King's College London

Research portal

Professor Helen Cox

  1. Synthetic GPBA agonists and bile acids act via basolateral receptors in ileal and colonic mucosa

    Cox, H. M., Tough, I. R. & Schwartz, T. W., 2020, (Submitted) In : Neurogastroenterology and Motility.

    Research output: Contribution to journalArticle

  2. The extracellular matrix glycoprotein tenascin-X regulates peripheral sensory and motor neurones

    Aktar, R., Peiris, M., Fikree, A., Cibert-Goton, V., Walmsley, M., Tough, I. R., Watanabe, P., Araujo, E. J. A., Mohammed, S. D., Delalande, J. M., Bulmer, D. C., Scott, S. M., Cox, H. M., Voermans, N. C., Aziz, Q. & Blackshaw, L. A., 1 Sep 2018, In : Journal of Physiology. 596, 17, p. 4237-4251 15 p.

    Research output: Contribution to journalArticle

  3. Bidirectional GPR119 agonism requires peptide YY and glucose for activity in mouse and human colon mucosa

    Tough, I. R., Forbes, S., Herzog, H., Jones, R. M., Schwartz, T. W. & Cox, H. M., 1 Apr 2018, In : Endocrinology. 159, 4, p. 1704–1717

    Research output: Contribution to journalArticle

  4. Agonism of free fatty acid receptors 1 and 4 generates peptide YY-mediated inhibitory responses in mouse colon

    Moodaley, R., Smith, D. M., Tough, I. R., Schindler, M. & Cox, H. M., 8 Nov 2017, In : British Journal of Pharmacology.

    Research output: Contribution to journalArticle

  5. Identification and Characterization of the First Selective Y4 Receptor Positive Allosteric Modulator

    Schubert, M., Stichel, J., Du, Y., Tough, I. R., Sliwoski, G., Meiler, J., Cox, H. M., Weaver, C. D. & Beck-Sickinger, A. G., 14 Sep 2017, In : Journal of Medicinal Chemistry. 60, 17, p. 7605-7612 8 p.

    Research output: Contribution to journalArticle

  6. High molecular weight PEGylation of human pancreatic polypeptide at position 22 improves stability and reduces food intake in mice

    Thieme, V., Jolly, N., Madsen, A. N., Bellmann-Sickert, K., Schwartz, T. W., Holst, B., Cox, H. & Beck-Sickinger, A. G., 1 Nov 2016, In : British Journal of Pharmacology. 173, 22, p. 3208-3221 14 p.

    Research output: Contribution to journalArticle

  7. L-arginine promotes gut hormone release and reduces food intake in rodents

    Alamshah, A., Mcgavigan, A. K., Spreckley, E., Kinsey-Jones, J. S., Amin, A., Tough, I. R., O'Hara, H. C., Moolla, A., Banks, K., France, R., Hyberg, G., Norton, M., Cheong, W., Lehmann, A., Bloom, S. R., Cox, H. M. & Murphy, K. G., May 2016, In : DIABETES OBESITY AND METABOLISM. 18, 5, p. 508-518 11 p.

    Research output: Contribution to journalArticle

  8. Intestinal chemosensory mechanisms involving PYY and GLP-1: Advances in NPY Research

    Cox, H. M., Feb 2016, In : Neuropeptides. 55, p. 27 1 p.

    Research output: Contribution to journalArticle

  9. Selective FFA2 Agonism Appears to Act via Intestinal PYY to Reduce Transit and Food Intake but Does Not Improve Glucose Tolerance in Mouse Models

    Forbes, S., Stafford, S., Coope, G., Heffron, H., Real, K., Newman, R., Davenport, R., Barnes, M., Grosse, J. & Cox, H., 1 Nov 2015, In : Diabetes. 64, 11, p. 3763-3771 9 p.

    Research output: Contribution to journalArticle

  10. G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons

    Ghamari-Langroudi, M., Digby, G. J., Sebag, J. A., Millhauser, G. L., Palomino, R., Matthews, R., Gillyard, T., Panaro, B. L., Tough, I. R., Cox, H. M., Denton, J. S. & Cone, R. D., 2 Apr 2015, In : NATURE. 520, 7545, p. 94-98 5 p.

    Research output: Contribution to journalLetter

  11. The melanocortin-4 receptor is expressed in enteroendocrine l cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo

    Panaro, B. L., Tough, I. R., Engelstoft, M. S., Matthews, R. T., Digby, G. J., Møller, C. L., Svendsen, B., Gribble, F., Reimann, F., Holst, J. J., Holst, B., Schwartz, T. W., Cox, H. M. & Cone, R. D., 2 Dec 2014, In : CELL METABOLISM. 20, 6, p. 1018-1029 12 p.

    Research output: Contribution to journalArticle

  12. Gastrointestinal hormonal responses on GPR119 activation in lean and diseased rodent models of type 2 diabetes

    Patel, S., Mace, O. J., Tough, I. R., White, J., Cock, T. A., Warpman Berglund, U., Schindler, M. & Cox, H. M., 1 Oct 2014, In : INTERNATIONAL JOURNAL OF OBESITY. 38, 10, p. 1365-1373 9 p.

    Research output: Contribution to journalArticle

  13. Peptide modifications differentially alter G protein-coupled receptor internalization and signaling bias

    Mäde, V., Babilon, S., Jolly, N., Wanka, L., Bellmann-Sickert, K., Diaz Gimenez, L. E., Mörl, K., Cox, H. M., Gurevich, V. V. & Beck-Sickinger, A. G., 15 Sep 2014, In : ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 53, 38, p. 10067-10071 5 p.

    Research output: Contribution to journalArticle

  14. Properties of cholinergic and non-cholinergic submucosal neurons along the mouse colon

    Foong, J. P. P., Tough, I. R., Cox, H. M. & Bornstein, J. C., 15 Feb 2014, In : J Physiol - London. 592, 4, p. 777-793 18 p.

    Research output: Contribution to journalArticle

  15. The Concise Guide to PHARMACOLOGY 2013/14: overview

    Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Dec 2013, In : British Journal of Pharmacology. 170, 8, p. 1449-1458 10 p.

    Research output: Contribution to journalArticle

  16. Endogenous PYY and GLP-1 mediate L-glutamine responses in intestinal mucosa

    Joshi, S., Tough, I. R. & Cox, H. M., Nov 2013, In : British Journal of Pharmacology. 170, 5, p. 1092–1101 9 p., N/A.

    Research output: Contribution to journalArticle

  17. A role for neuropeptide Y in the gender-specific gastrointestinal, corticosterone and feeding responses to stress

    Forbes, S., Herzog, H. & Cox, H., Aug 2012, In : British Journal of Pharmacology. 166, 8, p. 2307-2316 10 p.

    Research output: Contribution to journalArticle

  18. Endogenous peptide YY and neuropeptide Y inhibit colonic ion transport, contractility and transit differentially via Y-1 and Y-2 receptors

    Tough, I. R., Forbes, S., Tolhurst, R., Ellis, M., Herzog, H., Bornstein, J. C. & Cox, H. M., Sep 2011, In : British Journal of Pharmacology. 164, 2B, p. 471 - 484 14 p.

    Research output: Contribution to journalArticle

  19. Peptide YY Is Critical for Acylethanolamine Receptor Gpr119-Induced Activation of Gastrointestinal Mucosal Responses

    Cox, H. M., Tough, I. R., Woolston, A-M., Zhang, L., Nguyen, A. D., Sainsbury, A. & Herzog, H., 9 Jun 2010, In : CELL METABOLISM. 11, 6, p. 532 - 542 11 p.

    Research output: Contribution to journalArticle

  20. Identification of a novel 5-HT4 receptor splice variant (r5-HT4c1) and preliminary characterisation of specific 5-HT4a and 5-HT4b receptor antibodies

    Ray, A. M., Kelsell, R. E., Houp, J. A., Kelly, F. M., Medhurst, A. D., Cox, H. M. & Calver, A. R., 14 Feb 2009, In : European Journal of Pharmacology. 604, 1-3, p. 1 - 11 11 p.

    Research output: Contribution to journalArticle

  21. Endogenous PYY and NPY mediate tonic Y-l- and Y-2-mediated absorption in human and mouse colon

    Cox, H. M., Sep 2008, In : Nutrition. 24, 9, p. 900 - 906 7 p.

    Research output: Contribution to journalArticle

  22. Importance of constitutive activity and arrestin independent mechanisms for intracellular trafficking of the ghrelin receptor

    Holliday, N. D., Holst, B., Rodionova, E. A., Schwartz, T. W. & Cox, H. M., Dec 2007, In : Molecular Endocrinology. 21, 12, p. 3100 - 3112 13 p.

    Research output: Contribution to journalArticle

  23. Human pancreatic secretory trypsin inhibitor stabilizes intestinal mucosa against noxious agents

    Marchbank, T., Mahmood, A., FitzGerald, A. J., Domin, J., Butler, M., Goodlad, R. A., Elia, G., Cox, H. M., van Heel, D. A., Ghosh, S. & Playford, R. J., Nov 2007, In : American Journal of Pathology. 171, 5, p. 1462 - 1473 12 p.

    Research output: Contribution to journalArticle

  24. A functional comparison of recombinant and native somatostatin sst(2) receptor variants in epithelia

    Holliday, N. D., Tough, I. R. & Cox, H. M., Sep 2007, In : British Journal of Pharmacology. 152, 1, p. 132 - 140 9 p.

    Research output: Contribution to journalArticle

  25. Neuropeptide Y receptors; antisecretory control of intestinal epithelial function

    Cox, H. M., 30 Apr 2007, In : Autonomic Neuroscience-Basic & Clinical. 133, 1, p. 76 - 85 10 p.

    Research output: Contribution to journalLiterature review

  26. In preparation

    A functional comparison of recombinant and native somatostatin sst2 receptor variants in epithelia.

    Holliday, ND., Tough, IR. & Cox, HM., 2007, (In preparation) In : British Journal of Pharmacology.

    Research output: Contribution to journalArticle

  27. Neuropeptides and their receptors: innovative science providing novel therapeutic targets

    Brain, S. D. & Cox, H. M., Jan 2006, In : British Journal of Pharmacology. 147, SUPPL. 1, p. S202 - S211

    Research output: Contribution to journalArticle

  28. Role of the C terminus in neuropeptide Y Y1 receptor desensitization and internalization

    Holliday, N. D., Lam, C. W., Tough, I. R. & Cox, H. M., Mar 2005, In : Molecular Pharmacology. 67, 3, p. 655 - 664 10 p.

    Research output: Contribution to journalArticle

  29. Neuropeptide Y receptors and their signalling

    Holliday, N. D., Michel, M. C. & Cox, H. M., 2005, Neuropeptide Y and related peptides. Michel, M. C. (ed.). Springer, p. 45 - 73 29 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  30. Common structural basis for constitutive activity of the ghrelin receptor family

    Holst, B., Holliday, N. D., Bach, A., Elling, C. E., Cox, H. M. & Schwartz, T. W., 17 Dec 2004, In : Journal of Biological Chemistry. 279, 51, p. 53806 - 53817 12 p.

    Research output: Contribution to journalArticle

  31. NPY receptor types and their signal transduction

    Holliday, N. D., Cox, H. M. & Michel, M., 2004, Neuropeptide Y and related peptides. Michel, M. C. (ed.). Springer, p. 45 - 73 29 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  32. NPY-like peptides, their receptors and gastrointestinal function

    Cox, H. M., Hyland, N. P. & Michel, M. (ed.), 2004, Neuropeptide Y and related peptides. Michel, M. C. (ed.). Springer

    Research output: Chapter in Book/Report/Conference proceedingChapter

  33. Peptide YY

    Cox, H. M., 2004, Encyclopedia of Endocrinology and Endocrine Diseases. Martini, L. & Rehfeld, J. (eds.). San Diego: Academic Press, p. 585 - 588 4 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  34. Rafts, little caves and large potholes: how lipid structure interacts with membrane proteins to create functionally diverse membrane environments

    Morris, R. J., Cox, H. M., Mombelli, E. & Quinn, P. J., 2004, Membrane Dynamics and Domains. Quinn, P. J. (ed.). New York: Kluwer Academic, p. 35 - 118 84 p. (Subcellular Biochemistry; vol. 37).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  35. The ability of neuropeptide Y to mediate responses in the murine cutaneous microvasculature: an analysis of the contribution of Y-1 and Y-2 receptors

    Chu, D. Q., Cox, H. M., Costa, S. K. P., Herzog, H. & Brain, S. D., Sep 2003, In : British Journal of Pharmacology. 140, 2, p. 422 - 430 9 p.

    Research output: Contribution to journalArticle

  36. Control of signalling efficacy by palmitoylation of the rat Y-1 receptor

    Holliday, N. D. & Cox, H. M., Jun 2003, In : British Journal of Pharmacology. 139, 3, p. 501 - 512 12 p.

    Research output: Contribution to journalArticle

  37. Functional consequences of neuropeptide YY2 receptor knockout and Y-2 antagonism in mouse and human colonic tissues

    Hyland, N. P., Sjoberg, F., Tough, I. R., Herzog, H. & Cox, H. M., Jun 2003, In : British Journal of Pharmacology. 139, 4, p. 863 - 871 9 p.

    Research output: Contribution to journalArticle

  38. Dual and selective antagonism of neurokinin NK1 and NK2 receptor-mediated responses in human colon mucosa

    Tough, I. R., Lewis, C. A., Fozard, J. & Cox, H. M., 1 Feb 2003, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 367, 2, p. 104 - 108 5 p.

    Research output: Contribution to journalArticle

  39. Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice

    Sainsbury, A., Schwarzer, C., Couzens, M., Fetissov, S., Furtinger, S., Jenkins, A., Cox, H. M., Sperk, G., Hokfelt, T. & Herzog, H., 25 Jun 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 13, p. 8938 - 8943 6 p.

    Research output: Contribution to journalArticle

  40. Neuropeptide Y, Y-1, Y-2 and Y-4 receptors mediate Y agonist responses in isolated human colon mucosa

    Cox, H. M. & Tough, I. R., 2002, In : British Journal of Pharmacology. 135, 6, p. 1505 - 1512 8 p.

    Research output: Contribution to journalArticle

  41. Effect of ectopic expression of rat trefoil factor family 3 (intestinal trefoil factor) in the jejunum of transgenic mice

    Marchbank, T., Cox, H. M., Goodlad, R. A., Giraud, A. S., Moss, S. F., Poulsom, R., Wright, N. A., Jankowski, J. & Playford, R. J., 29 Jun 2001, In : Journal of Biological Chemistry. 276, 26, p. 24088 - 24096 9 p.

    Research output: Contribution to journalArticle

  42. Tachykinin NK2 receptor mediates contraction and ion transport in rat colon by different mechanisms

    Patacchini, R., Cox, H. M., Stahl, S., Tough, I. R. & Maggi, C. A., 16 Mar 2001, In : European Journal of Pharmacology. 415, 2-3, p. 277 - 283 7 p.

    Research output: Contribution to journalArticle

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