Research output per year
Research output per year
Personal profile
Research interests
The enteric nervous system and neuroendocrine systems and their roles in co-ordinating intestinal functions in health and disease. We utilise physiological, pharmacological and molecular strategies to elucidate peptide-receptor actions in complex (isolated human tissue) and simple models (epithelial cells in culture).
Research interests (short)
Neuropeptide receptor signalling.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Cellular Pharmacology, Doctor of Philosophy, Angiotensin Receptor Cellular Pharmacology, University of Southampton
Award Date: 2 Feb 1983
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Highly Selective Y4Receptor Antagonist Binds in an Allosteric Binding Pocket
Schüß, C., Vu, O., Schubert, M., Du, Y., Mishra, N. M., Tough, I. R., Stichel, J., Weaver, C. D., Emmitte, K. A., Cox, H. M., Meiler, J. & Beck-Sickinger, A. G., 11 Mar 2021, In: Journal of Medicinal Chemistry. 64, 5, p. 2801-2814 14 p.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
Oleh Hornykiewicz, a giant in the understanding and treatment of Parkinson disease
Salvage, S., Hikima, A., Tough, I. R., Pritchard, S., Jackson, M., Jenner, P., Chaudhuri, K., Cox, H., Iravani, MM. & Coletto, E., 23 Jan 2021, In: Nature Parkinson's Journal. 7, 1, 9 p., 1.Research output: Contribution to journal › Editorial › peer-review
Open Access3 Citations (Scopus) -
Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist
Grunddal, K. V., Diep, T. A., Petersen, N., Tough, I. R., Skov, L. J., Liu, L., Buijink, J. A., Mende, F., Jin, C., Jepsen, S. L., Sørensen, L. M. E., Achiam, M. P., Strandby, R. B., Bach, A., Hartmann, B., Frimurer, T. M., Hjorth, S. A., Bouvier, M., Cox, H. & Holst, B., Jul 2021, In: Molecular Metabolism. 49, 101207.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
Synthetic G protein-coupled bile acid receptor agonists and bile acids act via basolateral receptors in ileal and colonic mucosa
Tough, I. R., Schwartz, T. W. & Cox, H. M., Dec 2020, In: Neurogastroenterology and Motility. 32, 12, e13943.Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus) -
Bidirectional GPR119 agonism requires peptide YY and glucose for activity in mouse and human colon mucosa
Tough, I. R., Forbes, S., Herzog, H., Jones, R. M., Schwartz, T. W. & Cox, H. M., 1 Apr 2018, In: Endocrinology. 159, 4, p. 1704–1717Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)167 Downloads (Pure)
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Intestinal G protein-coupled receptors (GPCRs): characterising gut GPCR-signalling with potential to treat colitis
1/10/2022 → 30/09/2026
Project: Research
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UKRI CoA: Functional investigations of enteroendocrine cell signalling in the intestine.
EPSRC Engineering and Physical Sciences Research Council
1/07/2020 → 31/07/2021
Project: Research
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G protein-coupled receptor (GPCR) signaling in the mouse and human gastrointestinal (GI) tract.
1/10/2019 → 30/09/2023
Project: Research
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Functional investigations of enteroendocrine cell signalling in the intestine.
BBSRC Biotechnology and Biological Sciences Research Council
1/07/2016 → 30/06/2019
Project: Research
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MICA: Targeting the calcium sensing receptor to modulate energy homeostasis
1/10/2015 → 30/09/2018
Project: Research
Activities
- 5 Types of External academic engagement - Contribution to the work of national or international committees and working groups
- 4 Types of Business and Community - Work on advisory panel to industry or government or non-government organisation
- 3 Types of External academic engagement - Membership of external research organisation
- 2 Editorial activity
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More
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Co-organiser of Joint European Neuropeptide Club (ENC) and British Pharmacological Society (BPS) meeting at Kings College London June 7th-9th 2012
Helen Cox (Chair)
2011 → 2012Activity: Other › Types of External academic engagement - Contribution to the work of national or international committees and working groups
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Council and Trustee of the British Pharmacological Society
Helen Cox (Committee Member)
2010 → 2014Activity: Other › Types of External academic engagement - Membership of external research organisation
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Current Opinions in Pharmacology (Journal)
Helen Cox (Editorial board member)
2010 → …Activity: Publication peer-review and editorial work › Editorial activity
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Co-organiser of 10th International Meeting on Neuropeptide Y and related Peptides, Montreal, Jun 30th - Jul 4th 2012
Helen Cox (Committee Member)
2010 → 2012Activity: Other › Types of External academic engagement - Contribution to the work of national or international committees and working groups
Prizes
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Fellowship of British Pharmacological Society
Cox, Helen (Recipient), 2017
Prize: Fellowship awarded competitively