Ian Tomlinson

2021

Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma

PEACE Consortium, TRACERx Renal Consortium, Au, L., Hatipoglu, E., Robert de Massy, M., Litchfield, K., Beattie, G., Rowan, A., Schnidrig, D., Thompson, R., Byrne, F., Horswell, S., Fotiadis, N., Hazell, S., Nicol, D., Shepherd, S. T. C., Fendler, A., Mason, R., Del Rosario, L. & Edmonds, K. & 32 others, Lingard, K., Sarker, S., Mangwende, M., Carlyle, E., Attig, J., Joshi, K., Uddin, I., Becker, P. D., Sunderland, M. W., Akarca, A., Puccio, I., Yang, W. W., Lund, T., Dhillon, K., Vasquez, M. D., Parker, P., Moore, D., Hiley, C., Josephs, D., Chandra, A., Spicer, J., Rudman, S., Tutt, A., Tomlinson, I., Challacombe, B., Chowdhury, S., Harrison-Phipps, K., Hill, P., Horsfield, C., O'Brien, T., Olsburgh, J. & Polson, A., 8 Nov 2021, In: CANCER CELL. 39, 11, p. 1497-1518.e11

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131 Citations (Scopus)

2019

Frequency of pathogenic germline variants in CDH1, BRCA2, CHEK2, PALB2, BRCA1 and TP53 in sporadic lobular breast cancer

Petridis, C., Arora, I., Shah, V., Moss, C. L., Mera, A., Clifford, A., Gillett, C., Pinder, S. E., Tomlinson, I., Roylance, R., Simpson, M. A. & Sawyer, E. J., Jul 2019, In: Cancer Epidemiology Biomarkers and Prevention. 28, 7, p. 1162-1168 7 p.

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28 Citations (Scopus)

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2018

Management and 5-year outcomes in 9938 women with screen-detected ductal carcinoma in situ: the UK Sloane Project

Thompson, A., Clements, K., Cheung, S., Pinder, S. E., Lawrence, G., Sawyer, E., Kearins, O., Ball, G. R., Tomlinson, I., Hanby, A., Thomas, J. S. J., Maxwell, A. J., Wallis, M., Dodwell, D. J., Thompson, A., Francis, A., Sibbering, M., Bishop, H., Carpenter, R. & George, W. D. & 20 others, Lee, M., Nicholson, S., Dobson, H., Evans, A., Maxwell, A., Wallis, M., Dodwell, D., Adlard, J., Dewar, J., Ross, G., Wilcox, M., Pinder, S. E., Speirs, V., Thomas, J., Ellis, I., Lakhani, S., Macartney, J., Ball, G., Hilton, B. & Wheaton, M., Sept 2018, In: European Journal of Cancer. 101, p. 210-219 10 p.

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61 Citations (Scopus)

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2016

Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation

Ghoussaini, M., French, J., Michailidou, K., Nord, S., Beesley, J., Canisus, S., Hillman, K., Kaufmann, S., Sivakumaran, H., Moradi Marjaneh, M., Lee, J., Dennis, J., Bolla, M., Wang, Q., Dicks, E., Milne, R., Hopper, J., Southey, M., Schmidt, M. & Broeks, A. & 103 others, Muir, K., Lophatananon, A., Fasching, P., Beckmann, M., Fletcher, O., Johnson, N., Sawyer, E., Tomlinson, I., Burwinkel, B., Marme, F., Guénel, P., Truong, T., Bojesen, S., Flyger, H., Benitez, J., González-Neira, A., Alonso, M. ., Pita, G., Neuhausen, S., Anton-Culver, H., Brenner, H., Arndt, V., Meindl, A., Schmutzler, R., Brauch, H., Hamann, U., Tessier, D., Vincent, D., Nevanlinna, H., Khan, S., Matsuo, K., Ito, H., Dörk, T., Bogdanova, N., Lindblom, A., Margolin, S., Mannermaa, A., Kosma, V.-M., Wu, A., Van Den Berg, D., Lambrechts, D., Floris, G., Chang-Claude, J., Rudolph, A., Radice, P., Barile, M., Couch, F., Hallberg, E., Giles, G., Haiman, C., Le Marchand, L., Goldberg, M., Teo, S., Yip, C., Borresen-Dale, A.-L., Zheng, W., Cai, Q., Winqvist, R., Pylkäs, K., Andrulis, I., Devilee, P., Tollenaar, R. E. M., García-Closas, M., Figueroa, J., Hall, P., Czene, K., Brand, J., Darabi, H., Eriksson, M., Hooning, M., Koppert, L., Li, J., Shu, X.-O., Zheng, Y., Cox, A., Cross, S., Shah, M., Rhenius, V., Choi, J.-Y., Kang, D., Hartman, M., Chia, K., Kabisch, M., Torres, D., Luccarini, C., Conroy, D., Jakubowska, A., Lubinski, J., Sangrajrang, S., Brennan, P., Olswold, C., Slager, S., Shen, C.-Y., Hou, M.-F., Swerdlow, A., Schoemaker, M., Simard, J., Pharoah, P. P., Kristensen, V., Chenevix-Trench, G., Easton, D., Dunning, A. & Edwards, S., 15 Sept 2016, (E-pub ahead of print) In: American Journal of Human Genetics.

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54 Citations (Scopus)

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Genetic predisposition to ductal carcinoma in situ of the breast

Petridis, C., Brook, M. N., Shah, V., Kohut, K., Gorman, P., Caneppele, M., Levi, D., Papouli, E., Orr, N., Cox, A., Cross, S. S., Dos-Santos-Silva, I., Peto, J., Swerdlow, A., Schoemaker, M. J., Bolla, M. K., Wang, Q., Dennis, J., Michailidou, K. & Benitez, J. & 75 others, González-Neira, A., Tessier, D. C., Vincent, D., Li, J., Figueroa, J., Kristensen, V., Borresen-Dale, A.-L., Soucy, P., Simard, J., Milne, R. L., Giles, G. G., Margolin, S., Lindblom, A., Brüning, T., Brauch, H., Southey, M. C., Hopper, J. L., Dörk, T., Bogdanova, N. V., Kabisch, M., Hamann, U., Schmutzler, R. K., Meindl, A., Brenner, H., Arndt, V., Winqvist, R., Pylkäs, K., Fasching, P. A., Beckmann, M. W., Lubinski, J., Jakubowska, A., Mulligan, A. M., Andrulis, I. L., Tollenaar, R. A. E. M., Devilee, P., Le Marchand, L., Haiman, C. A., Mannermaa, A., Kosma, V.-M., Radice, P., Peterlongo, P., Marme, F., Burwinkel, B., van Deurzen, C. H. M., Hollestelle, A., Miller, N., Kerin, M. J., Lambrechts, D., Floris, G., Wesseling, J., Flyger, H., Bojesen, S. E., Yao, S., Ambrosone, C. B., Chenevix-Trench, G., Truong, T., Guénel, P., Rudolph, A., Chang-Claude, J., Nevanlinna, H., Blomqvist, C., Czene, K., Brand, J. S., Olson, J. E., Couch, F. J., Dunning, A. M., Hall, P., Easton, D. F., Pharoah, P. D. P., Pinder, S. E., Schmidt, M. K., Tomlinson, I., Roylance, R., García-Closas, M. & Sawyer, E. J., 17 Feb 2016, In: Breast Cancer Research. 18, 1, p. 22

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49 Citations (Scopus)

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2015

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

Day, F. R., Ruth, K. S., Thompson, D. J., Lunetta, K. L., Pervjakova, N., Chasman, D. I., Stolk, L., Finucane, H. K., Sulem, P., Bulik-Sullivan, B., Esko, T., Johnson, A. D., Elks, C. E., Franceschini, N., He, C., Altmaier, E., Brody, J. A., Franke, L. L., Huffman, J. E. & Keller, M. F. & 227 others, McArdle, P. F., Nutile, T., Porcu, E., Robino, A., Rose, L. M., Schick, U. M., Smith, J. A., Teumer, A., Traglia, M., Vuckovic, D., Yao, J., Zhao, W., Albrecht, E., Amin, N., Corre, T., Hottenga, J.-J., Mangino, M., Smith, A. V., Tanaka, T., Abecasis, G. R., Andrulis, I. L., Anton-Culver, H., Antoniou, A. C., Arndt, V., Arnold, A. M., Barbieri, C., Beckmann, M. W., Beeghly-Fadiel, A., Benitez, J., Bernstein, L., Bielinski, S. J., Blomqvist, C., Boerwinkle, E., Bogdanova, N. V., Bojesen, S. E., Bolla, M. K., Borresen-Dale, A.-L., Boutin, T. S., Brauch, H., Brenner, H., Brüning, T., Burwinkel, B., Campbell, A., Campbell, H., Chanock, S. J., Chapman, J. R., Chen, Y.-D. I., Chenevix-Trench, G., Couch, F. J., Coviello, A. D., Cox, A., Czene, K., Darabi, H., De Vivo, I., Demerath, E. W., Dennis, J., Devilee, P., Dörk, T., Dos-Santos-Silva, I., Dunning, A. M., Eicher, J. D., Fasching, P. A., Faul, J. D., Figueroa, J., Flesch-Janys, D., Gandin, I., Garcia, M. E., García-Closas, M., Giles, G. G., Girotto, G. G., Goldberg, M. S., González-Neira, A., Goodarzi, M. O., Grove, M. L., Gudbjartsson, D. F., Guénel, P., Guo, X., Haiman, C. A., Hall, P., Hamann, U., Henderson, B. E., Hocking, L. J., Hofman, A., Homuth, G., Hooning, M. J., Hopper, J. L., Hu, F. B., Huang, J., Humphreys, K., Hunter, D. J., Jakubowska, A., Jones, S. E., Kabisch, M., Karasik, D., Knight, J. A., Kolcic, I., Kooperberg, C., Kosma, V.-M., Kriebel, J., Kristensen, V., Lambrechts, D., Langenberg, C., Li, J., Li, X., Lindström, S., Liu, Y., Luan, J., Lubinski, J., Mägi, R., Mannermaa, A., Manz, J., Margolin, S., Marten, J., Martin, N. G., Masciullo, C., Meindl, A., Michailidou, K., Mihailov, E., Milani, L., Milne, R. L., Müller-Nurasyid, M., Nalls, M., Neale, B. M., Nevanlinna, H., Neven, P., Newman, A. B., Nordestgaard, B. G., Olson, J. E., Padmanabhan, S., Peterlongo, P., Peters, U., Petersmann, A., Peto, J., Pharoah, P. D. P., Pirastu, N. N., Pirie, A., Pistis, G., Polasek, O., Porteous, D., Psaty, B. M., Pylkäs, K., Radice, P., Raffel, L. J., Rivadeneira, F., Rudan, I., Rudolph, A., Ruggiero, D., Sala, C. F., Sanna, S., Sawyer, E. J., Schlessinger, D., Schmidt, M. K., Schmidt, F., Schmutzler, R. K., Schoemaker, M. J., Scott, R. A., Seynaeve, C. M., Simard, J., Sorice, R., Southey, M. C., Stöckl, D., Strauch, K., Swerdlow, A., Taylor, K. D., Thorsteinsdottir, U., Toland, A. E., Tomlinson, I., Truong, T., Tryggvadottir, L., Turner, S. T., Vozzi, D., Wang, Q., Wellons, M., Willemsen, G., Wilson, J. F., Winqvist, R., Wolffenbuttel, B. B. H. R., Wright, A. F., Yannoukakos, D., Zemunik, T., Zheng, W., Zygmunt, M., Bergmann, S., Boomsma, D. I., Buring, J. E., Ferrucci, L., Montgomery, G. W., Gudnason, V., Spector, T. D., van Duijn, C. M., Alizadeh, B. Z., Ciullo, M., Crisponi, L., Easton, D. F., Gasparini, P. P., Gieger, C., Harris, T. B., Hayward, C., Kardia, S. L. R., Kraft, P., McKnight, B., Metspalu, A., Morrison, A. C., Reiner, A. P., Ridker, P. M., Rotter, J. I., Toniolo, D., Uitterlinden, A. G., Ulivi, S., Völzke, H., Wareham, N. J., Weir, D. R., Yerges-Armstrong, L. M., Consortium, P., Investigators, K., Investigators, A., Scotland, G., Consortium, E.-I., Study, L. C., Price, A. L., Stefansson, K., Visser, J. A., Ong, K. K., Chang-Claude, J., Murabito, J. M., Perry, J. R. B. & Murray, A., Nov 2015, In: Nature Genetics. 47, 11, p. 1294—1303

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Prioritizing rare variants with conditional likelihood ratios

Li, W., Dobbins, S., Tomlinson, I., Houlston, R., Pal, D. K. & Strug, L. J., Mar 2015, In: Human Heredity. 79, 1, p. 5-13 9 p.

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4 Citations (Scopus)

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2014

Association analysis using next-generation sequence data from publicly available control groups: the robust variance score statistic

Derkach, A., Chiang, T., Gong, J., Addis, L., Dobbins, S., Tomlinson, I., Houlston, R., Pal, D. K. & Strug, L. J., 1 Aug 2014, In: BIOINFORMATICS. 30, 15, p. 2179-2188 10 p.

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24 Citations (Scopus)

AT-43 * MULTI-CENTRE, RANDOMIZED, DOUBLE-BLIND PHASE II STUDY COMPARING CEDIRANIB (AZD2171) PLUS GEFITINIB (IRESSA, ZD1839) WITH CEDIRANIB PLUS PLACEBO IN SUBJECTS WITH RECURRENT/PROGRESSIVE GLIOBLASTOMA

Mulholland, P., Krell, D., Khan, I., Mcbain, C., Patel, C., Wanek, K., Hopkins, K., Jeffries, S., Jager, R., Smith, P., Liu, Q., Stupp, R. & Tomlinson, I., 1 Nov 2014, In: NEURO-ONCOLOGY. 16, suppl 5, p. v18-v18

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2012

CYP3A variation, premenopausal estrone levels, and breast cancer risk

Johnson, N., Walker, K., Gibson, L. J., Orr, N., Folkerd, E., Haynes, B., Palles, C., Coupland, B., Schoemaker, M., Jones, M., Broderick, P., Sawyer, E., Kerin, M., Tomlinson, I. P., Zvelebil, M., Chilcott-Burns, S., Tomczyk, K., Simpson, G., Williamson, J. & Hillier, S. G. & 8 others, Ross, G., Houlston, R. S., Swerdlow, A., Ashworth, A., Dowsett, M., Peto, J., Dos Santos Silva, I. & Fletcher, O., 2 May 2012, In: Journal of the National Cancer Institute. 104, 9, p. 657-69 13 p.

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