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Research portal

Professor Hannah Gould

Research interests

Hannah Gould is Professor of Biophysics and is one of the four principal investigators in the Allergy and Asthma Group in the Randall Division of Cell and Molecular Biophysics. She is also a principal investigator in the Asthma, Allergy and Lung Biology, and the MRC Centre in Allergic Mechanisms of Asthma. Her research is focused on the biology of IgE and the basis of allergic disease. She has a very active group who work on a diverse range of topics, extending from 'molecules to the bedside'. With Professors Brian Sutton and Jim McDonnell and Dr Andrew Beavil, she collaborates in studies of the relation of the structure to function of IgE and its receptors FcepsilonRI and CD23. With clinical collaborators, Professors Christopher Corrigan, Gideon Lack, Stephen Durham and others in the MRC Centre in Allergic Mechanisms of Asthma, she collaborates on problems relating to allergic mechanisms in rhinitis and asthma. With Dr David Fear in the Division of Asthma , Allergy and Lung Biology, she collaborates on chromatin remodelling in the regulation of IgE synthesis; her main contribution is single cell imaging of immunoglobulin genes by in situ hybridisation and proteins by immunofluoresence in class switch recombination, using confocal microscopy. Local germinal centre reactions (comprising somatic hypermutation, class switch recombination, and receptor revision) in allergic inflammation, is a passionate interest. She participates in the design and execution of two current clinical trials, one on the efficacy of an anti-IgE in the treatment of non-atopic asthma and the other on IgE immunotherapy of ovarian cancer. She collaborates with scientists in the US, France, and Belgium<br /><br />References:<br />1. IgE in allergy and asthma today, H.J. Gould &amp; B.J. Sutton, Nature Reveiws in Immunology, 8, 205-217, 2008<br />2. Germinal-centre reactions in allergic inflammation. Trends in Immunology 27, 446-452, 2006

Participation in conference

“Regulation of IgE“ in Basic & Clinical Allergy Course. Imperial College

Gould, H. (Keynote/plenary speaker)
Apr 2010 → …

Activity: Participating in or organising an eventParticipation in conference

"Cytokinergic activities of human IgE in human mast cells", Johns Hopkins Asthma and Allergy Center, Baltimore MD

Gould, H. (Keynote/plenary speaker)
Nov 2008 → …

Activity: Participating in or organising an eventParticipation in conference

“Regulation of IgE” in Basic & Clinical Allergy Course. Imperial College London

Gould, H. (Keynote/plenary speaker)
Apr 2007 → …

Activity: Participating in or organising an eventParticipation in conference

“Harnessing IgE for immunotherapy of ovarian cancer in “Clemens von Pirquet Symposium”, Vienna, Austria

Gould, H. (Keynote/plenary speaker)
Dec 2006 → …

Activity: Participating in or organising an eventParticipation in conference

“Immunological diseases other than allergy”, Randall Retreat, Sussex University, Brighton

Gould, H. (Keynote/plenary speaker)
Sep 2006 → …

Activity: Participating in or organising an eventParticipation in conference

“Local clonal selection of B cells”, Symposium on IgE BACI meeting, Loughborough

Gould, H. (Keynote/plenary speaker)
Jul 2006 → …

Activity: Participating in or organising an eventParticipation in conference

“Biology of IgE” in Workshop “The IgE Molecule and its Receptors”, EAACI Congress, Vienna, Austria

Gould, H. (Keynote/plenary speaker)
Jun 2006 → …

Activity: Participating in or organising an eventParticipation in conference

“IgE switching and hyupermutation in tissues”.in Keystone meeting “Allergy, Allergic Inflammation and Asthma”, Breckenridge, CO, USA

Gould, H. (Keynote/plenary speaker)
Apr 2006 → …

Activity: Participating in or organising an eventParticipation in conference

“Regulation of IgE“ in Basic & Clinical Allergy Course. Imperial College London

Gould, H. (Keynote/plenary speaker)
Mar 2006 → …

Activity: Participating in or organising an eventParticipation in conference

“Superantigen effects on B cells” in Symposium on “Superantigens in airway disease” Ghent, Belgium

Gould, H. (Keynote/plenary speaker)
Nov 2005 → …

Activity: Participating in or organising an eventParticipation in conference

“Is IgE a remedy for ovarian cancer?” at CRUK Oncology Unit, Cancer Sciences Division, School of Medicine, University of Southampton

Gould, H. (Keynote/plenary speaker)
Oct 2005 → …

Activity: Participating in or organising an eventParticipation in conference

“IgE and You” at 75th birthday symposium for Gary Felsenfeld, Bethesda, MD, USA

Gould, H. (Keynote/plenary speaker)
Apr 2005 → …

Activity: Participating in or organising an eventParticipation in conference

“IgE-IgE rececptor interaction and antagonits in Symposium IgE regulation, World Allergy Congress, Munich, Austria

Gould, H. (Keynote/plenary speaker)
2005 → …

Activity: Participating in or organising an eventParticipation in conference

Publication peer-review

J. Immunol (Journal)

Gould, H. (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Clin. Exp. allergy (Journal)

Gould, H. (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Journal of Allergy and Clinical Immunology (Journal)

Gould, H. (Editor)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Types of External academic engagement - Membership of external research organisation

Collegium Allergolicum Internationale

Gould, H. (Member)
2001 → …

Activity: OtherTypes of External academic engagement - Membership of external research organisation

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