James Clark

James Clark

Professor, Dr, BSc (Hons)

  • Phone020 7848 7364
  • United Kingdom

  • 1576

Personal profile

Research interests

Research interests involve the application of both in vivo and in vitro physiological and molecular techniques to investigate the response of the myocardium to the stresses of ischaemia, reperfusion and trophy. My current research programme addresses how the activation of both protective and detrimental signalling pathways may influence the outcome of these stresses. This includes studies on the role and function of p38-mitogen-activated protein kinase in cardioprotection/injury, the physiological mechanisms and adaptations during the development of heart failure and the application of novel techniques for measuring cardiac haemodynamics and contractility.

Areas of interest include:

  • The signaling pathways involved in carbon monoxide (CO)-mediated cardiac protection,
  • The role of the p38-MAP kinase isoforms in cardiac physiology,
  • The involvement of mTORC1 and mTORC2 in cardiac trophy during physiological and patho-physiological loading and unloading of the heart,
  • Developing and characterizing new methodologies for measuring cardiac function in murine models.

Research interests (short)

The response of the myocardium to the stresses of ischaemia, reperfusion and trophic signalling.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Surgery, Doctor of Philosophy, Role of the Haem Oxygenase Pathway in Protection against Vascular Dysfunction, UCL University College London


Award Date: 1 Jan 2000

Applied Biology, Bachelor of Science, University of Bath


Award Date: 1 Jul 1995

External positions

Brand Ambassador for Lt, AD Instruments

Sept 2019 → …

University Representative, Physiological Society

Aug 2019 → …

Education Consultant, GraphPad

Dec 2018 → …


  • QP Physiology
  • Cardiovascular Physiology
  • heart failure
  • infarction
  • cardioprotection
  • Cardiac muscle
  • hypertrophy
  • in vivo models
  • ischaemia
  • remodelling
  • trophy
  • RD Surgery
  • in vivo models
  • ischaemia
  • infarction
  • cardiac function
  • Imaging
  • physiology
  • remodelling


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