King's College London

Research portal

Professor Guillermina Girardi

  1. Pravastatin therapy during preeclampsia prevents long-term adverse health effects in mice

    Garrett, N., Pombo, J., Umpierrez, M., Clark, J. E., Simmons, M. & Girardi, G., 19 Apr 2018, In : JCI Insight. 3, 8

    Research output: Contribution to journalArticle

  2. Placental insufficiency and the fetal brain

    Giardi, G., Sep 2017, In : Placenta. 57, p. 230 1 p.

    Research output: Contribution to journalArticle

  3. MRI-based methods to detect placental and fetal brain abnormalities in utero

    Girardi, G., 1 Apr 2016, In : Journal of Reproductive Immunology. 114, p. 86-91 6 p.

    Research output: Contribution to journalArticle

  4. Statins prevent cervical remodeling, myometrial contractions and preterm labor through a mechanism that involves hemoxygenase-1 and complement inhibition

    Gonzalez, J. M., Pedroni, S. M. A. & Girardi, G., Jun 2014, In : MOLECULAR HUMAN REPRODUCTION. 20, 6, p. 579-589 11 p.

    Research output: Contribution to journalArticle

  5. Complement inhibition and statins prevent fetal brain cortical abnormalities in a mouse model of preterm birth.

    Pedroni, S. M. A., Gonzalez, J. M., Wade, J., Jansen, M. A., Serio, A., Marshall, I., Lennen, R. J. & Girardi, G., Jan 2014, In : Biochimica et Biophysica Acta. 1842, 1, p. 107-115 9 p., N/A.

    Research output: Contribution to journalArticle

  6. Comparison of the mechanisms responsible for cervical remodeling in preterm and term labor

    Gonzalez, J. M., Romero, R. & Girardi, G., Mar 2013, In : Journal of Reproductive Immunology. 97, 1, p. 112-119 8 p., N/A.

    Research output: Contribution to journalArticle

  7. Can statins prevent pregnancy complications?

    Girardi, G., 2013, In : Journal of Reproductive Immunology. N/A, N/A, p. N/A 7 p., N/A.

    Research output: Contribution to journalArticle

  8. Classical complement activation as a footprint for murine and human antiphospholipid antibody-induced fetal loss

    Cohen, D., Buurma, A., Goemaere, N. N., Girardi, G., le Cessie, S., Scherjon, S., Bloemenkamp, K. W. M., de Heer, E., Bruijn, J. A. & Bajema, I. M., Dec 2011, In : The Journal of Pathology. 225, 4, p. 502-511 10 p., N/A.

    Research output: Contribution to journalArticle

  9. Cervical remodeling/ripening at term and preterm delivery: the same mechanism initiated by different mediators and different effector cells

    Gonzalez, J. M., Dong, Z., Romero, R. & Girardi, G., 2 Nov 2011, In : PLoS ONE. 6, 11, p. N/A 8 p., e26877.

    Research output: Contribution to journalArticle

  10. Role of complement component C1q in the onset of preeclampsia in mice

    Singh, J., Ahmed, A. & Girardi, G., Oct 2011, In : Hypertension. 58, 4, p. 716-724 9 p., N/A.

    Research output: Contribution to journalArticle

  11. Complement activation in animal and human pregnancies as a model for immunological recognition

    Girardi, G., Prohászka, Z., Bulla, R., Tedesco, F. & Scherjon, S., Aug 2011, In : Molecular Immunology. 48, 14, p. 1621-1630 10 p., N/A.

    Research output: Contribution to journalArticle

  12. Complement activation triggers metalloproteinases release inducing cervical remodeling and preterm birth in mice

    Gonzalez, J. M., Franzke, C-W., Yang, F., Romero, R. & Girardi, G., Aug 2011, In : The American journal of pathology. 179, 2, p. 838-849 12 p., N/A.

    Research output: Contribution to journalArticle

  13. Role of tissue factor in pregnancy complications: crosstalk between coagulation and inflammation

    Girardi, G., Feb 2011, In : Thrombosis Research. 127 , Suppl 3, p. S43-S46 4 p., N/A.

    Research output: Contribution to journalArticle

  14. Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2

    Ramesh, S., Morrell, C. N., Tarango, C., Thomas, G. D., Yuhanna, I. S., Girardi, G., Herz, J., Urbanus, R. T., de Groot, P. G., Thorpe, P. E., Salmon, J. E., Shaul, P. W. & Mineo, C., 4 Jan 2011, In : Journal of Clinical Investigation. 121, 1, p. 120-131 12 p., N/A.

    Research output: Contribution to journalArticle

  15. A new mouse model to explore therapies for preeclampsia

    Ahmed, A., Singh, J., Khan, Y., Seshan, S. V. & Girardi, G., 27 Oct 2010, In : PLoS ONE. 5, 10, p. N/A 9 p., e13663.

    Research output: Contribution to journalArticle

  16. An alternative role of C1q in cell migration and tissue remodeling: contribution to trophoblast invasion and placental development

    Agostinis, C., Bulla, R., Tripodo, C., Gismondi, A., Stabile, H., Bossi, F., Guarnotta, C., Garlanda, C., De Seta, F., Spessotto, P., Santoni, A., Ghebrehiwet, B., Girardi, G. & Tedesco, F., 1 Oct 2010, In : Journal of Immunology. 185, 7, p. 4420-4429 10 p., N/A.

    Research output: Contribution to journalArticle

  17. Pravastatin prevents miscarriages in antiphospholipid antibody-treated mice

    Girardi, G., Nov 2009, In : Journal of Reproductive Immunology. 82, 2, p. 126-131 6 p., N/A.

    Research output: Contribution to journalArticle

  18. Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodies

    Seshan, S. V., Franzke, C-W., Redecha, P., Monestier, M., Mackman, N. & Girardi, G., 20 Aug 2009, In : Blood. 114, 8, p. 1675-1683 9 p., N/A.

    Research output: Contribution to journalArticle

  19. Pravastatin prevents miscarriages in mice: role of tissue factor in placental and fetal injury

    Redecha, P., van Rooijen, N., Torry, D. & Girardi, G., 23 Apr 2009, In : Blood. 113, 17, p. 4101-4109 9 p., N/A.

    Research output: Contribution to journalArticle

  20. Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome

    Redecha, P., Franzke, C-W., Ruf, W., Mackman, N. & Girardi, G., 1 Oct 2008, In : Journal of Clinical Investigation. 118, 10, p. 3453-3461 9 p., N/A.

    Research output: Contribution to journalArticle

  21. Guilty as charged: all available evidence implicates complement's role in fetal demise

    Girardi, G., Mar 2008, In : American Journal of Reproductive Immunology. 59, 3, p. 183-192 10 p., N/A.

    Research output: Contribution to journalArticle

  22. Antiphospholipid antibodies and pregnancy loss: a disorder of inflammation

    Salmon, J. E. & Girardi, G., Jan 2008, In : Journal of Reproductive Immunology. 77, 1, p. 51-56 6 p., N/A.

    Research output: Contribution to journalArticle

  23. Complement inhibition keeps mothers calm and avoids fetal rejection

    Girardi, G., 2008, In : Immunological Investigations. 37, 5-6, p. 645-659 15 p., N/A.

    Research output: Contribution to journalArticle

  24. Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury

    Redecha, P., Tilley, R., Tencati, M., Salmon, J. E., Kirchhofer, D., Mackman, N. & Girardi, G., 1 Oct 2007, In : Blood. 110, 7, p. 2423-2431 9 p., N/A.

    Research output: Contribution to journalArticle

  25. Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers

    Sood, R., Zogg, M., Westrick, R. J., Guo, Y-H., Kerschen, E. J., Girardi, G., Salmon, J. E., Coughlin, S. R. & Weiler, H., 14 May 2007, In : Journal of Experimental Medicine. 204, 5, p. 1049-1056 8 p., N/A.

    Research output: Contribution to journalArticle

  26. The antiphospholipid syndrome as a disorder initiated by inflammation: implications for the therapy of pregnant patients

    Salmon, J. E., Girardi, G. & Lockshin, M. D., Mar 2007, In : NATURE CLINICAL PRACTICE RHEUMATOLOGY. 3, 3, p. 140-147; quiz 1 p following 187 8 p., N/A.

    Research output: Contribution to journalArticle

  27. Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction

    Girardi, G., Yarilin, D., Thurman, J. M., Holers, V. M. & Salmon, J. E., 4 Sep 2006, In : Journal of Experimental Medicine. 203, 9, p. 2165-2175 11 p., N/A.

    Research output: Contribution to journalArticle

  28. The complement system in the pathophysiology of pregnancy

    Girardi, G., Bulla, R., Salmon, J. E. & Tedesco, F., Jan 2006, In : Molecular Immunology. 43, 1-2, p. 68-77 10 p.

    Research output: Contribution to journalArticle

  29. Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia

    Pierangeli, S. S., Girardi, G., Vega-Ostertag, M., Liu, X., Espinola, R. G. & Salmon, J., Jul 2005, In : Arthritis & Rheumatism. 52, 7, p. 2120-2124 5 p.

    Research output: Contribution to journalArticle

  30. Complement activation: a novel pathogenic mechanism in the antiphospholipid syndrome

    Pierangeli, S. S., Vega-Ostertag, M., Liu, X. & Girardi, G., Jun 2005, In : Annals of the New York Academy of Sciences. 1051, N/A, p. 413-420 8 p., N/A.

    Research output: Contribution to journalArticle

  31. TNF-alpha is a critical effector and a target for therapy in antiphospholipid antibody-induced pregnancy loss

    Berman, J., Girardi, G. & Salmon, J. E., 1 Jan 2005, In : Journal of Immunology. 174, 1, p. 485-490 6 p.

    Research output: Contribution to journalArticle

  32. A novel inhibitor of the alternative complement pathway prevents antiphospholipid antibody-induced pregnancy loss in mice

    Thurman, J. M., Kraus, D. M., Girardi, G., Hourcade, D., Kang, H. J., Royer, P. A., Mitchell, L. M., Giclas, P. C., Salmon, J., Gilkeson, G. & Holers, V. M., Jan 2005, In : Molecular Immunology. 42, 1, p. 87-97 11 p., N/A.

    Research output: Contribution to journalArticle

  33. Anti-phospholipid antibodies restore mesenteric ischemia/reperfusion-induced injury in complement receptor 2/complement receptor 1-deficient mice

    Fleming, S. D., Egan, R. P., Chai, C., Girardi, G., Holers, V. M., Salmon, J., Monestier, M. & Tsokos, G. C., 1 Dec 2004, In : Journal of Immunology. 173, 11, p. 7055-7061 7 p., N/A.

    Research output: Contribution to journalArticle

  34. Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation

    Girardi, G., Redecha, P. & Salmon, J. E., Nov 2004, In : Nature Medicine. 10, 11, p. 1222-1226 5 p.

    Research output: Contribution to journalArticle

  35. The role of complement in the antiphospholipid syndrome

    Salmon, J. E. & Girardi, G., 2004, In : Current directions in autoimmunity. 7, p. 133-148 16 p.

    Research output: Contribution to journalArticle

  36. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome

    Girardi, G., Berman, J., Redecha, P., Spruce, L., Thurman, J. M., Kraus, D., Hollmann, T. J., Casali, P., Caroll, M. C., Wetsel, R. A., Lambris, J. D., Holers, V. M. & Salmon, J. E., Dec 2003, In : Journal of Clinical Investigation. 112, 11, p. 1644-1654 11 p., N/A.

    Research output: Contribution to journalArticle

  37. The role of complement in pregnancy and fetal loss

    Girardi, G. & Salmon, J. B., Feb 2003, In : Autoimmunity. 36, 1, p. 19-26 8 p.

    Research output: Contribution to journalArticle

  38. Complement C3 activation is required for antiphospholipid antibody-induced fetal loss

    Holers, V. M., Girardi, G., Mo, L., Guthridge, J. M., Molina, H., Pierangeli, S. S., Espinola, R., Xiaowei, L. E., Mao, D., Vialpando, C. G. & Salmon, J. E., 21 Jan 2002, In : Journal of Experimental Medicine. 195, 2, p. 211-220 10 p., N/A.

    Research output: Contribution to journalArticle

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