King's College London

Research portal

Professor Guillermina Girardi

Biographical details

Since her graduation, in Rosario, Argentina, Prof Girardi has been working in animal models of human diseases, in particular inflammatory disorders. In 2000, she moved to the Unites States to pursue a postdoctoral fellowship that will advance her career. During this time at Weill Cornell Medical College in New York City, she developed several mouse models to understand pregnancy pathologies and to identify novel therapeutic interventions. In 2004, she received a career development award from the Lupus Foundation USA  to study the cross-talk between inflammation and thrombosis in pregnancy loss in the antiphospholipid syndrome. She identified a previously unrecognized role for complement activation as an early effector in pregnancy loss associated with placental inflammation. Moreover, she found that tissue factor (TF), the initiator of the coagulation cascade, is a proinflammatory molecule not only in recurrent miscarriages induced by aPL but also in other models of immune-mediated miscarriages and preeclampsia. Following this line of studies she discovered that statins prevent pregnancy loss, intrauterine growth restriction and preeclampsia in different mouse models. Prof Girardi is a strong advocate for the health of women and their unborn children. Knowing that preterm birth is the most frequent cause of infant death she decided to expand her research to the field of premature delivery. She developed a mouse model of spontaneous preterm labour which resembles most clinical scenarios in that localized inflammation occurs without systemic maternal illness. In 2011 she was awarded a Royal Society Wolfson Merit Award and moved to the United Kingdom.  At the University of Edinburgh, her group has identified important mechanisms behind prematurity and discovered potential strategies for the prevention and treatment of this serious pregnancy complication. While in Edinburgh, Prof Girardi got interested in the abnormal foetal brain development associated with premature birth, antiphospholipid antibodies and preeclampsia.  Using cutting edge non-invasive MRI and 1HMRS (spectroscopy), she characterized foetal brain metabolic abnormalities in their mouse model.  Prof Girardi recently joined the Lupus Unit at King’s College London. She was happy to be able to continue her research in aPL, a subject that she was always passionate about.  Her ultimate motivation is to improve the health and clinical choices available to women and their babies. Her new position as Chair in women’s health will help her pursue this goal. Working together with clinicians, Prof Girardi will be able to fill in important gaps in understanding the aetiology of pregnancy complications and to identify therapeutic interventions.

Participation in conference

International Workshop on Preeclampsia- L'Reunion Island

Guillermina Girardi (Invited speaker)
2014

Activity: Participating in or organising an eventParticipation in conference

XVI Ten Topics Josep Font in Autoimmune Diseases & Rheumatology

Guillermina Girardi (Invited speaker)
2014

Activity: Participating in or organising an eventParticipation in conference

Society of Gynaecological Investigations (SGI).

Guillermina Girardi (Invited speaker)
2014

Activity: Participating in or organising an eventParticipation in conference

Neonatal Society Summer meeting

Guillermina Girardi (Invited speaker)
2013

Activity: Participating in or organising an eventParticipation in conference

Pediatric Academic Society

Guillermina Girardi (Speaker)
2013

Activity: Participating in or organising an eventParticipation in conference

British Society of immunology

Guillermina Girardi (Invited speaker)
2012

Activity: Participating in or organising an eventParticipation in conference

9th International Conference on Innate Immunity

Guillermina Girardi (Invited speaker)
2012

Activity: Participating in or organising an eventParticipation in conference

Autumn School: “Reproductive Biology and Immunology”. Magdeburg, Germany

Guillermina Girardi (Invited speaker)
2011

Activity: Participating in or organising an eventParticipation in conference

4th International Symposium on Women’s health Issues in Thrombosis and Haemostasis

Guillermina Girardi (Invited speaker)
2011

Activity: Participating in or organising an eventParticipation in conference

European Congress of Pathology

Guillermina Girardi (Invited speaker)
2011

Activity: Participating in or organising an eventParticipation in conference

3rd Symposium on Reproductive Immunology organized by the American Society of Reproductive Immunology (ASRI) Latin American Chapter

Guillermina Girardi (Invited speaker)
2011

Activity: Participating in or organising an eventParticipation in conference

European Society of Reproductive Immunology

Guillermina Girardi (Invited speaker)
2010

Activity: Participating in or organising an eventParticipation in conference

XI International Congress in Reproductive Immunology, Reproductive Immunobiology at the Great Barrier Reef

Guillermina Girardi (Invited speaker)
2010

Activity: Participating in or organising an eventParticipation in conference

4th Symposium on HLA and Diseases / II Symposium on Reproductive Immunology.

Guillermina Girardi (Invited speaker)
2009

Activity: Participating in or organising an eventParticipation in conference

Japan Society for Immunology of Reproduction

Guillermina Girardi (Keynote/plenary speaker)
2009

Activity: Participating in or organising an eventParticipation in conference

Phagocyte Gordon Research Conference. Session “Innate Immune Cells and Disease”

Guillermina Girardi (Invited speaker)
2009

Activity: Participating in or organising an eventParticipation in conference

Society of Gynaecological Investigations (SGI).

Guillermina Girardi (Invited speaker)
2009

Activity: Participating in or organising an eventParticipation in conference

American College of Rheumatology (ACR)

Guillermina Girardi (Speaker)
2008

Activity: Participating in or organising an eventParticipation in conference

American Society of Reproductive Immunology (ASRI) Annual Meeting

Guillermina Girardi (Keynote/plenary speaker)
2008

Activity: Participating in or organising an eventParticipation in conference

Hemostasis Gordon Research Conference. Hot Topics session.

Guillermina Girardi (Invited speaker)
2008

Activity: Participating in or organising an eventParticipation in conference

American Society of Hematology (ASH) Annual Meeting

Guillermina Girardi (Invited speaker)
2007

Activity: Participating in or organising an eventParticipation in conference

Xth International Congress of Reproductive Immunology

Guillermina Girardi (Invited speaker)
2007

Activity: Participating in or organising an eventParticipation in conference

American College of Rheumatology (ACR)

Guillermina Girardi (Keynote/plenary speaker)
2005

Activity: Participating in or organising an eventParticipation in conference

American College of Rheumatology (ACR)

Guillermina Girardi (Keynote/plenary speaker)
2004

Activity: Participating in or organising an eventParticipation in conference

American College of Rheumatology (ACR)

Guillermina Girardi (Keynote/plenary speaker)
2001

Activity: Participating in or organising an eventParticipation in conference

Types of Public engagement and outreach - Public lecture/debate/seminar

Sick placentae and soaring blood pressure – the medical conundrum of pre-eclampsia

Guillermina Girardi (Speaker)
20 Mar 2013

Activity: OtherTypes of Public engagement and outreach - Public lecture/debate/seminar

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