Search results

• Active

  Halting prion-like propagation of tau by astrocyte-secreted chaperones

  Jimenez Sanchez, M. (Primary Investigator) & Mitchell, J. (Co-Investigator)

  Alzheimer's Research UK

  1/06/2025 → 31/05/2028

  Project: Research

• Nuclear to synaptic signalling dysregulation by Annexin A11 in ALS

  Smith, B. (Primary Investigator), Mitchell, J. (Co-Investigator), Mizielinska, S. (Co-Investigator), Ruepp, M.-D. (Co-Investigator), Troakes, C. (Co-Investigator) & Vance, C. (Co-Investigator)

  MNDA Motor Neurone Disease Association

  1/04/2025 → 31/03/2026

  Project: Research

• MNDSTaR (MND: MNDSTaR: The King's-LifeArc Solution for Motor Neurone Disease Target Validation

  Al Khleifat, A. (Primary Investigator), Al-Chalabi, A. (Co-Investigator), Iacoangeli, A. (Co-Investigator), Mitchell, J. (Co-Investigator) & Smith, B. (Co-Investigator)

  LifeArc

  1/05/2024 → 30/04/2026

  Project: Research

• Structural and functional studies of the VAPB-PTPIP51 ER-mitochondria tethering proteins in neurodegenerative diseases

  Miller, C. (Primary Investigator), Atherton, J. (Co-Investigator), Mitchell, J. (Co-Investigator), Noble, W. (Co-Investigator) & Vagnoni, A. (Co-Investigator)

  MRC Medical Research Council

  30/10/2023 → 29/10/2026

  Project: Research

• The Sigma-1 receptor and ER-mitochondria signaling in fronto-temporal dementia

  Miller, C. (Primary Investigator), Mitchell, J. (Co-Investigator) & Vagnoni, A. (Primary Investigator)

  Alzheimer's Research UK

  1/03/2018 → 31/12/2025

  Project: Research

• Finished

  Validating new promising drug targets in Amyotrophic Lateral Sclerosis

  Iacoangeli, A. (Primary Investigator), Al Khleifat, A. (Co-Investigator), Al-Chalabi, A. (Co-Investigator), Mitchell, J. (Co-Investigator), Smith, B. (Co-Investigator) & Sreedharan, J. (Co-Investigator)

  Alzheimer's Research UK

  1/01/2023 → 31/01/2025

  Project: Research

• Alzheimer’s Research UK London Network Centre Grant sub-project: Andrea Markovinovic

  Markovinovic, A. (Primary Investigator), Mitchell, J. (Co-Investigator) & Vance, C. (Co-Investigator)

  Alzheimer's Research UK

  1/01/2022 → 30/06/2024

  Project: Research

• Identifying ALS associated molecular and cellular changes in an Annexin A11 mutant knock-in mouse model

  Smith, B. (Primary Investigator), Mitchell, J. (Co-Investigator) & Vance, C. (Co-Investigator)

  Frick Foundation Frick Foundation for ALS Research

  1/03/2021 → 31/08/2024

  Project: Research

• Alzheimer’s Research UK King’s College London Network Centre Grant

  Bateman, J. (Primary Investigator), Aarsland, D. (Co-Investigator), Cash, D. (Co-Investigator), Fanto, M. (Co-Investigator), Giese, P. (Co-Investigator), Hanger, D. (Co-Investigator), Hirth, F. (Co-Investigator), Malcangio, M. (Co-Investigator), Miller, C. (Co-Investigator), Mitchell, J. (Co-Investigator), Mondal, M. (Co-Investigator), Noble, W. (Co-Investigator), Parsons, R. (Co-Investigator), Ruepp, M.-D. (Co-Investigator), Serrano Navacerrada, M. E. (Co-Investigator), So, P.-W. (Co-Investigator), Sreedharan, J. (Co-Investigator), Troakes, C. (Co-Investigator), Vagnoni, A. (Co-Investigator), Vance, C. (Co-Investigator), Vernon, A. (Co-Investigator) & academic, A. (Co-Investigator)

  Alzheimer's Research UK

  1/09/2020 → 30/09/2022

  Project: Research

• Endoplasmic reticulum (ER)-mitochondria signaling as a new therapeutic target for dementia.

  Miller, C. (Primary Investigator), Noble, W. (Co-Investigator), Mitchell, J. (Co-Investigator) & Vagnoni, A. (Co-Investigator)

  Alzheimer's Research UK

  1/08/2019 → 31/08/2024

  Project: Research

  • Endoplasmic reticulum 100%
  • Mitochondrion 100%

• Studying the role of TDP-43 induced damage to the VAPB-PTPIP51 ER-mitochondria tethers in fronto-temporal dementia/amyotrophic lateral sclerosis

  Miller, C. (Primary Investigator), Shaw, C. (Co-Investigator) & Mitchell, J. (Co-Investigator)

  MRC Medical Research Council

  1/10/2018 → 30/04/2023

  Project: Research

• Damage to ER-mitochondria signaling by fronto-temporal dementia and amyotrophic lateral sclerosis linked TDP-43

  Miller, C. (Primary Investigator), Mitchell, J. (Co-Investigator) & Shaw, C. (Co-Investigator)

  1/03/2018 → 28/02/2021

  Project: Research

• TDP disease - Investigating disease mechanisms in TDP-43 linked neurodegenerative disease

  Mitchell, J. (Primary Investigator)

  1/05/2017 → 30/04/2022

  Project: Research

• The role of post-translational modification in the pathogenesis of ALS-FUS and FTD-FUS

  Vance, C. (Primary Investigator), Miller, C. (Co-Investigator) & Mitchell, J. (Co-Investigator)

  1/10/2016 → 30/09/2019

  Project: Research

• Neuronal function of FUS: characterisation and determination of cell specific vulnerability

  Vance, C. (Primary Investigator), Mitchell, J. (Co-Investigator) & Srivastava, D. (Co-Investigator)

  1/10/2016 → 30/09/2019

  Project: Research

• Investigating mechanisms underlying TDP-43 linked neurodegenerative disease

  Mitchell, J. (Primary Investigator)

  1/04/2016 → 31/03/2021

  Project: Research

• Using organotypic slice cultures as an alternative to in vivo research to investigate developing pathology in a mouse model of motor neuron disease

  Mitchell, J. (Primary Investigator)

  1/01/2016 → 31/12/2018

  Project: Research

• Investigating the role of autophagy and the UPS in TDP-ALS

  Mitchell, J. (Primary Investigator) & Shaw, C. (Co-Investigator)

  Motor Neurone Disease Association

  1/04/2015 → 31/03/2018

  Project: Research

• Investigating the role of autophagy and the UPS in TDP-ALS

  Mitchell, J. (Primary Investigator) & Shaw, C. (Co-Investigator)

  1/09/2014 → 31/08/2017

  Project: Research

• Investigating the roles of RNA binding proteins in transgenic mouse neurons

  Vance, C. (Primary Investigator), Mitchell, J. (Co-Investigator) & Shaw, C. (Co-Investigator)

  1/10/2013 → 30/09/2016

  Project: Research