-Sattler, R., Wichmann, H. E., de Angelis, M. H., Illig, T., Adamski, J., Deloukas, P., Spector, T. D., Suhre, K., Gieger, C., & 1 othersSoranzo, N., 28 Mar 2014, In: Genome medicine. 6, 3, 16 p., 25.

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)
  • 2013

    A Meta-Analysis of Thyroid-Related Traits Reveals Novel Loci and Gender-Specific Differences in the Regulation of Thyroid Function

    Porcu, E., Medici, M., Pistis, G., Volpato, C. B., Wilson, S. G., Cappola, A. R., Bos, S. D., Deelen, J., den Heijer, M., Freathy, R. M., Lahti, J., Liu, C., Lopez, L. M., Nolte, I. M., O'Connell, J. R., Tanaka, T., Trompet, S., Arnold, A., Bandinelli, S., Beekman, M., & 74 othersBohringer, S., Brown, S. J., Buckley, B. M., Camaschella, C., de Craen, A. J. M., Davies, G., de Visser, M. C. H., Ford, I., Forsen, T., Frayling, T. M., Fugazzola, L., Goegele, M., Hattersley, A. T., Hermus, A. R., Hofman, A., Houwing-Duistermaat, J. J., Jensen, R. A., Kajantie, E., Kloppenburg, M., Lim, E. M., Masciullo, C., Mariotti, S., Minelli, C., Mitchell, B. D., Nagaraja, R., Netea-Maier, R. T., Palotie, A., Persani, L., Piras, M. G., Psaty, B. M., Raikkonen, K., Richards, J. B., Rivadeneira, F., Sala, C., Sabra, M. M., Sattar, N., Shields, B. M., Soranzo, N., Starr, J. M., Stott, D. J., Sweep, F. C. G. J., Usala, G., van der Klauw, M. M., van Heemst, D., van Mullem, A., Vermeulen, S. H., Visser, W. E., Walsh, J. P., Westendorp, R. G. J., Widen, E., Zhai, G., Cucca, F., Deary, I. J., Eriksson, J. G., Ferrucci, L., Fox, C. S., Jukema, J. W., Kiemeney, L. A., Pramstaller, P. P., Schlessinger, D., Shuldiner, A. R., Slagboom, E. P., Uitterlinden, A. G., Vaidya, B., Visser, T. J., Wolffenbuttel, B. H. R., Meulenbelt, I., Rotter, J. I., Spector, T. D., Hicks, A. A., Toniolo, D., Sanna, S., Peeters, R. P. & Naitza, S., 7 Feb 2013, In: PL o S Genetics. 9, 2, p. N/A 20 p., e1003266.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    177 Citations (Scopus)
  • Association of Adiposity Genetic Variants With Menarche Timing in 92,105 Women of European Descent

    Fernandez-Rhodes, L., Demerath, E. W., Cousminer, D. L., Tao, R., Dreyfus, J. G., Esko, T., Smith, A. V., Gudnason, V., Harris, T. B., Launer, L., McArdle, P. F., Yerges-Armstrong, L. M., Elks, C. E., Strachan, D. P., Kutalik, Z., Vollenweider, P., Feenstra, B., Boyd, H. A., Metspalu, A., Mihailov, E., & 55 othersBroer, L., Zillikens, M. C., Oostra, B., van Duijn, C. M., Lunetta, K. L., Perry, J. R. B., Murray, A., Koller, D. L., Lai, D., Corre, T., Toniolo, D., Albrecht, E., Stoeckl, D., Grallert, H., Gieger, C., Hayward, C., Polasek, O., Rudan, I., Wilson, J. F., He, C., Kraft, P., Hu, F. B., Hunter, D. J., Hottenga, J-J., Willemsen, G., Boomsma, D. I., Byrne, E. M., Martin, N. G., Montgomery, G. W., Warrington, N. M., Pennell, C. E., Stolk, L., Visser, J. A., Hofman, A., Uitterlinden, A. G., Rivadeneira, F., Lin, P., Fisher, S. L., Bierut, L. J., Crisponi, L., Porcu, E., Mangino, M., Zhai, G., Spector, T. D., Buring, J. E., Rose, L. M., Ridker, P. M., Poole, C., Hirschhorn, J. N., Murabito, J. M., Chasman, D. I., Widen, E., North, K. E., Ong, K. K. & Franceschini, N., 1 Aug 2013, In: American Journal of Epidemiology. 178, 3, p. 451-460 10 p., N/A.

    Research output: Contribution to journalArticlepeer-review

    52 Citations (Scopus)
  • Targeted metabolomics profiles are strongly correlated with nutritional patterns in women

    Menni, C., Zhai, G., Macgregor, A., Prehn, C., Römisch-Margl, W., Suhre, K., Adamski, J., Cassidy, A., Illig, T., Spector, T. D. & Valdes, A. M., Apr 2013, In: Metabolomics. 9, 2, p. 506-514 9 p., N/A.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    99 Citations (Scopus)
  • 2012

    A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone-Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

    Coviello, A. D., Haring, R., Wellons, M., Vaidya, D., Lehtimaki, T., Keildson, S., Lunetta, K. L., He, C., Fornage, M., Lagou, V., Mangino, M., Onland-Moret, N. C., Chen, B., Eriksson, J., Garcia, M., Mei, Y., Koster, A., Lohman, K., Lyytikainen, L-P., Petersen, A-K., & 79 othersPrescott, J., Stolk, L., Vandenput, L., Wood, A. R., Zhuang, W. V., Ruokonen, A., Hartikainen, A-L., Pouta, A., Bandinelli, S., Biffar, R., Brabant, G., Cox, D. G., Chen, Y., Cummings, S., Ferrucci, L., Gunter, M. J., Hankinson, S. E., Martikainen, H., Hofman, A., Homuth, G., Illig, T., Jansson, J-O., Johnson, A. D., Karasik, D., Karlsson, M., Kettunen, J., Kiel, D. P., Kraft, P., Liu, J., Ljunggren, O., Lorentzon, M., Maggio, M., Markus, M. R. P., Mellstrom, D., Miljkovic, I., Mirel, D., Nelson, S., Papunen, L. M., Peeters, P. H. M., Prokopenko, I., Raffel, L., Reincke, M., Reiner, A. P., Rexrode, K., Rivadeneira, F., Schwartz, S. M., Siscovick, D., Soranzo, N., Stockl, D., Tworoger, S., Uitterlinden, A. G., van Gils, C. H., Vasan, R. S., Wichmann, H. -E., Zhai, G., Bhasin, S., Bidlingmaier, M., Chanock, S. J., De Vivo, I., Harris, T. B., Hunter, D. J., Kahonen, M., Liu, S., Ouyang, P., Spector, T. D., van der Schouw, Y. T., Viikari, J., Wallaschofski, H., McCarthy, M. I., Frayling, T. M., Murray, A., Franks, S., Jarvelin, M-R., de Jong, F. H., Raitakari, O., Teumer, A., Ohlsson, C., Murabito, J. M. & Perry, J. R. B., 19 Jul 2012, In: PL o S Genetics. 8, 7, p. N/A 12 p., e1002805.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    132 Citations (Scopus)
  • Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population

    Bell, J. T., Tsai, P-C., Yang, T-P., Pidsley, R., Nisbet, J., Glass, D., Mangino, M., Zhai, G., Zhang, F., Valdes, A., Shin, S-Y., Dempster, E. L., Murray, R. M., Grundberg, E., Hedman, A. K., Nica, A., Small, K. S., Dermitzakis, E. T., McCarthy, M. I., Mill, J., & 3 othersSpector, T. D., Deloukas, P. & MuTHER Consortium, Apr 2012, In: PL o S Genetics. 8, 4, p. 189-200 12 p., e1002629.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    545 Citations (Scopus)
  • Human serum metabolic profiles are age dependent

    Yu, Z., Zhai, G., Singmann, P., He, Y., Xu, T., Prehn, C., Roemisch-Margl, W., Lattka, E., Gieger, C., Soranzo, N., Heinrich, J., Standl, M., Thiering, E., Mittelstrass, K., Wichmann, H-E., Peters, A., Suhre, K., Li, Y., Adamski, J., Spector, T. D., & 2 othersIllig, T. & Wang-Sattler, R., Dec 2012, In: AGING CELL. 11, 6, p. 960-967 8 p., N/A.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    238 Citations (Scopus)
  • Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study

    Zeggini, E., Panoutsopoulou, K., Southam, L., Rayner, N. W., Day-Williams, A. G., Lopes, M. C., Boraska, V., Esko, T., Evangelou, E., Hofman, A., Houwing-Duistermaat, J. J., Ingvarsson, T., Jonsdottir, I., Jonsson, H., Kerkhof, H. J. M., Kloppenburg, M., Bos, S. D., Mangino, M., Metrustry, S., Slagboom, P. E., & 31 othersThorleifsson, G., Raine, E. V. A., Ratnayake, M., Ricketts, M., Beazley, C., Blackburn, H., Bumpstead, S., Elliott, K. S., Hunt, S. E., Potter, S. C., Shin, S-Y., Yadav, V. K., Zhai, G., Sherburn, K., Dixon, K., Arden, E., Aslam, N., Battley, P-K., Carluke, I., Doherty, S., Gordon, A., Joseph, J., Keen, R., Koller, N. C., Mitchell, S., O'Neill, F., Paling, E., Reed, M. R., Valdes, A. M., Spector, T. D. & arcOGEN Consortium & arcOGEN Colla, 1 Sept 2012, In: The Lancet. 380, 9844, p. 815-823 9 p.

    Research output: Contribution to journalArticlepeer-review

    310 Citations (Scopus)
  • Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

    Stolk, L., Perry, J. R. B., Chasman, D. I., He, C., Mangino, M., Sulem, P., Barbalic, M., Broer, L., Byrne, E. M., Ernst, F., Esko, T., Franceschini, N., Gudbjartsson, D. F., Hottenga, J-J., Kraft, P., McArdle, P. F., Porcu, E., Shin, S-Y., Smith, A. V., van Wingerden, S., & 159 othersZhai, G., Zhuang, W. V., Albrecht, E., Alizadeh, B. Z., Aspelund, T., Bandinelli, S., Lauc, L. B., Beckmann, J. S., Boban, M., Boerwinkle, E., Broekmans, F. J., Burri, A., Campbell, H., Chanock, S. J., Chen, C., Cornelis, M. C., Corre, T., Coviello, A. D., d'Adamo, P., Davies, G., de Faire, U., de Geus, E. J. C., Deary, I. J., Dedoussis, G. V. Z., Deloukas, P., Ebrahim, S., Eiriksdottir, G., Emilsson, V., Eriksson, J. G., Fauser, B. C. J. M., Ferreli, L., Ferrucci, L., Fischer, K., Folsom, A. R., Garcia, M. E., Gasparini, P., Gieger, C., Glazer, N., Grobbee, D. E., Hall, P., Haller, T., Hankinson, S. E., Hass, M., Hayward, C., Heath, A. C., Hofman, A., Ingelsson, E., Janssens, A. C. J. W., Johnson, A. D., Karasik, D., Kardia, S. L. R., Keyzer, J., Kiel, D. P., Kolcic, I., Kutalik, Z., Lahti, J., Lai, S., Laisk, T., Laven, J. S. E., Lawlor, D. A., Liu, J., Lopez, L. M., Louwers, Y. V., Magnusson, P. K. E., Marongiu, M., Martin, N. G., Klaric, I. M., Masciullo, C., McKnight, B., Medland, S. E., Melzer, D., Mooser, V., Navarro, P., Newman, A. B., Nyholt, D. R., Onland-Moret, N. C., Palotie, A., Pare, G., Parker, A. N., Pedersen, N. L., Peeters, P. H. M., Pistis, G., Plump, A. S., Polasek, O., Pop, V. J. M., Psaty, B. M., Raikkonen, K., Rehnberg, E., Rotter, J. I., Rudan, I., Sala, C., Salumets, A., Scuteri, A., Singleton, A., Smith, J. A., Snieder, H., Soranzo, N., Stacey, S. N., Starr, J. M., Stathopoulou, M. G., Stirrups, K., Stolk, R. P., Styrkarsdottir, U., Sun, Y. V., Tenesa, A., Thorand, B., Toniolo, D., Tryggvadottir, L., Tsui, K., Ulivi, S., van Dam, R. M., van der Schouw, Y. T., van Gils, C. H., van Nierop, P., Vink, J. M., Visscher, P. M., Voorhuis, M., Waeber, G., Wallaschofski, H., Wichmann, H. E., Widen, E., Wijnands-van Gent, C. J. M., Willemsen, G., Wilson, J. F., Wolffenbuttel, B. H. R., Wright, A. F., Yerges-Armstrong, L. M., Zemunik, T., Zgaga, L., Zillikens, M. C., Zygmunt, M., Arnold, A. M., Boomsma, D. I., Buring, J. E., Crisponi, L., Demerath, E. W., Gudnason, V., Harris, T. B., Hu, F. B., Hunter, D. J., Launer, L. J., Metspalu, A., Montgomery, G. W., Oostra, B. A., Ridker, P. M., Sanna, S., Schlessinger, D., Spector, T. D., Stefansson, K., Streeten, E. A., Thorsteinsdottir, U., Uda, M., Uitterlinden, A. G., van Duijn, C. M., Voelzke, H., Murray, A., Murabito, J. M., Visser, J. A. & Lunetta, K. L., Mar 2012, In: Nature Genetics. 44, 3, p. 260 - U55 9 p.

    Research output: Contribution to journalArticlepeer-review

    282 Citations (Scopus)
  • Serum Metabolite Concentrations and Decreased GFR in the General Population

    Goek, O-N., Doering, A., Gieger, C., Heier, M., Koenig, W., Prehn, C., Roemisch-Margl, W., Wang-Sattler, R., Illig, T., Suhre, K., Sekula, P., Zhai, G., Adamski, J., Koettgen, A. & Meisinger, C., Aug 2012, In: American Journal of Kidney Diseases. 60, 2, p. 197-206 10 p.

    Research output: Contribution to journalArticlepeer-review

    95 Citations (Scopus)
  • 2011

    A Comprehensive Evaluation of Potential Lung Function Associated Genes in the SpiroMeta General Population Sample

    Obeidat, M., Wain, L. V., Shrine, N., Kalsheker, N., Artigas, M. S., Repapi, E., Burton, P. R., Johnson, T., Ramasamy, A., Zhao, J. H., Zhai, G., Huffman, J. E., Vitart, V., Albrecht, E., Igl, W., Hartikainen, A-L., Pouta, A., Cadby, G., Hui, J., Palmer, L. J., & 44 othersHadley, D., McArdle, W. L., Rudnicka, A. R., Barroso, I., Loos, R. J. F., Wareham, N. J., Mangino, M., Soranzo, N., Spector, T. D., Glaeser, S., Homuth, G., Voelzke, H., Deloukas, P., Granell, R., Henderson, J., Grkovic, I., Jankovic, S., Zgaga, L., Polasek, O., Rudan, I., Wright, A. F., Campbell, H., Wild, S. H., Wilson, J. F., Heinrich, J., Imboden, M., Probst-Hensch, N. M., Gyllensten, U., Johansson, A., Zaboli, G., Mustelin, L., Rantanen, T., Surakka, I., Kaprio, J., Jarvelin, M-R., Hayward, C., Evans, D. M., Koch, B., Musk, A. W., Elliott, P., Strachan, D. P., Tobin, M. D., Sayers, I. & Hall, I. P., 2011, In: PL o S One . 6, 5, e19382.

    Research output: Contribution to journalArticlepeer-review

    50 Citations (Scopus)
  • Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study

    Fox, E. R., Young, J. H., Li, Y., Dreisbach, A. W., Keating, B. J., Musani, S. K., Liu, K., Morrison, A. C., Ganesh, S., Kutlar, A., Ramachandran, V. S., Polak, J. F., Fabsitz, R. R., Dries, D. L., Farlow, D. N., Redline, S., Adeyemo, A., Hirschorn, J. N., Sun, Y. V., Wyatt, S. B., & 347 othersPenman, A. D., Palmas, W., Rotter, J. I., Townsend, R. R., Doumatey, A. P., Tayo, B. O., Mosley, T. H., Lyon, H. N., Kang, S. J., Rotimi, C. N., Cooper, R. S., Franceschini, N., Curb, J. D., Martin, L. W., Eaton, C. B., Kardia, S. L. R., Taylor, H. A., Caulfield, M. J., Ehret, G. B., Johnson, T., Munroe, P. B., Rice, K. M., Bochud, M., Johnson, A. D., Chasman, D. I., Smith, A. V., Tobin, M. D., Verwoert, G. C., Hwang, S., Pihur, V., Vollenweider, P., O'reilly, P. F., Amin, N., Bragg-gresham, J. L., Teumer, A., Glazer, N. L., Launer, L., Zhao, J. H., Aulchenko, Y., Heath, S., Sober, S., Parsa, A., Luan, J., Arora, P., Dehghan, A., Zhang, F., Lucas, G., Hicks, A. A., Jackson, A. U., Peden, J. F., Tanaka, T., Wild, S. H., Rudan, I., Igl, W., Milaneschi, Y., Parker, A. N., Fava, C., Chambers, J. C., Kumari, M., Jingo, M., Van Der Harst, P., Kao, W. H. L., Sjogren, M., Vinay, D. G., Alexander, M., Tabara, Y., Shaw-hawkins, S., Whincup, P. H., Liu, Y., Shi, G., Kuusisto, J., Seielstad, M., Sim, X., Nguyen, K. H., Lehtimaki, T., Matullo, G., Wu, Y., Gaunt, T. R., Charlotte Onland-moret, N., Cooper, M. N., Platou, C. G. P., Org, E., Hardy, R., Dahgam, S., Palmen, J., Vitart, V., Braund, P. S., Kuznetsova, T., Uiterwaal, C. S. P. M., Campbell, H., Ludwig, B., Tomaszewski, M., Tzoulaki, I., Palmer, N. D., Aspelund, T., Garcia, M., Chang, Y. C., O'connell, J. R., Steinle, N. I., Grobbee, D. E., Arking, D. E., Hernandez, D., Najjar, S., Mcardle, W. L., Hadley, D., Brown, M. J., Connell, J. M., Hingorani, A. D., Day, I. N. M., Lawlor, D. A., Beilby, J. P., Lawrence, R. W., Clarke, R., Collins, R., Hopewell, J. C., Ongen, H., Bis, J. C., Kahonen, M., Viikari, J., Adair, L. S., Lee, N. R., Chen, M., Olden, M., Pattaro, C., Hoffman Bolton, J. A., Kottgen, A., Bergmann, S., Mooser, V., Chaturvedi, N., Frayling, T. M., Islam, M., Jafar, T. H., Erdmann, J., Kulkarni, S. R., Bornstein, S. R., Grassler, J., Groop, L., Voight, B. F., Kettunen, J., Howard, P., Taylor, A., Guarrera, S., Ricceri, F., Emilsson, V., Plump, A., Barroso, I., Khaw, K., Weder, A. B., Hunt, S. C., Bergman, R. N., Collins, F. S., Bonnycastle, L. L., Scott, L. J., Stringham, H. M., Peltonen, L., Perola, M., Vartiainen, E., Brand, S., Staessen, J. A., Wang, T. J., Burton, P. R., Solerartigas, M., Dong, Y., Snieder, H., Wang, X., Zhu, H., Lohman, K. K., Rudock, M. E., Heckbert, S. R., Smith, N. L., Wiggins, K. L., Shriner, D., Veldre, G., Viigimaa, M., Kinra, S., Prabhakaran, D., Tripathy, V., Langefeld, C. D., Rosengren, A., Thelle, D. S., Mariacorsi, A., Singleton, A., Forrester, T., Hilton, G., Mckenzie, C. A., Salako, T., Iwai, N., Kita, Y., Ogihara, T., Ohkubo, T., Okamura, T., Ueshima, H., Umemura, S., Eyheramendy, S., Meitinger, T., Wichmann, H. . E., Cho, Y. S., Kim, H., Lee, J., Scott, J., Sehmi, J. S., Zhang, W., Hedblad, B., Nilsson, P., Smith, G. D., Wong, A., Narisu, N., Stancakova, A., Raffel, L. J., Yao, J., Kathiresan, S., O'donnell, C., Schwartz, S. M., Arfan Ikram, M., Longstreth, W. T., Seshadri, S., Shrine, N. R. G., Wain, L. V., Morken, M. A., Swift, A. J., Laitinen, J., Prokopenko, I., Zitting, P., Cooper, J. A., Humphries, S. E., Danesh, J., Rasheed, A., Goel, A., Hamsten, A., Watkins, H., Bakker, S. J. L., Van Gilst, W. H., Janipalli, C. S., Radha Mani, K., Yajnik, C. S., Hofman, A., Mattace-raso, F. U. S., Oostra, B. A., Demirkan, A., Isaacs, A., Rivadeneira, F., Lakatta, E. G., Orru, M., Scuteri, A., Ala-korpela, M., Kangas, A. J., Lyytikainen, L., Soininen, P., Tukiainen, T., Wurz, P., Twee-hee Ong, R., Dorr, M., Kroemer, H. K., Volker, U., Volzke, H., Galan, P., Hercberg, S., Lathrop, M., Zelenika, D., Deloukas, P., Mangino, M., Spector, T. D., Zhai, G., Meschia, J. F., Nalls, M. A., Sharma, P., Terzic, J., Kranthi Kumar, M. J., Denniff, M., Zukowska-szczechowska, E., Wagenknecht, L. E., Fowkes, G. R., Charchar, F. J., Schwarz, P. E. H., Hayward, C., Guo, X., Bots, M. L., Brand, E., Samani, N. J., Polasek, O., Talmud, P. J., Nyberg, F., Kuh, D., Laan, M., Hveem, K., Palmer, L. J., Van Der Schouw, Y. T., Casas, J. P., Mohlke, K. L., Vineis, P., Raitakari, O., Wong, T. Y., Shyong Tai, E., Laakso, M., Rao, D. C., Harris, T. B., Morris, R. W., Dominiczak, A. F., Kivimaki, M., Marmot, M. G., Miki, T., Saleheen, D., Chandak, G. R., Coresh, J., Navis, G., Salomaa, V., Han, B., Kooner, J. S., Melander, O., Ridker, P. M., Bandinelli, S., Gyllensten, U. B., Wright, A. F., Wilson, J. F., Ferrucci, L., Farrall, M., Tuomilehto, J., Pramstaller, P. P., Elosua, R., Soranzo, N., Sijbrands, E. J. G., Altshuler, D., Loos, R. J. F., Shuldiner, A. R., Gieger, C., Meneton, P., Uitterlinden, A. G., Wareham, N. J., Gudnason, V., Rettig, R., Uda, M., Strachan, D. P., Witteman, J. C. M., Hartikainen, A., Beckmann, J. S., Boerwinkle, E., Boehnke, M., Larson, M. G., Jarvelin, M., Psaty, B. M., Abecasis, G. R., Elliott, P., Van Duijn, C. M., Newton-cheh, C., Chakravarti, A., Zhu, X. & Levy, D., 1 Jun 2011, In: Human Molecular Genetics. 20, 11, p. 2273-2284 12 p., N/A.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    147 Citations (Scopus)
  • Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms

    Zhai, G., Teumer, A., Stolk, L., Perry, J. R. B., Vandenput, L., Coviello, A. D., Koster, A., Bell, J. T., Bhasin, S., Eriksson, J., Eriksson, A., Ernst, F., Ferrucci, L., Frayling, T. M., Glass, D., Grundberg, E., Haring, R., Hedman, A. K., Hofman, A., Kiel, D. P., & 26 othersKroemer, H. K., Liu, Y., Lunetta, K. L., Maggio, M., Lorentzon, M., Mangino, M., Melzer, D., Miljkovic, I., Nica, A., Penninx, B. W. J. H., Vasan, R. S., Rivadeneira, F., Small, K. S., Soranzo, N., Uitterlinden, A. G., Voelzke, H., Wilson, S. G., Xi, L., Zhuang, W. V., Harris, T. B., Murabito, J. M., Ohlsson, C., Murray, A., de Jong, F. H., Spector, T. D. & Wallaschofski, H., Apr 2011, In: PL o S Genetics. 7, 4, e1002025.

    Research output: Contribution to journalArticlepeer-review

    79 Citations (Scopus)
  • EIGHT COMMON GENETIC VARIANTS ASSOCIATED WITH SERUM DHEAS LEVELS SUGGESTS A KEY ROLE IN AGEING MECHANISMS

    Zhai, G., Teumer, A., Stolk, L., Perry, J. R. B., Vandenput, L., Coviello, A. D., Koster, A., Bandinelli, S., Bell, J. T., Bhasin, S., Eriksson, J., Eriksson, A., Ernst, F., Ferrucci, L., Frayling, T. M., Glass, D., Grundberg, E., Haring, R., Hedman, A. K., Hofman, A., & 22 othersKiel, D. P., Kroemer, H. K., Liu, Y., Lunetta, L., Lorentzon, M., Mangino, M., Melzer, D., Nica, A., Vasan, R. S., Small, K. S., Soranzo, N., Uitterlinden, A. G., Voelzke, H., Wilson, S., Zhuang, W., Harris, T., Murabito, J. M., Ohlsson, C., Murray, A., Jong, F., Spector, T. D. & Wallaschofski, H., Apr 2011, In: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 49, 4, p. S425 - S425 e1002025.

    Research output: Contribution to journalMeeting abstract

    79 Citations (Scopus)
  • Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

    Ehret, G. B., Munroe, P. B., Rice, K. M., Bochud, M., Johnson, A. D., Chasman, D. I., Smith, A. V., Tobin, M. D., Verwoert, G. C., Hwang, S-J., Pihur, V., Vollenweider, P., O'Reilly, P., Amin, N., Bragg-Gresham, J. L., Teumer, A., Glazer, N. L., Launer, L., Zhao, J. H., Aulchenko, Y., & 31 othersHeath, S., Sõber, S., Parsa, A., Luan, J., Arora, P., Dehghan, A., Zhang, F., Lucas, G., Hicks, A. A., Jackson, A. U., Peden, J. F., Tanaka, T., Wild, S. H., Rudan, I., Igl, W., Milaneschi, Y., Parker, A. N., Fava, C., Chambers, J. C., Fox, E. R., Kumari, M., Go, M. J., van der Harst, P., Kao, W. H. L., Wong, A., Spector, T. D., Zhai, G., Morris, R. W., Wilson, J. F., International Consortium for Blood Pressure Genome-Wide Association Studies & Hernandez Fuentes, M., 6 Oct 2011, In: NATURE. 478, 7367, p. 103-109 7 p., N/A.

    Research output: Contribution to journalArticlepeer-review

    1671 Citations (Scopus)
  • Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

    Schumann, G., Coin, L. J., Lourdusamy, A., Charoen, P., Berger, K. H., Stacey, D., Desrivieres, S., Aliev, F. A., Khan, A. A., Amin, N., Aulchenko, Y. S., Bakalkin, G., Bakker, S. J., Balkau, B., Beulens, J. W., Bilbao, A., de Boer, R. A., Beury, D., Bots, M. L., Breetvelt, E. J., & 96 othersCauchi, S., Cavalcanti-Proenca, C., Chambers, J. C., Clarke, T-K., Dahmen, N., de Geus, E. J., Dick, D., Ducci, F., Easton, A., Edenberg, H. J., Esk, T., Fernandez-Medarde, A., Foroud, T., Freimer, N. B., Girault, J-A., Grobbee, D. E., Guarrera, S., Gudbjartsson, D. F., Hartikainen, A-L., Heath, A. C., Hesselbrock, V., Hofman, A., Hottenga, J-J., Isohanni, M. K., Kaprio, J., Khaw, K-T., Kuehnel, B., Laitinen, J., Lobbens, S., Luan, J., Mangino, M., Maroteaux, M., Matullo, G., McCarthy, M. I., Mueller, C., Navis, G., Numans, M. E., Nunez, A., Nyholt, D. R., Onland-Moret, C. N., Oostra, B. A., O'Reilly, P. F., Palkovits, M., Penninx, B. W., Polidoro, S., Pouta, A., Prokopenko, I., Ricceri, F., Santos, E., Smit, J. H., Soranzo, N., Song, K., Sovio, U., Stumvoll, M., Surakk, I., Thorgeirsson, T. E., Thorsteinsdottir, U., Troakes, C., Tyrfingsson, T., Toenjes, A., Uiterwaal, C. S., Uitterlinden, A. G., van der Harst, P., van der Schouw, Y. T., Staehlin, O., Vogelzangs, N., Vollenweider, P., Waeber, G., Wareham, N. J., Waterworth, D. M., Whitfield, J. B., Wichmann, E. H., Willemsen, G., Witteman, J. C., Yuan, X., Zhai, G., Zhao, J. H., Zhang, W., Martin, N. G., Metspalu, A., Doering, A., Scott, J., Spector, T. D., Loos, R. J., Boomsma, D. I., Mooser, V., Peltonen, L., Stefansson, K., van Duijn, C. M., Vineis, P., Sommer, W. H., Kooner, J. S., Spanagel, R., Heberlein, U. A., Jarvelin, M-R. & Elliott, P., 26 Apr 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 17, p. 7119 - 7124 6 p.

    Research output: Contribution to journalArticlepeer-review

    224 Citations (Scopus)
  • Human metabolic individuality in biomedical and pharmaceutical research

    Suhre, K., Shin, S-Y., Petersen, A-K., Mohney, R. P., Meredith, D., Wägele, B., Altmaier, E., Deloukas, P., Erdmann, J., Grundberg, E., Hammond, C. J., de Angelis, M. H., Kastenmüller, G., Köttgen, A., Kronenberg, F., Mangino, M., Meisinger, C., Meitinger, T., Mewes, H-W., Milburn, M. V., & 14 othersPrehn, C., Raffler, J., Ried, J. S., Römisch-Margl, W., Samani, N. J., Small, K. S., Wichmann, H-E., Zhai, G., Illig, T., Spector, T. D., Adamski, J., Soranzo, N., Gieger, C. & CARDIoGRAM, 1 Sept 2011, In: NATURE. 477, 7362, p. 54-60 7 p.

    Research output: Contribution to journalArticlepeer-review

    818 Citations (Scopus)
  • Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study

    Panoutsopoulou, K., Southam, L., Elliott, K. S., Wrayner, N., Zhai, G., Beazley, C., Thorleifsson, G., Arden, N. K., Carr, A., Chapman, K., Deloukas, P., Doherty, M., McCaskie, A., Ollier, W. E. R., Ralston, S. H., Spector, T. D., Valdes, A. M., Wallis, G. A., Wilkinson, J. M., Arden, E., & 55 othersBattley, K., Blackburn, H., Blanco, F. J., Bumpstead, S., Cupples, L. A., Day-Williams, A. G., Dixon, K., Doherty, S. A., Esko, T., Evangelou, E., Felson, D., Gomez-Reino, J. J., Gonzalez, A., Gordon, A., Gwilliam, R., Halldorsson, B. V., Hauksson, V. B., Hofman, A., Hunt, S. E., Ioannidis, J. P. A., Ingvarsson, T., Jonsdottir, I., Jonsson, H., Keen, R., Kerkhof, H. J. M., Kloppenburg, M. G., Koller, N., Lakenberg, N., Lane, N. E., Lee, A. T., Metspalu, A., Meulenbelt, I., Nevitt, M. C., O'Neill, F., Parimi, N., Potter, S. C., Rego-Perez, I., Riancho, J. A., Sherburn, K., Slagboom, P. E., Stefansson, K., Styrkarsdottir, U., Sumillera, M., Swift, D., Thorsteinsdottir, U., Tsezou, A., Uitterlinden, A. G., van Meurs, J. B. J., Watkins, B., Wheeler, M., Mitchell, S., Zhu, Y., Zmuda, J. M., Zeggini, E. & Loughlin, J., May 2011, In: Annals of the Rheumatic Diseases. 70, 5, p. 864 - 867 4 p.

    Research output: Contribution to journalArticlepeer-review

    100 Citations (Scopus)
  • Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis

    Kerkhof, H. J. M., Doherty, M., Arden, N. K., Abramson, S. B., Attur, M., Bos, S. D., Cooper, C., Dennison, E. M., Doherty, S. A., Evangelou, E., Hart, D. J., Hofman, A., Javaid, K., Kerna, I., Kisand, K., Kloppenburg, M., Krasnokutsky, S., Maciewicz, R. A., Meulenbelt, I., Muir, K. R., & 14 othersRivadeneira, F., Samuels, J., Sezgin, M., Slagboom, E., Smith, A. J. P., Spector, T. D., Tamm, A., Tamm, A., Uitterlinden, A. G., Wheeler, M., Zhai, G., Zhang, W., van Meurs, J. B. J. & Valdes, A. M., Mar 2011, In: Osteoarthritis and Cartilage. 19, 3, p. 265 - 271 7 p.

    Research output: Contribution to journalArticlepeer-review

    78 Citations (Scopus)
  • Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22

    Evangelou, E., Valdes, A. M., Kerkhof, H. J. M., Styrkarsdottir, U., Zhu, Y., Meulenbelt, I., Lories, R. J., Karassa, F. B., Tylzanowski, P., Bos, S. D., Akune, T., Arden, N. K., Carr, A., Chapman, K., Cupples, L. A., Dai, J., Deloukas, P., Doherty, M., Doherty, S., Engstrom, G., & 51 othersGonzalez, A., Halldorsson, B. V., Hammond, C. L., Hart, D. J., Helgadottir, H., Hofman, A., Ikegawa, S., Ingvarsson, T., Jiang, Q., Jonsson, H., Kaprio, J., Kawaguchi, H., Kisand, K., Kloppenburg, M., Kujala, U. M., Lohmander, L. S., Loughlin, J., Luyten, F. P., Mabuchi, A., McCaskie, A., Nakajima, M., Nilsson, P. M., Nishida, N., Ollier, W. E. R., Panoutsopoulou, K., van de Putte, T., Ralston, S. H., Rivadeneira, F., Saarela, J., Schulte-Merker, S., Shi, D., Slagboom, P. E., Sudo, A., Tamm, A., Tamm, A., Thorleifsson, G., Thorsteinsdottir, U., Tsezou, A., Wallis, G. A., Wilkinson, J. M., Yoshimura, N., Zeggini, E., Zhai, G., Zhang, F., Jonsdottir, I., Uitterlinden, A. G., Felson, D. T., van Meurs, J. B., Stefansson, K., Ioannidis, J. P. A. & Spector, T. D., Feb 2011, In: Annals of the Rheumatic Diseases. 70, 2, p. 349 - 355 7 p.

    Research output: Contribution to journalArticlepeer-review

    113 Citations (Scopus)
  • 2010

    A Genome-Wide Association Study Identifies an Osteoarthritis Susceptibility Locus on Chromosome 7q22

    Kerkhof, H. J. M., Lories, R. J., Meulenbelt, I., Jonsdottir, I., Valdes, A. M., Arp, P., Ingvarsson, T., Jhamai, M., Jonsson, H., Stolk, L., Thorleifsson, G., Zhai, G., Zhang, F., Zhu, Y., van der Breggen, R., Carr, A., Doherty, M., Doherty, S., Felson, D. T., Gonzalez, A., & 22 othersHalldorsson, B. V., Hart, D. J., Hauksson, V. B., Hofman, A., Ioannidis, J. P. A., Kloppenburg, M., Lane, N. E., Loughlin, J., Luyten, F. P., Nevitt, M. C., Parimi, N., Pols, H. A. P., Rivadeneira, F., Slagboom, E. P., Styrkarsdottir, U., Tsezou, A., van de Putte, T., Zmuda, J., Spector, T. D., Stefansson, K., Uitterlinden, A. G. & van Meurs, J. B. J., Feb 2010, In: Arthritis & Rheumatism. 62, 2, p. 499 - 510 12 p.

    Research output: Contribution to journalArticlepeer-review

    179 Citations (Scopus)
  • A genome-wide perspective of genetic variation in human metabolism

    Illig, T., Gieger, C., Zhai, G., Roemisch-Margl, W., Wang-Sattler, R., Prehn, C., Altmaier, E., Kastenmueller, G., Kato, B. S., Mewes, H-W., Meitinger, T., de Angelis, M. H., Kronenberg, F., Soranzo, N., Wichmann, H-E., Spector, T. D., Adamski, J. & Suhre, K., Feb 2010, In: Nature Genetics. 42, 2, p. 137 - U66 5 p.

    Research output: Contribution to journalArticlepeer-review

    546 Citations (Scopus)
  • An Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis-Related Traits

    Hsu, Y-H., Zillikens, M. C., Wilson, S. G., Farber, C. R., Demissie, S., Soranzo, N., Bianchi, E. N., Grundberg, E., Liang, L., Richards, J. B., Estrada, K., Zhou, Y., van Nas, A., Moffatt, M. F., Zhai, G., Hofman, A., van Meurs, J. B., Pols, H. A. P., Price, R. I., Nilsson, O., & 10 othersPastinen, T., Cupples, L. A., Lusis, A. J., Schadt, E. E., Ferrari, S., Uitterlinden, A. G., Rivadeneira, F., Spector, T. D., Karasik, D. & Kiel, D. P., 2010, In: PL o S Genetics. 6, 6, e1000977.

    Research output: Contribution to journalArticlepeer-review

    174 Citations (Scopus)
  • Association of JAG1 with Bone Mineral Density and Osteoporotic Fractures: A Genome-wide Association Study and Follow-up Replication Studies

    Kung, A. W. C., Xiao, S-M., Cherny, S., Li, G. H. Y., Gao, Y., Tso, G., Lau, K. S., Luk, K. D. K., Liu, J., Cui, B., Zhang, M-J., Zhang, Z., He, J., Yue, H., Xia, W., Luo, L., He, S., Kiel, D. P., Karasik, D., Hsu, Y-H., & 13 othersCupples, L. A., Demissie, S., Styrkarsdottir, U., Halldorsson, B. V., Sigurdsson, G., Thorsteinsdottir, U., Stefansson, K., Richards, J. B., Zhai, G., Soranzo, N., Valdes, A., Spector, T. D. & Sham, P. C., 12 Feb 2010, In: American Journal of Human Genetics. 86, 2, p. 229 - 239 11 p.

    Research output: Contribution to journalArticlepeer-review

    153 Citations (Scopus)
  • Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults

    Dore, D., Martens, A., Quinn, S., Ding, C., Winzenberg, T., Zhai, G., Pelletier, J-P., Martel-Pelletier, J., Abram, F., Cicuttini, F. & Jones, G., 29 Dec 2010, In: Arthritis Research and Therapy. 12, 6, R222.

    Research output: Contribution to journalArticlepeer-review

    92 Citations (Scopus)
  • Common genetic determinants of vitamin D insufficiency: a genome-wide association study

    Wang, T. J., Zhang, F., Richards, J. B., Kestenbaum, B., van Meurs, J. B., Berry, D., Kiel, D. P., Streeten, E. A., Ohlsson, C., Koller, D. L., Peltonen, L., Cooper, J. D., O'Reilly, P., Houston, D. K., Glazer, N. L., Vandenput, L., Peacock, M., Shi, J., Rivadeneira, F., McCarthy, M. I., & 56 othersAnneli, P., de Boer, I. H., Mangino, M., Kato, B., Smyth, D. J., Booth, S. L., Jacques, P. F., Burke, G. L., Goodarzi, M., Cheung, C-L., Wolf, M., Rice, K., Goltzman, D., Hidiroglou, N., Ladouceur, M., Wareham, N. J., Hocking, L. J., Hart, D., Arden, N. K., Cooper, C., Malik, S., Fraser, W. D., Hartikainen, A-L., Zhai, G., Macdonald, H. M., Forouhi, N. G., Loos, R. J. F., Reid, D. M., Hakim, A., Dennison, E., Liu, Y., Power, C., Stevens, H. E., Jaana, L., Vasan, R. S., Soranzo, N., Bojunga, J., Psaty, B. M., Lorentzon, M., Foroud, T., Harris, T. B., Hofman, A., Jonsson, J-O., Cauley, J. A., Uitterlinden, A. G., Gibson, Q., Jarvelin, M-R., Karasik, D., Siscovick, D. S., Econs, M. J., Kritchevsky, S. B., Florez, J. C., Todd, J. A., Dupuis, J., Hyppoenen, E. & Spector, T. D., 1 Jul 2010, In: The Lancet. 376, 9736, p. 180 - 188 9 p.

    Research output: Contribution to journalArticlepeer-review

    1348 Citations (Scopus)
  • Common variants near TERC are associated with mean telomere length

    Codd, V., Mangino, M., van der Harst, P., Braund, P. S., Kaiser, M., Beveridge, A. J., Rafelt, S., Moore, J., Nelson, C., Soranzo, N., Zhai, G., Valdes, A. M., Blackburn, H., Leach, I. M., de Boer, R. A., Goodall, A. H., Ouwehand, W., van Veldhuisen, D. J., van Gilst, W. H., Navis, G., & 6 othersBurton, P. R., Tobin, M. D., Hall, A. S., Thompson, J. R., Spector, T. & Samani, N. J., Mar 2010, In: Nature Genetics. 42, 3, p. 197 - 199 3 p.

    Research output: Contribution to journalArticlepeer-review

    280 Citations (Scopus)
  • Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults

    Dore, D., Quinn, S., Ding, C., Winzenberg, T., Zhai, G., Cicuttini, F. & Jones, G., 29 Dec 2010, In: Arthritis Research and Therapy. 12, 6, R223.

    Research output: Contribution to journalArticlepeer-review

    115 Citations (Scopus)
  • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

    Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A. U., Wheeler, E., Glazer, N. L., Bouatia-Naji, N., Gloyn, A. L., Lindgren, C. M., Magi, R., Morris, A. P., Randall, J., Johnson, T., Elliott, P., Rybin, D., Thorleifsson, G., Steinthorsdottir, V., Henneman, P., & 283 othersGrallert, H., Dehghan, A., Hottenga, J. J., Franklin, C. S., Navarro, P., Song, K., Goel, A., Perry, J. R. B., Egan, J. M., Lajunen, T., Grarup, N., Sparso, T., Doney, A., Voight, B. F., Stringham, H. M., Li, M., Kanoni, S., Shrader, P., Cavalcanti-Proenca, C., Kumari, M., Qi, L., Timpson, N. J., Gieger, C., Zabena, C., Rocheleau, G., Ingelsson, E., An, P., O'Connell, J., Luan, J., Elliott, A., McCarroll, S. A., Payne, F., Roccasecca, R. M., Pattou, F., Sethupathy, P., Ardlie, K., Ariyurek, Y., Balkau, B., Barter, P., Beilby, J. P., Ben-Shlomo, Y., Benediktsson, R., Bennett, A. J., Bergmann, S., Bochud, M., Boerwinkle, E., Bonnefond, A., Bonnycastle, L. L., Borch-Johnsen, K., Boettcher, Y., Brunner, E., Bumpstead, S. J., Charpentier, G., Chen, Y-D. I., Chines, P., Clarke, R., Coin, L. J. M., Cooper, M. N., Cornelis, M., Crawford, G., Crisponi, L., Day, I. N. M., de Geus, E. J. C., Delplanque, J., Dina, C., Erdos, M. R., Fedson, A. C., Fischer-Rosinsky, A., Forouhi, N. G., Fox, C. S., Frants, R., Franzosi, M. G., Galan, P., Goodarzi, M. O., Graessler, J., Groves, C. J., Grundy, S., Gwilliam, R., Gyllensten, U., Hadjadj, S., Hallmans, G., Hammond, N., Han, X., Hartikainen, A-L., Hassanali, N., Hayward, C., Heath, S. C., Hercberg, S., Herder, C., Hicks, A. A., Hillman, D. R., Hingorani, A. D., Hofman, A., Hui, J., Hung, J., Isomaa, B., Johnson, P. R. V., Jorgensen, T., Jula, A., Kaakinen, M., Kaprio, J., Kesaniemi, Y. A., Kivimaki, M., Knight, B., Koskinen, S., Kovacs, P., Kyvik, K. O., Lathrop, G. M., Lawlor, D. A., Le Bacquer, O., Lecoeur, C., Li, Y., Lyssenko, V., Mahley, R., Mangino, M., Manning, A. K., Teresa Martinez-Larrad, M., McAteer, J. B., McCulloch, L. J., McPherson, R., Meisinger, C., Melzer, D., Meyre, D., Mitchell, B. D., Morken, M. A., Mukherjee, S., Naitza, S., Narisu, N., Neville, M. J., Oostra, B. A., Orru, M., Pakyz, R., Palmer, C. N. A., Paolisso, G., Pattaro, C., Pearson, D., Peden, J. F., Pedersen, N. L., Perola, M., Pfeiffer, A. F. H., Pichler, I., Polasek, O., Posthuma, D., Potter, S. C., Pouta, A., Province, M. A., Psaty, B. M., Rathmann, W., Rayner, N. W., Rice, K., Ripatti, S., Rivadeneira, F., Roden, M., Rolandsson, O., Sandbaek, A., Sandhu, M., Sanna, S., Sayer, A. A., Scheet, P., Scott, L. J., Seedorf, U., Sharp, S. J., Shields, B., Sigurosson, G., Sijbrands, E. J. G., Silveira, A., Simpson, L., Singleton, A., Smith, N. L., Sovio, U., Swift, A., Syddall, H., Syvanen, A-C., Tanaka, T., Thorand, B., Tichet, J., Tonjes, A., Tuomi, T., Uitterlinden, A. G., van Dijk, K. W., van Hoek, M., Varma, D., Visvikis-Siest, S., Vitart, V., Vogelzangs, N., Waeber, G., Wagner, P. J., Walley, A., Walters, G. B., Ward, K. L., Watkins, H., Weedon, M. N., Wild, S. H., Willemsen, G., Witteman, J. C. M., Yarnell, J. W. G., Zeggini, E., Zelenika, D., Zethelius, B., Zhai, G., Zhao, J. H., Zillikens, M. C., Borecki, I. B., Loos, R. J. F., Meneton, P., Magnusson, P. K. E., Nathan, D. M., Williams, G. H., Hattersley, A. T., Silander, K., Salomaa, V., Smith, G. D., Bornstein, S. R., Schwarz, P., Spranger, J., Karpe, F., Shuldiner, A. R., Cooper, C., Dedoussis, G. V., Serrano-Rios, M., Morris, A. D., Lind, L., Palmer, L. J., Hu, F. B., Franks, P. W., Ebrahim, S., Marmot, M., Kao, W. H. L., Pankow, J. S., Sampson, M. J., Kuusisto, J., Laakso, M., Hansen, T., Pedersen, O., Pramstaller, P. P., Wichmann, H. E., Illig, T., Rudan, I., Wright, A. F., Stumvoll, M., Campbell, H., Wilson, J. F., Bergman, R. N., Buchanan, T. A., Collins, F. S., Mohlke, K. L., Tuomilehto, J., Valle, T. T., Altshuler, D., Rotter, J. I., Siscovick, D. S., Penninx, B. W. J. H., Boomsma, D. I., Deloukas, P., Spector, T. D., Frayling, T. M., Ferrucci, L., Kong, A., Thorsteinsdottir, U., Stefansson, K., van Duijn, C. M., Aulchenko, Y. S., Cao, A., Scuteri, A., Schlessinger, D., Uda, M., Ruokonen, A., Jarvelin, M-R., Waterworth, D. M., Vollenweider, P., Peltonen, L., Mooser, V., Abecasis, G. R., Wareham, N. J., Sladek, R., Froguel, P., Watanabe, R. M., Meigs, J. B., Groop, L., Boehnke, M., McCarthy, M. I., Florez, J. C. & Barroso, I., Feb 2010, In: Nature Genetics. 42, 2, p. 105 - U32 12 p.

    Research output: Contribution to journalArticlepeer-review

    1756 Citations (Scopus)
  • Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis

    Zhai, G., Wang-Sattler, R., Hart, D. J., Arden, N. K., Hakim, A. J., Illig, T. & Spector, T. D., Jun 2010, In: Annals of the Rheumatic Diseases. 69, 6, p. 1227 - 1231 5 p.

    Research output: Contribution to journalArticlepeer-review

    143 Citations (Scopus)
  • THE arcOGEN CONSORTIUM: STAGE 1 OF A GENOME-WIDE ASSOCIATION SCAN FOR OSTEOARTHRITIS

    Panoutsopoulou, K., Southam, L., Rayner, W., Zhai, G., Beazley, C., Arden, N., Carr, A., Chapman, K., Deloukas, P., Doherty, M., McCaskie, A., Olher, W., Ralston, S., Spector, T., Valdes, A., Wallis, G., Wilkinson, M., Arden, E., Battley, K., Blackburn, H., & 46 othersBlanco, F., Bumpstead, S., Cupples, A., Day-Williams, A., Dixon, K., Dohertys, S., Elliott, K., Evangelou, E., Felson, D., Gomez-Reino, J., Gonzalez, A., Gordon, A., Gwilliam, R., Hofman, A., Hunt, S., Ioannidis, J., Jonsdottir, I., Keen, R., Kerkhof, H., Kloppenburg, M., Koller, N., Lakenberg, N., Lane, N., Lee, A., Meulenbelt, I., Nevitt, M., O'Neill, F., Parimi, N., Potter, S., Rego-Perez, I., Riancho, J., Sherburn, K., Slagboom, E., Styrkarsdottir, U., Sumillera, M., Swift, D., Tsezou, A., Uitterlinden, A., van Meurs, J., Watkins, B., Wheeler, M., Mitchelle, S., Zhu, Y., Zmuda, J., Zeggini, E. & Loughlin, J., 2010, In: Osteoarthritis and Cartilage. 18, p. S166 - S167

    Research output: Contribution to journalMeeting abstract

  • Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

    Elks, C. E., Perry, J. R. B., Sulem, P., Chasman, D. I., Franceschini, N., He, C., Lunetta, K. L., Visser, J. A., Byrne, E. M., Cousminer, D. L., Gudbjartsson, D. F., Esko, T., Feenstra, B., Hottenga, J-J., Koller, D. L., Kutalik, Z., Lin, P., Mangino, M., Marongiu, M., McArdle, P. F., & 154 othersSmith, A. V., Stolk, L., Van Wingerden, S. H., Zhao, J. H., Albrecht, E., Corre, T., Ingelsson, E., Hayward, C., Magnusson, P. K. E., Smith, E. N., Ulivi, S., Warrington, N. M., Zgaga, L., Alavere, H., Amin, N., Aspelund, T., Bandinelli, S., Barroso, I., Berenson, G. S., Bergmann, S., Blackburn, H., Boerwinkle, E., Buring, J. E., Busonero, F., Campbell, H., Chanock, S. J., Chen, W., Cornelis, M. C., Couper, D., Coviello, A. D., d'Adamo, P., de Faire, U., de Geus, E. J. C., Deloukas, P., Doering, A., Smith, G. D., Easton, D. F., Eiriksdottir, G., Emilsson, V., Eriksson, J., Ferrucci, L., Folsom, A. R., Foroud, T., Garcia, M., Gasparini, P., Geller, F., Gieger, C., Gudnason, V., Hall, P., Hankinson, S. E., Ferreli, L., Heath, A. C., Hernandez, D. G., Hofman, A., Hu, F. B., Illig, T., Jaervelin, M-R., Johnson, A. D., Karasik, D., Khaw, K-T., Kiel, D. P., Kilpelaeinen, T. O., Kolcic, I., Kraft, P., Launer, L. J., Laven, J. S. E., Li, S., Liu, J., Levy, D., Martin, N. G., McArdle, W. L., Melbye, M., Mooser, V., Murray, J. C., Murray, S. S., Nalls, M. A., Navarro, P., Nelis, M., Ness, A. R., Northstone, K., Oostra, B. A., Peacock, M., Palmer, L. J., Palotie, A., Pare, G., Parker, A. N., Pedersen, N. L., Peltonen, L., Pennell, C. E., Pharoah, P., Polasek, O., Plump, A. S., Pouta, A., Porcu, E., Rafnar, T., Rice, J. P., Ring, S. M., Rivadeneira, F., Rudan, I., Sala, C., Salomaa, V., Sanna, S., Schlessinger, D., Schork, N. J., Scuteri, A., Segre, A. V., Shuldiner, A. R., Soranzo, N., Sovio, U., Srinivasan, S. R., Strachan, D. P., Tammesoo, M-L., Tikkanen, E., Toniolo, D., Tsui, K., Tryggvadottir, L., Tyrer, J., Uda, M., van Dam, R. M., van Meurs, J. B. J., Vollenweider, P., Waeber, G., Wareham, N. J., Waterworth, D. M., Weedon, M. N., Wichmann, H. E., Willemsen, G., Wilson, J. F., Wright, A. F., Young, L., Zhai, G., Zhuang, W. V., Bierut, L. J., Boomsma, D. I., Boyd, H. A., Crisponi, L., Demerath, E. W., van Duijn, C. M., Econs, M. J., Harris, T. B., Hunter, D. J., Loos, R. J. F., Metspalu, A., Montgomery, G. W., Ridker, P. M., Spector, T. D., Streeten, E. A., Stefansson, K., Thorsteinsdottir, U., Uitterlinden, A. G., Widen, E., Murabito, J. M., Ong, K. K. & Murray, A., Dec 2010, In: Nature Genetics. 42, 12, p. 1077 - U73 9 p.

    Research output: Contribution to journalArticlepeer-review

    416 Citations (Scopus)
  • 2009

    A genome-wide association study identifies a common variant near the GRP22 gene as a new locus involved in prevalence and progression of osteoarthritis

    Kerkhof, H. J. M., Jonsdottir, I., Meulenbelt, I., Stolk, L., Valdes, A. M., Zhai, G., Zhu, Y., Doherty, M., Doherty, S., Tsezou, A., Gonzalez, A., Carr, A., Felson, D. T., Styrkarsdottir, U., Slagboom, E. P., Loughlin, J., Rivadeneira, F., Hofman, A., Pols, H. A. P., Spector, T. D., & 2 othersUitterlinden, A. G. & van Meurs, J. B. J., 2009, In: Bone. 44, 2, p. S224 - S224

    Research output: Contribution to journalMeeting abstract

  • A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length

    Mangino, M., Richards, J. B., Soranzo, N., Zhai, G., Aviv, A., Valdes, A. M., Samani, N. J., Deloukas, P. & Spector, T. D., Jul 2009, In: Journal of Medical Genetics. 46, 7, p. 451 - 454 4 p.

    Research output: Contribution to journalArticlepeer-review

    68 Citations (Scopus)
  • A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium

    Zhai, G., van Meurs, J. B. J., Livshits, G., Meulenbelt, I., Valdes, A. M., Soranzo, N., Hart, D., Zhang, F., Kato, B. S., Richards, J. B., Williams, F. M. K., Inouye, M., Kloppenburg, M., Deloukas, P., Slagboom, E., Uitterlinden, A. & Spector, T. D., Sept 2009, In: Journal of Medical Genetics. 46, 9, p. 614 - 616 3 p.

    Research output: Contribution to journalArticlepeer-review

    51 Citations (Scopus)
  • An Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis Related Traits

    Hsu, Y-H., Zillikens, M. C., Wilson, S. G., Farber, C. R., Demissie, S., Bianchi, E. N., Liang, L., Richards, J. B., Estrada, K., Zhou, Y., Soranzo, N., van Nas, A., Moffatt, M. F., Zhai, G., Hofman, A., van Meurs, J. B., Price, R. I., Cupples, L. A., Lusis, A. J., Schadt, E. E., & 6 othersFerrari, S., Uitterlinden, A. G., Rivadeneira, F., Spector, T. D., Karasik, D. & Kiel, D. P., 2009, In: Genetic Epidemiology. 33, 8, p. 752 - 753 2 p.

    Research output: Contribution to journalMeeting abstract

  • Common variants in the region around Osterix are associated with bone mineral density and growth in childhood

    Timpson, N. J., Tobias, J. H., Richards, J. B., Soranzo, N., Duncan, E. L., Sims, A-M., Whittaker, P., Kumanduri, V., Zhai, G., Glaser, B., Eisman, J., Jones, G., Nicholson, G., Prince, R., Seeman, E., Spector, T. D., Brown, M. A., Peltonen, L., Smith, G. D., Deloukas, P., & 1 othersEvans, D. M., 2009, In: Human Molecular Genetics. 18, 8, p. 1510 - 1517 8 p.

    Research output: Contribution to journalArticlepeer-review

    107 Citations (Scopus)
  • Effective measurements of knee alignment using AP knee radiographs

    Colebatch, AN., Hart, DJ., Zhai, G., Williams, FM., Spector, TD. & Arden, NK., Jan 2009, In: Knee. 16, 1, p. 42 - 45 4 p.

    Research output: Contribution to journalArticlepeer-review

    95 Citations (Scopus)
  • 33 Citations (Scopus)
  • Interleukin-6 Is a Significant Predictor of Radiographic Knee Osteoarthritis The Chingford Study

    Livshits, G., Zhai, G., Hart, D. J., Kato, B. S., Wang, H., Williams, F. M. K. & Spector, T. D., Jul 2009, In: Arthritis & Rheumatism. 60, 7, p. 2037 - 2045 9 p.

    Research output: Contribution to journalArticlepeer-review

    311 Citations (Scopus)
  • Loci at chromosomes 13, 19 and 20 influence age at natural menopause

    Stolk, L., Zhai, G., van Meurs, J. B. J., Verbiest, M. M. P. J., Visser, J. A., Estrada, K., Rivadeneira, F., Williams, F. M., Cherkas, L., Deloukas, P., Soranzo, N., de Keyzer, J. J., Pop, V. J. M., Lips, P., Lebrun, C. E. I., van der Schouw, Y. T., Grobbee, D. E., Witteman, J., Hofman, A., Pols, H. A. P., & 3 othersLaven, J. S. E., Spector, T. D. & Uitterlinden, A. G., Jun 2009, In: Nature Genetics. 41, 6, p. 645 - 647 3 p.

    Research output: Contribution to journalArticlepeer-review

    140 Citations (Scopus)
  • Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

    Perry, J. R. B., Stolk, L., Franceschini, N., Lunetta, K. L., Zhai, G., McArdle, P. F., Smith, A. V., Aspelund, T., Bandinelli, S., Boerwinkle, E., Cherkas, L., Eiriksdottir, G., Estrada, K., Ferrucci, L., Folsom, A. R., Garcia, M., Gudnason, V., Hofman, A., Karasik, D., Kiel, D. P., & 19 othersLauner, L. J., van Meurs, J., Nalls, M. A., Rivadeneira, F., Shuldiner, A. R., Singleton, A., Soranzo, N., Tanaka, T., Visser, J. A., Weedon, M. N., Wilson, S. G., Zhuang, V., Streeten, E. A., Harris, T. B., Murray, A., Spector, T. D., Demerath, E. W., Uitterlinden, A. G. & Murabito, J. M., Jun 2009, In: Nature Genetics. 41, 6, p. 648 - 650 3 p.

    Research output: Contribution to journalArticlepeer-review

    244 Citations (Scopus)
  • 2008

    A genome-wide association study reveals a novel locus for hand osteoarthritis

    Zhai, G., van Meurs, JB., Valdes, AM., Hart, D., Livshits, G., Inouye, M., Soranzo, N., Deloukas, P., Uitterlinden, A. & Spector, TD., 2008, In: Osteoarthritis and Cartilage. 16, p. S31 - S31

    Research output: Contribution to journalMeeting abstract

  • Association between leptin, body composition, sex and knee cartilage morphology in older adults: the Tasmanian older adult cohort (TASOAC) study

    Ding, C., Parameswaran, V., Cicuttini, F., Burgess, J., Zhai, G., Quinn, S. & Jones, G., Sept 2008, In: Annals of the Rheumatic Diseases. 67, 9, p. 1256 - 1261 6 p.

    Research output: Contribution to journalArticlepeer-review

    77 Citations (Scopus)
  • Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study: a genome-wide association study

    Richards, J. B., Rivadeneira, F., Inouye, M., Pastinen, T. M., Soranzo, N., Wilson, S. G., Andrew, T., Falchi, M., Gwilliam, R., Ahmadi, K. R., Valdes, A. M., Arp, P., Whittaker, P., Verlaan, D. J., Jhamai, M., Kumanduri, V., Moorhouse, M., van Meurs, J. B., Hofman, A., Pols, H. A. P., & 8 othersHart, D., Zhai, G., Kato, B. S., Mullin, B. H., Zhang, F., Deloukas, P., Uitterlinden, A. G. & Spector, T. D., 3 May 2008, In: The Lancet. 371, 9623, p. 1505-12 8 p.

    Research output: Contribution to journalArticlepeer-review

    571 Citations (Scopus)
  • Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis

    Valdes, A. M., Loughlin, J., Timms, K. M., van Meurs, J. J. B., Southam, L., Wilson, S. G., Doherty, S., Lories, R. J., Luyten, F. P., Gutin, A., Abkevich, V., Ge, D., Hofman, A., Uitterlinden, A. G., Hart, D. J., Zhang, F., Zhai, G., Egli, R. J., Doherty, M., Lanchbury, J., & 1 othersSpector, T. D., 6 Jun 2008, In: American Journal of Human Genetics. 82, 6, p. 1231 - 1240 10 p.

    Research output: Contribution to journalArticlepeer-review

    99 Citations (Scopus)
  • Natural history and risk factors for bone loss in postmenopausal Caucasian women: a 15-year follow-up population-based study

    Zhai, G., Hart, D. J., Valdes, A. M., Kato, B. S., Richards, J. B., Hakim, A. & Spector, T. D., Aug 2008, In: Osteoporosis International. 19, 8, p. 1211 - 1217 7 p.

    Research output: Contribution to journalArticlepeer-review

    34 Citations (Scopus)
  • Osteoprotegerin (OPG) gene variants and the incidence of knee osteoarthritis in the Chingford study.

    Zhang, F., Valdes, A., Hart, DJ., Uitterlinden, A., Zhai, GJ. & Spector, TD., 2008, In: Osteoarthritis and Cartilage. 16, p. S158 - S158

    Research output: Contribution to journalPoster abstract

    2 Citations (Scopus)
  • 2007

    Association between KLOTHO gene and hand osteoarthritis in a female Caucasian population

    Zhang, F., Zhai, G., Kato, B. S., Hart, D. J., Hunter, D., Spector, T. D. & Ahmadi, K. R., Jun 2007, In: Osteoarthritis and Cartilage. 15, 6, p. 624 - 629 6 p.

    Research output: Contribution to journalArticlepeer-review

    44 Citations (Scopus)
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