King's College London

Research portal

Dr James Mason

  1. Modification of KL4 Peptide Revealed the Importance of Alpha-Helical Structure for Efficient Small Interfering RNA Delivery

    Qiu, Y., Lo, J., Kwok, K., Mason, J. & Lam, J. K. W., 29 Apr 2020, In : Nucleic Acid Therapeutics.

    Research output: Contribution to journalArticle

  2. Accepted/In press
  3. Synthetic antimicrobial peptide tuning permits membrane disruption and interpeptide synergy

    Fields, F., Manzo, G., Hind, C. K., Janardhanan, J., Foik, I., Do Carmo Silva, P., Balsara, R., Clifford, M., Vu, H., Ross, J., Kalwajtys, V., Gonzalez, A., Bui, T., Ploplis, V., Castellino, F., Siryaporn, A., Chang, M., Sutton, J. M., Mason, J. & Lee, S., 21 Feb 2020, In : ACS Pharmacology & Translational Science.

    Research output: Contribution to journalArticle

  4. Temporin L and aurein 2.5 have identical conformations but subtly distinct membrane and antibacterial activities

    Manzo, G., Ferguson, P. M., Hind, C. K., Clifford, M., Gustilo, V. B., Ali, H., Bansal, S., Bui, T., Drake, A. F., Atkinson, R. A., Sutton, J. M., Lorenz, C., Phoenix, D. & Mason, A. J., 1 Dec 2019, In : Scientific Reports. 9, 1, 10934.

    Research output: Contribution to journalArticle

  5. Histidine-Rich Cationic Cell-Penetrating Peptides for Plasmid DNA and siRNA Delivery

    Kichler, A., Mason, A. J., Marquette, A. & Bechinger, B., 6 Mar 2019, Methods in Molecular Biology: Nanotechnology for Nucleic Acid Delivery. 978-1-4939-9092-4: Springer, Vol. 1943. p. 39-59 21 p. (Methods in Molecular Biology; vol. 1943).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  6. Minor sequence modifications in temporin B cause drastic changes in antibacterial potency and selectivity by fundamentally altering membrane activity

    Manzo, G., Ferguson, P. M., Gustilo, V. B., Hind, C., Clifford, M., Bui, T., Drake, A., Atkinson, R. A., Sutton, J. M., Batoni, G., Lorenz, C., Phoenix, D. & Mason, A. J., 4 Feb 2019, In : Scientific Reports. 9, 1, 1385.

    Research output: Contribution to journalArticle

  7. Opportunistic bacteria confer the ability to ferment prebiotic starch in the adult cystic fibrosis gut

    Wang, Y., Leong, L. E. X., Keating, R. L., Kanno, T., Abell, G. C. J., Mobegi, F. M., Choo, J. M., Wesselingh, S. L., Mason, A. J., Burr, L. D. & Rogers, G. B., 2019, In : Gut Microbes. 19, 3, p. 367-381

    Research output: Contribution to journalArticle

  8. Erratum to: Antimicrobial Peptide Potency is Facilitated by Greater Conformational Flexibility when Binding to Gram-negative Bacterial Inner Membranes (Scientific Reports, (2016), 6, 1, (37639), 10.1038/srep37639)

    Amos, S. B. T. A., Vermeer, L. S., Ferguson, P. M., Kozlowska, J., Davy, M., Bui, T. T., Drake, A. F., Lorenz, C. D. & Mason, A. J., 1 Dec 2018, In : Scientific Reports. 8, 1, 17073.

    Research output: Contribution to journalComment/debate

  9. Minor sequence modifications in temporin B cause drastic changes in antibacterial potency and selectivity by fundamentally altering membrane activity

    Manzo, G., Ferguson, P. M., Gustilo, V. B., Hind, C., Clifford, M., Bui, T., Drake, A., Atkinson, R. A., Sutton, J. M., Batoni, G., Lorenz, C., Phoenix, D. & Mason, A. J., 1 May 2018, (bioRxiv).

    Research output: Working paperPre-print

  10. Cationic antimicrobial peptides do not change recombination frequency in Escherichia coli

    Rodríguez-Rojas, A., Moreno-Morales, J., Mason, A. J. & Rolff, J., 21 Mar 2018, In : BIOLOGY LETTERS. 14, 20180006, 20180006.

    Research output: Contribution to journalArticle

  11. Histidine-rich designer peptides of the LAH4 family promote cell delivery of a multitude of cargo

    Moulay, G., Leborgne, C., Mason, A. J., Aisenbrey, C., Kichler, A. & Bechinger, B., Apr 2017, In : JOURNAL OF PEPTIDE SCIENCE.

    Research output: Contribution to journalArticle

  12. Divergent Relationships between Fecal Microbiota and Metabolome following Distinct Antibiotic-Induced Disruptions

    Choo, J. M., Kanno, T., Mohd Zain, N. M., Leong, L. E. X., Abell, G. C. J., Keeble, J. E., Bruce, K. D., Mason, A. J. & Rogers, G. B., 8 Feb 2017, In : mSphere. 2, 16 p., 2:e00005-17.

    Research output: Contribution to journalArticle

  13. Incorporation of a Nuclear Localization Signal in pH Responsive LAH4-L1 Peptide Enhances Transfection and Nuclear Uptake of Plasmid DNA

    Xu, Y., Liang, W., Qiu, Y., Cespi, M., Palmieri, G., Mason, A. J. & Lam, J., 26 Jul 2016, In : Molecular Pharmaceutics.

    Research output: Contribution to journalArticle

  14. Inhalable spray-dried formulation of D-LAK antimicrobial peptides targeting tuberculosis

    Kwok, P. C. L., Grabarek, A., Chow, M. Y. T., Lan, Y., Li, J. C. W., Casettari, L., Mason, A. J. & Lam, J. K. W., 13 Jul 2015, In : INTERNATIONAL JOURNAL OF PHARMACEUTICS. 491, 1-2, p. 367-374 8 p.

    Research output: Contribution to journalArticle

  15. New Techniques to Assess In Vitro Release of siRNA from Nanoscale Polyplexes

    Krieg, B., Hirsch, M., Scholz, E., Nuhn, L., Tabujew, I., Bauer, H., Decker, S., Khobta, A., Schmidt, M., Tremel, W., Zentel, R., Peneva, K., Koynov, K., Mason, J. & Helm, M., 1 Jun 2015, In : Pharmaceutical Research. 32, 6, p. 1957-1964 18 p.

    Research output: Contribution to journalArticle

  16. Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice

    Rogers, G. B., Kozlowska, J., Keeble, J., Metcalfe, K., Fao, M., Dowd, S. E., Mason, A. J., McGuckin, M. A. & Bruce, K. D., 2015, In : Scientific Reports. 4, 5 p., 5437.

    Research output: Contribution to journalArticle

  17. Inhalable dry powder formulations of siRNA and pH responsive peptides with antiviral activity against H1N1 influenza virus

    Liang, W., Chow, M. Y. T., Lau, P. N., Zhou, Q. T., Kwok, P. C. L., Leung, G. P. H., Mason, J., Chan, H-K., Poon, L. L. M. & Lam, J. K. W., 2015, In : Mol. Pharm.. 12 p.

    Research output: Contribution to journalArticle

  18. Cationic amphipathic D-enantiomeric antimicrobial peptides with in vitro and ex vivo activity against drug-resistant Mycobacterium tuberculosis

    Lan, Y., Lam, J., Siu, G., Yam, W. C., Mason, J. & Lam, J., Dec 2014, In : TUBERCULOSIS. 94, 6, p. 678-689 12 p.

    Research output: Contribution to journalArticle

  19. Combined Systems Approaches Reveal Highly Plastic Responses to Antimicrobial Peptide Challenge in Escherichia coli

    Kozlowska, J., Vermeer, L., Rogers, G., Rehnnuma, N., Amos, S-B., Koller, G., McArthur, M., Bruce, K. & Mason, J., 1 May 2014, In : PLoS Pathogens. 10, 5, 14 p., e1004104.

    Research output: Contribution to journalArticle

  20. Formulation of pH responsive peptides as inhalable dry powders for pulmonary delivery of nucleic acids

    Liang, W., Kwok, P., Chow, M. Y. T., Tang, P., Mason, J., Chan, H-K. & Lam, J., Jan 2014, In : EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 86, 1, p. 64-73 10 p.

    Research output: Contribution to journalArticle

  21. Manipulating the pH response of 2,3-diaminopropionic acid rich peptides to mediate highly effective gene silencing with low-toxicity

    Abbate, V., Liang, W., Patel, J., Lan, Y., Capriotti, L., Iacobucci, V., Bui, T., Chaudhuri, P., Kudsiova, L., Vermeer, L., Chan, P., Kong, X., Drake, A., Lam, J., Bansal, S. & Mason, J., 28 Dec 2013, In : JOURNAL OF CONTROLLED RELEASE. 172, 3, p. 929-938 10 p., N/A.

    Research output: Contribution to journalArticle

  22. Conformational flexibility determines selectivity and antibacterial, antiplasmodial and anticancer potency of cationic α-helical peptides

    Vermeer, L., Lan, Y., Abbate, V., Ruh, E., Bui, T., Wilkinson, L., Kanno, T., Jumagulova, E., Kozlowska, J., Patel, J., McIntyre, C. A., Yam, WC., Siu, G., Atkinson, R. A., Lam, J., Bansal, S., Drake, A., Mitchell, G. H. & Mason, J., 5 Oct 2012, In : Journal of Biological Chemistry. 287, 41, p. 34120-34133 14 p.

    Research output: Contribution to journalArticle

  23. Lipid-peptide vesicle nanoscale hybrids for triggered drug release by mild hyperthermia in vitro and in vivo

    Al-Ahmady, Z. S., Al-Jamal, W. T., Bossche, J. V., Bui, T. T., Drake, A. F., Mason, A. J. & Kostarelos, K., Oct 2012, In : ACS Nano. 6, 10, p. 9335-9346 12 p.

    Research output: Contribution to journalArticle

  24. Control of pH responsive peptide self-association during endocytosis is required for effective gene transfer.

    Iacobucci, V., Di Giuseppe, F., Bui, T. T., Vermeer, L. S., Patel, J., Scherman, D., Kichler, A., Drake, A. F. & Mason, J., May 2012, In : BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 1818, 5, p. 1332-1341 10 p.

    Research output: Contribution to journalArticle

  25. Effective endogenous gene silencing mediated by pH responsive peptides proceeds via multiple pathways

    Lam, J. K. W., Liang, W., Lan, Y., Chaudhuri, P., Chow, M. Y. T., Witt, K., Kudsiova, L. & Mason, A. J., 10 Mar 2012, In : JOURNAL OF CONTROLLED RELEASE. 158, 2, p. 293 - 303 11 p.

    Research output: Contribution to journalArticle

  26. Structural contributions to the intracellular targeting strategies of antimicrobial peptides

    Lan, Y., Ye, Y., Kozlowska, J., Lam, J., Drake, A. & Mason, J., Oct 2010, In : Biochimica et Biophysica Acta. 1798, 10, p. 1934-1943 10 p.

    Research output: Contribution to journalArticle

  27. Design and Evaluation of Histidine-Rich Amphipathic Peptides for siRNA Delivery

    Langlet-Bertin, B., Leborgne, C., Scherman, D., Bechinger, B., Mason, A. J. & Kichler, A., Jul 2010, In : Pharmaceutical Research. 27, 7, p. 1426 - 1436 11 p.

    Research output: Contribution to journalArticle

  28. Incorporation of 2,3-Diaminopropionic Acid into Linear Cationic Amphipathic Peptides Produces pH-Sensitive Vectors

    Lan, Y., Langlet-Bertin, B., Abbate, V., Vermeer, L. S., Kong, X., Sullivan, K. E., Leborgne, C., Scherman, D., Hider, R. C., Drake, A. F., Bansal, S. S., Kichler, A. & Mason, A. J., 14 Jun 2010, In : Chembiochem : a European journal of chemical biology. 11, 9, p. 1266 - 1272 7 p.

    Research output: Contribution to journalArticle

  29. Incorporation of 2,3-diaminopropionic acid in linear cationic amphipathic peptides produces pH sensitive vectors

    Lan, Y., Langlet-Bertin, B., Abbate, V., Vermeer, L., King, X., Sullivan, K., Leborgne, C., Scherman, D., Hider, RC., Drake, AF., Bansal, S., Kichler, A. & Mason, AJ., 14 Jun 2010, In : CHEMBIOCHEM. 11, 9, p. 1266 - 1272 7 p.

    Research output: Contribution to journalArticle

  30. Membrane order perturbation in the presence of antimicrobial peptides by H-2 solid-state NMR spectroscopy

    Salnikov, E. S., Mason, A. J. & Bechinger, B., Jun 2009, In : Biochimie. 91, 6, p. 734-743 10 p.

    Research output: Contribution to journalArticle

  31. Structural Determinants of Antimicrobial and Antiplasmodial Activity and Selectivity in Histidine-rich Amphipathic Cationic Peptides

    Mason, A. J., Moussaoui, W., Abdelrahman, T., Boukhari, A., Bertani, P., Marquette, A., Shooshtarizaheh, P., Moulay, G., Boehm, N., Guerold, B., Sawers, R. J. H., Kichler, A., Metz-Boutigue, M-H., Candolfi, E., Prevost, G. & Bechinger, B., 2 Jan 2009, In : Journal of Biological Chemistry. 284, 1, p. 119 - 133 15 p.

    Research output: Contribution to journalArticle

  32. Membrane-disordering in the presence of antimicrobial peptides by 2H solid-state NMR spectroscopy

    Salnikov, ES., Mason, AJ. & Bechinger, B., 2009, In : Biochimie. 91, p. 734 - 743 10 p.

    Research output: Contribution to journalArticle

  33. Aggregation and membrane permeabilising properties of designed histidine-containing cationic linear peptide antibiotics

    Marquette, A., Mason, AJ. & Bechinger, B., 2008, In : JOURNAL OF PEPTIDE SCIENCE. 14, p. 488 - 495 8 p.

    Research output: Contribution to journalArticle

  34. Membrane interaction of chrysophsin-1, a histidine-rich antimicrobial peptide from red sea bream

    Mason, A. J., Bertani, P., Moulay, G., Marquette, A., Perrone, B., Drake, A. F., Kichler, A. & Bechinger, B., 25 Dec 2007, In : Biochemistry. 46, 51, p. 15175 - 15187 13 p.

    Research output: Contribution to journalArticle

  35. Zwitterionic phospholipids and sterols modulate antimicrobial peptide-induced membrane destabilization

    Mason, A. J., Marquette, A. & Bechinger, B., 15 Dec 2007, In : Biophysical Journal. 93, 12, p. 4289 - 4299 11 p.

    Research output: Contribution to journalArticle

  36. Rational design of vector and antibiotic peptides using solid-state NMR

    Mason, AJ., Bechinger, B. & Kichler, A., May 2007, In : MINI-REVIEWS IN MEDICINAL CHEMISTRY. 7, 5, p. 491 - 497 7 p.

    Research output: Contribution to journalArticle

  37. Rational design of vector and antibiotic peptides using solid-state NMR

    Mason, AJ., Bechinger, B. & Kichler, A., May 2007, In : MINI-REVIEWS IN MEDICINAL CHEMISTRY. 7, 5, p. 491 - 497 7 p.

    Research output: Contribution to journalLiterature review

  38. Optimising histidine rich peptides for efficient DNA delivery in the presence of serum

    Mason, AJ., Leborgne, C., Moulay, G., Martinez, A. & Bechinger Danos, B., 12 Mar 2007, In : JOURNAL OF CONTROLLED RELEASE. 118, 1, p. 95 - 104 10 p.

    Research output: Contribution to journalArticle

  39. Separated local field NMR experiments on oriented samples rotating at the magic angle

    Lopez, JJ., Mason, AJ., Kaiser, C. & Glaubitz, C., Feb 2007, In : Journal of Biomolecular NMR. 37, 2, p. 97 - 111 15 p.

    Research output: Contribution to journalArticle

  40. The membrane interaction of Chrysophsin-1, a histidine rich antimicrobial peptide from red sea bream

    Mason, AJ., Bertani, P., Moulay, G., Marquette, A., Perrone, B., Drake, AF., Kichler, A. & Bechinger, B., 2007, In : Biochemistry. 46, 51, p. 15175 - 15187 13 p.

    Research output: Contribution to journalArticle

  41. Enhanced membrane disruption and antibiotic action against pathogenic bacteria by designed histidine-rich peptides at acidic pH

    Mason, AJ., Gasnier, C., Kichler, A., Prévost, G., Aunis, D., Metz-Boutigue, MH. & Bechinger, B., Oct 2006, In : Antimicrobial Agents and Chemotherapy. 50, 10, p. 3305 - 3311 7 p.

    Research output: Contribution to journalArticle

  42. A spectroscopic study of the membrane interaction of the antimicrobial peptide Pleurocidin

    Mason, AJ., Chotimah, INH., Bertani, P. & Bechinger, B., Mar 2006, In : Molecular Membrane Biology. 23, 2, p. 185 - 194 10 p.

    Research output: Contribution to journalArticle

  43. Cationic amphipathic histidine-rich peptides for gene delivery

    Kichler, A., Mason, AJ. & Bechinger, B., Mar 2006, In : Biochimica et Biophysica Acta. 1758, 3, p. 301 - 307 7 p.

    Research output: Contribution to journalLiterature review

  44. The antibiotic and DNA transfecting peptide LAH4 selectively associates with, and disorders, anionic lipids in mixed membranes

    Mason, AJ., Martinez, A., Glaubitz, C., Danos, O., Kichler, A. & Bechinger, B., Feb 2006, In : Faseb Journal. 20, 2, p. 320 - 322 3 p.

    Research output: Contribution to journalArticle

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