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Biographical details

Dr Hashim Ali is a Research Associate within the School of Cardiovascular Medicine & Sciences at James Black Centre, King’s College London.

He did his PhD in the lab of Prof. Mauro Giacca at International Center for Genetic Engineering and Biotechnology (ICGEB), Trieste, ITALY. During his PhD, he contributed to the identification of the host factors regulating HIV-1 integration, transcription and integrase protein stability. He also contributed to show for the first time the topological location of the integrated HIV-1 inside the cell nucleus. In his PhD, he identified that the host ubiquitin E3 ligase TRIM33, degrades HIV-1 integrase. Sideways, he also worked on a project involved in the identification and characterization of the mechanisms of extracellular secretion of the HIV-1 Tat protein and identified that the cellular Na+K+ATPase alpha1 subunit plays a key role in non-canonical extracellular release of Tat protein. His entire work is well presented and a significant advancement in the field that identifies the important role of the cellular factors regulating HIV-1 integration.

After gaining expertise in ubiquitin-proteasomal degradation pathway, he got interested in identifying endogenous pathways/human miRNAs regulating cardiomyocyte proliferation that could potentially be used as cardiac regenerative therapeutics. This led him to join the group of Prof. Mauro Giacca at ICGEB, Trieste, ITALY and later at King’s College London, UK. During his early postdoctoral training, he deeply studied the role of human miRNAs/endogenous pathways regulating cardiac regeneration.

At King’s College London, his research interest includes investigating the novel ubiquitin-conjugation factors capable of modulating cardiomyocyte proliferation. He is also interested in the understanding of the crucial endogenous pathways regulating cardiac regeneration and how posttranslational modifications of proteins and remodeling of cardiac cytoskeletons contribute to cardiac dysfunction.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Molecular Virology, Doctor of Medicine (research), HIV-1 integration, International Centre for Genetic Engineering and Biotechnology

1 Jan 201113 Jul 2015

Award Date: 25 Aug 2015

Biotechnology, Master in Science, Jamia Hamdard University, New Delhi

Award Date: 10 May 2008

Biotechnology, Bachelor of Science, Jamia Millia Islamia

Award Date: 29 Oct 2006

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