Hannah Gould is Professor of Biophysics and is one of the four principal investigators in the Allergy and Asthma Group in the Randall Division of Cell and Molecular Biophysics. She is also a principal investigator in the Asthma, Allergy and Lung Biology, and the MRC Centre in Allergic Mechanisms of Asthma. Her research is focused on the biology of IgE and the basis of allergic disease. She has a very active group who work on a diverse range of topics, extending from 'molecules to the bedside'. With Professors Brian Sutton and Jim McDonnell and Dr Andrew Beavil, she collaborates in studies of the relation of the structure to function of IgE and its receptors FcepsilonRI and CD23. With clinical collaborators, Professors Christopher Corrigan, Gideon Lack, Stephen Durham and others in the MRC Centre in Allergic Mechanisms of Asthma, she collaborates on problems relating to allergic mechanisms in rhinitis and asthma. With Dr David Fear in the Division of Asthma , Allergy and Lung Biology, she collaborates on chromatin remodelling in the regulation of IgE synthesis; her main contribution is single cell imaging of immunoglobulin genes by in situ hybridisation and proteins by immunofluoresence in class switch recombination, using confocal microscopy. Local germinal centre reactions (comprising somatic hypermutation, class switch recombination, and receptor revision) in allergic inflammation, is a passionate interest. She participates in the design and execution of two current clinical trials, one on the efficacy of an anti-IgE in the treatment of non-atopic asthma and the other on IgE immunotherapy of ovarian cancer. She collaborates with scientists in the US, France, and Belgium<br /><br />References:<br />1. IgE in allergy and asthma today, H.J. Gould &amp; B.J. Sutton, Nature Reveiws in Immunology, 8, 205-217, 2008<br />2. Germinal-centre reactions in allergic inflammation. Trends in Immunology 27, 446-452, 2006