Helen Rooks

2024

Reduced GATA1 levels are associated with ineffective erythropoiesis in sickle cell anemia

El Hoss, S., Shangaris, P., Brewin, J., Psychogyiou, M. E., Ng, C., Pedler, L., Rooks, H., Gotardo, É. M. F., Gushiken, L. F. S., Brito, P. L., Nicolaides, K. H., Conran, N., Rees, D. C. & Strouboulis, J., 5 Dec 2024, (E-pub ahead of print) In: Haematologica.

Research output: Contribution to journal › Article › peer-review

Open Access

The genetic dissection of fetal haemoglobin persistence in sickle cell disease in Nigeria

Ojewunmi, O. O., Adeyemo, T. A., Oyetunji, A. I., Inyang, B., Akinrindoye, A., Mkumbe, B. S., Gardner, K., Rooks, H., Brewin, J., Patel, H., Lee, S. H., Chung, R., Rashkin, S., Kang, G., Chianumba, R., Sangeda, R., Mwita, L., Isa, H., Agumadu, U.-N. & Ekong, R. & 15 others, Faruk, J. A., Jamoh, B. Y., Adebiyi, N. M., Umar, I. A., Hassan, A., Grace, C., Goel, A., Inusa, B. P. D., Falchi, M., Nkya, S., Makani, J., Ahmad, H. R., Nnodu, O., Strouboulis, J. & Menzel, S., 15 May 2024, In: Human Molecular Genetics. 33, 10, p. 919-929 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

2020

F cell numbers are associated with an X-linked genetic polymorphism and correlate with haematological parameters in patients with sickle cell disease

Urio, F., Nkya, S., Rooks, H., Mgaya, J. A., Masamu, U., Zozimus Sangeda, R., Mmbando, B. P., Brumat, M., Mselle, T., Menzel, S., Luzzatto, L. & Makani, J., Dec 2020, In: British Journal of Haematology. 191, 5, p. 888-896 9 p.

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Genome wide association study of silent cerebral infarction in sickle cell disease (HbSS and HbSC)

Brewin, J. N., Rooks, H., Gardner, K., Senior, H., Morje, M., Patel, H., Calvet, D., Bartolucci, P., Thein, S.-L., Menzel, S. & Rees, D. C., 23 Dec 2020, In: Haematologica. Online ahead of print

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

2018

A survey of genetic fetal-haemoglobin modifiers in Nigerian patients with sickle cell anaemia

Adeyemo, T. A., Ojewunmi, O. O., Oyetunji, I. A., Rooks, H., Rees, D. C., Akinsulie, A. O., Akanmu, A. S., Thein, S. L. & Menzel, S., 7 Jun 2018, In: PLoS ONE. 13, 6, e0197927.

Research output: Contribution to journal › Article › peer-review

Open Access

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19 Citations (Scopus)

120 Downloads (Pure)

A survey of genetic fetal-haemoglobin modifiers in Nigerian patients with sickle cell anaemia

Adeyemo, T. A., Ojewunmi, O., Oyetunji, I. A., Rooks, H., Rees, D., Akinsulie, A. O., Akanmu, A. S., Thein, S. L. & Menzel, S., Oct 2018, In: PLoS One.

Research output: Contribution to journal › Article › peer-review

Open Access

g(HbF): a genetic model of fetal hemoglobin in sickle cell disease

Gardner, K., Fulford, T., Silver, N., Rooks, H., Angelis, N., Allman, M., Nkya, S., Makani, J., Howard, J., Kesse-Adu, R., Rees, D. C., Stuart-Smith, S., Yeghen, T., Awogbade, M., Sangeda, R. Z., Mgaya, J., Patel, H., Newhouse, S., Menzel, S. & Thein, S. L., 13 Feb 2018, In: Blood Advances. 2, 3, p. 235-239 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

34 Citations (Scopus)

351 Downloads (Pure)

2016

Beta thalassaemia intermedia due to co-inheritance of three unique alpha globin cluster duplications characterised by next generation sequencing analysis

Clark, B., Shooter, C., Smith, F., Brawand, D., Steedman, L., Oakley, M., Rushton, P., Rooks, H., Wang, X., Drousiotou, A., Kyrri, A., Hadjigavriel, M., Will, A., Fisher, C., Higgs, D. R., Phylipsen, M., Harteveld, C., Kleanthous, M. & Thein, S. L., 29 Jul 2016, (E-pub ahead of print) In: British Journal of Haematology.

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

2015

Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer

Mtatiro, S. N., Mgaya, J., Singh, T., Mariki, H., Rooks, H., Soka, D., Mmbando, B., Thein, S. L., Barrett, J. C., Makani, J., Cox, S. E. & Menzel, S., 10 Feb 2015, In: BMC Medical Genetics. 16, 1, 4.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Citations (Scopus)

Next generation sequencing identifies a novel rearrangement in the HBB cluster permitting to-the-base characterization

Shooter, C., Rooks, H., Thein, S. L. & Clark, B., 1 Jan 2015, In: Human Mutation. 36, 1, p. 142-150 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Citations (Scopus)

2014

Genome wide association study of fetal hemoglobin in sickle cell Anemia in Tanzania

Mtatiro, S. N., Singh, T., Rooks, H., Mgaya, J., Mariki, H., Soka, D., Mmbando, B., Msaki, E., Kolder, I., Thein, S. L., Menzel, S., Cox, S. E., Makani, J. & Barrett, J. C., 5 Nov 2014, In: PL o S One . 9, 11, e111464.

Research output: Contribution to journal › Article › peer-review

Open Access

76 Citations (Scopus)

Global Genetic Architecture of an Erythroid Quantitative Trait Locus, HMIP-2

Menzel, S., Rooks, H., Zelenika, D., Mtatiro, S. N., Gnanakulasekaran, A., Drasar, E., Cox, S., Liu, L., Masood, M., Silver, N., Garner, C., Vasavda, N., Howard, J., Makani, J., Adekile, A., Pace, B., Spector, T., Farrall, M., Lathrop, M. & Thein, S. L., 1 Nov 2014, In: Annals of Human Genetics. 78, 6, p. 434-451 18 p.

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

HBS1L-MYB intergenic variants modulate fetal hemoglobin via long-range MYB enhancers

Stadhouders, R., Aktuna, S., Thongjuea, S., Aghajanirefah, A., Pourfarzad, F., van IJcken, W., Lenhard, B., Rooks, H., Best, S., Menzel, S., Grosveld, F., Thein, S. L. & Soler, E., 1 Apr 2014, In: Journal of Clinical Investigation. 124, 4, p. 1699-1710 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

157 Citations (Scopus)

2013

Genetic determinants of haemolysis in sickle cell anaemia

Milton, J. N., Rooks, H., Drasar, E., McCabe, E. L., Baldwin, C. T., Melista, E., Gordeuk, V. R., Nouraie, M., Kato, G. R., Minniti, C., Taylor, J., Campbell, A., Luchtman-Jones, L., Rana, S., Castro, O., Zhang, Y., Thein, S. L., Sebastiani, P., Gladwin, M. T. & Steinberg, M. H. & 1 others, Walk-PHAAST Investigators, Apr 2013, In: British Journal of Haematology. 161, 2, p. 270-278 9 p.

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

HbA2 levels in normal adults are influenced by two distinct genetic mechanisms

Menzel, S., Garner, C., Rooks, H., Spector, T. D. & Thein, S. L., Jan 2013, In: British Journal of Haematology. 160, 1, p. 101-105 5 p.

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

2012

A novel 506 kb deletion causing epsilon gamma delta beta thalassemia

Rooks, H., Clark, B., Best, S., Rushton, P., Oakley, M., Thein, O. S., Cuthbert, A. C., Britland, A., Ruf, A. & Thein, S. L., 15 Oct 2012, In: Blood Cells Molecules and Diseases. 49, 3-4, p. 121-127 7 p.

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Helen Rooks

Research output

Search results