Research interests involve the application of both in vivo and in vitro physiological and molecular techniques to investigate the response of the myocardium to the stresses of ischaemia, reperfusion and trophy. My current research programme addresses how the activation of both protective and detrimental signalling pathways may influence the outcome of these stresses. This includes studies on the role and function of p38-mitogen-activated protein kinase in cardioprotection/injury, the physiological mechanisms and adaptations during the development of heart failure and the application of novel techniques for measuring cardiac haemodynamics and contractility.

Areas of interest include:

• The signaling pathways involved in carbon monoxide (CO)-mediated cardiac protection,
• The role of the p38-MAP kinase isoforms in cardiac physiology,
• The involvement of mTORC1 and mTORC2 in cardiac trophy during physiological and patho-physiological loading and unloading of the heart,
• Developing and characterizing new methodologies for measuring cardiac function in murine models.

The response of the myocardium to the stresses of ischaemia, reperfusion and trophic signalling.