Research output per year
Research output per year
Personal profile
Research interests
Research interests involve the application of both in vivo and in vitro physiological and molecular techniques to investigate the response of the myocardium to the stresses of ischaemia, reperfusion and trophy. My current research programme addresses how the activation of both protective and detrimental signalling pathways may influence the outcome of these stresses. This includes studies on the role and function of p38-mitogen-activated protein kinase in cardioprotection/injury, the physiological mechanisms and adaptations during the development of heart failure and the application of novel techniques for measuring cardiac haemodynamics and contractility.
Areas of interest include:
- The signaling pathways involved in carbon monoxide (CO)-mediated cardiac protection,
- The role of the p38-MAP kinase isoforms in cardiac physiology,
- The involvement of mTORC1 and mTORC2 in cardiac trophy during physiological and patho-physiological loading and unloading of the heart,
- Developing and characterizing new methodologies for measuring cardiac function in murine models.
Research interests (short)
The response of the myocardium to the stresses of ischaemia, reperfusion and trophic signalling.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Surgery, Doctor of Philosophy, Role of the Haem Oxygenase Pathway in Protection against Vascular Dysfunction, UCL University College London
1995 → 1999
Award Date: 1 Jan 2000
Applied Biology, Bachelor of Science, University of Bath
1991 → 1995
Award Date: 1 Jul 1995
External positions
Brand Ambassador for Lt, AD Instruments
Sept 2019 → …
University Representative, Physiological Society
Aug 2019 → …
Education Consultant, GraphPad
Dec 2018 → …
Keywords
- QP Physiology
- Cardiovascular Physiology
- heart failure
- infarction
- cardioprotection
- Cardiac muscle
- hypertrophy
- in vivo models
- ischaemia
- remodelling
- trophy
- RD Surgery
- in vivo models
- ischaemia
- infarction
- cardiac function
- Imaging
- physiology
- remodelling
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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p38γ MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin
Loonat, A. A., Martin, E. D., Sarafraz-Shekary, N., Tilgner, K., Hertz, N. T., Levin, R., Shokat, K. M., Burlingame, A. L., Arabacilar, P., Uddin, S., Thomas, M., Marber, M. S. & Clark, J. E., 31 Dec 2019, In: Faseb Journal. 33, 12, p. 13131-13144 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)265 Downloads (Pure) -
Tissue acidosis does not mediate the hypoxia selectivity of [64Cu][Cu(ATSM)] in the isolated perfused rat heart
Baark, F., Shaughnessy, F., Pell, V. R., Clark, J. E., Eykyn, T. R., Blower, P. & Southworth, R., 24 Jan 2019, In: Scientific Reports. 9, 10 p., 499.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)241 Downloads (Pure) -
Detection of anthracycline-induced cardiotoxicity using perfusion-corrected 99mTc sestamibi SPECT
Safee, Z. M., Baark, F., Waters, E. C. T., Veronese, M., Pell, V. R., Clark, J. E., Mota, F., Livieratos, L., Eykyn, T. R., Blower, P. J. & Southworth, R., 2019, In: Scientific Reports. 9, p. 216-227 11 p., 216.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)244 Downloads (Pure) -
Aged-senescent cells contribute to impaired heart regeneration
Lewis-McDougall, F. C., Ruchaya, P. J., Domenjo-Vila, E., Teoh, T. S., Prata, L., Cottle, B. J., Clark, J. E., Punjabi, P. P., Awad, W., Torella, D., Tchkonia, T., Kirkland, J. L. & Ellison-Hughes, G. M., Jun 2019, In: AGING CELL. 18, 3, e12931.Research output: Contribution to journal › Article › peer-review
Open AccessFile223 Citations (Scopus)416 Downloads (Pure) -
Dynamic heart rate response to multi-day unsupported ultra-endurance cycle racing: a case report
Brayson, D., Frigiola, A. & Clark, J. E., 12 Dec 2018, (Accepted/In press) In: Experimental Physiology.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus)
Projects
- 13 Finished
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Curtailing maladaptive cardiac hypertrophy with inhibitors against the surface-expressed NBCn1 (Slc4a7) protein: a novel and accessible anti-hypertrophic target with reduced burden of side-effects
Clark, J. (Primary Investigator)
1/02/2022 → 31/01/2025
Project: Research
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Development of new hypoxia-avid PET agents for the imaging of chronic cardiovascular disease
Southworth, R. (Primary Investigator), Blower, P. (Co-Investigator), Clark, J. (Co-Investigator) & Eykyn, T. (Co-Investigator)
1/01/2017 → 31/12/2019
Project: Research
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Comparison between Propofol and Inhaled Anaesthesia on cardiovascular morbidity and mortality following cardiac surgery (COPIA) - a Multicentre Randomised Controlled Trial
academic, A. (Primary Investigator), Clark, J. (Co-Investigator), Marber, M. (Co-Investigator) & Mayr, M. (Co-Investigator)
1/05/2015 → 30/04/2016
Project: Research
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Non-invasive PET imaging of microvascular disease and cardiac hypertrophy by hypoxia-specific copper bis(thiosemicarbazones)
Southworth, R. (Primary Investigator), Blower, P. (Co-Investigator), Chiribiri, A. (Co-Investigator), Clark, J. (Co-Investigator) & Eykyn, T. (Co-Investigator)
1/10/2014 → 1/10/2017
Project: Research
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USING COMPUTATION, METABOLOMICS AND NEXT GENERATION SEQUENCING TO STUDY THE METABOLISM OF THE FAILING HEART
Edwards, L. (Primary Investigator), Clark, J. (Co-Investigator), Shattock, M. (Co-Investigator) & Weale, M. (Co-Investigator)
1/05/2014 → 30/04/2017
Project: Research
Activities
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Teaching physiology: Past, present, and future
Clark, J. (Speaker)
12 Jul 2021Activity: Talk or presentation › Invited talk
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Educating Through COVID19
Clark, J. (Speaker)
23 Sept 2020Activity: Talk or presentation › Invited talk
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Study Medical physiology BSc at King's College London
Clark, J. (Reviewer)
17 Apr 2020Activity: Other › Types of Public engagement and outreach - Media article or participation
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Human & Applied Physiology MSc @ King's College London
Clark, J. (Reviewer)
23 Jan 2020Activity: Other › Types of Public engagement and outreach - Media article or participation
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Diving and Hyperbaric Physiology – What Don’t We Know?
Clark, J. (Speaker)
18 Nov 2019Activity: Talk or presentation › Invited talk
Thesis
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Role of the Haem Oxygenase Pathway in Protection against Vascular Dysfunction
Clark, J. (Author), Motterlini, R. (Supervisor), 28 Dec 2000Student thesis: Doctoral Thesis › Doctor of Philosophy
Prizes
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King's Award - Most Innovative Teacher
Clark, J. (Recipient), 21 Nov 2017
Prize: Prize (including medals and awards)
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Otto Hutter Prize for teaching Excellence
Clark, J. (Recipient), 24 Dec 2019
Prize: National/international honour