Research output per year
Research output per year
Personal profile
Research interests
Hannah Gould is Professor of Biophysics and is one of the four principal investigators in the Allergy and Asthma Group in the Randall Division of Cell and Molecular Biophysics. She is also a principal investigator in the Asthma, Allergy and Lung Biology, and the MRC Centre in Allergic Mechanisms of Asthma. Her research is focused on the biology of IgE and the basis of allergic disease. She has a very active group who work on a diverse range of topics, extending from 'molecules to the bedside'. With Professors Brian Sutton and Jim McDonnell and Dr Andrew Beavil, she collaborates in studies of the relation of the structure to function of IgE and its receptors FcepsilonRI and CD23. With clinical collaborators, Professors Christopher Corrigan, Gideon Lack, Stephen Durham and others in the MRC Centre in Allergic Mechanisms of Asthma, she collaborates on problems relating to allergic mechanisms in rhinitis and asthma. With Dr David Fear in the Division of Asthma , Allergy and Lung Biology, she collaborates on chromatin remodelling in the regulation of IgE synthesis; her main contribution is single cell imaging of immunoglobulin genes by in situ hybridisation and proteins by immunofluoresence in class switch recombination, using confocal microscopy. Local germinal centre reactions (comprising somatic hypermutation, class switch recombination, and receptor revision) in allergic inflammation, is a passionate interest. She participates in the design and execution of two current clinical trials, one on the efficacy of an anti-IgE in the treatment of non-atopic asthma and the other on IgE immunotherapy of ovarian cancer. She collaborates with scientists in the US, France, and Belgium<br /><br />References:<br />1. IgE in allergy and asthma today, H.J. Gould & B.J. Sutton, Nature Reveiws in Immunology, 8, 205-217, 2008<br />2. Germinal-centre reactions in allergic inflammation. Trends in Immunology 27, 446-452, 2006
Research interests (short)
IgE, receptor structure and function; the pathogenesis of allergy; antibody engineering.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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AllergoOnkologie: Gefahrensignale in der Allergologie und Onkologie Ein Positionspapier der European Academy of Allergy and Clinical Immunology (EAACI)
Translated title of the contribution :AllergoOncology: Danger signals in allergology and oncology. A European Academy of Allergy and Clinical Immunology (EAACI) Position Paper Research output: Contribution to journal › Article › peer-review
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The crystal structure of human IgD-Fc reveals unexpected differences with other antibody isotypes
Davies, A. M., Bui, T., Pacheco-Gómez, R., Vester, S., Beavil, A., Gould, H., Sutton, B. & McDonnell, J., 25 Nov 2024, (E-pub ahead of print) In: Proteins.Research output: Contribution to journal › Article › peer-review
Open Access -
Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4
Chauhan, J., Grandits, M., Palhares, L. C. G. F., Mele, S., Nakamura, M., López-Abente, J., Crescioli, S., Laddach, R., Romero-Clavijo, P., Cheung, A., Stavraka, C., Chenoweth, A. M., Sow, H. S., Chiaruttini, G., Gilbert, A. E., Dodev, T., Koers, A., Pellizzari, G., Ilieva, K. M. & Man, F. & 20 others, , 25 Apr 2023, In: Nature Communications. 14, 1, p. 2192Research output: Contribution to journal › Article › peer-review
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Crystal structures of the human IgD Fab reveal insights into CH1 domain diversity
Davies, A. M., Beavil, R., Barbolov, M., Sandhar, B., Gould, H., Beavil, A., Sutton, B. & McDonnell, J., 1 Jun 2023, In: Molecular Immunology. 159, p. 28-37 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)64 Downloads (Pure) -
Expanding the Anti-Phl p 7 Antibody Toolkit: An Anti-Idiotype Nanobody Inhibitor
Vester, S., Davies, A. M., Beavil, R., Sandhar, B., Beavil, A., Gould, H., Sutton, B. & McDonnell, J., Dec 2023, In: Antibodies. 12, 4, 75.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus)
Projects
- 63 Finished
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Long-lived IgE+ plasma cells as a new therapeutic target for treatment of allergies and asthma
Ramadani, F. (Primary Investigator) & Gould, H. (Co-Investigator)
19/06/2017 → 18/06/2018
Project: Research
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NIHR Biomedical Research Centre. Funding for Financial Years 2017/18, 2018/19
Wolfe, C. (Primary Investigator), Parsons, M. (Primary Investigator), Gould, H. (Primary Investigator), Corrigan, C. (Primary Investigator), Greenough, A. (Primary Investigator), Peakman, M. (Primary Investigator), Vyse, T. (Primary Investigator), Antoniou, M. (Primary Investigator), Oakey, R. (Primary Investigator), McGrath, J. (Primary Investigator), Karagiannis, S. (Primary Investigator), Barker, J. (Primary Investigator), Flohr, C. (Primary Investigator), Tziotzios, C. (Primary Investigator), Whittaker, S. (Primary Investigator), Spector, T. (Primary Investigator), Watt, F. (Primary Investigator), Hayday, A. (Primary Investigator), Spencer, J. (Primary Investigator), Cope, A. (Primary Investigator), Malim, M. (Primary Investigator), Martin Serrano, J. (Primary Investigator), Edgeworth, J. (Primary Investigator), Cason, J. (Primary Investigator), Lord, G. (Primary Investigator), Dorling, A. (Primary Investigator), Sacks, S. (Primary Investigator), Sanchez Fueyo, A. (Primary Investigator), Lombardi, G. (Primary Investigator), Ostermann, M. (Primary Investigator), Shah, A. (Primary Investigator), Marber, M. (Primary Investigator), Mayr, M. (Primary Investigator), Chowienczyk, P. (Primary Investigator), Wells, C. (Primary Investigator), Grigoriadis, A. (Primary Investigator), Sawyer, E. (Primary Investigator), Maher, J. (Primary Investigator), Tribe, R. (Primary Investigator), Ilic, D. (Primary Investigator), Poston, L. (Primary Investigator), Rutherford, M. (Primary Investigator), Gee, T. (Primary Investigator), Blower, P. (Primary Investigator), Edwards, D. (Primary Investigator), Sharpe, P. (Primary Investigator), Streit, A. (Primary Investigator), Naglik, J. (Primary Investigator), Tavassoli, M. (Primary Investigator) & McNaughton, P. (Primary Investigator)
NIHR National Institute For Health & Care Research
1/04/2017 → 31/03/2022
Project: Research
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Impact of the distinctive properties of human IgE on the activities of the B cell receptor and its implications for allergic disease and asthma
Sutton, B. (Primary Investigator), Beavil, A. (Co-Investigator), Cox, S. (Co-Investigator), Gould, H. (Co-Investigator) & McDonnell, J. (Co-Investigator)
1/04/2017 → 31/03/2022
Project: Research
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Determining the pathways leading to IgE production in allergy
Fear, D. (Primary Investigator) & Gould, H. (Co-Investigator)
1/02/2017 → 31/01/2020
Project: Research
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Development of a novel research approach to understand how IgE B cells cause asthma
Wu, B. (Primary Investigator) & Gould, H. (Co-Investigator)
4/04/2016 → 3/10/2017
Project: Research
Activities
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“Regulation of IgE“ in Basic & Clinical Allergy Course. Imperial College
Gould, H. (Keynote/plenary speaker)
Apr 2010 → …Activity: Participating in or organising an event › Participation in conference
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"Cytokinergic activities of human IgE in human mast cells", Johns Hopkins Asthma and Allergy Center, Baltimore MD
Gould, H. (Keynote/plenary speaker)
Nov 2008 → …Activity: Participating in or organising an event › Participation in conference
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Invited co-chairman and speaker in Minisymposium “Mediators of allergic inflammation” n 13th International Congress of Immunology, Rio de Janeiro, Brazil
Gould, H. (Chair)
Aug 2007 → …Activity: Participating in or organising an event › Participation in conference
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“Regulation of IgE” in Basic & Clinical Allergy Course. Imperial College London
Gould, H. (Keynote/plenary speaker)
Apr 2007 → …Activity: Participating in or organising an event › Participation in conference
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“Harnessing IgE for immunotherapy of ovarian cancer in “Clemens von Pirquet Symposium”, Vienna, Austria
Gould, H. (Keynote/plenary speaker)
Dec 2006 → …Activity: Participating in or organising an event › Participation in conference