King's College London

Research portal

Dr James MacCabe

  1. A genome-wide association study in individuals of African ancestry reveals the importance of the Duffy-null genotype in the assessment of clozapine-related neutropenia

    Legge, S. E., Pardiñas, A. F., Helthuis, M., Jansen, J. A., Jollie, K., Knapper, S., MacCabe, J. H., Rujescu, D., Collier, D. A., O’Donovan, M. C., Owen, M. J. & Walters, J. T. R., 15 Jan 2019, In : Molecular Psychiatry.

    Research output: Contribution to journalArticle

  2. Negative symptoms in early-onset psychosis and their association with antipsychotic treatment failure

    Downs, J., Dean, H., Lechler, S., Sears, N., Patel, R., Shetty, H., Hotopf, M., Ford, T., Kyriakopoulos, M., Diaz-Caneja, C. M., Arango, C., MacCabe, J. H., Hayes, R. D. & Pina-Camacho, L., 1 Jan 2019, In : Schizophrenia Bulletin. 45, 1, p. 69-79 11 p.

    Research output: Contribution to journalArticle

  3. Accepted/In press

    Hyoscine for clozapine-induced hypersalivation: a double-blind, randomised, placebo-controlled crossover trial

    Segev, A., Evans, A., Hodsoll, J., Whiskey, E., Syed Sheriff, R., Shergill, S. S. & MacCabe, J. H., 10 Dec 2018, (Accepted/In press) In : International Clinical Psychopharmacology.

    Research output: Contribution to journalArticle

  4. Accepted/In press
  5. Neuropsychological function at first episode in treatment-resistant psychosis: Findings from the ÆsOP-10 study

    Kravariti, E., Demjaha, A., Zanelli, J., Ibrahim, F., Wise, C., Maccabe, J. H., Reichenberg, A., Pilecka, I., Morgan, K., Fearon, P., Morgan, C., Doody, G. A., Donoghue, K., Jones, P. B., Kaçar, A. Ş., Dazzan, P., Lappin, J. & Murray, R. M., 23 Oct 2018, In : Psychological Medicine.

    Research output: Contribution to journalArticle

  6. Constipation, ileus and medication use during clozapine treatment in patients with schizophrenia in Iceland

    Ingimarsson, O., MacCabe, J. H. & Sigurdsson, E., 22 Oct 2018, In : Nordic Journal of Psychiatry. p. 1-4 4 p.

    Research output: Contribution to journalArticle

  7. Biological predictors of clozapine response: A systematic review

    Samanaite, R., Gillespie, A., Sendt, K. V., McQueen, G., MacCabe, J. H. & Egerton, A., 26 Jul 2018, In : Frontiers in Psychiatry. 9, JUL, 327.

    Research output: Contribution to journalReview article

  8. Artistic creativity and risk for schizophrenia, bipolar disorder and unipolar depression: a Swedish population-based case-control study and sib-pair analysis

    MacCabe, J. H., Sariaslan, A., Almqvist, C., Lichtenstein, P., Larsson, H. & Kyaga, S., Jun 2018, In : The British journal of psychiatry : the journal of mental science. 212, 6, p. 370-376

    Research output: Contribution to journalArticle

  9. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

    Pardiñas, A. F., Holmans, P., Pocklington, A. J., Escott-Price, V., Ripke, S., Carrera, N., Legge, S. E., Bishop, S., Cameron, D., Hamshere, M. L., Han, J., Hubbard, L., Lynham, A., Mantripragada, K., Rees, E., MacCabe, J. H., McCarroll, S. A., Baune, B. T., Breen, G., Byrne, E. M. & 31 othersDannlowski, U., Eley, T. C., Hayward, C., Martin, N. G., McIntosh, A. M., Plomin, R., Porteous, D. J., Wray, N. R., Caballero, A., Geschwind, D. H., Huckins, L. M., Ruderfer, D. M., Santiago, E., Sklar, P., Stahl, E. A., Won, H., Agerbo, E., Als, T. D., Andreassen, O. A., Bækvad-Hansen, M., Mortensen, P. B., Pedersen, C. B., Børglum, A. D., Bybjerg-Grauholm, J., Djurovic, S., Durmishi, N., Pedersen, M. G., Golimbet, V., Grove, J., Collier, D. A. & GERAD1 Consortium:, 26 Feb 2018, In : Nature Genetics.

    Research output: Contribution to journalArticle

  10. Validation of an algorithm-based definition of treatment resistance in patients with schizophrenia

    Ajnakina, O., Horsdal, H. T., Lally, J., MacCabe, J. H., Murray, R. M., Gasse, C. & Wimberley, T., 19 Feb 2018, In : Schizophrenia Research.

    Research output: Contribution to journalArticle

  11. Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia

    Legge, S. E., Hamshere, M. L., Ripke, S., Pardinas, A. F., Goldstein, J. I., Rees, E., Richards, A. L., Leonenko, G., Jorskog, L. F., Chambert, K. D., Collier, D. A., Genovese, G., Giegling, I., Holmans, P., Jonasdottir, A., Kirov, G., McCarroll, S. A., MacCabe, J. H., Mantripragada, K., Moran, J. L. & 9 othersNeale, B. M., Stefansson, H., Rujescu, D., Daly, M. J., Sullivan, P. F., Owen, M. J., O'Donovan, M. C., Walters, J. T. R. & Clozapine-Induced Agranulocytosis Consortium, Jan 2018, In : Molecular Psychiatry. 23, 1, p. 162-163 2 p.

    Research output: Contribution to journalArticle

  12. Mortality and Self-Harm in Association With Clozapine in Treatment-Resistant Schizophrenia

    Wimberley, T., MacCabe, J. H., Laursen, T. M., Sørensen, H. J., Astrup, A., Horsdal, H. T., Gasse, C. & Støvring, H., 1 Oct 2017, In : The American Journal of Psychiatry. 174, 10, p. 990-998 9 p.

    Research output: Contribution to journalArticle

  13. The Use of Granulocyte Colony-Stimulating Factor in Clozapine Rechallenge: A Systematic Review

    Lally, J., Malik, S., Krivoy, A., Whiskey, E., Taylor, D. M., Gaughran, F. P., Flanagan, R. J., Mijovic, A. & Maccabe, J. H., 1 Oct 2017, In : Journal of Clinical Psychopharmacology. 37, 5, p. 600-604 5 p.

    Research output: Contribution to journalReview article

  14. Polygenic Risk Score for Schizophrenia and Treatment-Resistant Schizophrenia

    Wimberley, T., Gasse, C., Meier, S. M., Agerbo, E., MacCabe, J. H. & Horsdal, H. T., Sep 2017, In : Schizophrenia Bulletin. 43, 5, p. 1064–1069

    Research output: Contribution to journalArticle

  15. Risk of diabetes and dyslipidemia during clozapine and other antipsychotic drug treatment of schizophrenia in Iceland

    Ingimarsson, O., MacCabe, J. H., Haraldsson, M., Jónsdóttir, H. & Sigurdsson, E., 20 Jun 2017, In : Nordic Journal of Psychiatry. p. 1-7 7 p.

    Research output: Contribution to journalArticle

  16. Educational level, underachievement and general mental health problems in 10 866 adolescents

    Tempelaar, W. M., de Vos, N., Plevier, C. M., van Gastel, W. A., Termorshuizen, F., MacCabe, J. H. & Boks, M. P. M., 26 Apr 2017, In : Academic Pediatrics.

    Research output: Contribution to journalArticle

  17. Predictors of nonhospitalization and functional response in clozapine treatment: A nationwide, population-based cohort study

    Köhler-Forsberg, O., Horsdal, H. T., Legge, S. E., MacCabe, J. & Gasse, C., 1 Apr 2017, In : Journal of Clinical Psychopharmacology. 37, 2, p. 148-154 7 p.

    Research output: Contribution to journalArticle

  18. Effects of a smoking ban on clozapine plasma concentrations in a nonsecure psychiatric unit

    Gee, S. H., Taylor, D. M., Shergill, S. S., Flanagan, R. & MacCabe, J. H., 1 Feb 2017, In : Therapeutic Advances in Psychopharmacology. 7, 2, p. 79-83 5 p.

    Research output: Contribution to journalArticle

  19. Neutropenia and agranulocytosis during treatment of schizophrenia with clozapine versus other antipsychotics: an observational study in Iceland

    Ingimarsson, O., Maccabe, J. H., Haraldsson, M., Jónsdóttir, H. & Sigurdsson, E., 12 Dec 2016, In : BMC Psychiatry. 16, 1, 441.

    Research output: Contribution to journalArticle

  20. Treatment-Resistant Schizophrenia: Treatment Response and Resistance in Psychosis (TRRIP) Working Group Consensus Guidelines on Diagnosis and Terminology

    Howes, O. D., McCutcheon, R., Agid, O., de Bartolomeis, A., van Beveren, N. J. M., Birnbaum, M. L., Bloomfield, M. A. P., Bressan, R. A., Buchanan, R. W., Carpenter, W. T., Castle, D. J., Citrome, L., Daskalakis, Z. J., Davidson, M., Drake, R. J., Dursun, S., Ebdrup, B. H., Elkis, H., Falkai, P., Fleischacker, W. W. & 31 othersGadelha, A., Gaughran, F., Glenthøj, B. Y., Graff-Guerrero, A., Hallak, J. E. C., Honer, W. G., Kennedy, J., Kinon, B. J., Lawrie, S. M., Lee, J., Leweke, F. M., MacCabe, J. H., McNabb, C. B., Meltzer, H., Möller, H-J., Nakajima, S., Pantelis, C., Reis Marques, T., Remington, G., Rossell, S. L., Russell, B. R., Siu, C. O., Suzuki, T., Sommer, I. E., Taylor, D., Thomas, N., Üçok, A., Umbricht, D., Walters, J. T. R., Kane, J. & Correll, C. U., 6 Dec 2016, In : The American Journal of Psychiatry. appiajp201616050503.

    Research output: Contribution to journalArticle

  21. Educational achievement in psychiatric patients and their siblings: a register-based study in 30 000 individuals in The Netherlands

    Tempelaar, W. M., Termorshuizen, F., MacCabe, J. H., Boks, M. P. M. & Kahn, R. S., 22 Nov 2016, In : Psychological Medicine. 9 p.

    Research output: Contribution to journalArticle

  22. Schizophrenia

    Meyer, N. & MacCabe, J. H., 1 Nov 2016, In : Medicine. 44, 11, p. 649-653 5 p.

    Research output: Contribution to journalArticle

  23. SleepSight: A wearables-based relapse prevention system for Schizophrenia

    Kerz, M., Folarin, A., Meyer, N., Begale, M., MacCabe, J. & Dobson, R. J., 12 Sep 2016, UbiComp 2016 Adjunct - Proceedings of the 2016 ACM International Joint Conference on Pervasive and Ubiquitous Computing. Association for Computing Machinery, Inc, p. 113-116 4 p.

    Research output: Chapter in Book/Report/Conference proceedingConference paper

  24. Analysis of Intellectual Disability Copy Number Variants for Association With Schizophrenia

    Rees, E., Kendall, K., Pardiñas, A. F., Legge, S. E., Pocklington, A., Escott-Price, V., MacCabe, J. H., Collier, D. A., Holmans, P., O'Donovan, M. C., Owen, M. J., Walters, J. T. R. & Kirov, G., 1 Sep 2016, In : JAMA Psychiatry. 73, 9, p. 963-9 7 p.

    Research output: Contribution to journalArticle

  25. Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia

    Legge, S. E., Hamshere, M. L., Ripke, S., Pardinas, A. F., Goldstein, J. I., Rees, E., Richards, A. L., Leonenko, G., Jorskog, L. F., Chambert, K. D., Collier, D. A., Genovese, G., Giegling, I., Holmans, P., Jonasdottir, A., Kirov, G., McCarroll, S. A., MacCabe, J. H., Mantripragada, K., Moran, J. L. & 9 othersNeale, B. M., Stefansson, H., Rujescu, D., Daly, M. J., Sullivan, P. F., Owen, M. J., O'Donovan, M. C., Walters, J. T. R. & Clozapine-Induced Agranulocytosis Consortium, 12 Jul 2016, In : Molecular Psychiatry.

    Research output: Contribution to journalArticle

  26. Reasons for discontinuing clozapine: A cohort study of patients commencing treatment

    Legge, S. E., Hamshere, M., Hayes, R. D., Downs, J., O'Donovan, M. C., Owen, M. J., Walters, J. T. R. & MacCabe, J., 1 Jul 2016, In : Schizophrenia Research. 174, 1-3, p. 113-119 7 p.

    Research output: Contribution to journalArticle

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